- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2009-06-17 12:44:46+12:00
- Desc:
- committing version02 of chang_fujita_2001
- Permanent Source URI:
- https://models.cellml.org/workspace/chang_fujita_2001/rawfile/3154891c06dfcd5cdb61375c7e916e39fa7d41d0/chang_fujita_2001_variant01.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : renal_H_ATPase_model.xml
CREATED : 29th May 2007
LAST MODIFIED : 29th May 2007
AUTHOR : Catherine Lloyd
The Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.1 Specification.
DESCRIPTION : This file contains a CellML description of Chang and Fujita's 2001 mathematical model of a H-ATPase in the distal tubule of the rat: it is one component of an overall model of acid/base transport in a distal tubule.
CHANGES:
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="renal_H_ATPase_model" name="chang_fujita_2001_version03">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Mathematical Models of Ionic Transport in the Distal Tubule of the Rat</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This CellML model is a description of Chang and Fujita's 2001 mathematical model of a H-ATPase in the distal tubule of the rat: it is one component of an overall model of acid/base transport in a distal tubule. </para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Acid-base transport in the rat distal tubule of the kidney has been extensively studied by a variety of different experimental methods. These experiments have shown that in the early part of the distal tubule, H<superscript>+</superscript> is secreted into the tubular fluid via a Na/H exchanger embedded in the luminal membrane. Closely linked with this process is the transport of HCO<subscript>3</subscript>
<superscript>-</superscript> out of the cytosolic space into the basolateral space. This probably occurs via an anion exchanger. In the late distal tubule, distinct cell types called intercalated cells are present. These cells are specifically involved in acid-base transport. Type A cells secrete H<superscript>+</superscript> via a luminal H-ATPase (see <xref linkend="fig_reaction_diagram3"/> and <xref linkend="fig_reaction_diagram4"/> below), and they extrude HCO<subscript>3</subscript>
<superscript>-</superscript> via a basolateral anion exchanger. Type B cells have anion transporters on their opposite side, and they function to secrete HCO<subscript>3</subscript>
<superscript>-</superscript> into the tubular fluid.
</para>
<para>
The features of acid-base transport described above are captured in the mathematical models of Hangil Chang and Toshiro Fujita (2001). Their models of transporters simulate the transport kinetics of the Na/H exchanger, anion exchanger and the H-ATPase. The raw CellML descriptions of the models can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://ajprenal.physiology.org/cgi/content/abstract/281/2/F222">A numerical model of acid-base transport in rat distal tubule</ulink>, Hangil Chang and Toshiro Fujita, 2001, <ulink url="http://ajpcon.physiology.org/">
<emphasis>American Journal of Physiology</emphasis>
</ulink>, 281, F222-F243. (<ulink url="http://ajprenal.physiology.org/cgi/reprint/281/2/F222.pdf">PDF</ulink> and <ulink url="http://ajprenal.physiology.org/cgi/content/full/281/2/F222">text</ulink> versions of the article are available to Journal subscribers. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11457714&dopt=Abstract">PubMed ID: 11457714</ulink>)
</para>
<informalfigure float="0" id="fig_reaction_diagram3">
<mediaobject>
<imageobject>
<objectinfo>
<title>reaction_diagram3</title>
</objectinfo>
<imagedata fileref="chang_2001c.png"/>
</imageobject>
</mediaobject>
<caption>Conceptual diagram of the H-ATPase. The transporter consists of two components: a transmembrane channel and an intracellular catalytic unit. Between these two components there is a buffer space known as the antechamber, in which hydrogen ions (H<subscript>a</subscript>) are in equilibrium with extracellular hydrogen ions (H) due to a large conductance of the transmembrane channel. Hydrogen ions are also moved between the antechamber and the cytosol via the catalytic unit. This ion transport is coupled to ATP hydrolysis/synthesis.</caption>
