Location: FCU_ExcitationContraction_Coupling @ b0053261d627 / FCU_EC_coupling_Exported_flat.cellml
- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2022-01-28 09:04:00+13:00
- Desc:
- With crossbridge_TRPN module
- Permanent Source URI:
- https://models.cellml.org/workspace/8a0/rawfile/b0053261d627657778bfeb4174d9dc011e0a926c/FCU_EC_coupling_Exported_flat.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="FCU_EC_coupling" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#">
<units name="per_sec">
<unit exponent="-1" units="second"/>
</units>
<units name="J_per_K_per_mol">
<unit units="joule"/>
<unit exponent="-1" units="kelvin"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="C_per_mol">
<unit units="coulomb"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="J_per_C">
<unit units="joule"/>
<unit exponent="-1" units="coulomb"/>
</units>
<units name="fmol">
<unit prefix="femto" units="mole"/>
</units>
<units name="fF">
<unit prefix="femto" units="farad"/>
</units>
<units name="fC">
<unit prefix="femto" units="coulomb"/>
</units>
<units name="fA">
<unit prefix="femto" units="ampere"/>
</units>
<units name="fmol_per_L">
<unit prefix="femto" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="fmol_per_L_per_sec">
<unit units="fmol_per_L"/>
<unit exponent="-1" units="second"/>
</units>
<units name="per_sec_per_fmol_per_L">
<unit exponent="-1" units="second"/>
<unit exponent="-1" units="fmol_per_L"/>
</units>
<units name="per_fmol">
<unit exponent="-1" units="fmol"/>
</units>
<units name="fmol_per_sec">
<unit units="fmol"/>
<unit exponent="-1" units="second"/>
</units>
<units name="J_per_mol">
<unit units="joule"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="mM">
<unit prefix="milli" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="uM">
<unit prefix="micro" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="mM_per_sec">
<unit units="mM"/>
<unit exponent="-1.0" units="second"/>
</units>
<units name="uM_per_sec">
<unit units="uM"/>
<unit exponent="-1.0" units="second"/>
</units>
<units name="pL">
<unit prefix="pico" units="litre"/>
</units>
<units name="m_to_u">
<unit prefix="micro" units="second"/>
<unit prefix="milli" units="second"/>
</units>
<component name="BG_parameters">
<variable initial_value="45.5263" name="kappa_PLBph1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="6.55904" name="kappa_PLBph2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.386674" name="kappa_PLBd1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.21269" name="kappa_PLBd2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="431.435" name="kappa_Inh" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.80718e-05" name="kappa_SERCA_R1_2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="109628" name="kappa_SERCA_R2_4" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2.08432e+06" name="kappa_SERCA_R2_2a" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="109628" name="kappa_SERCA_R4_5" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3974.36" name="kappa_SERCA_R5_6" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.35422e+06" name="kappa_SERCA_R6_8" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.43841e+07" name="kappa_SERCA_R8_9" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.43841e+07" name="kappa_SERCA_R9_10" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00842322" name="kappa_SERCA_R10_1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.8838e+06" name="kappa_RyR" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="8.83262" name="kappa_OC" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.12618" name="kappa_CCI" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="883.262" name="kappa_CII" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="73.6052" name="kappa_IO" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="10.2101" name="kappa_Ca1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="19.0927" name="kappa_Ca2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0968812" name="kappa_K1" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.181165" name="kappa_K2" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="812.745" name="kappa_d000" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="20.0517" name="kappa_d010" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="37.4961" name="kappa_d020" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.190685" name="kappa_d001" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0047045" name="kappa_d011" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00879728" name="kappa_d021" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.49728" name="kappa_f1_000" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="7.43512" name="kappa_f1_100" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00035129" name="kappa_f1_001" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00174442" name="kappa_f1_101" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="2.74219" name="kappa_f2_000" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="13.617" name="kappa_f2_100" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.000643368" name="kappa_f2_001" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0031948" name="kappa_f2_101" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="7703.17" name="kappa_f3_010" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="38252" name="kappa_f3_110" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1.80731" name="kappa_f3_011" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="8.97463" name="kappa_f3_111" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="65290.3" name="kappa_fCa000" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="324215" name="kappa_fCa100" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="1610.82" name="kappa_fCa010" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="7998.9" name="kappa_fCa110" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="3012.18" name="kappa_fCa020" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="14957.7" name="kappa_fCa120" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="232.12" name="kappa_R_TRPNCa" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00235741" name="K_PLB" public_interface="out" units="per_fmol"/>
<variable initial_value="0.395191" name="K_PKACI" public_interface="out" units="per_fmol"/>
<variable initial_value="0.638527" name="K_PLB_PKACI" public_interface="out" units="per_fmol"/>
<variable initial_value="0.361989" name="K_PP1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.203757" name="K_PLBp_PP1" public_interface="out" units="per_fmol"/>
<variable initial_value="0.326014" name="K_PLBp" public_interface="out" units="per_fmol"/>
<variable initial_value="5.41093" name="K_Ip" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0673793" name="K_Ip_PP1" public_interface="out" units="per_fmol"/>
<variable initial_value="853.972" name="K_P1_SERCA" public_interface="out" units="per_fmol"/>
<variable initial_value="3243" name="K_P2_SERCA" public_interface="out" units="per_fmol"/>
<variable initial_value="361.225" name="K_P2a_SERCA" public_interface="out" units="per_fmol"/>
<variable initial_value="6867.82" name="K_P4_SERCA" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0185784" name="K_P5_SERCA" public_interface="out" units="per_fmol"/>
<variable initial_value="2789.64" name="K_P6_SERCA" public_interface="out" units="per_fmol"/>
<variable initial_value="47.7378" name="K_P8_SERCA" public_interface="out" units="per_fmol"/>
<variable initial_value="52.3431" name="K_P9_SERCA" public_interface="out" units="per_fmol"/>
<variable initial_value="70.7485" name="K_P10_SERCA" public_interface="out" units="per_fmol"/>
<variable initial_value="297.061" name="K_H" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0464875" name="K_Cai" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0992057" name="K_Ca_SR" public_interface="out" units="per_fmol"/>
<variable initial_value="1418.2" name="K_MgATP" public_interface="out" units="per_fmol"/>
<variable initial_value="5.12197e-06" name="K_MgADP" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0175044" name="K_P" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0992057" name="K_Ca_di" public_interface="out" units="per_fmol"/>
<variable initial_value="115.191" name="K_C_RyR" public_interface="out" units="per_fmol"/>
<variable initial_value="1.15191" name="K_CI_RyR" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00197471" name="K_I_RyR" public_interface="out" units="per_fmol"/>
<variable initial_value="0.197471" name="K_O_RyR" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0464875" name="K_Cao" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00385122" name="K_Ki" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00385122" name="K_Ko" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0174102" name="K_000_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="0.705678" name="K_010_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="0.377374" name="K_020_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00350606" name="K_100_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="0.142109" name="K_110_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0759954" name="K_120_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="74.2064" name="K_001_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="3007.77" name="K_011_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="1608.46" name="K_021_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="14.9436" name="K_101_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="605.703" name="K_111_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="323.91" name="K_121_LCC" public_interface="out" units="per_fmol"/>
<variable initial_value="7.83132" name="K_TRPN" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0250472" name="K_Ca_TRPN" public_interface="out" units="per_fmol"/>
</component>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
<variable initial_value="34.4" name="vol_myo" public_interface="out" units="pL"/>
<variable initial_value="500" name="freq" units="dimensionless"/>
