Location: Courtemanche, Ramirez, Nattel, 1998 @ 783354206204 / courtemanche_ramirez_nattel_1998.cellml

Author:
Tommy Yu <tommy.yu@auckland.ac.nz>
Date:
2010-08-26 12:15:05+12:00
Desc:
xml:base fix
Permanent Source URI:
https://models.cellml.org/workspace/courtemanche_ramirez_nattel_1998/rawfile/78335420620450b2eab817577c0faf4450bbf8cb/courtemanche_ramirez_nattel_1998.cellml

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<!--
This CellML file was generated on 29/10/2007 at 15:10:29 using:

COR (0.9.31.801)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Mathematical Model Of A Human Atrial Action Potential, 1998</title>
  <author>
    <firstname>Noble</firstname>
          <surname>Penny</surname>
    <affiliation>
      <shortaffil>Oxford University</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This model has been validated by Penny Noble of Oxford University and is known to run in COR and PCEnv. 
          </para>
<para>
ValidateCellML verifies this model as valid CellML, but detects unit inconsistencies.
</para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
The ionic mechanisms underlying many important properties of the human atrial action potential are poorly understood.  Using specific formulations of the K<superscript>+</superscript>, Na<superscript>+</superscript> and Ca<superscript>2+</superscript> currents based on experimental data recorded from human atrial myocytes, along with representations of pump, exchange and background currents, Marc Courtemanche, Rafael J. Ramirez and Stanley Nattel developed a mathematical model of the action potential (see the figure below).
</para>

<para>
This mathematical model builds mostly on the classical work of Luo and Rudy (see The Luo-Rudy Ventricular Model II (dynamic), 1994).  Courtemanche <emphasis>et al</emphasis> effectively develop a working model of the human atrial action potential from the Luo-Rudy model which is based on guinea pig ventricular cells.  Their primary goal was to develop a useful model of the action potential from which they could gain insights into experimental observations made on human atrial cells and tissues and make predictions regarding the behaviour of these cells under previously untested conditions
</para>

<para>
The complete original paper reference is cited below:
</para>

<para>
Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model, Marc Courtemanche, Rafael J. Ramirez and Stanley Nattel, 1998,
            <emphasis>American Journal of Physiology</emphasis>
          , 275, H301-H321.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=9688927&amp;dopt=Abstract">PubMed ID: 9688927</ulink> 
</para>

<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>schematic diagram of a human atrial myocyte</title>
    </objectinfo>
    <imagedata fileref="courtemanche_1998.png"/>
  </imageobject>
</mediaobject>
<caption>A schematic representation of currents, pumps and exchangers included in the model.  The cell includes three intracellular compartments: cytoplasm, sarcoplasmic reticulum (SR) release compartment [junctional SR (JSR)], and SR uptake compartment [network SR (NSR)].</caption>
</informalfigure>

</sect1>
</article>
</documentation>

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                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.311</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">79.23</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.1212</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.01052</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1378</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40.14</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.3</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt">2.535<sep/>-7</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">32</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>j_inf</ci>
            <apply>
               <divide/>
               <ci>alpha_j</ci>
               <apply>
                  <plus/>
                  <ci>alpha_j</ci>
                  <ci>beta_j</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_j</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_j</ci>
                  <ci>beta_j</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>j</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>j_inf</ci>
                  <ci>j</ci>
               </apply>
               <ci>tau_j</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current">
      <variable cmeta:id="time_independent_potassium_current_i_K1" name="i_K1" public_interface="out" units="picoA"/>
      <variable name="E_K" public_interface="out" units="millivolt"/>
      <variable initial_value="0.09" name="g_K1" units="nanoS_per_picoF"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="K_o" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="K_i" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_K</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>K_o</ci>
                     <ci>K_i</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K1</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Cm</ci>
                  <ci>g_K1</ci>
                  <apply>
                     <minus/>
                     <ci>V</ci>
                     <ci>E_K</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.07</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_K_current">
      <variable cmeta:id="transient_outward_K_current_i_to" name="i_to" public_interface="out" units="picoA"/>
      <variable initial_value="3" name="K_Q10" private_interface="out" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.1652" name="g_to" units="nanoS_per_picoF"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="oa" private_interface="in" units="dimensionless"/>
      <variable name="oi" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_to</ci>
            <apply>
               <times/>
               <ci>Cm</ci>
               <ci>g_to</ci>
               <apply>
                  <power/>
                  <ci>oa</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>oi</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_K_current_oa_gate">
      <variable initial_value="3.043e-2" name="oa" public_interface="out" units="dimensionless"/>
      <variable name="alpha_oa" units="per_millisecond"/>
      <variable name="beta_oa" units="per_millisecond"/>
      <variable name="tau_oa" units="millisecond"/>