</informalfigure>
<informalfigure float="0" id="fig_reaction_diagram4">
<mediaobject>
<imageobject>
<objectinfo>
<title>reaction_diagram4</title>
</objectinfo>
<imagedata fileref="chang_2001d.png"/>
</imageobject>
</mediaobject>
<caption>State diagram of the catalytic unit of the H-ATPase. The catalytic unit (E) has two binding sites for H. Symbols with the asterisk (*) indicate conformations of the catalytic unit in which the binding sites face the cytosol, and symbols without the asterisk represent conformations in which the binding sites face the antechamber. Transition between the unloaded conformations is coupled with ATP synthesis/hydrolysis.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="micromolar">
<unit units="mole" prefix="micro"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="first_order_rate_constant">
<unit units="second" exponent="-1"/>
</units>
<units name="second_order_rate_constant">
<unit units="millimolar" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units name="third_order_rate_constant">
<unit units="millimolar" exponent="-2"/>
<unit units="second" exponent="-1"/>
</units>
<units name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units name="joule_per_mole_kelvin">
<unit units="joule"/>
<unit units="mole" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units name="coulomb_per_mole">
<unit units="coulomb"/>
<unit units="mole" exponent="-1"/>
</units>
<component name="environment">
<variable units="second" public_interface="out" name="time"/>
</component>
<component name="EH">
<variable units="millimolar" public_interface="out" name="EH"/>
<variable units="second_order_rate_constant" public_interface="in" name="k1"/>
<variable units="first_order_rate_constant" public_interface="in" name="k2"/>
<variable units="second_order_rate_constant" public_interface="in" name="k3"/>
<variable units="first_order_rate_constant" public_interface="in" name="k4"/>
<variable units="millimolar" public_interface="in" name="E"/>
<variable units="millimolar" public_interface="in" name="EH2"/>
<variable units="millimolar" public_interface="in" name="Ha"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci> EH </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> k1 </ci>
<ci> Ha </ci>
<ci> E </ci>
</apply>
<apply>
<times/>
<ci> k4 </ci>
<ci> EH2 </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> k2 </ci>
<ci> EH </ci>
</apply>
<apply>
<times/>
<ci> k3 </ci>
<ci> Ha </ci>
<ci> EH </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="E">
<variable units="millimolar" public_interface="out" name="E"/>
<variable units="second_order_rate_constant" public_interface="in" name="k1"/>
<variable units="first_order_rate_constant" public_interface="in" name="k2"/>
<variable units="second_order_rate_constant" public_interface="in" name="k9"/>
<variable units="third_order_rate_constant" public_interface="in" name="k10"/>
<variable units="millimolar" public_interface="in" name="EH"/>
<variable units="millimolar" public_interface="in" name="E_"/>
<variable units="millimolar" public_interface="in" name="Ha"/>
<variable units="millimolar" public_interface="in" name="ATP_"/>
<variable units="millimolar" public_interface="in" name="ADP_"/>
<variable units="millimolar" public_interface="in" name="Pi_"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci> E </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> k10 </ci>
<ci> ADP_ </ci>
<ci> Pi_ </ci>
<ci> E_ </ci>
</apply>
<apply>
<times/>
<ci> k2 </ci>
<ci> EH </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> k1 </ci>
<ci> Ha </ci>
<ci> E </ci>
</apply>
<apply>
<times/>
<ci> k9 </ci>
<ci> ATP_ </ci>
<ci> E </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="EH2">
<variable units="millimolar" public_interface="out" name="EH2"/>
<variable units="first_order_rate_constant" public_interface="in" name="k11"/>