<variable initial_value="1.381e5" name="C_m" public_interface="out" units="fF"/>
<variable initial_value="-13039" name="q_membrane" public_interface="out" units="fC"/>
<variable initial_value="-0.08" name="V_m" public_interface="out" units="volt"/>
<variable initial_value="1.381e5" name="C_m" units="fF"/>
<variable name="v_RyR" public_interface="in" units="fmol_per_sec"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable initial_value="1.888e-1" name="q_PLB_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_PKACI_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_PLB_PKACI_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_PP1_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_PLBp_PP1_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_PLBp_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_Ip_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_Ip_PP1_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_P1_SERCA_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_P2_SERCA_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_P2a_SERCA_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_P4_SERCA_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_P5_SERCA_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_P6_SERCA_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_P8_SERCA_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_P9_SERCA_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_P10_SERCA_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_H_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_Cai_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_MgATP_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_MgADP_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_P_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_Ca_SR_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_Ca_di_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_Cai_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_Cao_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_Ki_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_Ko_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_TRPN_init" units="fmol"/>
<variable initial_value="1.888e-1" name="q_Ca_TRPN_init" units="fmol"/>
<variable name="q_PLB" public_interface="out" units="fmol"/>
<variable name="q_PKACI" public_interface="out" units="fmol"/>
<variable name="q_PLB_PKACI" public_interface="out" units="fmol"/>
<variable name="q_PP1" public_interface="out" units="fmol"/>
<variable name="q_PLBp_PP1" public_interface="out" units="fmol"/>
<variable name="q_PLBp" public_interface="out" units="fmol"/>
<variable name="q_Ip" public_interface="out" units="fmol"/>
<variable name="q_Ip_PP1" public_interface="out" units="fmol"/>
<variable name="q_P1_SERCA" public_interface="out" units="fmol"/>
<variable name="q_P2_SERCA" public_interface="out" units="fmol"/>
<variable name="q_P2a_SERCA" public_interface="out" units="fmol"/>
<variable name="q_P4_SERCA" public_interface="out" units="fmol"/>
<variable name="q_P5_SERCA" public_interface="out" units="fmol"/>
<variable name="q_P6_SERCA" public_interface="out" units="fmol"/>
<variable name="q_P8_SERCA" public_interface="out" units="fmol"/>
<variable name="q_P9_SERCA" public_interface="out" units="fmol"/>
<variable name="q_P10_SERCA" public_interface="out" units="fmol"/>
<variable name="q_H" public_interface="out" units="fmol"/>
<variable name="q_Cai" public_interface="out" units="fmol"/>
<variable name="q_MgATP" public_interface="out" units="fmol"/>
<variable name="q_MgADP" public_interface="out" units="fmol"/>
<variable name="q_P" public_interface="out" units="fmol"/>
<variable name="q_Ca_SR" public_interface="out" units="fmol"/>
<variable name="q_Ca_di" public_interface="out" units="fmol"/>
<variable name="q_Cai" public_interface="out" units="fmol"/>
<variable name="q_Cao" public_interface="out" units="fmol"/>
<variable name="q_Ki" public_interface="out" units="fmol"/>
<variable name="q_Ko" public_interface="out" units="fmol"/>
<variable name="q_TRPN" public_interface="out" units="fmol"/>
<variable name="q_Ca_TRPN" public_interface="out" units="fmol"/>
<variable name="q_PLB_mPLB" public_interface="in" units="fmol"/>
<variable name="q_PKACI_mPLB" public_interface="in" units="fmol"/>
<variable name="q_PLB_PKACI_mPLB" public_interface="in" units="fmol"/>
<variable name="q_PP1_mPLB" public_interface="in" units="fmol"/>
<variable name="q_PLBp_PP1_mPLB" public_interface="in" units="fmol"/>
<variable name="q_PLBp_mPLB" public_interface="in" units="fmol"/>
<variable name="q_Ip_mPLB" public_interface="in" units="fmol"/>
<variable name="q_Ip_PP1_mPLB" public_interface="in" units="fmol"/>
<variable name="q_P1_SERCA_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_P2_SERCA_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_P2a_SERCA_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_P4_SERCA_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_P5_SERCA_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_P6_SERCA_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_P8_SERCA_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_P9_SERCA_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_P10_SERCA_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_H_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_Cai_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_Ca_SR_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_MgATP_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_MgADP_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_P_mSERCA" public_interface="in" units="fmol"/>
<variable name="q_Ca_SR_mRyR" public_interface="in" units="fmol"/>
<variable name="q_Ca_di_mRyR" public_interface="in" units="fmol"/>
<variable name="q_Cai_mLCC" public_interface="in" units="fmol"/>
<variable name="q_Cao_mLCC" public_interface="in" units="fmol"/>
<variable name="q_Ki_mLCC" public_interface="in" units="fmol"/>
<variable name="q_Ko_mLCC" public_interface="in" units="fmol"/>
<variable name="q_Cai_mTRPN" public_interface="in" units="fmol"/>
<variable name="q_TRPN_mTRPN" public_interface="in" units="fmol"/>
<variable name="q_Ca_TRPN_mTRPN" public_interface="in" units="fmol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>q_PLB</ci>
<apply>
<plus/>
<ci>q_PLB_init</ci>
<ci>q_PLB_mPLB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PKACI</ci>
<apply>
<plus/>
<ci>q_PKACI_init</ci>
<ci>q_PKACI_mPLB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PLB_PKACI</ci>
<apply>
<plus/>
<ci>q_PLB_PKACI_init</ci>
<ci>q_PLB_PKACI_mPLB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PP1</ci>
<apply>
<plus/>
<ci>q_PP1_init</ci>
<ci>q_PP1_mPLB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PLBp_PP1</ci>
<apply>
<plus/>
<ci>q_PLBp_PP1_init</ci>
<ci>q_PLBp_PP1_mPLB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_PLBp</ci>
<apply>
<plus/>
<ci>q_PLBp_init</ci>
<ci>q_PLBp_mPLB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Ip</ci>
<apply>
<plus/>
<ci>q_Ip_init</ci>
<ci>q_Ip_mPLB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Ip_PP1</ci>
<apply>
<plus/>
<ci>q_Ip_PP1_init</ci>
<ci>q_Ip_PP1_mPLB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_P1_SERCA</ci>
<apply>
<plus/>
<ci>q_P1_SERCA_init</ci>
<ci>q_P1_SERCA_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_P2_SERCA</ci>
<apply>
<plus/>
<ci>q_P2_SERCA_init</ci>
<ci>q_P2_SERCA_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_P2a_SERCA</ci>
<apply>
<plus/>
<ci>q_P2a_SERCA_init</ci>
<ci>q_P2a_SERCA_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_P4_SERCA</ci>
<apply>
<plus/>
<ci>q_P4_SERCA_init</ci>
<ci>q_P4_SERCA_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_P5_SERCA</ci>
<apply>
<plus/>
<ci>q_P5_SERCA_init</ci>
<ci>q_P5_SERCA_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_P6_SERCA</ci>
<apply>
<plus/>
<ci>q_P6_SERCA_init</ci>
<ci>q_P6_SERCA_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_P8_SERCA</ci>
<apply>
<plus/>
<ci>q_P8_SERCA_init</ci>
<ci>q_P8_SERCA_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_P9_SERCA</ci>
<apply>
<plus/>
<ci>q_P9_SERCA_init</ci>
<ci>q_P9_SERCA_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_P10_SERCA</ci>
<apply>
<plus/>
<ci>q_P10_SERCA_init</ci>
<ci>q_P10_SERCA_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_H</ci>
<apply>
<plus/>
<ci>q_H_init</ci>
<ci>q_H_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Cai</ci>
<apply>
<plus/>
<ci>q_Cai_init</ci>
<ci>q_Cai_mSERCA</ci>
<ci>q_Cai_mLCC</ci>
<ci>q_Cai_mTRPN</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Ca_SR</ci>
<apply>
<plus/>
<ci>q_Ca_SR_init</ci>
<ci>q_Ca_SR_mSERCA</ci>
<ci>q_Ca_SR_mRyR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_MgATP</ci>
<apply>
<plus/>
<ci>q_MgATP_init</ci>
<ci>q_MgATP_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_MgADP</ci>
<apply>
<plus/>
<ci>q_MgADP_init</ci>
<ci>q_MgADP_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_P</ci>
<apply>
<plus/>
<ci>q_P_init</ci>
<ci>q_P_mSERCA</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Ca_di</ci>
<apply>
<plus/>
<ci>q_Ca_di_init</ci>
<ci>q_Ca_di_mRyR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Cao</ci>
<apply>
<plus/>
<ci>q_Cao_init</ci>
<ci>q_Cao_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Ki</ci>
<apply>
<plus/>
<ci>q_Ki_init</ci>
<ci>q_Ki_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Ko</ci>
<apply>
<plus/>
<ci>q_Ko_init</ci>
<ci>q_Ko_mLCC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_TRPN</ci>
<apply>
<plus/>
<ci>q_TRPN_init</ci>
<ci>q_TRPN_mTRPN</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Ca_TRPN</ci>
<apply>
<plus/>
<ci>q_Ca_TRPN_init</ci>
<ci>q_Ca_TRPN_mTRPN</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V_m</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>v_RyR</ci>
</apply>
<ci>F</ci>
</apply>
<ci>C_m</ci>
</apply>
</apply>
</math>
</component>
<component name="constants">
<variable initial_value="8.31" name="R" public_interface="out" units="J_per_K_per_mol"/>
<variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96485" name="F" public_interface="out" units="C_per_mol"/>
