Location: Cardiovascular model with the feedback loops @ c334ac721b0c / models / cardiovascular.cellml
- Author:
- Weiwei Ai <wai484@aucklanduni.ac.nz>
- Date:
- 2024-07-08 12:47:04+12:00
- Desc:
- Seperate activation in cvs; add Gee_whiz model
- Permanent Source URI:
- https://models.cellml.org/workspace/b6e/rawfile/c334ac721b0c05be42d9ca7ba5250cab46d80f87/models/cardiovascular.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="cardiovascular" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<!-- Units-->
<import xlink:href="./units.cellml">
<units name="mmHg" units_ref="mmHg"/>
<units name="mL" units_ref="mL"/>
<units name="per_mL" units_ref="per_mL"/>
<units name="s_per_mL" units_ref="s_per_mL"/>
<units name="mL_per_s" units_ref="mL_per_s"/>
<units name="mL_per_mmHg" units_ref="mL_per_mmHg"/>
<units name="mmHg_s_per_mL" units_ref="mmHg_s_per_mL"/>
<units name="mmHg_per_mL" units_ref="mmHg_per_mL"/>
<units name="mmHg_s2_per_mL" units_ref="mmHg_s2_per_mL"/>
<units name="s2" units_ref="s2"/>
<units name="mmHg_per_s" units_ref="mmHg_per_s"/>
</import>
<component name="activation">
<variable name="t" public_interface="in" units="second"/>
<variable name="T" public_interface="out" units="second"/>
<variable name="T_0" public_interface="in" units="second"/>
<variable initial_value="0.4" name="T_sys_0" units="second"/>
<variable initial_value="0.075" name="k_sys" units="s2"/>
<variable name="T_sys" units="second"/>
<variable name="u" public_interface="out" units="dimensionless"/>
<variable name="phi" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>u</ci>
<apply>
<minus/>
<apply>
<divide/>
<ci>t</ci>
<ci>T_0</ci>
</apply>
<apply>
<floor/>
<apply>
<divide/>
<ci>t</ci>
<ci>T_0</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>T</ci>
<apply>
<minus/>
<ci>t</ci>
<apply>
<times/>
<ci>T_0</ci>
<apply>
<floor/>
<apply>
<divide/>
<ci>t</ci>
<ci>T_0</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>T_sys</ci>
<piecewise>
<piece>
<apply>
<minus/>
<ci>T_sys_0</ci>
<apply>
<divide/>
<ci>k_sys</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<gt/>
<ci>T</ci>
<cn cellml:units="second">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<minus/>
<ci>T_sys_0</ci>
<apply>
<divide/>
<ci>k_sys</ci>
<ci>T_0</ci>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>phi</ci>
<piecewise>
<piece>
<apply>
<power/>
<apply>
<sin/>
<apply>
<divide/>
<apply>
<times/>
<pi/>
<ci>u</ci>
<ci>T</ci>
</apply>
<ci>T_sys_0</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<and/>
<apply>
<geq/>
<ci>u</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<leq/>
<ci>u</ci>
<apply>
<divide/>
<ci>T_sys_0</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="cvs">
<variable name="t" public_interface="in" units="second"/>
<variable name="phi" public_interface="in" units="dimensionless"/>
<variable initial_value="4" name="q_ra" units="mL"/>
<variable initial_value="5" name="q_rv" units="mL"/>
<variable initial_value="4" name="q_la" units="mL"/>
<variable initial_value="10" name="q_lv" units="mL"/>
<variable initial_value="4" name="q_pa" units="mL"/>
<variable initial_value="5" name="q_pc" units="mL"/>
<variable initial_value="4" name="q_pv" units="mL"/>
<variable initial_value="5" name="q_sa" units="mL"/>
<variable initial_value="10" name="q_sc" units="mL"/>
<variable name="q_sv" units="mL"/>
<variable initial_value="5800" name="q_tot" units="mL"/>
<variable initial_value="3500" name="q_tot_u" units="mL"/>
<!--274.4+274.1+62.5+1121+1120+255+123+120=3500-->
<variable name="u_ra" units="mmHg"/>
<variable name="u_rv" units="mmHg"/>
<variable name="u_la" units="mmHg"/>
<variable name="u_lv" units="mmHg"/>
<variable name="u_pa" units="mmHg"/>
<variable name="u_pc" units="mmHg"/>
<variable name="u_pv" public_interface="out" units="mmHg"/>
<variable name="u_sa" public_interface="out" units="mmHg"/>
<!-- var u_sa1: mmHg {init: 17.85714285714286, pub: out};-->
<variable name="du_sa" public_interface="out" units="mmHg_per_s"/>
<variable name="u_sc" units="mmHg"/>
<variable name="u_sv" units="mmHg"/>
<variable name="v_TV" units="mL_per_s"/>
<variable name="v_PV" units="mL_per_s"/>