      <variable name="oa_infinity" units="dimensionless"/>
      <variable name="K_Q10" public_interface="in" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_oa</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.65</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                              </apply>
                           </apply>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8.5</cn>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                           </apply>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">59</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_oa</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.65</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.5</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">72</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_oa</ci>
            <apply>
               <divide/>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <ci>alpha_oa</ci>
                     <ci>beta_oa</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
               <ci>K_Q10</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>oa_infinity</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.47</cn>
                        </apply>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17.54</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>oa</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>oa_infinity</ci>
                  <ci>oa</ci>
               </apply>
               <ci>tau_oa</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_K_current_oi_gate">
      <variable initial_value="9.992e-1" name="oi" public_interface="out" units="dimensionless"/>
      <variable name="alpha_oi" units="per_millisecond"/>
      <variable name="beta_oi" units="per_millisecond"/>
      <variable name="tau_oi" units="millisecond"/>
      <variable name="oi_infinity" units="dimensionless"/>
      <variable name="K_Q10" public_interface="in" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_oi</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">18.53</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">103.7</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.95</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_oi</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">35.56</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8.74</cn>
                           </apply>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.44</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_oi</ci>
            <apply>
               <divide/>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <ci>alpha_oi</ci>
                     <ci>beta_oi</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
               <ci>K_Q10</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>oi_infinity</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">33.1</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.3</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>oi</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>oi_infinity</ci>
                  <ci>oi</ci>
               </apply>
               <ci>tau_oi</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ultrarapid_delayed_rectifier_K_current">
      <variable cmeta:id="ultrarapid_delayed_rectifier_K_current_i_Kur" name="i_Kur" public_interface="out" units="picoA"/>
      <variable name="g_Kur" units="nanoS_per_picoF"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="K_Q10" private_interface="out" public_interface="in" units="dimensionless"/>
      <variable name="ua" private_interface="in" units="dimensionless"/>
      <variable name="ui" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_Kur</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoS_per_picoF">0.005</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoS_per_picoF">0.05</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                           </apply>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Kur</ci>
            <apply>
               <times/>
               <ci>Cm</ci>
               <ci>g_Kur</ci>
               <apply>
                  <power/>
                  <ci>ua</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>ui</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ultrarapid_delayed_rectifier_K_current_ua_gate">
      <variable initial_value="4.966e-3" name="ua" public_interface="out" units="dimensionless"/>
      <variable name="alpha_ua" units="per_millisecond"/>
      <variable name="beta_ua" units="per_millisecond"/>
      <variable name="tau_ua" units="millisecond"/>
      <variable name="ua_infinity" units="dimensionless"/>
      <variable name="K_Q10" public_interface="in" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_ua</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.65</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                              </apply>
                           </apply>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8.5</cn>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                           </apply>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">59</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_ua</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.65</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.5</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">72</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_ua</ci>
            <apply>
               <divide/>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <ci>alpha_ua</ci>
                     <ci>beta_ua</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
               <ci>K_Q10</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ua_infinity</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20.3</cn>
                        </apply>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9.6</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ua</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ua_infinity</ci>
                  <ci>ua</ci>
               </apply>
               <ci>tau_ua</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ultrarapid_delayed_rectifier_K_current_ui_gate">
      <variable initial_value="9.986e-1" name="ui" public_interface="out" units="dimensionless"/>
      <variable name="alpha_ui" units="per_millisecond"/>
      <variable name="beta_ui" units="per_millisecond"/>