</component>
<component name="ion_valences">
<variable initial_value="1" name="zNa" public_interface="out" units="dimensionless"/>
<variable initial_value="-1" name="zCl" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="zK" public_interface="out" units="dimensionless"/>
<variable initial_value="2" name="zCa" public_interface="out" units="dimensionless"/>
</component>
<component name="PLB">
<variable name="time" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="kappa_PLBph1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_PLBph2" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_PLBd1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_PLBd2" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_Inh" public_interface="in" units="fmol_per_sec"/>
<variable name="K_PLB" public_interface="in" units="per_fmol"/>
<variable name="K_PKACI" public_interface="in" units="per_fmol"/>
<variable name="K_PLB_PKACI" public_interface="in" units="per_fmol"/>
<variable name="K_PP1" public_interface="in" units="per_fmol"/>
<variable name="K_PLBp_PP1" public_interface="in" units="per_fmol"/>
<variable name="K_PLBp" public_interface="in" units="per_fmol"/>
<variable name="K_Ip" public_interface="in" units="per_fmol"/>
<variable name="K_Ip_PP1" public_interface="in" units="per_fmol"/>
<variable name="vPLBph1" units="fmol_per_sec"/>
<variable name="vPLBph2" units="fmol_per_sec"/>
<variable name="vPLBd1" units="fmol_per_sec"/>
<variable name="vPLBd2" units="fmol_per_sec"/>
<variable name="vInh" units="fmol_per_sec"/>
<variable name="mu_PLB" units="J_per_mol"/>
<variable name="mu_PKACI" units="J_per_mol"/>
<variable name="mu_PLB_PKACI" units="J_per_mol"/>
<variable name="mu_PP1" units="J_per_mol"/>
<variable name="mu_PLBp_PP1" units="J_per_mol"/>
<variable name="mu_PLBp" units="J_per_mol"/>
<variable name="mu_Ip" units="J_per_mol"/>
<variable name="mu_Ip_PP1" units="J_per_mol"/>
<variable name="q_PLB_global" public_interface="in" units="fmol"/>
<variable name="q_PKACI_global" public_interface="in" units="fmol"/>
<variable name="q_PLB_PKACI_global" public_interface="in" units="fmol"/>
<variable name="q_PP1_global" public_interface="in" units="fmol"/>
<variable name="q_PLBp_PP1_global" public_interface="in" units="fmol"/>
<variable name="q_PLBp_global" public_interface="in" units="fmol"/>
<variable name="q_Ip_global" public_interface="in" units="fmol"/>
<variable name="q_Ip_PP1_global" public_interface="in" units="fmol"/>
<variable initial_value="1e-16" name="q_PLB" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_PKACI" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_PLB_PKACI" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_PP1" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_PLBp_PP1" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_PLBp" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Ip" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Ip_PP1" public_interface="out" units="fmol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu_PLB</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_PLB</ci>
<ci>q_PLB_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_PKACI</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_PKACI</ci>
<ci>q_PKACI_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_PLB_PKACI</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_PLB_PKACI</ci>
<ci>q_PLB_PKACI_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_PP1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_PP1</ci>
<ci>q_PP1_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_PLBp_PP1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_PLBp_PP1</ci>
<ci>q_PLBp_PP1_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_PLBp</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_PLBp</ci>
<ci>q_PLBp_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Ip</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ip</ci>
<ci>q_Ip_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Ip_PP1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ip_PP1</ci>
<ci>q_Ip_PP1_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>vPLBph1</ci>
<apply>
<times/>
<ci>kappa_PLBph1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_PLB</ci>
<ci>mu_PKACI</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_PLB_PKACI</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>vPLBph2</ci>
<apply>
<times/>
<ci>kappa_PLBph2</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_PLB_PKACI</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_PLBp</ci>
<ci>mu_PKACI</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>vPLBd1</ci>
<apply>
<times/>
<ci>kappa_PLBd1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_PLBp</ci>
<ci>mu_PP1</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_PLBp_PP1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>vPLBd2</ci>
<apply>
<times/>
<ci>kappa_PLBd2</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_PLBp_PP1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_PLB</ci>
<ci>mu_PP1</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>vInh</ci>
<apply>
<times/>
<ci>kappa_Inh</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_PP1</ci>
<ci>mu_Ip</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_Ip_PP1</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_PLB</ci>
</apply>
<apply>
<minus/>
<ci>vPLBd2</ci>
<ci>vPLBph1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_PKACI</ci>
</apply>
<apply>
<minus/>
<ci>vPLBph2</ci>
<ci>vPLBph1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_PLB_PKACI</ci>
</apply>
<apply>
<minus/>
<ci>vPLBph1</ci>
<ci>vPLBph2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_PP1</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>vPLBd2</ci>
<ci>vPLBd1</ci>
</apply>
<ci>vInh</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_PLBp_PP1</ci>
</apply>
<apply>
<minus/>
<ci>vPLBd1</ci>
<ci>vPLBd2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_PLBp</ci>
</apply>
<apply>
<minus/>
<ci>vPLBph2</ci>
<ci>vPLBd1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Ip</ci>
</apply>
<apply>
<minus/>
<ci>vInh</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Ip_PP1</ci>
</apply>
<ci>vInh</ci>
</apply>
</math>
</component>
<component name="SERCA">
<variable name="time" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="K_P1_SERCA" public_interface="in" units="per_fmol"/>
<variable name="K_P10_SERCA" public_interface="in" units="per_fmol"/>
<variable name="K_P2_SERCA" public_interface="in" units="per_fmol"/>
<variable name="K_P2a_SERCA" public_interface="in" units="per_fmol"/>
<variable name="K_P4_SERCA" public_interface="in" units="per_fmol"/>
<variable name="K_P5_SERCA" public_interface="in" units="per_fmol"/>
<variable name="K_P6_SERCA" public_interface="in" units="per_fmol"/>
<variable name="K_P8_SERCA" public_interface="in" units="per_fmol"/>
<variable name="K_P9_SERCA" public_interface="in" units="per_fmol"/>
<variable name="K_Cai" public_interface="in" units="per_fmol"/>
<variable name="K_Ca_SR" public_interface="in" units="per_fmol"/>
<variable name="K_H" public_interface="in" units="per_fmol"/>
<variable name="K_MgADP" public_interface="in" units="per_fmol"/>
<variable name="K_MgATP" public_interface="in" units="per_fmol"/>
<variable name="K_P" public_interface="in" units="per_fmol"/>
<variable name="kappa_SERCA_R10_1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_SERCA_R1_2" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_SERCA_R2_2a" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_SERCA_R2_4" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_SERCA_R4_5" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_SERCA_R5_6" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_SERCA_R6_8" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_SERCA_R8_9" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_SERCA_R9_10" public_interface="in" units="fmol_per_sec"/>
<variable initial_value="2" name="n_Cai" units="dimensionless"/>
<variable initial_value="2" name="n_Ca_SR" units="dimensionless"/>
<variable initial_value="2" name="n_H" units="dimensionless"/>
<variable name="q_Cai_global" public_interface="in" units="fmol"/>
<variable name="q_Ca_SR_global" public_interface="in" units="fmol"/>
<variable name="q_H_global" public_interface="in" units="fmol"/>
<variable name="q_P_global" public_interface="in" units="fmol"/>
<variable name="q_MgADP_global" public_interface="in" units="fmol"/>
<variable name="q_MgATP_global" public_interface="in" units="fmol"/>
<variable name="q_P1_SERCA_global" public_interface="in" units="fmol"/>
<variable name="q_P2_SERCA_global" public_interface="in" units="fmol"/>
<variable name="q_P2a_SERCA_global" public_interface="in" units="fmol"/>
<variable name="q_P4_SERCA_global" public_interface="in" units="fmol"/>
<variable name="q_P5_SERCA_global" public_interface="in" units="fmol"/>
<variable name="q_P10_SERCA_global" public_interface="in" units="fmol"/>
<variable name="q_P6_SERCA_global" public_interface="in" units="fmol"/>
<variable name="q_P8_SERCA_global" public_interface="in" units="fmol"/>
<variable name="q_P9_SERCA_global" public_interface="in" units="fmol"/>
<variable initial_value="1e-16" name="q_Cai" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Ca_SR" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_H" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_P" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_MgADP" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_MgATP" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_P1_SERCA" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_P2_SERCA" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_P2a_SERCA" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_P4_SERCA" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_P5_SERCA" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_P10_SERCA" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_P6_SERCA" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_P8_SERCA" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_P9_SERCA" public_interface="out" units="fmol"/>
