Location: Chauhan, Legewie, Westermark, Lorenzen and Herzel, 2008 @ cb29942c341e / chauhan_2008.cellml

Author:
Hanne Nielsen <hnie010@aucklanduni.ac.nz>
Date:
2011-03-11 10:32:27+13:00
Desc:
Added cellML file, does not run past t=1.143. To curate.
Permanent Source URI:
https://models.cellml.org/workspace/chauhan_legewie_westermark_lorenzen_herzel_2008/rawfile/cb29942c341e604d279b8320dc1d7ea02647a897/chauhan_2008.cellml

<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 11/03/2011 at 10:04:42 at a.m. using:

COR (0.9.31.1409)
Copyright 2002-2011 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
<model name="chauhan_2008" cmeta:id="chauhan_2008" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
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      <unit units="second" multiplier="3600"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="per_hour">
      <unit units="hour" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="mole_per_litre">
      <unit units="mole"/>
      <unit units="litre" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="per_mole_per_litre">
      <unit units="mole_per_litre" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="mole_per_litre_per_hour">
      <unit units="mole_per_litre"/>
      <unit units="hour" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="per_mole_per_litre_per_hour">
      <unit units="mole_per_litre" exponent="-1"/>
      <unit units="hour" exponent="-1"/>
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      <variable name="HBEGF" units="mole_per_litre" public_interface="in"/>
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      <variable name="v92" units="per_hour" public_interface="in"/>
      <variable name="CycD" units="mole_per_litre" public_interface="in"/>
      <variable name="k92" units="mole_per_litre" public_interface="in"/>
      <variable name="d11" units="per_hour" public_interface="in"/>
      <variable name="CycECKI" units="mole_per_litre" public_interface="in"/>
      <variable name="d9" units="per_hour" public_interface="in"/>
      <variable name="deg" units="mole_per_litre" public_interface="in"/>
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      <variable name="CKI" units="mole_per_litre" public_interface="in"/>
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                  <ci>time</ci>
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               <ci>CycE</ci>
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                     <divide/>
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                        <cn cellml:units="mole_per_litre">1</cn>
                        <ci>v91</ci>
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                           <power/>
                           <ci>HBEGF</ci>
                           <cn cellml:units="dimensionless">2</cn>
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                     <apply>
                        <plus/>
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                           <power/>
                           <ci>k91</ci>
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                           <power/>
                           <ci>HBEGF</ci>
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                     </apply>
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                     <divide/>
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                           <power/>
                           <ci>CycD</ci>
                           <cn cellml:units="dimensionless">4</cn>
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                     </apply>
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                        <plus/>
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                           <power/>
                           <ci>k92</ci>
                           <cn cellml:units="dimensionless">4</cn>
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                        <apply>
                           <power/>
                           <ci>CycD</ci>
                           <cn cellml:units="dimensionless">4</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>d11</ci>
                     <ci>CycECKI</ci>
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                  <times/>
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                     <plus/>
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                        <times/>
                        <ci>d9</ci>
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                           <power/>
                           <ci>deg</ci>
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                  <ci>CycE</ci>
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      <variable name="k8" units="mole_per_litre" public_interface="in"/>
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      <variable name="deg" units="mole_per_litre" public_interface="in"/>
      <variable name="v10" units="per_mole_per_litre_per_hour" public_interface="in"/>
      <variable name="CKI" units="mole_per_litre" public_interface="in"/>
      <variable name="CycDCKI" units="mole_per_litre" public_interface="in"/>
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               <diff/>
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               <minus/>
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                  <plus/>
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                     <divide/>
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                        <ci>IEG</ci>