<variable units="first_order_rate_constant" public_interface="in" name="k12"/>
<variable units="second_order_rate_constant" public_interface="in" name="k3"/>
<variable units="first_order_rate_constant" public_interface="in" name="k4"/>
<variable units="millimolar" public_interface="in" name="EH"/>
<variable units="millimolar" public_interface="in" name="EH2_"/>
<variable units="millimolar" public_interface="in" name="Ha"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci> EH2 </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> k3 </ci>
<ci> Ha </ci>
<ci> EH </ci>
</apply>
<apply>
<times/>
<ci> k12 </ci>
<ci> EH2_ </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> k4 </ci>
<ci> EH2 </ci>
</apply>
<apply>
<times/>
<ci> k11 </ci>
<ci> EH2 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="EH_">
<variable units="millimolar" public_interface="out" name="EH_"/>
<variable units="second_order_rate_constant" public_interface="in" name="k5"/>
<variable units="first_order_rate_constant" public_interface="in" name="k6"/>
<variable units="second_order_rate_constant" public_interface="in" name="k7"/>
<variable units="first_order_rate_constant" public_interface="in" name="k8"/>
<variable units="millimolar" public_interface="in" name="E_"/>
<variable units="millimolar" public_interface="in" name="EH2_"/>
<variable units="millimolar" public_interface="in" name="H_"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci> EH_ </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> k5 </ci>
<ci> H_ </ci>
<ci> E_ </ci>
</apply>
<apply>
<times/>
<ci> k8 </ci>
<ci> EH2_ </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> k6 </ci>
<ci> EH_ </ci>
</apply>
<apply>
<times/>
<ci> k7 </ci>
<ci> H_ </ci>
<ci> EH_ </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="E_">
<variable units="millimolar" public_interface="out" name="E_"/>
<variable units="second_order_rate_constant" public_interface="in" name="k5"/>
<variable units="first_order_rate_constant" public_interface="in" name="k6"/>
<variable units="second_order_rate_constant" public_interface="in" name="k9"/>
<variable units="third_order_rate_constant" public_interface="in" name="k10"/>
<variable units="millimolar" public_interface="in" name="EH_"/>
<variable units="millimolar" public_interface="in" name="E"/>
<variable units="millimolar" public_interface="in" name="H_"/>
<variable units="millimolar" public_interface="in" name="ATP_"/>
<variable units="millimolar" public_interface="in" name="ADP_"/>
<variable units="millimolar" public_interface="in" name="Pi_"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci> E_ </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> k9 </ci>
<ci> ATP_ </ci>
<ci> E </ci>
</apply>
<apply>
<times/>
<ci> k6 </ci>
<ci> EH_ </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> k5 </ci>
<ci> H_ </ci>
<ci> E_ </ci>
</apply>
<apply>
<times/>
<ci> k10 </ci>
<ci> ADP_ </ci>
<ci> Pi_ </ci>
<ci> E_ </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="EH2_">
<variable units="millimolar" public_interface="out" name="EH2_"/>
<variable units="first_order_rate_constant" public_interface="in" name="k11"/>
<variable units="first_order_rate_constant" public_interface="in" name="k12"/>
<variable units="second_order_rate_constant" public_interface="in" name="k7"/>
<variable units="first_order_rate_constant" public_interface="in" name="k8"/>
<variable units="millimolar" public_interface="in" name="EH_"/>
<variable units="millimolar" public_interface="in" name="EH2"/>
<variable units="millimolar" public_interface="in" name="H_"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci> EH2_ </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> k7 </ci>
<ci> H_ </ci>
<ci> EH_ </ci>
</apply>
<apply>
<times/>
<ci> k11 </ci>
<ci> EH2 </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> k8 </ci>
<ci> EH2_ </ci>
</apply>
<apply>
<times/>
<ci> k12 </ci>
<ci> EH2_ </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="reaction_constants">
<variable units="second_order_rate_constant" public_interface="out" name="k1" initial_value="8.33E9"/>