<variable name="c_Cai" units="mM"/>
<variable name="c_Ca_SR" units="mM"/>
<variable name="c_H" units="mM"/>
<variable name="c_MgADP" units="mM"/>
<variable name="c_MgATP" units="mM"/>
<variable name="c_P" units="mM"/>
<variable initial_value="34.0" name="vol_i" units="pL"/>
<variable name="vol_sr" units="pL"/>
<variable name="vol_isr" units="pL"/>
<variable name="mu_Cai" units="J_per_mol"/>
<variable name="v_Cai" units="fmol_per_sec"/>
<variable name="mu_Ca_SR" units="J_per_mol"/>
<variable name="v_Ca_SR" units="fmol_per_sec"/>
<variable name="mu_H" units="J_per_mol"/>
<variable name="v_H" units="fmol_per_sec"/>
<variable name="mu_MgADP" units="J_per_mol"/>
<variable name="v_MgADP" units="fmol_per_sec"/>
<variable name="mu_MgATP" units="J_per_mol"/>
<variable name="v_MgATP" units="fmol_per_sec"/>
<variable name="mu_P1" units="J_per_mol"/>
<variable name="v_P1" units="fmol_per_sec"/>
<variable name="mu_P" units="J_per_mol"/>
<variable name="v_P" units="fmol_per_sec"/>
<variable name="mu_P2" units="J_per_mol"/>
<variable name="v_P2" units="fmol_per_sec"/>
<variable name="mu_P2a" units="J_per_mol"/>
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<times/>
<ci>n_H</ci>
<ci>mu_H</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_R8_9</ci>
<ci>mu_P9</ci>
</apply>
<apply>
<eq/>
<ci>v_SERCA_R8_9</ci>
<apply>
<times/>
<ci>kappa_SERCA_R8_9</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_R8_9</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_R8_9</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_R9_10</ci>
<ci>mu_P9</ci>
</apply>
<apply>
<eq/>
<ci>Ar_R9_10</ci>
<apply>
<plus/>
<ci>mu_H</ci>
<ci>mu_P10</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_SERCA_R9_10</ci>
<apply>
<times/>
<ci>kappa_SERCA_R9_10</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_R9_10</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_R9_10</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="RyR">
<variable name="time" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="zCa" public_interface="in" units="dimensionless"/>
<variable name="V_m" public_interface="in" units="volt"/>
<variable initial_value="1" name="nCa_1" public_interface="out" units="dimensionless"/>
<variable initial_value="2" name="nCa_2" public_interface="out" units="dimensionless"/>
<variable name="kappa_RyR" public_interface="in" units="fmol_per_sec"/>
<variable name="K_Ca_SR" public_interface="in" units="per_fmol"/>
<variable name="K_Ca_di" public_interface="in" units="per_fmol"/>
<variable name="q_Ca_SR_global" public_interface="in" units="fmol"/>
<variable name="q_Ca_di_global" public_interface="in" units="fmol"/>
<variable initial_value="1e-16" name="q_Ca_SR" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Ca_di" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_C_RyR" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_CI_RyR" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_I_RyR" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_O_RyR" public_interface="out" units="fmol"/>
<variable name="mu_Ca_SR" units="J_per_mol"/>
<variable name="mu_Ca_di" public_interface="out" units="J_per_mol"/>
<variable name="v_RyR" public_interface="out" units="fmol_per_sec"/>
<variable name="v_gate_Ca_di" public_interface="out" units="fmol_per_sec"/>
<variable name="mu_O_RyR" public_interface="in" units="J_per_mol"/>
<variable name="v_OC" public_interface="in" units="fmol_per_sec"/>
<variable name="v_CCI" public_interface="in" units="fmol_per_sec"/>
<variable name="v_CII" public_interface="in" units="fmol_per_sec"/>
<variable name="v_IO" public_interface="in" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu_Ca_SR</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ca_SR</ci>
<ci>q_Ca_SR_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Ca_di</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ca_di</ci>
<ci>q_Ca_di_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_RyR</ci>
<apply>
<times/>
<ci>kappa_RyR</ci>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_O_RyR</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_Ca_SR</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>F</ci>
<ci>V_m</ci>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_Ca_di</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_gate_Ca_di</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<ci>nCa_2</ci>
</apply>
<ci>v_OC</ci>
</apply>
<apply>
<times/>
<ci>nCa_1</ci>
<ci>v_CCI</ci>
</apply>
</apply>
<apply>
<times/>
<ci>nCa_2</ci>
<ci>v_CII</ci>
</apply>
</apply>
<apply>
<times/>
<ci>nCa_1</ci>
<ci>v_IO</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Ca_SR</ci>
</apply>
<apply>
<minus/>
<ci>v_RyR</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Ca_di</ci>
</apply>
<apply>
<plus/>
<ci>v_RyR</ci>
<ci>v_gate_Ca_di</ci>
</apply>
</apply>
</math>
</component>
<component name="RyR_gate">
<variable name="time" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="kappa_OC" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_CCI" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_CII" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_IO" public_interface="in" units="fmol_per_sec"/>
<variable name="K_C_RyR" public_interface="in" units="per_fmol"/>
<variable name="K_CI_RyR" public_interface="in" units="per_fmol"/>
<variable name="K_I_RyR" public_interface="in" units="per_fmol"/>
<variable name="K_O_RyR" public_interface="in" units="per_fmol"/>
<variable name="nCa_1" public_interface="in" units="dimensionless"/>
<variable name="nCa_2" public_interface="in" units="dimensionless"/>
<variable initial_value="1e-16" name="q_C_RyR" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_CI_RyR" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_I_RyR" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_O_RyR" public_interface="out" units="fmol"/>
<variable name="mu_Ca_di" public_interface="in" units="J_per_mol"/>
<variable name="mu_C_RyR" units="J_per_mol"/>
<variable name="mu_CI_RyR" units="J_per_mol"/>
<variable name="mu_I_RyR" units="J_per_mol"/>
<variable name="mu_O_RyR" public_interface="out" units="J_per_mol"/>
<variable name="v_OC" public_interface="out" units="fmol_per_sec"/>
<variable name="v_CCI" public_interface="out" units="fmol_per_sec"/>
<variable name="v_CII" public_interface="out" units="fmol_per_sec"/>
<variable name="v_IO" public_interface="out" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu_C_RyR</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_C_RyR</ci>
<ci>q_C_RyR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_CI_RyR</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_CI_RyR</ci>
<ci>q_CI_RyR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_I_RyR</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_I_RyR</ci>
<ci>q_I_RyR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_O_RyR</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_O_RyR</ci>
<ci>q_O_RyR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_OC</ci>
<apply>
<times/>
<ci>kappa_OC</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_O_RyR</ci>
<apply>
<times/>
<ci>nCa_2</ci>
<ci>mu_Ca_di</ci>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_C_RyR</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_CCI</ci>
<apply>
<times/>
<ci>kappa_CCI</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_C_RyR</ci>
<apply>
<times/>
<ci>nCa_1</ci>
<ci>mu_Ca_di</ci>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_CI_RyR</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_CII</ci>
<apply>
<times/>
<ci>kappa_CII</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_CI_RyR</ci>
<apply>
<times/>
<ci>nCa_2</ci>
<ci>mu_Ca_di</ci>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_I_RyR</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_IO</ci>
<apply>
<times/>
<ci>kappa_IO</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_I_RyR</ci>
<apply>
<times/>
<ci>nCa_1</ci>
<ci>mu_Ca_di</ci>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_O_RyR</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_O_RyR</ci>
</apply>
<apply>
<minus/>
<ci>v_IO</ci>
<ci>v_OC</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_C_RyR</ci>
</apply>
<apply>
<minus/>
<ci>v_OC</ci>
<ci>v_CCI</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_CI_RyR</ci>
</apply>
<apply>
<minus/>
<ci>v_CCI</ci>
<ci>v_CII</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_I_RyR</ci>
</apply>
<apply>
<minus/>
<ci>v_CII</ci>
<ci>v_IO</ci>
</apply>
</apply>
</math>
</component>
<component name="LCC">
<variable name="time" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="RT" public_interface="out" units="J_per_mol"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="C_m" public_interface="in" units="fF"/>
<variable name="K_Cai" public_interface="in" units="per_fmol"/>
<variable name="K_Cao" public_interface="in" units="per_fmol"/>
<variable name="K_Ki" public_interface="in" units="per_fmol"/>
<variable name="K_Ko" public_interface="in" units="per_fmol"/>
<variable name="kappa_Ca1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_Ca2" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_K1" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_K2" public_interface="in" units="fmol_per_sec"/>
<variable name="zCa" public_interface="in" units="dimensionless"/>
<variable name="zK" public_interface="in" units="dimensionless"/>
<variable name="q_Cai_global" public_interface="in" units="fmol"/>
<variable name="q_Cao_global" public_interface="in" units="fmol"/>
<variable name="q_Ki_global" public_interface="in" units="fmol"/>
<variable name="q_Ko_global" public_interface="in" units="fmol"/>
<variable initial_value="1e-16" name="q_Cai" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Cao" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Ki" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Ko" public_interface="out" units="fmol"/>
<variable name="q_E" public_interface="in" units="fC"/>
<variable name="mu_E" public_interface="out" units="J_per_C"/>
<variable name="mu_mem_Ca" units="J_per_mol"/>
<variable name="mu_mem_K" units="J_per_mol"/>