      <variable name="tau_ui" units="millisecond"/>
      <variable name="ui_infinity" units="dimensionless"/>
      <variable name="K_Q10" public_interface="in" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_ui</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">21</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">195</cn>
                           </apply>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_ui</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">168</cn>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_ui</ci>
            <apply>
               <divide/>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <ci>alpha_ui</ci>
                     <ci>beta_ui</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
               <ci>K_Q10</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ui_infinity</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">109.45</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">27.48</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ui</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ui_infinity</ci>
                  <ci>ui</ci>
               </apply>
               <ci>tau_ui</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifier_K_current">
      <variable cmeta:id="rapid_delayed_rectifier_K_current_i_Kr" name="i_Kr" public_interface="out" units="picoA"/>
      <variable initial_value="0.029411765" name="g_Kr" units="nanoS_per_picoF"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="xr" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kr</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Cm</ci>
                  <ci>g_Kr</ci>
                  <ci>xr</ci>
                  <apply>
                     <minus/>
                     <ci>V</ci>
                     <ci>E_K</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">22.4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifier_K_current_xr_gate">
      <variable initial_value="3.296e-5" name="xr" public_interface="out" units="dimensionless"/>
      <variable name="alpha_xr" units="per_millisecond"/>
      <variable name="beta_xr" units="per_millisecond"/>
      <variable name="tau_xr" units="millisecond"/>
      <variable name="xr_infinity" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_xr</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0015</cn>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.1</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="millivolt">1<sep/>-10</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.0003</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.1</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.1</cn>
                              </apply>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_xr</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millisecond">3.7836118<sep/>-4</cn>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3.3328</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="millivolt">1<sep/>-10</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.000073898</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3.3328</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3.3328</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.1237</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xr</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <ci>alpha_xr</ci>
                  <ci>beta_xr</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>xr_infinity</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.1</cn>
                        </apply>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xr</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xr_infinity</ci>
                  <ci>xr</ci>
               </apply>
               <ci>tau_xr</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_K_current">
      <variable cmeta:id="slow_delayed_rectifier_K_current_i_Ks" name="i_Ks" public_interface="out" units="picoA"/>
      <variable initial_value="0.12941176" name="g_Ks" units="nanoS_per_picoF"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="xs" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <times/>
               <ci>Cm</ci>
               <ci>g_Ks</ci>
               <apply>
                  <power/>
                  <ci>xs</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_K_current_xs_gate">
      <variable initial_value="1.869e-2" name="xs" public_interface="out" units="dimensionless"/>
      <variable name="alpha_xs" units="per_millisecond"/>
      <variable name="beta_xs" units="per_millisecond"/>
      <variable name="tau_xs" units="millisecond"/>
      <variable name="xs_infinity" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_xs</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.00068</cn>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">19.9</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="millivolt">1<sep/>-10</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.00004</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">19.9</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">19.9</cn>
                              </apply>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_xs</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.000315</cn>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">19.9</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="millivolt">1<sep/>-10</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.000035</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">19.9</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">19.9</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <ci>alpha_xs</ci>
                     <ci>beta_xs</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>xs_infinity</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">19.9</cn>
                        </apply>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12.7</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs_infinity</ci>
                  <ci>xs</ci>
               </apply>
               <ci>tau_xs</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel">
      <variable cmeta:id="L_type_Ca_channel_i_Ca_L" name="i_Ca_L" public_interface="out" units="picoA"/>
      <variable initial_value="0.12375" name="g_Ca_L" units="nanoS_per_picoF"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Ca_i" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="d" private_interface="in" units="dimensionless"/>