                        <ci>HGF</ci>
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                        <plus/>
                        <ci>k8</ci>
                        <ci>IEG</ci>
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                     <ci>d10</ci>
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                           <power/>
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                              <divide/>
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                           </apply>
                           <cn cellml:units="dimensionless">1.5</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>v10</ci>
                        <ci>CKI</ci>
                     </apply>
                  </apply>
                  <ci>CycD</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="CycECKI">
      <variable name="v11" units="per_mole_per_litre_per_hour" public_interface="in"/>
      <variable name="CKI" units="mole_per_litre" public_interface="in"/>
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      <variable name="d11" units="per_hour" public_interface="in"/>
      <variable name="CycECKI" units="mole_per_litre" initial_value="0" public_interface="out"/>
      <variable name="time" units="hour" public_interface="in"/>
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         <apply>
            <eq/>
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               <diff/>
               <bvar>
                  <ci>time</ci>
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               <ci>CycECKI</ci>
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               <minus/>
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                  <times/>
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                  <ci>CKI</ci>
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                  <times/>
                  <ci>d11</ci>
                  <ci>CycECKI</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="CycDCKI">
      <variable name="v10" units="per_mole_per_litre_per_hour" public_interface="in"/>
      <variable name="CKI" units="mole_per_litre" public_interface="in"/>
      <variable name="CycD" units="mole_per_litre" public_interface="in"/>
      <variable name="d10" units="per_hour" public_interface="in"/>
      <variable name="CycDCKI" units="mole_per_litre" initial_value="0" public_interface="out"/>
      <variable name="time" units="hour" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
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               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CycDCKI</ci>
            </apply>
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               <minus/>
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                  <times/>
                  <ci>v10</ci>
                  <ci>CKI</ci>
                  <ci>CycD</ci>
               </apply>
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                  <times/>
                  <ci>d10</ci>
                  <ci>CycDCKI</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
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      <variable name="PIC" units="mole_per_litre" public_interface="in"/>
      <variable name="d10" units="per_hour" public_interface="in"/>
      <variable name="CycDCKI" units="mole_per_litre" public_interface="in"/>
      <variable name="d11" units="per_hour" public_interface="in"/>
      <variable name="CycECKI" units="mole_per_litre" public_interface="in"/>
      <variable name="d7" units="per_hour" public_interface="in"/>
      <variable name="v10" units="per_mole_per_litre_per_hour" public_interface="in"/>
      <variable name="CycD" units="mole_per_litre" public_interface="in"/>
      <variable name="v11" units="per_mole_per_litre_per_hour" public_interface="in"/>
      <variable name="CycE" units="mole_per_litre" public_interface="in"/>
      <variable name="time" units="hour" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CKI</ci>
            </apply>
            <apply>
               <minus/>
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                  <plus/>
                  <apply>
                     <times/>
                     <ci>v7</ci>
                     <ci>PIC</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>d10</ci>
                     <ci>CycDCKI</ci>
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                  <apply>
                     <times/>
                     <ci>d11</ci>
                     <ci>CycECKI</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <ci>d7</ci>
                     <apply>
                        <times/>
                        <ci>v10</ci>
                        <ci>CycD</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>v11</ci>
                        <ci>CycE</ci>
                     </apply>
                  </apply>
                  <ci>CKI</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
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      <variable name="k5" units="mole_per_litre" public_interface="in"/>
      <variable name="km5" units="mole_per_litre" public_interface="in"/>
      <variable name="PAI" units="mole_per_litre" public_interface="in"/>
      <variable name="f5" units="mole_per_litre_per_hour" public_interface="in"/>
      <variable name="d5" units="per_hour" public_interface="in"/>
      <variable name="time" units="hour" public_interface="in"/>
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               <diff/>