<variable name="v_CaGHK_i" units="fmol_per_sec"/>
<variable name="v_CaGHK_o" units="fmol_per_sec"/>
<variable name="v_KGHK_i" units="fmol_per_sec"/>
<variable name="v_KGHK_o" units="fmol_per_sec"/>
<variable name="mu_Cai" public_interface="out" units="J_per_mol"/>
<variable name="mu_Cao" units="J_per_mol"/>
<variable name="mu_Ki" units="J_per_mol"/>
<variable name="mu_Ko" units="J_per_mol"/>
<variable name="mu_S111" public_interface="in" units="J_per_mol"/>
<variable name="mu_S121" public_interface="in" units="J_per_mol"/>
<variable name="Af_Ca1" units="J_per_mol"/>
<variable name="Ar_Ca1" units="J_per_mol"/>
<variable name="v_Ca1" units="fmol_per_sec"/>
<variable name="Af_Ca2" units="J_per_mol"/>
<variable name="Ar_Ca2" units="J_per_mol"/>
<variable name="v_Ca2" units="fmol_per_sec"/>
<variable name="Af_K1" units="J_per_mol"/>
<variable name="Ar_K1" units="J_per_mol"/>
<variable name="v_K1" units="fmol_per_sec"/>
<variable name="Af_K2" units="J_per_mol"/>
<variable name="Ar_K2" units="J_per_mol"/>
<variable name="v_K2" public_interface="out" units="fmol_per_sec"/>
<variable name="v_fCa00" public_interface="in" units="fmol_per_sec"/>
<variable name="v_fCa01" public_interface="in" units="fmol_per_sec"/>
<variable name="v_fCa02" public_interface="in" units="fmol_per_sec"/>
<variable name="v_fCa10" public_interface="in" units="fmol_per_sec"/>
<variable name="v_fCa11" public_interface="in" units="fmol_per_sec"/>
<variable name="v_fCa12" public_interface="in" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>RT</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_E</ci>
<apply>
<divide/>
<ci>q_E</ci>
<ci>C_m</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Cai</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Cai</ci>
<ci>q_Cai_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Cao</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Cao</ci>
<ci>q_Cao_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Ki</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ki</ci>
<ci>q_Ki_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Ko</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ko</ci>
<ci>q_Ko_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_mem_Ca</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>F</ci>
<ci>mu_E</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_mem_K</ci>
<apply>
<times/>
<ci>zK</ci>
<ci>F</ci>
<ci>mu_E</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_Ca1</ci>
<apply>
<plus/>
<ci>mu_Cai</ci>
<ci>mu_mem_Ca</ci>
<ci>mu_S111</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_Ca1</ci>
<apply>
<plus/>
<ci>mu_Cao</ci>
<ci>mu_S111</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_Ca2</ci>
<apply>
<plus/>
<ci>mu_Cai</ci>
<ci>mu_mem_Ca</ci>
<ci>mu_S121</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_Ca2</ci>
<apply>
<plus/>
<ci>mu_Cao</ci>
<ci>mu_S121</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_K1</ci>
<apply>
<plus/>
<ci>mu_Ki</ci>
<ci>mu_mem_K</ci>
<ci>mu_S111</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_K1</ci>
<apply>
<plus/>
<ci>mu_Ko</ci>
<ci>mu_S111</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_K2</ci>
<apply>
<plus/>
<ci>mu_Ki</ci>
<ci>mu_mem_K</ci>
<ci>mu_S121</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_K2</ci>
<apply>
<plus/>
<ci>mu_Ko</ci>
<ci>mu_S121</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_Ca1</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>kappa_Ca1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_Ca1</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_Ca1</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_mem_Ca</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_Ca1</ci>
<ci>mu_mem_Ca</ci>
</apply>
<ci>RT</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_mem_Ca</ci>
<ci>RT</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_Ca1</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_Ca1</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>v_Ca2</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>kappa_Ca2</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_Ca2</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_Ca2</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_mem_Ca</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_Ca2</ci>
<ci>mu_mem_Ca</ci>
</apply>
<ci>RT</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_mem_Ca</ci>
<ci>RT</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_Ca2</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_Ca2</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>v_K1</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>kappa_K1</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_K1</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_K1</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_mem_K</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_K1</ci>
<ci>mu_mem_K</ci>
</apply>
<ci>RT</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_mem_K</ci>
<ci>RT</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_K1</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_K1</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>v_K2</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>kappa_K2</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_K2</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_K2</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_mem_K</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_K2</ci>
<ci>mu_mem_K</ci>
</apply>
<ci>RT</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_mem_K</ci>
<ci>RT</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_K2</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_K2</ci>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>v_CaGHK_i</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>zCa</ci>
<apply>
<plus/>
<ci>v_fCa10</ci>
<ci>v_fCa11</ci>
<ci>v_fCa02</ci>
<ci>v_fCa01</ci>
<ci>v_fCa00</ci>
<ci>v_fCa12</ci>
</apply>
</apply>
<ci>v_Ca1</ci>
</apply>
<ci>v_Ca2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_CaGHK_o</ci>
<apply>
<plus/>
<ci>v_Ca2</ci>
<ci>v_Ca1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_KGHK_i</ci>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_K1</ci>
</apply>
<ci>v_K2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_KGHK_o</ci>
<apply>
<plus/>
<ci>v_K2</ci>
<ci>v_K1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Cai</ci>
</apply>
<ci>v_CaGHK_i</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Cao</ci>
</apply>
<ci>v_CaGHK_o</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Ki</ci>
</apply>
<ci>v_KGHK_i</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Ko</ci>
</apply>
<ci>v_KGHK_o</ci>
</apply>
</math>
</component>
<component name="LCC_gate">
<variable name="time" public_interface="in" units="second"/>
<variable name="Vmem" public_interface="in" units="volt"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="RT" public_interface="in" units="J_per_mol"/>
<variable name="kappa_d000" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_d010" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_d020" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_d001" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_d011" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_d021" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f1_000" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f1_100" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f1_001" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f1_101" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f2_000" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f2_100" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f2_001" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f2_101" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f3_010" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f3_110" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f3_011" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_f3_111" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_fCa000" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_fCa100" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_fCa010" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_fCa110" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_fCa020" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_fCa120" public_interface="in" units="fmol_per_sec"/>
<variable name="K_000" public_interface="in" units="per_fmol"/>
<variable name="K_010" public_interface="in" units="per_fmol"/>
<variable name="K_020" public_interface="in" units="per_fmol"/>
<variable name="K_100" public_interface="in" units="per_fmol"/>
<variable name="K_110" public_interface="in" units="per_fmol"/>
<variable name="K_120" public_interface="in" units="per_fmol"/>
<variable name="K_001" public_interface="in" units="per_fmol"/>
<variable name="K_011" public_interface="in" units="per_fmol"/>
<variable name="K_021" public_interface="in" units="per_fmol"/>
<variable name="K_101" public_interface="in" units="per_fmol"/>
<variable name="K_111" public_interface="in" units="per_fmol"/>
<variable name="K_121" public_interface="in" units="per_fmol"/>
<variable initial_value="3.6989e-07" name="q_S000" units="fmol"/>
<variable initial_value="7.3239e-05" name="q_S010" units="fmol"/>
<variable initial_value="3.6989e-07" name="q_S020" units="fmol"/>
<variable initial_value="3.7363e-09" name="q_S100" units="fmol"/>
<variable initial_value="7.3979e-07" name="q_S110" units="fmol"/>
<variable initial_value="3.7363e-09" name="q_S120" units="fmol"/>
<variable initial_value="4.1099e-08" name="q_S001" units="fmol"/>
<variable initial_value="8.1377e-06" name="q_S011" units="fmol"/>
<variable initial_value="4.1099e-08" name="q_S021" units="fmol"/>
<variable initial_value="4.1514e-10" name="q_S101" units="fmol"/>
<variable initial_value="8.2199e-08" name="q_S111" units="fmol"/>
<variable initial_value="4.1514e-10" name="q_S121" units="fmol"/>
<variable name="mu_Cai" public_interface="in" units="J_per_mol"/>
<variable name="mu_S000" units="J_per_mol"/>
<variable name="mu_S010" units="J_per_mol"/>