<variable units="first_order_rate_constant" public_interface="out" name="k2" initial_value="1.00E3"/>
<variable units="second_order_rate_constant" public_interface="out" name="k3" initial_value="8.33E9"/>
<variable units="first_order_rate_constant" public_interface="out" name="k4" initial_value="1.00E4"/>
<variable units="second_order_rate_constant" public_interface="out" name="k5" initial_value="2.5E10"/>
<variable units="first_order_rate_constant" public_interface="out" name="k6" initial_value="1.0E3"/>
<variable units="second_order_rate_constant" public_interface="out" name="k7" initial_value="2.5E10"/>
<variable units="first_order_rate_constant" public_interface="out" name="k8" initial_value="2.5E2"/>
<variable units="second_order_rate_constant" public_interface="out" name="k9" initial_value="1.00E9"/>
<variable units="third_order_rate_constant" public_interface="out" name="k10" initial_value="1.80E5"/>
<variable units="first_order_rate_constant" public_interface="out" name="k11" initial_value="5.00E2"/>
<variable units="first_order_rate_constant" public_interface="out" name="k12" initial_value="1.00E2"/>
<variable units="millimolar" public_interface="out" name="Ha"/>
<variable units="millimolar" public_interface="out" name="H_" initial_value="1.0"/>
<variable units="millimolar" public_interface="out" name="ADP_" initial_value="1.0"/>
<variable units="millimolar" public_interface="out" name="ATP_" initial_value="1.0"/>
<variable units="millimolar" public_interface="out" name="Pi_" initial_value="1.0"/>
<variable units="millivolt" name="psi" initial_value="1.0"/>
<variable units="millivolt" name="psi_" initial_value="-89.6"/>
<variable units="millimolar" name="H" initial_value="1.0"/>
<variable units="joule_per_mole_kelvin" name="R" initial_value="8.314"/>
<variable units="kelvin" name="T" initial_value="310.0"/>
<variable units="coulomb_per_mole" name="F" initial_value="96500.0"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Ha </ci>
<apply>
<times/>
<ci> H </ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci> F </ci>
<apply>
<plus/>
<ci> psi </ci>
<ci> psi_ </ci>
</apply>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_2="environment" component_1="E"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="EH"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="EH2"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="E_"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="EH_"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="EH2_"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="EH" component_1="E"/>
<map_variables variable_2="E" variable_1="E"/>
<map_variables variable_2="EH" variable_1="EH"/>
</connection>
<connection>
<map_components component_2="EH2" component_1="EH"/>
<map_variables variable_2="EH" variable_1="EH"/>
<map_variables variable_2="EH2" variable_1="EH2"/>
</connection>
<connection>
<map_components component_2="EH_" component_1="E_"/>
<map_variables variable_2="E_" variable_1="E_"/>
<map_variables variable_2="EH_" variable_1="EH_"/>
</connection>
<connection>
<map_components component_2="EH2_" component_1="EH_"/>
<map_variables variable_2="EH_" variable_1="EH_"/>
<map_variables variable_2="EH2_" variable_1="EH2_"/>
</connection>
<connection>
<map_components component_2="E_" component_1="E"/>
<map_variables variable_2="E" variable_1="E"/>
<map_variables variable_2="E_" variable_1="E_"/>
</connection>
<connection>
<map_components component_2="EH2_" component_1="EH2"/>
<map_variables variable_2="EH2" variable_1="EH2"/>
<map_variables variable_2="EH2_" variable_1="EH2_"/>
</connection>
<connection>
<map_components component_2="reaction_constants" component_1="E"/>
<map_variables variable_2="Ha" variable_1="Ha"/>
<map_variables variable_2="ATP_" variable_1="ATP_"/>
<map_variables variable_2="ADP_" variable_1="ADP_"/>
<map_variables variable_2="Pi_" variable_1="Pi_"/>
<map_variables variable_2="k1" variable_1="k1"/>
<map_variables variable_2="k2" variable_1="k2"/>
<map_variables variable_2="k9" variable_1="k9"/>
<map_variables variable_2="k10" variable_1="k10"/>
