- Author:
- David Nickerson <nickerso@users.sourceforge.net>
- Date:
- 2011-06-21 15:56:12+12:00
- Desc:
- adding a standalone version of the SED-ML document for this example, updating to pass validation using Frank's new web tools
- Permanent Source URI:
- https://models.cellml.org/workspace/a1/rawfile/1e62f9a11a1b467aff7bc1ddd0b4fc8ac3f052c0/models/1991_luo/luo_rudy_I_model_1991_interface_model.xml
<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" name="luo_rudy_I_model_1991_interface_model" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<component name="luo_rudy_I_model_1991_interface_component">
<variable name="time" public_interface="in" private_interface="out" units="ms"/>
<variable name="V" private_interface="in" public_interface="out" units="mV"/>
<variable name="V_initial" private_interface="out" public_interface="in" units="mV"/>
<variable name="R" private_interface="out" public_interface="in" units="gas_constant_units"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="F" private_interface="out" public_interface="in" units="faradays_constant_units"/>
<variable name="C" private_interface="out" public_interface="in" units="uF_per_mm2"/>
<variable name="I_stim" private_interface="out" public_interface="in" units="uA_per_mm2"/>
<variable name="i_Na" private_interface="in" public_interface="out" units="uA_per_mm2"/>
<variable name="g_Na" private_interface="out" public_interface="in" units="mS_per_mm2"/>
<variable name="E_Na" private_interface="out" public_interface="in" units="mV"/>
<variable name="m" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="m_initial" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="alpha_m" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="beta_m" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="h" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="h_initial" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="alpha_h" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="beta_h" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="j" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="j_initial" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="alpha_j" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="beta_j" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="i_si" private_interface="in" public_interface="out" units="uA_per_mm2"/>
<variable name="E_si" private_interface="in" public_interface="out" units="mV"/>
<variable name="g_si" private_interface="out" public_interface="in" units="mS_per_mm2"/>
<variable name="d" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="d_initial" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="alpha_d" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="beta_d" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="f" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="f_initial" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="alpha_f" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="beta_f" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="i_K" private_interface="in" public_interface="out" units="uA_per_mm2"/>
<variable name="g_K" private_interface="out" public_interface="in" units="mS_per_mm2"/>
<variable name="g_K_max" private_interface="in" public_interface="out" units="mS_per_mm2"/>
<variable name="E_K" private_interface="in" public_interface="out" units="mV"/>
<variable name="PR_NaK" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="X" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="X_initial" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="alpha_X" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="beta_X" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="Xi" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="i_K1" private_interface="in" public_interface="out" units="uA_per_mm2"/>
<variable name="E_K1" private_interface="in" public_interface="out" units="mV"/>
<variable name="g_K1" private_interface="out" public_interface="in" units="mS_per_mm2"/>
<variable name="g_K1_max" private_interface="in" public_interface="out" units="mS_per_mm2"/>
<variable name="K1_infinity" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="alpha_K1" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="beta_K1" private_interface="in" public_interface="out" units="per_ms"/>
<variable name="i_Kp" private_interface="in" public_interface="out" units="uA_per_mm2"/>
<variable name="E_Kp" private_interface="in" public_interface="out" units="mV"/>
<variable name="g_Kp" private_interface="out" public_interface="in" units="mS_per_mm2"/>
<variable name="Kp" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="i_b" private_interface="in" public_interface="out" units="uA_per_mm2"/>
<variable name="E_b" private_interface="out" public_interface="in" units="mV"/>
<variable name="g_b" private_interface="out" public_interface="in" units="mS_per_mm2"/>
<variable name="Nao" private_interface="out" public_interface="in" units="concentration_units"/>
<variable name="Nai" private_interface="out" public_interface="in" units="concentration_units"/>
<variable name="Cao" private_interface="out" public_interface="in" units="concentration_units"/>
<variable name="Ki" private_interface="out" public_interface="in" units="concentration_units"/>
<variable name="Ko" private_interface="out" public_interface="in" units="concentration_units"/>
<variable name="Cai" private_interface="in" public_interface="out" units="concentration_units"/>
<variable name="Cai_initial" private_interface="out" public_interface="in" units="concentration_units"/>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="luo_rudy_I_model_1991_interface_component">
<component_ref component="membrane"/>
<component_ref component="fast_sodium_current"/>
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