<variable name="v_MV" units="mL_per_s"/>
<variable name="v_AV" units="mL_per_s"/>
<variable initial_value="5" name="v_pa" units="mL_per_s"/>
<variable name="v_pv" units="mL_per_s"/>
<variable name="v_la" units="mL_per_s"/>
<variable initial_value="5" name="v_sa" units="mL_per_s"/>
<variable name="v_sc" units="mL_per_s"/>
<variable name="v_sv" units="mL_per_s"/>
<variable initial_value="31.25" name="C_ra" units="mL_per_mmHg"/>
<variable initial_value="0.76" name="C_pa" units="mL_per_mmHg"/>
<variable initial_value="5.8" name="C_pc" units="mL_per_mmHg"/>
<variable initial_value="25.37" name="C_pv" units="mL_per_mmHg"/>
<variable initial_value="19.23" name="C_la" units="mL_per_mmHg"/>
<variable initial_value="0.28" name="C_sa" units="mL_per_mmHg"/>
<variable initial_value="3.72" name="C_sc" units="mL_per_mmHg"/>
<!-- 2.05+1.36+0.31=3.72-->
<variable initial_value="111.11" name="C_sv" units="mL_per_mmHg"/>
<!--43.11+28.4+6.6+33
var R_rv: mmHg_s_per_mL {init: 5};
var R_lv: mmHg_s_per_mL {init: 5};-->
<variable initial_value="2.5e-3" name="R_TV" units="mmHg_s_per_mL"/>
<variable name="R_PV" units="mmHg_s_per_mL"/>
<variable initial_value="2.5e-3" name="R_MV" units="mmHg_s_per_mL"/>
<variable name="R_AV" units="mmHg_s_per_mL"/>
<variable initial_value="0.023" name="R_pa" units="mmHg_s_per_mL"/>
<variable initial_value="0.0894" name="R_pv" units="mmHg_s_per_mL"/>
<!-- R_pp-->
<variable initial_value="0.0056" name="R_la" units="mmHg_s_per_mL"/>
<!-- R_pv-->
<variable initial_value="0.0054" name="R_sv" units="mmHg_s_per_mL"/>
<!--R_tv-->
<variable initial_value="0.8895" name="R_sc" units="mmHg_s_per_mL"/>
<!--1/( 1/R_sp+1/R_ep+1/R_mp)-->
<variable initial_value="0.06" name="R_sa" units="mmHg_s_per_mL"/>
<variable initial_value="1.8e-4" name="L_pa" units="mmHg_s2_per_mL"/>
<variable initial_value="2.2e-4" name="L_sa" units="mmHg_s2_per_mL"/>
<variable initial_value="1.4e-3" name="k_PV_R" units="s_per_mL"/>
<variable initial_value="3.75e-4" name="k_AV_R" units="s_per_mL"/>
<variable initial_value="0.014" name="k_lv_E" units="per_mL"/>
<variable initial_value="0.011" name="k_rv_E" units="per_mL"/>
<variable initial_value="16.77" name="q_lv_u" units="mL"/>
<variable initial_value="40.8" name="q_rv_u" units="mL"/>
<variable initial_value="1.5" name="u_lv_0" units="mmHg"/>
<variable initial_value="1.5" name="u_rv_0" units="mmHg"/>
<variable initial_value="1.283" name="E_lv_max" units="mmHg_per_mL"/>
<variable initial_value="0.757" name="E_rv_max" units="mmHg_per_mL"/>
<variable name="u_rv_max" units="mmHg"/>
<variable name="u_lv_max" units="mmHg"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>u_lv_max</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>phi</ci>
<ci>E_lv_max</ci>
<apply>
<minus/>
<ci>q_lv</ci>
<ci>q_lv_u</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>phi</ci>
</apply>
<ci>u_lv_0</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<ci>k_lv_E</ci>
<ci>q_lv</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>u_rv_max</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>phi</ci>
<ci>E_rv_max</ci>
<apply>
<minus/>
<ci>q_rv</ci>
<ci>q_rv_u</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>phi</ci>
</apply>
<ci>u_rv_0</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<ci>k_rv_E</ci>
<ci>q_rv</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_ra</ci>
</apply>
<apply>
<minus/>
<ci>v_sv</ci>
<ci>v_TV</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_rv</ci>
</apply>
<apply>
<minus/>
<ci>v_TV</ci>
<ci>v_PV</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_pa</ci>
</apply>
<apply>
<minus/>
<ci>v_PV</ci>
<ci>v_pa</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_pc</ci>
</apply>
<apply>
<minus/>
<ci>v_pa</ci>
<ci>v_pv</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_pv</ci>
</apply>
<apply>
<minus/>
<ci>v_pv</ci>
<ci>v_la</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_la</ci>
</apply>
<apply>
<minus/>
<ci>v_la</ci>
<ci>v_MV</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_lv</ci>
</apply>
<apply>
<minus/>
<ci>v_MV</ci>
<ci>v_AV</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_sa</ci>
</apply>
<apply>