      <variable name="f" private_interface="in" units="dimensionless"/>
      <variable name="f_Ca" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_L</ci>
            <apply>
               <times/>
               <ci>Cm</ci>
               <ci>g_Ca_L</ci>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_d_gate">
      <variable initial_value="1.367e-4" name="d" public_interface="out" units="dimensionless"/>
      <variable name="d_infinity" units="dimensionless"/>
      <variable name="tau_d" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>d_infinity</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_d</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">4.579</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                              </apply>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.24</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="millivolt">1<sep/>-10</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                              </apply>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.24</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.035</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.24</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>d_infinity</ci>
                  <ci>d</ci>
               </apply>
               <ci>tau_d</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f_gate">
      <variable initial_value="9.996e-1" name="f" public_interface="out" units="dimensionless"/>
      <variable name="f_infinity" units="dimensionless"/>
      <variable name="tau_f" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_infinity</ci>
            <apply>
               <divide/>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.9</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.9</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">9</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0197</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <power/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0337</cn>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 </apply>
                              </apply>
                              <apply>
                                 <power/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>f_infinity</ci>
                  <ci>f</ci>
               </apply>
               <ci>tau_f</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f_Ca_gate">
      <variable initial_value="7.755e-1" name="f_Ca" public_interface="out" units="dimensionless"/>
      <variable name="f_Ca_infinity" units="dimensionless"/>
      <variable name="tau_f_Ca" units="millisecond"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_Ca_infinity</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Ca_i</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.00035</cn>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f_Ca</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">2</cn>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f_Ca</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>f_Ca_infinity</ci>
                  <ci>f_Ca</ci>
               </apply>
               <ci>tau_f_Ca</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_potassium_pump">
      <variable cmeta:id="sodium_potassium_pump_i_NaK" name="i_NaK" public_interface="out" units="picoA"/>
      <variable initial_value="10" name="Km_Na_i" units="millimolar"/>
      <variable initial_value="1.5" name="Km_K_o" units="millimolar"/>
      <variable initial_value="0.59933874" name="i_NaK_max" units="picoA_per_picoF"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="f_NaK" units="dimensionless"/>
      <variable name="sigma" units="dimensionless"/>
      <variable name="K_o" public_interface="in" units="millimolar"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="Na_o" public_interface="in" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>sigma</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Na_o</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">67.3</cn>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f_NaK</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                              </apply>
                              <ci>F</ci>
                              <ci>V</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
                     <ci>sigma</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>F</ci>
                              </apply>
                              <ci>V</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Cm</ci>
                        <ci>i_NaK_max</ci>
                        <ci>f_NaK</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Km_Na_i</ci>
                              <ci>Na_i</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>K_o</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>K_o</ci>
                  <ci>Km_K_o</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="background_currents">
      <variable cmeta:id="background_currents_i_B_Na" name="i_B_Na" public_interface="out" units="picoA"/>
      <variable cmeta:id="background_currents_i_B_Ca" name="i_B_Ca" public_interface="out" units="picoA"/>
      <variable name="i_B_K" public_interface="out" units="picoA"/>
      <variable initial_value="0.0006744375" name="g_B_Na" units="nanoS_per_picoF"/>
      <variable initial_value="0.001131" name="g_B_Ca" units="nanoS_per_picoF"/>
      <variable initial_value="0" name="g_B_K" units="nanoS_per_picoF"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="E_Ca" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="Ca_o" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Ca</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ca_o</ci>
                     <ci>Ca_i</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_B_Na</ci>
            <apply>
               <times/>
               <ci>Cm</ci>
               <ci>g_B_Na</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_B_Ca</ci>
            <apply>
               <times/>
               <ci>Cm</ci>
               <ci>g_B_Ca</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_B_K</ci>
            <apply>
               <times/>
               <ci>Cm</ci>
               <ci>g_B_K</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Na_Ca_exchanger_current">
      <variable cmeta:id="Na_Ca_exchanger_current_i_NaCa" name="i_NaCa" public_interface="out" units="picoA"/>