<component_ref component="fast_sodium_current_j_gate"/>
<component_ref component="slow_inward_current"/>
<component_ref component="slow_inward_current_d_gate"/>
<component_ref component="slow_inward_current_f_gate"/>
<component_ref component="time_dependent_potassium_current"/>
<component_ref component="time_dependent_potassium_current_X_gate"/>
<component_ref component="time_dependent_potassium_current_Xi_gate"/>
<component_ref component="time_independent_potassium_current"/>
<component_ref component="time_independent_potassium_current_K1_gate"/>
<component_ref component="plateau_potassium_current"/>
<component_ref component="background_current"/>
<component_ref component="ionic_concentrations"/>
<component_ref component="intracellular_calcium_concentration"/>
</component_ref>
</group>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="membrane_model.xml">
<component component_ref="membrane" name="membrane"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="fast_sodium_current_model.xml">
<component component_ref="fast_sodium_current" name="fast_sodium_current"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="fast_sodium_current_m_gate_model.xml">
<component component_ref="fast_sodium_current_m_gate" name="fast_sodium_current_m_gate"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="fast_sodium_current_h_gate_model.xml">
<component component_ref="fast_sodium_current_h_gate" name="fast_sodium_current_h_gate"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="fast_sodium_current_j_gate_model.xml">
<component component_ref="fast_sodium_current_j_gate" name="fast_sodium_current_j_gate"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="slow_inward_current_model.xml">
<component component_ref="slow_inward_current" name="slow_inward_current"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="slow_inward_current_d_gate_model.xml">
<component component_ref="slow_inward_current_d_gate" name="slow_inward_current_d_gate"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="slow_inward_current_f_gate_model.xml">
<component component_ref="slow_inward_current_f_gate" name="slow_inward_current_f_gate"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="time_dependent_potassium_current_model.xml">
<component component_ref="time_dependent_potassium_current" name="time_dependent_potassium_current"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="time_dependent_potassium_current_X_gate_model.xml">
<component component_ref="time_dependent_potassium_current_X_gate" name="time_dependent_potassium_current_X_gate"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="time_dependent_potassium_current_Xi_gate_model.xml">
<component component_ref="time_dependent_potassium_current_Xi_gate" name="time_dependent_potassium_current_Xi_gate"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="time_independent_potassium_current_model.xml">
<component component_ref="time_independent_potassium_current" name="time_independent_potassium_current"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="time_independent_potassium_current_K1_gate_model.xml">
<component component_ref="time_independent_potassium_current_K1_gate" name="time_independent_potassium_current_K1_gate"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="plateau_potassium_current_model.xml">
<component component_ref="plateau_potassium_current" name="plateau_potassium_current"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="background_current_model.xml">
<component component_ref="background_current" name="background_current"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="ionic_concentrations_model.xml">
<component component_ref="ionic_concentrations" name="ionic_concentrations"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="intracellular_calcium_concentration_model.xml">
<component component_ref="intracellular_calcium_concentration" name="intracellular_calcium_concentration"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="luo_rudy_I_model_1991_units_model.xml">
<units name="ms" units_ref="ms"/>
<units name="per_ms" units_ref="per_ms"/>
<units name="mV" units_ref="mV"/>
<units name="per_mV" units_ref="per_mV"/>
<units name="per_mV_ms" units_ref="per_mV_ms"/>
<units name="mS_per_mm2" units_ref="mS_per_mm2"/>
<units name="uF_per_mm2" units_ref="uF_per_mm2"/>
<units name="uA_per_mm2" units_ref="uA_per_mm2"/>
<units name="concentration_units" units_ref="concentration_units"/>
<units name="gas_constant_units" units_ref="gas_constant_units"/>
<units name="faradays_constant_units" units_ref="faradays_constant_units"/>
</import>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="V_initial" variable_2="V_initial"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="C" variable_2="C"/>
<map_variables variable_1="I_stim" variable_2="I_stim"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current_m_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current_h_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current_j_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="slow_inward_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_si" variable_2="i_si"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="slow_inward_current_d_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="slow_inward_current_f_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_dependent_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K" variable_2="i_K"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_dependent_potassium_current_X_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_dependent_potassium_current_Xi_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_potassium_current_K1_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="plateau_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kp" variable_2="i_Kp"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_b" variable_2="i_b"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="time_dependent_potassium_current"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_K" variable_2="i_K"/>