<minus/>
<ci>v_AV</ci>
<ci>v_sa</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_sc</ci>
</apply>
<apply>
<minus/>
<ci>v_sa</ci>
<ci>v_sc</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_sv</ci>
<apply>
<minus/>
<apply>
<minus/>
<ci>q_tot</ci>
<ci>q_tot_u</ci>
</apply>
<apply>
<plus/>
<ci>q_ra</ci>
<ci>q_rv</ci>
<ci>q_pa</ci>
<ci>q_pc</ci>
<ci>q_pv</ci>
<ci>q_la</ci>
<ci>q_lv</ci>
<ci>q_sa</ci>
<ci>q_sc</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>u_ra</ci>
<apply>
<divide/>
<ci>q_ra</ci>
<ci>C_ra</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>u_rv</ci>
<apply>
<minus/>
<ci>u_rv_max</ci>
<apply>
<times/>
<ci>R_PV</ci>
<ci>v_PV</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>u_pa</ci>
<apply>
<divide/>
<ci>q_pa</ci>
<ci>C_pa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>u_pc</ci>
<apply>
<divide/>
<ci>q_pc</ci>
<ci>C_pc</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>u_pv</ci>
<apply>
<divide/>
<ci>q_pv</ci>
<ci>C_pv</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>u_la</ci>
<apply>
<divide/>
<ci>q_la</ci>
<ci>C_la</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>u_lv</ci>
<apply>
<minus/>
<ci>u_lv_max</ci>
<apply>
<times/>
<ci>R_AV</ci>
<ci>v_AV</ci>
</apply>
</apply>
</apply>
<!-- ode(u_sa1,t) = du_sa;-->
<apply>
<eq/>
<ci>u_sa</ci>
<apply>
<divide/>
<ci>q_sa</ci>
<ci>C_sa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>u_sc</ci>
<apply>
<divide/>
<ci>q_sc</ci>
<ci>C_sc</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>u_sv</ci>
<apply>
<divide/>
<ci>q_sv</ci>
<ci>C_sv</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>du_sa</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>v_AV</ci>
<ci>v_sa</ci>
</apply>
<ci>C_sa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_TV</ci>
<piecewise>
<piece>
<cn cellml:units="mL_per_s">0</cn>
<apply>
<lt/>
<ci>u_ra</ci>
<ci>u_rv</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<minus/>
<ci>u_ra</ci>
<ci>u_rv</ci>
</apply>
<ci>R_TV</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>v_PV</ci>
<piecewise>
<piece>
<cn cellml:units="mL_per_s">0</cn>
<apply>
<lt/>
<ci>u_rv_max</ci>
<ci>u_pa</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<minus/>
<ci>u_rv_max</ci>
<ci>u_pa</ci>
</apply>
<ci>R_PV</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>R_PV</ci>
<apply>
<times/>
<ci>k_PV_R</ci>
<ci>u_rv_max</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>v_pa</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>u_pa</ci>
<ci>u_pc</ci>
</apply>
<apply>
<times/>
<ci>R_pa</ci>
<ci>v_pa</ci>
</apply>
</apply>
<ci>L_pa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_pv</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>u_pc</ci>
<ci>u_pv</ci>
</apply>
<ci>R_pv</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_la</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>u_pv</ci>
<ci>u_la</ci>
</apply>
<ci>R_la</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_MV</ci>
<piecewise>
<piece>
<cn cellml:units="mL_per_s">0</cn>
<apply>
<lt/>
<ci>u_la</ci>
<ci>u_lv</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<minus/>
<ci>u_la</ci>
<ci>u_lv</ci>
</apply>
<ci>R_MV</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>v_AV</ci>
<piecewise>
<piece>
<cn cellml:units="mL_per_s">0</cn>
<apply>
<lt/>
<ci>u_lv_max</ci>
<ci>u_sa</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<minus/>
<ci>u_lv_max</ci>
<ci>u_sa</ci>
</apply>
<ci>R_AV</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>R_AV</ci>
<apply>
<times/>
<ci>k_AV_R</ci>
<ci>u_lv_max</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>v_sa</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>u_sa</ci>
<ci>u_sc</ci>
</apply>
<apply>
<times/>
<ci>R_sa</ci>
<ci>v_sa</ci>
</apply>
</apply>
<ci>L_sa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_sc</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>u_sc</ci>
<ci>u_sv</ci>
</apply>
<ci>R_sc</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_sv</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>u_sv</ci>
<ci>u_ra</ci>
</apply>
<ci>R_sv</ci>
</apply>
</apply>
</math>
</component>
</model>