Location: Bingzheng, Zhenye, Liansong, 1990 @ a3029e18f8b8 / bingzheng_zhenye_liansong_1990.cellml

Author:
Catherine Lloyd <c.lloyd@auckland.ac.nz>
Date:
2010-06-29 20:28:56+12:00
Desc:
Removed xml:base="" from the model.
Permanent Source URI:
https://models.cellml.org/workspace/bingzheng_zhenye_liansong_1990/rawfile/a3029e18f8b884664bfe5078b352e2aba093cca9/bingzheng_zhenye_liansong_1990.cellml

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CREATED :  14th November 2007

LAST MODIFIED : 14th November 2007

AUTHOR :  Catherine Lloyd
          Bioengineering Institute
          The University of Auckland
          
MODEL STATUS :  This model conforms to the CellML 1.1 Specification.

DESCRIPTION :  This file contains a CellML description of Bingzheng, Zhenye, and Liansong's 1990 mathematical model of the regulation system of the secretion of glucocorticoids.

CHANGES:  
  
-->
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  <title>A mathematical model of the regulation system of the secretion of glucocorticoids</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
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            This CellML model is known to run in OpenCell and COR and can recreate the published results. The units have been checked and are consistent.
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<title>Model Structure</title>

<para>
ABSTRACT: We propose a mathematical model for the regulation system of the secretion of glucocorticoids and determined the coefficients in the system of ordinary differential equations. Some results are calculated which agree with the experimental results.
</para>

<para>
The original paper reference is cited below:
</para>

<para>
A mathematical model of the regulation system of the secretion of glucocorticoids, Liu Bingzheng, Zhao Zhenye and Chen Liansong, 1990, 
            <emphasis>Journal of Biological Physics</emphasis>, volume 17, issue 4, 221-233.  
</para>

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<caption>The HPA axis model has three compartments, namely the hypothalamus, pituitary and adrenals.  Neural signals trigger CRF secretion by the hypothalamus.  In turn, this signals to the pituitary to release ACTH which stimulates the adrenal gland to release cortisol.  Cortisol acts on the hypothalamus and the pituitary to have a negative feedback effect on the release of CRH and ACTH respectively.</caption>
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  <rdf:Description rdf:about="rdf:#cf8804ae-a03f-4001-b1da-e5c1f9aa1275">
    <vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine Lloyd</vCard:FN>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#f4c6ee28-3643-4b50-b9bb-b1d708297869">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Liu</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Bingzheng</vCard:Family>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#af4b0ec3-8580-4d6e-b5cb-6b0579e26a39">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">James</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lawson</vCard:Family>
    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Richard</vCard:Other>
  </rdf:Description>
</rdf:RDF>
</model>