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               <ci>HGF</ci>
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            <apply>
               <minus/>
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                  <times/>
                  <apply>
                     <divide/>
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                        <times/>
                        <ci>v5</ci>
                        <ci>IEG</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>PAI</ci>
                              <ci>km5</ci>
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                           <cn cellml:units="dimensionless">4</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
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                        <divide/>
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                           <times/>
                           <ci>f5</ci>
                           <ci>HGF</ci>
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                           <plus/>
                           <ci>k5</ci>
                           <ci>HGF</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
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                  <times/>
                  <ci>d5</ci>
                  <ci>HGF</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
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               <minus/>
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                  <times/>
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                  <times/>
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      <variable name="PGE" units="mole_per_litre" public_interface="in"/>
      <variable name="km1" units="mole_per_litre" public_interface="in"/>
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               <minus/>
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                  <divide/>
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                     <times/>
                     <apply>
                        <divide/>
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                           <plus/>
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                              <power/>
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                                 <divide/>
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   </component>
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                        <minus/>
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                  <times/>
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                     <root/>
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                        <divide/>
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                              <divide/>
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                                 <plus/>
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                                    <power/>
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                           <plus/>
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                     <plus/>
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                  <times/>
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               <minus/>
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                  <divide/>
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                     <times/>
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                        <power/>
                        <ci>PIC</ci>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <power/>
                        <ci>k3</ci>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                     <apply>
                        <power/>
                        <ci>PIC</ci>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>d3</ci>
                  <ci>IEG</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="PAI">
      <variable name="PAI" units="mole_per_litre" initial_value="0" public_interface="out"/>
      <variable name="v4" units="mole_per_litre_per_hour" public_interface="in"/>
      <variable name="PIC" units="mole_per_litre" public_interface="in"/>
      <variable name="k4" units="mole_per_litre" public_interface="in"/>
      <variable name="d4" units="per_hour" public_interface="in"/>
      <variable name="time" units="hour" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>PAI</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>v4</ci>
                     <apply>
                        <power/>
                        <ci>PIC</ci>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <power/>
                        <ci>k4</ci>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                     <apply>
                        <power/>
                        <ci>PIC</ci>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>d4</ci>
                  <ci>PAI</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="model_parameters">
      <variable name="I0" units="mole_per_litre" initial_value="4" public_interface="out"/>
      <variable name="d0" units="per_hour" initial_value="0.05" public_interface="out"/>
      <variable name="v1" units="mole_per_litre_per_hour" initial_value="2" public_interface="out"/>
      <variable name="km1" units="mole_per_litre" initial_value="1" public_interface="out"/>
      <variable name="k1" units="mole_per_litre" initial_value="0.5" public_interface="out"/>