      <variable initial_value="1600" name="I_NaCa_max" units="picoA_per_picoF"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable initial_value="87.5" name="K_mNa" units="millimolar"/>
      <variable initial_value="1.38" name="K_mCa" units="millimolar"/>
      <variable initial_value="0.1" name="K_sat" units="dimensionless"/>
      <variable initial_value="0.35" name="gamma" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="Na_o" public_interface="in" units="millimolar"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="Ca_o" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Cm</ci>
                  <ci>I_NaCa_max</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>gamma</ci>
                                 <ci>F</ci>
                                 <ci>V</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Na_i</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Ca_o</ci>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>gamma</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <ci>F</ci>
                                 <ci>V</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Na_o</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Ca_i</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <apply>
                        <power/>
                        <ci>K_mNa</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <apply>
                        <power/>
                        <ci>Na_o</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>K_mCa</ci>
                     <ci>Ca_o</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <ci>K_sat</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>gamma</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sarcolemmal_calcium_pump_current">
      <variable cmeta:id="sarcolemmal_calcium_pump_current_i_CaP" name="i_CaP" public_interface="out" units="picoA"/>
      <variable initial_value="0.275" name="i_CaP_max" units="picoA_per_picoF"/>
      <variable name="Cm" public_interface="in" units="picoF"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_CaP</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Cm</ci>
                  <ci>i_CaP_max</ci>
                  <ci>Ca_i</ci>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0005</cn>
                  <ci>Ca_i</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_release_current_from_JSR">
      <variable cmeta:id="Ca_release_current_from_JSR_i_rel" name="i_rel" public_interface="out" units="millimolar_per_millisecond"/>
      <variable name="Fn" private_interface="out" units="dimensionless"/>
      <variable initial_value="30" name="K_rel" units="per_millisecond"/>
      <variable name="V_rel" public_interface="in" units="micrometre_3"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="Ca_rel" public_interface="in" units="millimolar"/>
      <variable name="i_Ca_L" public_interface="in" units="picoA"/>
      <variable name="i_NaCa" public_interface="in" units="picoA"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="u" private_interface="in" units="dimensionless"/>
      <variable name="v" private_interface="in" units="dimensionless"/>
      <variable name="w" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Fn</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="millisecond_per_millimolar">1<sep/>3</cn>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_micrometre_3">1<sep/>-15</cn>
                     <ci>V_rel</ci>
                     <ci>i_rel</ci>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_micrometre_3">1<sep/>-15</cn>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <ci>F</ci>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
                           <ci>i_Ca_L</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                           <ci>i_NaCa</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_rel</ci>
            <apply>
               <times/>
               <ci>K_rel</ci>
               <apply>
                  <power/>
                  <ci>u</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <ci>v</ci>
               <ci>w</ci>
               <apply>
                  <minus/>
                  <ci>Ca_rel</ci>
                  <ci>Ca_i</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_release_current_from_JSR_u_gate">
      <variable initial_value="2.35e-112" name="u" public_interface="out" units="dimensionless"/>
      <variable name="tau_u" units="millisecond"/>
      <variable name="u_infinity" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Fn" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>tau_u</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">8</cn>
         </apply>
         <apply>
            <eq/>
            <ci>u_infinity</ci>
            <apply>
               <power/>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>Fn</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">3.4175<sep/>-13</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">13.67<sep/>-16</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>u</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>u_infinity</ci>
                  <ci>u</ci>
               </apply>
               <ci>tau_u</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_release_current_from_JSR_v_gate">
      <variable initial_value="1" name="v" public_interface="out" units="dimensionless"/>
      <variable name="tau_v" units="millisecond"/>
      <variable name="v_infinity" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Fn" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>tau_v</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1.91</cn>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">2.09</cn>
                  <apply>
                     <power/>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>Fn</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">3.4175<sep/>-13</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">13.67<sep/>-16</cn>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_infinity</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>Fn</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">6.835<sep/>-14</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">13.67<sep/>-16</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>v</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>v_infinity</ci>
                  <ci>v</ci>
               </apply>
