Location: A review of cardiac cellular electrophysiology models @ 1e62f9a11a1b / models / 1991_luo / fast_sodium_current_j_gate_model.xml

Author:
David Nickerson <nickerso@users.sourceforge.net>
Date:
2011-06-21 15:56:12+12:00
Desc:
adding a standalone version of the SED-ML document for this example, updating to pass validation using Frank's new web tools
Permanent Source URI:
https://models.cellml.org/workspace/a1/rawfile/1e62f9a11a1b467aff7bc1ddd0b4fc8ac3f052c0/models/1991_luo/fast_sodium_current_j_gate_model.xml

<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" name="fast_sodium_current_j_gate_model">
  <component name="fast_sodium_current_j_gate">
    <variable initial_value="j_initial" name="j" private_interface="out" public_interface="out" units="dimensionless"/>
    <variable name="j_initial" public_interface="in" units="dimensionless"/>
    <variable name="alpha_j" private_interface="out" public_interface="out" units="per_ms"/>
    <variable name="beta_j" private_interface="out" public_interface="out" units="per_ms"/>
    <variable name="V" private_interface="out" public_interface="in" units="mV"/>
    <variable name="time" private_interface="out" public_interface="in" units="ms"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="alpha_j_calculation_eq">
      <apply id="alpha_j_calculation"><eq/>
        <ci> alpha_j </ci>
        <piecewise>
          <piece>
            <apply><times/>
              <apply><minus/>
                <apply><times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV_ms"> -127140.0 </cn>
                  <apply><exp/>
                    <apply><times/> 
                      <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV"> 0.2444 </cn>
                      <ci> V </ci>
                    </apply>
                  </apply>
                </apply>
                <apply><times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV_ms"> 0.00003474 </cn>
                  <apply><exp/>
                    <apply><times/>
                      <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV"> -0.04391 </cn>
                      <ci> V </ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply><divide/>
                <apply><plus/>
                  <ci> V </ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV"> 37.78 </cn>
                </apply>
                <apply><plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless"> 1.0 </cn>
                  <apply><exp/>
                    <apply><times/>
                      <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV"> 0.311 </cn>
                      <apply><plus/>
                        <ci> V </ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV"> 79.23 </cn>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
            <apply><lt/>
              <ci> V </ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV"> -40.0 </cn>
            </apply>
          </piece>
          <otherwise>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_ms"> 0.0 </cn>
          </otherwise>
        </piecewise>
      </apply>
    </math>
    <math xmlns="http://www.w3.org/1998/Math/MathML" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="beta_j_calculation_eq">
      <apply id="beta_j_calculation"><eq/>
        <ci> beta_j </ci>
        <piecewise>
          <piece>
            <apply><times/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_ms"> 0.1212 </cn>
              <apply><divide/>
                <apply><exp/>
                  <apply><times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV"> -0.01052 </cn>
                    <ci> V </ci>
                  </apply>
                </apply>
                <apply><plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless"> 1.0 </cn>
                  <apply><exp/>
                    <apply><times/>
                      <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV"> -0.1378 </cn>
                      <apply><plus/>       
                        <ci> V </ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV"> 40.14 </cn>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
            <apply><lt/>
              <ci> V </ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV"> -40.0 </cn>
            </apply>
          </piece>
          <otherwise>
            <apply><times/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_ms"> 0.3 </cn>
              <apply><divide/>
                <apply><exp/>
                  <apply><times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV"> -0.0000002535 </cn>
                    <ci> V </ci>                                                
                  </apply>
                </apply>
                <apply><plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless"> 1.0 </cn>
                  <apply><exp/>
                    <apply><times/>
                      <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV"> -0.1 </cn>
                      <apply><plus/>
                        <ci> V </ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV"> 32.0 </cn>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>                                                            
          </otherwise> 
        </piecewise>
      </apply>
    </math>
    <math xmlns="http://www.w3.org/1998/Math/MathML" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="dj_dt_eq">
      <apply id="dj_dt"><eq/>
        <apply><diff/>
          <bvar><ci> time </ci></bvar>
          <ci> j </ci>
        </apply>
        <apply><minus/>
          <apply><times/>
            <ci> alpha_j </ci>
            <apply><minus/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless"> 1.0 </cn>
              <ci> j </ci>
            </apply>
          </apply>
          <apply><times/>
            <ci> beta_j </ci>
            <ci> j </ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="luo_rudy_I_model_1991_units_model.xml">
    <units name="ms" units_ref="ms"/>
    <units name="per_ms" units_ref="per_ms"/>
    <units name="mV" units_ref="mV"/>
    <units name="per_mV" units_ref="per_mV"/>
    <units name="per_mV_ms" units_ref="per_mV_ms"/>
    <units name="mS_per_mm2" units_ref="mS_per_mm2"/>
    <units name="uF_per_mm2" units_ref="uF_per_mm2"/>
    <units name="uA_per_mm2" units_ref="uA_per_mm2"/>
    <units name="concentration_units" units_ref="concentration_units"/>
    <units name="gas_constant_units" units_ref="gas_constant_units"/>
    <units name="faradays_constant_units" units_ref="faradays_constant_units"/>
  </import>
</model>