</connection>
<connection>
<map_components component_2="reaction_constants" component_1="EH"/>
<map_variables variable_2="Ha" variable_1="Ha"/>
<map_variables variable_2="k1" variable_1="k1"/>
<map_variables variable_2="k2" variable_1="k2"/>
<map_variables variable_2="k3" variable_1="k3"/>
<map_variables variable_2="k4" variable_1="k4"/>
</connection>
<connection>
<map_components component_2="reaction_constants" component_1="EH2"/>
<map_variables variable_2="Ha" variable_1="Ha"/>
<map_variables variable_2="k11" variable_1="k11"/>
<map_variables variable_2="k12" variable_1="k12"/>
<map_variables variable_2="k3" variable_1="k3"/>
<map_variables variable_2="k4" variable_1="k4"/>
</connection>
<connection>
<map_components component_2="reaction_constants" component_1="E_"/>
<map_variables variable_2="H_" variable_1="H_"/>
<map_variables variable_2="ATP_" variable_1="ATP_"/>
<map_variables variable_2="ADP_" variable_1="ADP_"/>
<map_variables variable_2="Pi_" variable_1="Pi_"/>
<map_variables variable_2="k5" variable_1="k5"/>
<map_variables variable_2="k6" variable_1="k6"/>
<map_variables variable_2="k9" variable_1="k9"/>
<map_variables variable_2="k10" variable_1="k10"/>
</connection>
<connection>
<map_components component_2="reaction_constants" component_1="EH_"/>
<map_variables variable_2="H_" variable_1="H_"/>
<map_variables variable_2="k5" variable_1="k5"/>
<map_variables variable_2="k6" variable_1="k6"/>
<map_variables variable_2="k7" variable_1="k7"/>
<map_variables variable_2="k8" variable_1="k8"/>
</connection>
<connection>
<map_components component_2="reaction_constants" component_1="EH2_"/>
<map_variables variable_2="H_" variable_1="H_"/>
<map_variables variable_2="k11" variable_1="k11"/>
<map_variables variable_2="k12" variable_1="k12"/>
<map_variables variable_2="k7" variable_1="k7"/>
<map_variables variable_2="k8" variable_1="k8"/>
</connection>
<rdf:RDF>
<rdf:Bag rdf:about="rdf:#35acf3e3-18b1-4518-bde2-8cfd8c7ee1ed">
<rdf:li>kidney</rdf:li>
<rdf:li>electrophysiology</rdf:li>
<rdf:li>distal tubule</rdf:li>
<rdf:li>renal</rdf:li>
<rdf:li>acid-base transport</rdf:li>
</rdf:Bag>
<rdf:Seq rdf:about="rdf:#5983efbf-2cf8-4d36-9de5-10ca91e31540">
<rdf:li rdf:resource="rdf:#b07d2d63-b508-4b0d-9f19-90f956ba1108"/>
<rdf:li rdf:resource="rdf:#d07e5835-41b3-4589-a6dc-1f166446c113"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#bd9ee214-d7c0-4738-9b8f-aa6dbb2fc0e5">
<vCard:ORG rdf:resource="rdf:#1874a94e-ffba-42b8-b3b9-91ee526a18b7"/>
<vCard:EMAIL rdf:resource="rdf:#6d779a8c-1830-4c79-b105-a26f6a24de90"/>
<vCard:N rdf:resource="rdf:#a5a71012-dc0b-43fb-9da5-73558f9d8700"/>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher>The University of Auckland, Bioengineering Institute</dc:publisher>
<cmeta:comment rdf:resource="rdf:#6178f046-fbaf-4065-9f92-f172a5230666"/>
<dcterms:created rdf:resource="rdf:#df754649-a053-4044-a5b2-6caf16dd5350"/>
<dc:creator rdf:resource="rdf:#bd9ee214-d7c0-4738-9b8f-aa6dbb2fc0e5"/>
<cmeta:modification rdf:resource="rdf:#35902352-7cc0-4181-bf07-f1f73e90956b"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3a4bd135-2eb3-45c4-93ed-bad58aa3d1d2">
<dc:title>American Journal of Physiology</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#6ca7c35d-64e6-4d14-bc97-937bd12069ce">
<dcterms:W3CDTF>2001-08</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d88da72b-8a46-453b-adbe-3f53e7be8036">
<vCard:N rdf:resource="rdf:#7abcf947-9092-4800-9056-bf5da0cbeb2d"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#1874a94e-ffba-42b8-b3b9-91ee526a18b7">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>The Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b07d2d63-b508-4b0d-9f19-90f956ba1108">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#08a1413b-bdd3-44d2-a58d-5e63804335c7"/>
</rdf:Description>
<rdf:Description rdf:about="#renal_H_ATPase_model">
<dc:title>
Chang and Fujita's 2001 mathematical model of a H-ATPase in the distal
tubule of the rat: it is one component of an overall model of acid/base
transport in a distal tubule.