               <ci>tau_v</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_release_current_from_JSR_w_gate">
      <variable initial_value="0.9992" name="w" public_interface="out" units="dimensionless"/>
      <variable name="tau_w" units="millisecond"/>
      <variable name="w_infinity" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>tau_w</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">6</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.3</cn>
                  </apply>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.9</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="millivolt">1<sep/>-10</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">6</cn>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <minus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.9</cn>
                                    </apply>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <plus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.3</cn>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <divide/>
                                    <apply>
                                       <minus/>
                                       <apply>
                                          <minus/>
                                          <ci>V</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.9</cn>
                                       </apply>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">1</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.9</cn>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>w_infinity</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>w</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>w_infinity</ci>
                  <ci>w</ci>
               </apply>
               <ci>tau_w</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transfer_current_from_NSR_to_JSR">
      <variable cmeta:id="transfer_current_from_NSR_to_JSR_i_tr" name="i_tr" public_interface="out" units="millimolar_per_millisecond"/>
      <variable initial_value="180" name="tau_tr" units="millisecond"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Ca_rel" public_interface="in" units="millimolar"/>
      <variable name="Ca_up" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_tr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Ca_up</ci>
                  <ci>Ca_rel</ci>
               </apply>
               <ci>tau_tr</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_uptake_current_by_the_NSR">
      <variable initial_value="0.005" name="I_up_max" public_interface="out" units="millimolar_per_millisecond"/>
      <variable cmeta:id="Ca_uptake_current_by_the_NSR_i_up" name="i_up" public_interface="out" units="millimolar_per_millisecond"/>
      <variable initial_value="0.00092" name="K_up" units="millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_up</ci>
            <apply>
               <divide/>
               <ci>I_up_max</ci>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>K_up</ci>
                     <ci>Ca_i</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_leak_current_by_the_NSR">
      <variable cmeta:id="Ca_leak_current_by_the_NSR_i_up_leak" name="i_up_leak" public_interface="out" units="millimolar_per_millisecond"/>
      <variable initial_value="15" name="Ca_up_max" units="millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Ca_up" public_interface="in" units="millimolar"/>
      <variable name="I_up_max" public_interface="in" units="millimolar_per_millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_up_leak</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_up_max</ci>
                  <ci>Ca_up</ci>
               </apply>
               <ci>Ca_up_max</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_buffers">
      <variable initial_value="0.05" name="CMDN_max" public_interface="out" units="millimolar"/>
      <variable initial_value="0.07" name="TRPN_max" public_interface="out" units="millimolar"/>
      <variable initial_value="10" name="CSQN_max" public_interface="out" units="millimolar"/>
      <variable initial_value="0.00238" name="Km_CMDN" public_interface="out" units="millimolar"/>
      <variable initial_value="0.0005" name="Km_TRPN" public_interface="out" units="millimolar"/>
      <variable initial_value="0.8" name="Km_CSQN" public_interface="out" units="millimolar"/>
      <variable name="Ca_CMDN" units="millimolar"/>
      <variable name="Ca_TRPN" units="millimolar"/>
      <variable name="Ca_CSQN" units="millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="Ca_rel" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Ca_CMDN</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>CMDN_max</ci>
                  <ci>Ca_i</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ca_i</ci>
                  <ci>Km_CMDN</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ca_TRPN</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>TRPN_max</ci>
                  <ci>Ca_i</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ca_i</ci>
                  <ci>Km_TRPN</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ca_CSQN</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>CSQN_max</ci>
                  <ci>Ca_rel</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ca_rel</ci>
                  <ci>Km_CSQN</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="intracellular_ion_concentrations">
      <variable initial_value="1.117e+01" name="Na_i" public_interface="out" units="millimolar"/>
      <variable initial_value="1.013e-4" name="Ca_i" public_interface="out" units="millimolar"/>
      <variable initial_value="1.39e+02" name="K_i" public_interface="out" units="millimolar"/>
      <variable initial_value="1.488" name="Ca_rel" public_interface="out" units="millimolar"/>
      <variable initial_value="1.488" name="Ca_up" public_interface="out" units="millimolar"/>
      <variable initial_value="20100" name="V_cell" units="micrometre_3"/>
      <variable name="V_i" units="micrometre_3"/>
      <variable name="V_rel" public_interface="out" units="micrometre_3"/>
      <variable name="V_up" units="micrometre_3"/>
      <variable name="B1" units="millimolar_per_millisecond"/>
      <variable name="B2" units="dimensionless"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="i_NaK" public_interface="in" units="picoA"/>
      <variable name="i_NaCa" public_interface="in" units="picoA"/>
