Location: Cooling, Hunter, Crampin, 2009 @ 00be32aed712 / calcineurin_TomidaProtocol.cellml

Author:
Mike Cooling <m.cooling@auckland.ac.nz>
Date:
2010-06-02 13:32:24+12:00
Desc:
Removed the sub-folder structure and pulling all three models into one folder, to avoid UI issues with the Repository.
Permanent Source URI:
https://models.cellml.org/workspace/cooling_hunter_crampin_2009/rawfile/00be32aed712c03ef96e6cd04f55cc5d219406c9/calcineurin_TomidaProtocol.cellml

<?xml version="1.0" encoding="iso-8859-1"?>
<model
    name="calcineurin"
    cmeta:id="calcineurin"
    xmlns="http://www.cellml.org/cellml/1.1#"
    xmlns:cellml="http://www.cellml.org/cellml/1.1#"
    xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
    
<rdf:RDF
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
    xmlns:bqs="http://www.cellml.org/bqs/1.0#"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
    <rdf:Description rdf:about="#calcineurin">
        <dc:creator rdf:parseType="Resource">
            <vCard:N rdf:parseType="Resource">
                <vCard:Family>Cooling</vCard:Family>
                <vCard:Given>Michael</vCard:Given>
            </vCard:N>
            <vCard:EMAIL rdf:parseType="Resource">
                <rdf:value>m.cooling@auckland.ac.nz</rdf:value>
                <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet" />
            </vCard:EMAIL>
        </dc:creator>

        <dc:title>Cooling's calcineurin module for the Tomida-derived protocol</dc:title>
    </rdf:Description>
</rdf:RDF> 
<!--
*******************************************************
***         U   N   I   T   S                       ***
*******************************************************
-->
   <units name="s">
      <unit units="second"/>
   </units>
   
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="nM">
         <unit units="mole" prefix="nano"/>
         <unit units="liter" exponent="-1"/>
      </units>

<!--
*********************************************************
***       C   O   M   P   O   N   E   N   T   S       ***
*********************************************************
-->
     <component name="calcineurin">
         <variable name="t"   units="s" public_interface="in"/>
         <variable name="Ca" units="nM" public_interface="in"/>
         <variable name="M" units="nM" initial_value="6000"/>
         <variable name="Ntot" units="nM" initial_value="1000" public_interface="out"/>
         <variable name="K_mN" units="nM" initial_value="535"/>
         <variable name="n" units="dimensionless" initial_value="2.92"/>
         <variable name="K_dN" units="nM" initial_value="1760"/>
         <variable name="act_N" units="dimensionless" public_interface="out"/>
      
       <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
                  <eq/>
                  <ci>act_N</ci>
                  <apply>
                     <divide/>
                     <apply>
                        <power/>
                        <ci>Ca</ci>
                        <ci>n</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <ci>Ca</ci>
                           <ci>n</ci>
                        </apply>
                        <apply>
                           <times/>
                           <apply>
                              <power/>
                              <ci>K_mN</ci>
                              <ci>n</ci>
                           </apply>
                           <apply>
                              <plus/>
                              <cn cellml:units="dimensionless">1</cn>
                              <apply>
                                 <divide/>
                                 <ci>K_dN</ci>
                                 <ci>M</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
         </math>
   </component>

</model>