<variable name="mu_S020" units="J_per_mol"/>
<variable name="mu_S100" units="J_per_mol"/>
<variable name="mu_S110" units="J_per_mol"/>
<variable name="mu_S120" units="J_per_mol"/>
<variable name="mu_S001" units="J_per_mol"/>
<variable name="mu_S011" units="J_per_mol"/>
<variable name="mu_S021" units="J_per_mol"/>
<variable name="mu_S101" units="J_per_mol"/>
<variable name="mu_S111" public_interface="out" units="J_per_mol"/>
<variable name="mu_S121" public_interface="out" units="J_per_mol"/>
<variable name="v_fCa00" public_interface="out" units="fmol_per_sec"/>
<variable name="v_fCa01" public_interface="out" units="fmol_per_sec"/>
<variable name="v_fCa02" public_interface="out" units="fmol_per_sec"/>
<variable name="v_fCa10" public_interface="out" units="fmol_per_sec"/>
<variable name="v_fCa11" public_interface="out" units="fmol_per_sec"/>
<variable name="v_fCa12" public_interface="out" units="fmol_per_sec"/>
<variable name="v_f1_000" units="fmol_per_sec"/>
<variable name="v_f2_000" units="fmol_per_sec"/>
<variable name="v_f3_010" units="fmol_per_sec"/>
<variable name="v_f1_100" units="fmol_per_sec"/>
<variable name="v_f2_100" units="fmol_per_sec"/>
<variable name="v_f3_110" units="fmol_per_sec"/>
<variable name="v_d000" units="fmol_per_sec"/>
<variable name="v_d010" units="fmol_per_sec"/>
<variable name="v_d020" units="fmol_per_sec"/>
<variable name="v_d001" units="fmol_per_sec"/>
<variable name="v_d011" units="fmol_per_sec"/>
<variable name="v_d021" units="fmol_per_sec"/>
<variable name="v_f1_001" units="fmol_per_sec"/>
<variable name="v_f2_001" units="fmol_per_sec"/>
<variable name="v_f3_011" units="fmol_per_sec"/>
<variable name="v_f1_101" units="fmol_per_sec"/>
<variable name="v_f2_101" units="fmol_per_sec"/>
<variable name="v_f3_111" units="fmol_per_sec"/>
<variable name="v_S000" units="fmol_per_sec"/>
<variable name="v_S010" units="fmol_per_sec"/>
<variable name="v_S020" units="fmol_per_sec"/>
<variable name="v_S100" units="fmol_per_sec"/>
<variable name="v_S110" units="fmol_per_sec"/>
<variable name="v_S120" units="fmol_per_sec"/>
<variable name="v_S001" units="fmol_per_sec"/>
<variable name="v_S011" units="fmol_per_sec"/>
<variable name="v_S021" units="fmol_per_sec"/>
<variable name="v_S101" units="fmol_per_sec"/>
<variable name="v_S111" units="fmol_per_sec"/>
<variable name="v_S121" units="fmol_per_sec"/>
<variable initial_value="2" name="zCa" units="dimensionless"/>
<variable initial_value="2.1404" name="z_fd" units="dimensionless"/>
<variable initial_value="-1.1495" name="z_ff1" units="dimensionless"/>
<variable initial_value="0.72162" name="z_ff2" units="dimensionless"/>
<variable initial_value="4.2933" name="z_ff3" units="dimensionless"/>
<variable initial_value="-2.1404" name="z_rd" units="dimensionless"/>
<variable initial_value="1.8993" name="z_rf1" units="dimensionless"/>
<variable initial_value="-0.52288" name="z_rf2" units="dimensionless"/>
<variable initial_value="0" name="z_rf3" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu_S000</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_000</ci>
<ci>q_S000</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_S001</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_001</ci>
<ci>q_S001</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_S010</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_010</ci>
<ci>q_S010</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_S011</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_011</ci>
<ci>q_S011</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_S020</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_020</ci>
<ci>q_S020</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_S021</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_021</ci>
<ci>q_S021</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_S100</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_100</ci>
<ci>q_S100</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_S101</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_101</ci>
<ci>q_S101</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_S110</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_110</ci>
<ci>q_S110</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_S111</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_111</ci>
<ci>q_S111</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_S120</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_120</ci>
<ci>q_S120</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_S121</ci>
<apply>
<times/>
<ci>RT</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_121</ci>
<ci>q_S121</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_fCa00</ci>
<apply>
<times/>
<ci>kappa_fCa000</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_S000</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S001</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>mu_Cai</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_fCa01</ci>
<apply>
<times/>
<ci>kappa_fCa010</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_S010</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S011</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>mu_Cai</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_fCa02</ci>
<apply>
<times/>
<ci>kappa_fCa020</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_S020</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S021</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>mu_Cai</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_fCa10</ci>
<apply>
<times/>
<ci>kappa_fCa100</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_S100</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S101</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>mu_Cai</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_fCa11</ci>
<apply>
<times/>
<ci>kappa_fCa110</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_S110</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S111</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>mu_Cai</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_fCa12</ci>
<apply>
<times/>
<ci>kappa_fCa120</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>mu_S120</ci>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S121</ci>
<apply>
<times/>
<ci>zCa</ci>
<ci>mu_Cai</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_d000</ci>
<apply>
<times/>
<ci>kappa_d000</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S000</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S100</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_d010</ci>
<apply>
<times/>
<ci>kappa_d010</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S010</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S110</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_d020</ci>
<apply>
<times/>
<ci>kappa_d020</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S020</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S120</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_d001</ci>
<apply>
<times/>
<ci>kappa_d001</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S001</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S101</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_d011</ci>
<apply>
<times/>
<ci>kappa_d011</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S011</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S111</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_d021</ci>
<apply>
<times/>
<ci>kappa_d021</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S021</ci>
<apply>
<times/>
<ci>z_fd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S121</ci>
<apply>
<times/>
<ci>z_rd</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f1_000</ci>
<apply>
<times/>
<ci>kappa_f1_000</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S000</ci>
<apply>
<times/>
<ci>z_ff1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S010</ci>
<apply>
<times/>
<ci>z_rf1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f2_000</ci>
<apply>
<times/>
<ci>kappa_f2_000</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S000</ci>
<apply>
<times/>
<ci>z_ff2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S020</ci>
<apply>
<times/>
<ci>z_rf2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f3_010</ci>
<apply>
<times/>
<ci>kappa_f3_010</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S010</ci>
<apply>
<times/>
<ci>z_ff3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S020</ci>
<apply>
<times/>
<ci>z_rf3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f1_100</ci>
<apply>
<times/>
<ci>kappa_f1_100</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S100</ci>
<apply>
<times/>
<ci>z_ff1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S110</ci>
<apply>
<times/>
<ci>z_rf1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f2_100</ci>
<apply>
<times/>
<ci>kappa_f2_100</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S100</ci>
<apply>
<times/>
<ci>z_ff2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S120</ci>
<apply>
<times/>
<ci>z_rf2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f3_110</ci>
<apply>
<times/>
<ci>kappa_f3_110</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S110</ci>
<apply>
<times/>
<ci>z_ff3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S120</ci>
<apply>
<times/>
<ci>z_rf3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f1_001</ci>
<apply>
<times/>
<ci>kappa_f1_001</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S001</ci>
<apply>
<times/>
<ci>z_ff1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S011</ci>
<apply>
<times/>
<ci>z_rf1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f2_001</ci>
<apply>
<times/>
<ci>kappa_f2_001</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S001</ci>
<apply>
<times/>
<ci>z_ff2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S021</ci>
<apply>
<times/>
<ci>z_rf2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f3_011</ci>
<apply>
<times/>
<ci>kappa_f3_011</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S011</ci>
<apply>
<times/>
<ci>z_ff3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S021</ci>
<apply>
<times/>