      <variable name="d1" units="per_hour" initial_value="0.7" public_interface="out"/>
      <variable name="v2" units="per_hour" initial_value="0.8" public_interface="out"/>
      <variable name="d2" units="per_hour" initial_value="0.01" public_interface="out"/>
      <variable name="v3" units="mole_per_litre_per_hour" initial_value="6" public_interface="out"/>
      <variable name="k3" units="mole_per_litre" initial_value="0.5" public_interface="out"/>
      <variable name="d3" units="per_hour" initial_value="10" public_interface="out"/>
      <variable name="v4" units="mole_per_litre_per_hour" initial_value="60" public_interface="out"/>
      <variable name="k4" units="mole_per_litre" initial_value="0.5" public_interface="out"/>
      <variable name="d4" units="per_hour" initial_value="10" public_interface="out"/>
      <variable name="v5" units="per_mole_per_litre" initial_value="8.1" public_interface="out"/>
      <variable name="f5" units="mole_per_litre_per_hour" initial_value="5" public_interface="out"/>
      <variable name="k5" units="mole_per_litre" initial_value="0.125" public_interface="out"/>
      <variable name="km5" units="mole_per_litre" initial_value="0.18" public_interface="out"/>
      <variable name="d5" units="per_hour" initial_value="0.008" public_interface="out"/>
      <variable name="v6" units="mole_per_litre_per_hour" initial_value="40" public_interface="out"/>
      <variable name="k61" units="mole_per_litre" initial_value="0.9" public_interface="out"/>
      <variable name="k62" units="mole_per_litre" initial_value="0.0005" public_interface="out"/>
      <variable name="k63" units="mole_per_litre" initial_value="1" public_interface="out"/>
      <variable name="d6" units="per_hour" initial_value="0.16" public_interface="out"/>
      <variable name="v7" units="per_hour" initial_value="1.6" public_interface="out"/>
      <variable name="d7" units="per_hour" initial_value="0.3" public_interface="out"/>
      <variable name="v8" units="per_hour" initial_value="0.4" public_interface="out"/>
      <variable name="k8" units="mole_per_litre" initial_value="0.005" public_interface="out"/>
      <variable name="d8" units="per_hour" initial_value="0.0008" public_interface="out"/>
      <variable name="v91" units="per_hour" initial_value="0.7" public_interface="out"/>
      <variable name="k91" units="mole_per_litre" initial_value="40" public_interface="out"/>
      <variable name="v92" units="per_hour" initial_value="0.5" public_interface="out"/>
      <variable name="k92" units="mole_per_litre" initial_value="10" public_interface="out"/>
      <variable name="d9" units="per_hour" initial_value="0.0001" public_interface="out"/>
      <variable name="v10" units="per_mole_per_litre_per_hour" initial_value="0.32" public_interface="out"/>
      <variable name="d10" units="per_hour" initial_value="3.25" public_interface="out"/>
      <variable name="v11" units="per_mole_per_litre_per_hour" initial_value="800" public_interface="out"/>
      <variable name="d11" units="per_hour" initial_value="800" public_interface="out"/>
      <variable name="v12" units="mole_per_litre_per_hour" initial_value="0.45" public_interface="out"/>
      <variable name="d12" units="per_hour" initial_value="0.02" public_interface="out"/>
   </component>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycE" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycD" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycECKI" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycDCKI" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="PIC" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CKI" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="HGF" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="PGE" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="D" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="deg" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="HBEGF" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="IEG" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="PAI" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="D" component_2="PIC"/>
      <map_variables variable_1="D" variable_2="D"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="PGE" component_2="PIC"/>
      <map_variables variable_1="PIC" variable_2="PIC"/>
      <map_variables variable_1="PGE" variable_2="PGE"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="IEG" component_2="PIC"/>
      <map_variables variable_1="PIC" variable_2="PIC"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="PAI" component_2="PIC"/>
      <map_variables variable_1="PIC" variable_2="PIC"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="IEG" component_2="HGF"/>
      <map_variables variable_1="IEG" variable_2="IEG"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="IEG" component_2="HBEGF"/>
      <map_variables variable_1="IEG" variable_2="IEG"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="IEG" component_2="CycD"/>
      <map_variables variable_1="IEG" variable_2="IEG"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="PAI" component_2="HGF"/>
      <map_variables variable_1="PAI" variable_2="PAI"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="HGF" component_2="CycD"/>
      <map_variables variable_1="HGF" variable_2="HGF"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="HBEGF" component_2="CycE"/>
      <map_variables variable_1="HBEGF" variable_2="HBEGF"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="HBEGF" component_2="D"/>
      <map_variables variable_1="D" variable_2="D"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="HBEGF" component_2="HGF"/>