<map_variables variable_1="g_K" variable_2="g_K"/>
<map_variables variable_1="g_K_max" variable_2="g_K_max"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
<map_variables variable_1="PR_NaK" variable_2="PR_NaK"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="time_independent_potassium_current"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="E_K1" variable_2="E_K1"/>
<map_variables variable_1="g_K1" variable_2="g_K1"/>
<map_variables variable_1="g_K1_max" variable_2="g_K1_max"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="fast_sodium_current"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="g_Na" variable_2="g_Na"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="fast_sodium_current_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="m_initial" variable_2="m_initial"/>
<map_variables variable_1="alpha_m" variable_2="alpha_m"/>
<map_variables variable_1="beta_m" variable_2="beta_m"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current_m_gate" component_2="fast_sodium_current"/>
<map_variables variable_1="m" variable_2="m"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="fast_sodium_current_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="h_initial" variable_2="h_initial"/>
<map_variables variable_1="alpha_h" variable_2="alpha_h"/>
<map_variables variable_1="beta_h" variable_2="beta_h"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current_h_gate" component_2="fast_sodium_current"/>
<map_variables variable_1="h" variable_2="h"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="fast_sodium_current_j_gate"/>
<map_variables variable_1="j" variable_2="j"/>
<map_variables variable_1="j_initial" variable_2="j_initial"/>
<map_variables variable_1="alpha_j" variable_2="alpha_j"/>
<map_variables variable_1="beta_j" variable_2="beta_j"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current_j_gate" component_2="fast_sodium_current"/>
<map_variables variable_1="j" variable_2="j"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="slow_inward_current"/>
<map_variables variable_1="i_si" variable_2="i_si"/>
<map_variables variable_1="E_si" variable_2="E_si"/>
<map_variables variable_1="g_si" variable_2="g_si"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="slow_inward_current" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="i_si" variable_2="i_si"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="slow_inward_current_d_gate"/>
<map_variables variable_1="d" variable_2="d"/>
<map_variables variable_1="d_initial" variable_2="d_initial"/>
<map_variables variable_1="alpha_d" variable_2="alpha_d"/>
<map_variables variable_1="beta_d" variable_2="beta_d"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="slow_inward_current_d_gate" component_2="slow_inward_current"/>
<map_variables variable_1="d" variable_2="d"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="slow_inward_current_f_gate"/>
<map_variables variable_1="f" variable_2="f"/>
<map_variables variable_1="f_initial" variable_2="f_initial"/>
<map_variables variable_1="alpha_f" variable_2="alpha_f"/>
<map_variables variable_1="beta_f" variable_2="beta_f"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="slow_inward_current_f_gate" component_2="slow_inward_current"/>
<map_variables variable_1="f" variable_2="f"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="time_dependent_potassium_current_X_gate"/>
<map_variables variable_1="X" variable_2="X"/>
<map_variables variable_1="X_initial" variable_2="X_initial"/>
<map_variables variable_1="alpha_X" variable_2="alpha_X"/>
<map_variables variable_1="beta_X" variable_2="beta_X"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_dependent_potassium_current_X_gate" component_2="time_dependent_potassium_current"/>
<map_variables variable_1="X" variable_2="X"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="time_dependent_potassium_current_Xi_gate"/>
<map_variables variable_1="Xi" variable_2="Xi"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_dependent_potassium_current_Xi_gate" component_2="time_dependent_potassium_current"/>
<map_variables variable_1="Xi" variable_2="Xi"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="time_independent_potassium_current_K1_gate"/>
<map_variables variable_1="E_K1" variable_2="E_K1"/>
<map_variables variable_1="K1_infinity" variable_2="K1_infinity"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="plateau_potassium_current"/>
<map_variables variable_1="E_K1" variable_2="E_K1"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="time_independent_potassium_current_K1_gate"/>
<map_variables variable_1="K1_infinity" variable_2="K1_infinity"/>
<map_variables variable_1="alpha_K1" variable_2="alpha_K1"/>
<map_variables variable_1="beta_K1" variable_2="beta_K1"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="plateau_potassium_current"/>
<map_variables variable_1="i_Kp" variable_2="i_Kp"/>
<map_variables variable_1="E_Kp" variable_2="E_Kp"/>
<map_variables variable_1="g_Kp" variable_2="g_Kp"/>
<map_variables variable_1="Kp" variable_2="Kp"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="background_current"/>
<map_variables variable_1="i_b" variable_2="i_b"/>
<map_variables variable_1="E_b" variable_2="E_b"/>
<map_variables variable_1="g_b" variable_2="g_b"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="ionic_concentrations"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="intracellular_calcium_concentration"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Cai_initial" variable_2="Cai_initial"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
</model>