<ci>z_rf3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f1_101</ci>
<apply>
<times/>
<ci>kappa_f1_101</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S101</ci>
<apply>
<times/>
<ci>z_ff1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S111</ci>
<apply>
<times/>
<ci>z_rf1</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f2_101</ci>
<apply>
<times/>
<ci>kappa_f2_101</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S101</ci>
<apply>
<times/>
<ci>z_ff2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S121</ci>
<apply>
<times/>
<ci>z_rf2</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_f3_111</ci>
<apply>
<times/>
<ci>kappa_f3_111</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S111</ci>
<apply>
<times/>
<ci>z_ff3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>mu_S121</ci>
<apply>
<times/>
<ci>z_rf3</ci>
<ci>F</ci>
<ci>Vmem</ci>
</apply>
</apply>
<ci>RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S000</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_d000</ci>
</apply>
<ci>v_f1_000</ci>
</apply>
<ci>v_f2_000</ci>
</apply>
<ci>v_fCa00</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S001</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_d001</ci>
</apply>
<ci>v_f1_001</ci>
</apply>
<ci>v_f2_001</ci>
</apply>
<ci>v_fCa00</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S010</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_d010</ci>
</apply>
<ci>v_f3_010</ci>
</apply>
<ci>v_f1_100</ci>
</apply>
<ci>v_fCa01</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S011</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_d011</ci>
</apply>
<ci>v_f3_011</ci>
</apply>
<ci>v_f1_101</ci>
<ci>v_fCa01</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S020</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_d020</ci>
</apply>
<ci>v_f3_010</ci>
<ci>v_f2_000</ci>
</apply>
<ci>v_fCa02</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S021</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_d021</ci>
</apply>
<ci>v_f3_011</ci>
<ci>v_f2_001</ci>
<ci>v_fCa02</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S100</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_f2_100</ci>
</apply>
<ci>v_d000</ci>
</apply>
<ci>v_f1_100</ci>
</apply>
<ci>v_fCa10</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S101</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v_f2_101</ci>
</apply>
<ci>v_d001</ci>
</apply>
<ci>v_f1_101</ci>
</apply>
<ci>v_fCa10</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S110</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_f1_100</ci>
<ci>v_d010</ci>
</apply>
<ci>v_fCa11</ci>
</apply>
<ci>v_f3_110</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S111</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_f1_101</ci>
<ci>v_d011</ci>
<ci>v_fCa11</ci>
</apply>
<ci>v_f3_111</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S120</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_f2_100</ci>
<ci>v_d020</ci>
</apply>
<ci>v_fCa12</ci>
</apply>
<ci>v_f3_110</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_S121</ci>
<apply>
<plus/>
<ci>v_f2_101</ci>
<ci>v_d021</ci>
<ci>v_fCa12</ci>
<ci>v_f3_111</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_S000</ci>
</apply>
<ci>v_S000</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_S001</ci>
</apply>
<ci>v_S001</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_S010</ci>
</apply>
<ci>v_S010</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_S011</ci>
</apply>
<ci>v_S011</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_S020</ci>
</apply>
<ci>v_S020</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_S021</ci>
</apply>
<ci>v_S021</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_S100</ci>
</apply>
<ci>v_S100</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_S101</ci>
</apply>
<ci>v_S101</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_S110</ci>
</apply>
<ci>v_S110</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_S111</ci>
</apply>
<ci>v_S111</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_S120</ci>
</apply>
<ci>v_S120</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_S121</ci>
</apply>
<ci>v_S121</ci>
</apply>
</math>
</component>
<component name="TRPN">
<variable name="time" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="kappa_R_TRPNCa" public_interface="in" units="fmol_per_sec"/>
<variable name="K_Cai" public_interface="in" units="per_fmol"/>
<variable name="K_TRPN" public_interface="in" units="per_fmol"/>
<variable name="K_Ca_TRPN" public_interface="in" units="per_fmol"/>
<variable name="q_Cai_global" public_interface="in" units="fmol"/>
<variable name="q_TRPN_global" public_interface="in" units="fmol"/>
<variable name="q_Ca_TRPN_global" public_interface="in" units="fmol"/>
<variable initial_value="1e-16" name="q_Cai" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_TRPN" public_interface="out" units="fmol"/>
<variable initial_value="1e-16" name="q_Ca_TRPN" public_interface="out" units="fmol"/>
<variable name="mu_Cai" units="J_per_mol"/>
<variable name="mu_TRPN" units="J_per_mol"/>
<variable name="mu_Ca_TRPN" units="J_per_mol"/>
<variable name="v_R_TRPNCa" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu_Cai</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Cai</ci>
<ci>q_Cai_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_TRPN</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_TRPN</ci>
<ci>q_TRPN_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Ca_TRPN</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Ca_TRPN</ci>
<ci>q_Ca_TRPN_global</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_R_TRPNCa</ci>
<apply>
<times/>
<ci>kappa_R_TRPNCa</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<exp/>
<apply>
<plus/>
<ci>mu_Cai</ci>
<ci>mu_TRPN</ci>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<exp/>
<ci>mu_Ca_TRPN</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Cai</ci>
</apply>
<apply>
<minus/>
<ci>v_R_TRPNCa</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_TRPN</ci>
</apply>
<apply>
<minus/>
<ci>v_R_TRPNCa</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q_Ca_TRPN</ci>
</apply>
<ci>v_R_TRPNCa</ci>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="PLB"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_PLB_mPLB" variable_2="q_PLB"/>
<map_variables variable_1="q_PLB" variable_2="q_PLB_global"/>
<map_variables variable_1="q_PKACI_mPLB" variable_2="q_PKACI"/>
<map_variables variable_1="q_PKACI" variable_2="q_PKACI_global"/>
<map_variables variable_1="q_PLB_PKACI_mPLB" variable_2="q_PLB_PKACI"/>
<map_variables variable_1="q_PLB_PKACI" variable_2="q_PLB_PKACI_global"/>
<map_variables variable_1="q_PP1_mPLB" variable_2="q_PP1"/>
<map_variables variable_1="q_PP1" variable_2="q_PP1_global"/>
<map_variables variable_1="q_PLBp_PP1_mPLB" variable_2="q_PLBp_PP1"/>
<map_variables variable_1="q_PLBp_PP1" variable_2="q_PLBp_PP1_global"/>
<map_variables variable_1="q_PLBp_mPLB" variable_2="q_PLBp"/>
<map_variables variable_1="q_PLBp" variable_2="q_PLBp_global"/>
<map_variables variable_1="q_Ip_mPLB" variable_2="q_Ip"/>
<map_variables variable_1="q_Ip" variable_2="q_Ip_global"/>
<map_variables variable_1="q_Ip_PP1_mPLB" variable_2="q_Ip_PP1"/>
<map_variables variable_1="q_Ip_PP1" variable_2="q_Ip_PP1_global"/>
</connection>
<connection>
<map_components component_1="environment" component_2="SERCA"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_P1_SERCA_mSERCA" variable_2="q_P1_SERCA"/>
<map_variables variable_1="q_P1_SERCA" variable_2="q_P1_SERCA_global"/>
<map_variables variable_1="q_P2_SERCA_mSERCA" variable_2="q_P2_SERCA"/>
<map_variables variable_1="q_P2_SERCA" variable_2="q_P2_SERCA_global"/>
<map_variables variable_1="q_P2a_SERCA_mSERCA" variable_2="q_P2a_SERCA"/>
<map_variables variable_1="q_P2a_SERCA" variable_2="q_P2a_SERCA_global"/>
<map_variables variable_1="q_P4_SERCA_mSERCA" variable_2="q_P4_SERCA"/>
<map_variables variable_1="q_P4_SERCA" variable_2="q_P4_SERCA_global"/>
<map_variables variable_1="q_P5_SERCA_mSERCA" variable_2="q_P5_SERCA"/>
<map_variables variable_1="q_P5_SERCA" variable_2="q_P5_SERCA_global"/>
<map_variables variable_1="q_P6_SERCA_mSERCA" variable_2="q_P6_SERCA"/>
<map_variables variable_1="q_P6_SERCA" variable_2="q_P6_SERCA_global"/>
<map_variables variable_1="q_P8_SERCA_mSERCA" variable_2="q_P8_SERCA"/>
<map_variables variable_1="q_P8_SERCA" variable_2="q_P8_SERCA_global"/>
<map_variables variable_1="q_P9_SERCA_mSERCA" variable_2="q_P9_SERCA"/>
<map_variables variable_1="q_P9_SERCA" variable_2="q_P9_SERCA_global"/>
<map_variables variable_1="q_P10_SERCA_mSERCA" variable_2="q_P10_SERCA"/>
<map_variables variable_1="q_P10_SERCA" variable_2="q_P10_SERCA_global"/>
<map_variables variable_1="q_H_mSERCA" variable_2="q_H"/>
<map_variables variable_1="q_H" variable_2="q_H_global"/>
<map_variables variable_1="q_Cai_mSERCA" variable_2="q_Cai"/>
<map_variables variable_1="q_Cai" variable_2="q_Cai_global"/>
<map_variables variable_1="q_Ca_SR_mSERCA" variable_2="q_Ca_SR"/>
<map_variables variable_1="q_Ca_SR" variable_2="q_Ca_SR_global"/>
<map_variables variable_1="q_MgATP_mSERCA" variable_2="q_MgATP"/>
<map_variables variable_1="q_MgATP" variable_2="q_MgATP_global"/>
<map_variables variable_1="q_MgADP_mSERCA" variable_2="q_MgADP"/>
<map_variables variable_1="q_MgADP" variable_2="q_MgADP_global"/>
<map_variables variable_1="q_P_mSERCA" variable_2="q_P"/>
<map_variables variable_1="q_P" variable_2="q_P_global"/>
</connection>
<connection>
<map_components component_1="environment" component_2="RyR"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V_m" variable_2="V_m"/>
<map_variables variable_1="v_RyR" variable_2="v_RyR"/>
<map_variables variable_1="q_Ca_SR_mRyR" variable_2="q_Ca_SR"/>
<map_variables variable_1="q_Ca_SR" variable_2="q_Ca_SR_global"/>
<map_variables variable_1="q_Ca_di_mRyR" variable_2="q_Ca_di"/>
<map_variables variable_1="q_Ca_di" variable_2="q_Ca_di_global"/>
</connection>
<connection>
<map_components component_1="environment" component_2="RyR_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="LCC"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="C_m" variable_2="C_m"/>