</dc:title>
<cmeta:bio_entity>Renal Distal Tubule</cmeta:bio_entity>
<cmeta:comment rdf:resource="rdf:#9e6c1010-5605-4a78-9992-5403125ce223"/>
<bqs:reference rdf:resource="rdf:#25307320-acfc-4d52-b152-79c3b61ae355"/>
<bqs:reference rdf:resource="rdf:#ae6916fd-29d2-4763-a0ba-79ceec299157"/>
<cmeta:species>Rat</cmeta:species>
</rdf:Description>
<rdf:Description rdf:about="rdf:#92dbb897-b5d4-4696-b11c-ad6b55d5332f">
<vCard:FN>Catherine Lloyd</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#525c17d9-ad8f-425f-9732-3468096c2fcc">
<dcterms:W3CDTF>2007-06-05T09:56:00+12:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#6178f046-fbaf-4065-9f92-f172a5230666">
<dc:creator rdf:resource="rdf:#c29cc0b6-14f4-4866-84c0-f9fd689980db"/>
<rdf:value/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#6d779a8c-1830-4c79-b105-a26f6a24de90">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>c.lloyd@auckland.ac.nz</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#df754649-a053-4044-a5b2-6caf16dd5350">
<dcterms:W3CDTF>2007-05-29T00:00:00+00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a4fdda4e-fb2d-486a-b0f9-52e630ad30f4">
<vCard:Given>Toshiro</vCard:Given>
<vCard:Family>Fujita</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a5a71012-dc0b-43fb-9da5-73558f9d8700">
<vCard:Given>Catherine</vCard:Given>
<vCard:Family>Lloyd</vCard:Family>
<vCard:Other>May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9e6c1010-5605-4a78-9992-5403125ce223">
<dc:creator rdf:resource="rdf:#92dbb897-b5d4-4696-b11c-ad6b55d5332f"/>
<rdf:value>This is the CellML description of Chang and Fujita's 2001 mathematical model of a H-ATPase in the distal tubule of the rat: it is one component of an overall model of acid/base transport in a distal tubule.
These models can be run in PCEnv but they give a flat output. I suspect they need to be embedded within a whole cell model in order to give a reasonable output.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#08a1413b-bdd3-44d2-a58d-5e63804335c7">
<vCard:Given>Hangil</vCard:Given>
<vCard:Family>Chang</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#7abcf947-9092-4800-9056-bf5da0cbeb2d">
<vCard:Given>Catherine</vCard:Given>
<vCard:Family>Lloyd</vCard:Family>
<vCard:Other>May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#25307320-acfc-4d52-b152-79c3b61ae355">
<dc:subject rdf:resource="rdf:#8efd9e1e-2923-41fc-b13b-f5703584df68"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c29cc0b6-14f4-4866-84c0-f9fd689980db">
<vCard:FN/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ae6916fd-29d2-4763-a0ba-79ceec299157">
<bqs:Pubmed_id>11457714</bqs:Pubmed_id>
<bqs:JournalArticle rdf:resource="rdf:#cd12d814-dc56-4756-825b-8bc1b2408625"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#35902352-7cc0-4181-bf07-f1f73e90956b">
<dcterms:modified rdf:resource="rdf:#525c17d9-ad8f-425f-9732-3468096c2fcc"/>
<rdf:value>The new version of this model has been re-coded to remove the reaction element and replace it with a simple MathML description of the model reaction kinetics. This is thought to be truer to the original publication, and information regarding the enzyme kinetics etc will later be added to the metadata through use of an ontology.
The model runs in the PCEnv simulator but gives a flat output.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#d88da72b-8a46-453b-adbe-3f53e7be8036"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#cd12d814-dc56-4756-825b-8bc1b2408625">
<dc:creator rdf:resource="rdf:#5983efbf-2cf8-4d36-9de5-10ca91e31540"/>
<dc:title>A numerical model of acid-base transport in rat distal tubule</dc:title>
<bqs:volume>281</bqs:volume>
<bqs:first_page>F222</bqs:first_page>
<bqs:Journal rdf:resource="rdf:#3a4bd135-2eb3-45c4-93ed-bad58aa3d1d2"/>
<dcterms:issued rdf:resource="rdf:#6ca7c35d-64e6-4d14-bc97-937bd12069ce"/>
<bqs:last_page>F243</bqs:last_page>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d07e5835-41b3-4589-a6dc-1f166446c113">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#a4fdda4e-fb2d-486a-b0f9-52e630ad30f4"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8efd9e1e-2923-41fc-b13b-f5703584df68">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value rdf:resource="rdf:#35acf3e3-18b1-4518-bde2-8cfd8c7ee1ed"/>
</rdf:Description>
</rdf:RDF>
</model>