      <map_variables variable_1="HGF" variable_2="HGF"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CKI" component_2="CycD"/>
      <map_variables variable_1="CKI" variable_2="CKI"/>
      <map_variables variable_1="CycD" variable_2="CycD"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CKI" component_2="CycE"/>
      <map_variables variable_1="CKI" variable_2="CKI"/>
      <map_variables variable_1="CycE" variable_2="CycE"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CKI" component_2="CycECKI"/>
      <map_variables variable_1="CKI" variable_2="CKI"/>
      <map_variables variable_1="CycECKI" variable_2="CycECKI"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CKI" component_2="CycDCKI"/>
      <map_variables variable_1="CKI" variable_2="CKI"/>
      <map_variables variable_1="CycDCKI" variable_2="CycDCKI"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CKI" component_2="PIC"/>
      <map_variables variable_1="PIC" variable_2="PIC"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycD" component_2="CycE"/>
      <map_variables variable_1="CycD" variable_2="CycD"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycD" component_2="CycDCKI"/>
      <map_variables variable_1="CycD" variable_2="CycD"/>
      <map_variables variable_1="CycDCKI" variable_2="CycDCKI"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="deg" component_2="CycD"/>
      <map_variables variable_1="deg" variable_2="deg"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="deg" component_2="CycE"/>
      <map_variables variable_1="CycE" variable_2="CycE"/>
      <map_variables variable_1="deg" variable_2="deg"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycECKI" component_2="CycE"/>
      <map_variables variable_1="CycE" variable_2="CycE"/>
      <map_variables variable_1="CycECKI" variable_2="CycECKI"/>
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   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="CycE"/>
      <map_variables variable_1="v91" variable_2="v91"/>
      <map_variables variable_1="k91" variable_2="k91"/>
      <map_variables variable_1="v92" variable_2="v92"/>
      <map_variables variable_1="k92" variable_2="k92"/>
      <map_variables variable_1="d11" variable_2="d11"/>
      <map_variables variable_1="d9" variable_2="d9"/>
      <map_variables variable_1="v11" variable_2="v11"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="CycD"/>
      <map_variables variable_1="v8" variable_2="v8"/>
      <map_variables variable_1="k8" variable_2="k8"/>
      <map_variables variable_1="d10" variable_2="d10"/>
      <map_variables variable_1="d8" variable_2="d8"/>
      <map_variables variable_1="v10" variable_2="v10"/>
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   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="CycECKI"/>
      <map_variables variable_1="v11" variable_2="v11"/>
      <map_variables variable_1="d11" variable_2="d11"/>
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   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="CycDCKI"/>
      <map_variables variable_1="v10" variable_2="v10"/>
      <map_variables variable_1="d10" variable_2="d10"/>
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   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="CKI"/>
      <map_variables variable_1="v7" variable_2="v7"/>
      <map_variables variable_1="d7" variable_2="d7"/>
      <map_variables variable_1="d10" variable_2="d10"/>
      <map_variables variable_1="d11" variable_2="d11"/>
      <map_variables variable_1="v10" variable_2="v10"/>
      <map_variables variable_1="v11" variable_2="v11"/>
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   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="HGF"/>
      <map_variables variable_1="v5" variable_2="v5"/>
      <map_variables variable_1="d5" variable_2="d5"/>
      <map_variables variable_1="k5" variable_2="k5"/>
      <map_variables variable_1="f5" variable_2="f5"/>
      <map_variables variable_1="km5" variable_2="km5"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="PGE"/>
      <map_variables variable_1="v2" variable_2="v2"/>
      <map_variables variable_1="d2" variable_2="d2"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="PIC"/>
      <map_variables variable_1="v1" variable_2="v1"/>
      <map_variables variable_1="d1" variable_2="d1"/>
      <map_variables variable_1="k1" variable_2="k1"/>
      <map_variables variable_1="km1" variable_2="km1"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="D"/>
      <map_variables variable_1="I0" variable_2="I0"/>
      <map_variables variable_1="d0" variable_2="d0"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="deg"/>
      <map_variables variable_1="v12" variable_2="v12"/>
      <map_variables variable_1="d12" variable_2="d12"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="HBEGF"/>
      <map_variables variable_1="v6" variable_2="v6"/>
      <map_variables variable_1="d6" variable_2="d6"/>
      <map_variables variable_1="k63" variable_2="k63"/>
      <map_variables variable_1="k62" variable_2="k62"/>
      <map_variables variable_1="k61" variable_2="k61"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="IEG"/>
      <map_variables variable_1="v3" variable_2="v3"/>
      <map_variables variable_1="d3" variable_2="d3"/>
      <map_variables variable_1="k3" variable_2="k3"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="PAI"/>
      <map_variables variable_1="v4" variable_2="v4"/>
      <map_variables variable_1="k4" variable_2="k4"/>
      <map_variables variable_1="d4" variable_2="d4"/>
   </connection>
</model>