<map_variables variable_1="q_membrane" variable_2="q_E"/>
<map_variables variable_1="q_Cai_mLCC" variable_2="q_Cai"/>
<map_variables variable_1="q_Cai" variable_2="q_Cai_global"/>
<map_variables variable_1="q_Cao_mLCC" variable_2="q_Cao"/>
<map_variables variable_1="q_Cao" variable_2="q_Cao_global"/>
<map_variables variable_1="q_Ki_mLCC" variable_2="q_Ki"/>
<map_variables variable_1="q_Ki" variable_2="q_Ki_global"/>
<map_variables variable_1="q_Ko_mLCC" variable_2="q_Ko"/>
<map_variables variable_1="q_Ko" variable_2="q_Ko_global"/>
</connection>
<connection>
<map_components component_1="environment" component_2="TRPN"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="q_Cai_mTRPN" variable_2="q_Cai"/>
<map_variables variable_1="q_Cai" variable_2="q_Cai_global"/>
<map_variables variable_1="q_TRPN_mTRPN" variable_2="q_TRPN"/>
<map_variables variable_1="q_TRPN" variable_2="q_TRPN_global"/>
<map_variables variable_1="q_Ca_TRPN_mTRPN" variable_2="q_Ca_TRPN"/>
<map_variables variable_1="q_Ca_TRPN" variable_2="q_Ca_TRPN_global"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="PLB"/>
<map_variables variable_1="kappa_PLBph1" variable_2="kappa_PLBph1"/>
<map_variables variable_1="kappa_PLBph2" variable_2="kappa_PLBph2"/>
<map_variables variable_1="kappa_PLBd1" variable_2="kappa_PLBd1"/>
<map_variables variable_1="kappa_PLBd2" variable_2="kappa_PLBd2"/>
<map_variables variable_1="kappa_Inh" variable_2="kappa_Inh"/>
<map_variables variable_1="K_PLB" variable_2="K_PLB"/>
<map_variables variable_1="K_PKACI" variable_2="K_PKACI"/>
<map_variables variable_1="K_PLB_PKACI" variable_2="K_PLB_PKACI"/>
<map_variables variable_1="K_PP1" variable_2="K_PP1"/>
<map_variables variable_1="K_PLBp_PP1" variable_2="K_PLBp_PP1"/>
<map_variables variable_1="K_PLBp" variable_2="K_PLBp"/>
<map_variables variable_1="K_Ip" variable_2="K_Ip"/>
<map_variables variable_1="K_Ip_PP1" variable_2="K_Ip_PP1"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="SERCA"/>
<map_variables variable_1="kappa_SERCA_R1_2" variable_2="kappa_SERCA_R1_2"/>
<map_variables variable_1="kappa_SERCA_R2_4" variable_2="kappa_SERCA_R2_4"/>
<map_variables variable_1="kappa_SERCA_R2_2a" variable_2="kappa_SERCA_R2_2a"/>
<map_variables variable_1="kappa_SERCA_R4_5" variable_2="kappa_SERCA_R4_5"/>
<map_variables variable_1="kappa_SERCA_R5_6" variable_2="kappa_SERCA_R5_6"/>
<map_variables variable_1="kappa_SERCA_R6_8" variable_2="kappa_SERCA_R6_8"/>
<map_variables variable_1="kappa_SERCA_R8_9" variable_2="kappa_SERCA_R8_9"/>
<map_variables variable_1="kappa_SERCA_R9_10" variable_2="kappa_SERCA_R9_10"/>
<map_variables variable_1="kappa_SERCA_R10_1" variable_2="kappa_SERCA_R10_1"/>
<map_variables variable_1="K_P1_SERCA" variable_2="K_P1_SERCA"/>
<map_variables variable_1="K_P2_SERCA" variable_2="K_P2_SERCA"/>
<map_variables variable_1="K_P2a_SERCA" variable_2="K_P2a_SERCA"/>
<map_variables variable_1="K_P4_SERCA" variable_2="K_P4_SERCA"/>
<map_variables variable_1="K_P5_SERCA" variable_2="K_P5_SERCA"/>
<map_variables variable_1="K_P6_SERCA" variable_2="K_P6_SERCA"/>
<map_variables variable_1="K_P8_SERCA" variable_2="K_P8_SERCA"/>
<map_variables variable_1="K_P9_SERCA" variable_2="K_P9_SERCA"/>
<map_variables variable_1="K_P10_SERCA" variable_2="K_P10_SERCA"/>
<map_variables variable_1="K_H" variable_2="K_H"/>
<map_variables variable_1="K_Cai" variable_2="K_Cai"/>
<map_variables variable_1="K_Ca_SR" variable_2="K_Ca_SR"/>
<map_variables variable_1="K_MgATP" variable_2="K_MgATP"/>
<map_variables variable_1="K_MgADP" variable_2="K_MgADP"/>
<map_variables variable_1="K_P" variable_2="K_P"/>
</connection>
<connection>
<map_components component_1="RyR" component_2="BG_parameters"/>
<map_variables variable_1="kappa_RyR" variable_2="kappa_RyR"/>
<map_variables variable_1="K_Ca_SR" variable_2="K_Ca_SR"/>
<map_variables variable_1="K_Ca_di" variable_2="K_Ca_di"/>
</connection>
<connection>
<map_components component_1="RyR_gate" component_2="BG_parameters"/>
<map_variables variable_1="kappa_OC" variable_2="kappa_OC"/>
<map_variables variable_1="kappa_CCI" variable_2="kappa_CCI"/>
<map_variables variable_1="kappa_CII" variable_2="kappa_CII"/>
<map_variables variable_1="kappa_IO" variable_2="kappa_IO"/>
<map_variables variable_1="K_C_RyR" variable_2="K_C_RyR"/>
<map_variables variable_1="K_CI_RyR" variable_2="K_CI_RyR"/>
<map_variables variable_1="K_I_RyR" variable_2="K_I_RyR"/>
<map_variables variable_1="K_O_RyR" variable_2="K_O_RyR"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="LCC"/>
<map_variables variable_1="kappa_Ca1" variable_2="kappa_Ca1"/>
<map_variables variable_1="kappa_Ca2" variable_2="kappa_Ca2"/>
<map_variables variable_1="kappa_K1" variable_2="kappa_K1"/>
<map_variables variable_1="kappa_K2" variable_2="kappa_K2"/>
<map_variables variable_1="K_Cai" variable_2="K_Cai"/>
<map_variables variable_1="K_Cao" variable_2="K_Cao"/>
<map_variables variable_1="K_Ki" variable_2="K_Ki"/>
<map_variables variable_1="K_Ko" variable_2="K_Ko"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="LCC_gate"/>
<map_variables variable_1="K_000_LCC" variable_2="K_000"/>
<map_variables variable_1="K_010_LCC" variable_2="K_010"/>
<map_variables variable_1="K_020_LCC" variable_2="K_020"/>
<map_variables variable_1="K_100_LCC" variable_2="K_100"/>
<map_variables variable_1="K_110_LCC" variable_2="K_110"/>
<map_variables variable_1="K_120_LCC" variable_2="K_120"/>
<map_variables variable_1="K_001_LCC" variable_2="K_001"/>
<map_variables variable_1="K_011_LCC" variable_2="K_011"/>
<map_variables variable_1="K_021_LCC" variable_2="K_021"/>
<map_variables variable_1="K_101_LCC" variable_2="K_101"/>
<map_variables variable_1="K_111_LCC" variable_2="K_111"/>
<map_variables variable_1="K_121_LCC" variable_2="K_121"/>
<map_variables variable_1="kappa_d000" variable_2="kappa_d000"/>
<map_variables variable_1="kappa_d010" variable_2="kappa_d010"/>
<map_variables variable_1="kappa_d020" variable_2="kappa_d020"/>
<map_variables variable_1="kappa_d001" variable_2="kappa_d001"/>
<map_variables variable_1="kappa_d011" variable_2="kappa_d011"/>
<map_variables variable_1="kappa_d021" variable_2="kappa_d021"/>
<map_variables variable_1="kappa_f1_000" variable_2="kappa_f1_000"/>
<map_variables variable_1="kappa_f1_100" variable_2="kappa_f1_100"/>
<map_variables variable_1="kappa_f1_001" variable_2="kappa_f1_001"/>
<map_variables variable_1="kappa_f1_101" variable_2="kappa_f1_101"/>
<map_variables variable_1="kappa_f2_000" variable_2="kappa_f2_000"/>
<map_variables variable_1="kappa_f2_100" variable_2="kappa_f2_100"/>
<map_variables variable_1="kappa_f2_001" variable_2="kappa_f2_001"/>
<map_variables variable_1="kappa_f2_101" variable_2="kappa_f2_101"/>
<map_variables variable_1="kappa_f3_010" variable_2="kappa_f3_010"/>
<map_variables variable_1="kappa_f3_110" variable_2="kappa_f3_110"/>
<map_variables variable_1="kappa_f3_011" variable_2="kappa_f3_011"/>
<map_variables variable_1="kappa_f3_111" variable_2="kappa_f3_111"/>
<map_variables variable_1="kappa_fCa000" variable_2="kappa_fCa000"/>
<map_variables variable_1="kappa_fCa100" variable_2="kappa_fCa100"/>
<map_variables variable_1="kappa_fCa010" variable_2="kappa_fCa010"/>
<map_variables variable_1="kappa_fCa110" variable_2="kappa_fCa110"/>
<map_variables variable_1="kappa_fCa020" variable_2="kappa_fCa020"/>
<map_variables variable_1="kappa_fCa120" variable_2="kappa_fCa120"/>
</connection>
<connection>
<map_components component_1="BG_parameters" component_2="TRPN"/>
<map_variables variable_1="kappa_R_TRPNCa" variable_2="kappa_R_TRPNCa"/>
<map_variables variable_1="K_Cai" variable_2="K_Cai"/>
<map_variables variable_1="K_TRPN" variable_2="K_TRPN"/>
<map_variables variable_1="K_Ca_TRPN" variable_2="K_Ca_TRPN"/>
</connection>
<connection>
<map_components component_1="constants" component_2="PLB"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="SERCA"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="constants" component_2="RyR"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="constants" component_2="RyR_gate"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="constants" component_2="LCC"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="constants" component_2="TRPN"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="ion_valences" component_2="LCC"/>
<map_variables variable_1="zCa" variable_2="zCa"/>
<map_variables variable_1="zK" variable_2="zK"/>
</connection>
<connection>
<map_components component_1="environment" component_2="LCC_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="constants" component_2="LCC_gate"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="constants" component_2="environment"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="ion_valences" component_2="RyR"/>
<map_variables variable_1="zCa" variable_2="zCa"/>
</connection>
<connection>
<map_components component_1="RyR" component_2="RyR_gate"/>
<map_variables variable_1="mu_Ca_di" variable_2="mu_Ca_di"/>
<map_variables variable_1="mu_O_RyR" variable_2="mu_O_RyR"/>
<map_variables variable_1="v_OC" variable_2="v_OC"/>
<map_variables variable_1="v_CCI" variable_2="v_CCI"/>
<map_variables variable_1="v_CII" variable_2="v_CII"/>
<map_variables variable_1="v_IO" variable_2="v_IO"/>
<map_variables variable_1="nCa_1" variable_2="nCa_1"/>
<map_variables variable_1="nCa_2" variable_2="nCa_2"/>
</connection>
<connection>
<map_components component_1="LCC" component_2="LCC_gate"/>
<map_variables variable_1="RT" variable_2="RT"/>
<map_variables variable_1="mu_E" variable_2="Vmem"/>
<map_variables variable_1="mu_Cai" variable_2="mu_Cai"/>
<map_variables variable_1="mu_S111" variable_2="mu_S111"/>
<map_variables variable_1="mu_S121" variable_2="mu_S121"/>
<map_variables variable_1="v_fCa00" variable_2="v_fCa00"/>
<map_variables variable_1="v_fCa01" variable_2="v_fCa01"/>
<map_variables variable_1="v_fCa02" variable_2="v_fCa02"/>
<map_variables variable_1="v_fCa10" variable_2="v_fCa10"/>
<map_variables variable_1="v_fCa11" variable_2="v_fCa11"/>
<map_variables variable_1="v_fCa12" variable_2="v_fCa12"/>
</connection>
</model>