      <variable name="i_B_Na" public_interface="in" units="picoA"/>
      <variable name="i_Na" public_interface="in" units="picoA"/>
      <variable name="i_K1" public_interface="in" units="picoA"/>
      <variable name="i_to" public_interface="in" units="picoA"/>
      <variable name="i_Kur" public_interface="in" units="picoA"/>
      <variable name="i_Kr" public_interface="in" units="picoA"/>
      <variable name="i_Ks" public_interface="in" units="picoA"/>
      <variable name="i_CaP" public_interface="in" units="picoA"/>
      <variable name="i_Ca_L" public_interface="in" units="picoA"/>
      <variable name="i_B_Ca" public_interface="in" units="picoA"/>
      <variable name="i_B_K" public_interface="in" units="picoA"/>
      <variable name="i_up" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="i_up_leak" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="i_tr" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="i_rel" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="Km_CMDN" public_interface="in" units="millimolar"/>
      <variable name="Km_CSQN" public_interface="in" units="millimolar"/>
      <variable name="Km_TRPN" public_interface="in" units="millimolar"/>
      <variable name="CMDN_max" public_interface="in" units="millimolar"/>
      <variable name="CSQN_max" public_interface="in" units="millimolar"/>
      <variable name="TRPN_max" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>V_i</ci>
            <apply>
               <times/>
               <ci>V_cell</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.68</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_rel</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0048</cn>
               <ci>V_cell</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_up</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0552</cn>
               <ci>V_cell</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Na_i</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <ci>i_NaK</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        <ci>i_NaCa</ci>
                     </apply>
                     <ci>i_B_Na</ci>
                     <ci>i_Na</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>V_i</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>K_i</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>i_NaK</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>i_K1</ci>
                     <ci>i_to</ci>
                     <ci>i_Kur</ci>
                     <ci>i_Kr</ci>
                     <ci>i_Ks</ci>
                     <ci>i_B_K</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>V_i</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_i</ci>
            </apply>
            <apply>
               <divide/>
               <ci>B1</ci>
               <ci>B2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>B1</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>i_NaCa</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>i_CaP</ci>
                        <ci>i_Ca_L</ci>
                        <ci>i_B_Ca</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>V_i</ci>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>V_up</ci>
                        <apply>
                           <minus/>
                           <ci>i_up_leak</ci>
                           <ci>i_up</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>i_rel</ci>
                        <ci>V_rel</ci>
                     </apply>
                  </apply>
                  <ci>V_i</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>B2</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>TRPN_max</ci>
                     <ci>Km_TRPN</ci>
                  </apply>
                  <apply>
                     <power/>
                     <apply>
                        <plus/>
                        <ci>Ca_i</ci>
                        <ci>Km_TRPN</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>CMDN_max</ci>
                     <ci>Km_CMDN</ci>
                  </apply>
                  <apply>
                     <power/>
                     <apply>
                        <plus/>
                        <ci>Ca_i</ci>
                        <ci>Km_CMDN</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_up</ci>
            </apply>
            <apply>
               <minus/>
               <ci>i_up</ci>
               <apply>
                  <plus/>
                  <ci>i_up_leak</ci>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>i_tr</ci>
                        <ci>V_rel</ci>
                     </apply>
                     <ci>V_up</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_rel</ci>
            </apply>
            <apply>
               <times/>
               <apply>
                  <minus/>
                  <ci>i_tr</ci>
                  <ci>i_rel</ci>
               </apply>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>CSQN_max</ci>
                           <ci>Km_CSQN</ci>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <plus/>
                              <ci>Ca_rel</ci>
                              <ci>Km_CSQN</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="standard_ionic_concentrations">
      <variable initial_value="140" name="Na_o" public_interface="out" units="millimolar"/>
      <variable initial_value="1.8" name="Ca_o" public_interface="out" units="millimolar"/>
      <variable initial_value="5.4" name="K_o" public_interface="out" units="millimolar"/>
   </component>
   <group>
      <relationship_ref relationship="containment"/>
      <component_ref component="membrane">
         <component_ref component="fast_sodium_current">
            <component_ref component="fast_sodium_current_m_gate"/>
            <component_ref component="fast_sodium_current_h_gate"/>
            <component_ref component="fast_sodium_current_j_gate"/>
         </component_ref>
         <component_ref component="time_independent_potassium_current"/>
         <component_ref component="transient_outward_K_current">
            <component_ref component="transient_outward_K_current_oa_gate"/>
            <component_ref component="transient_outward_K_current_oi_gate"/>
         </component_ref>
         <component_ref component="ultrarapid_delayed_rectifier_K_current">
            <component_ref component="ultrarapid_delayed_rectifier_K_current_ua_gate"/>
            <component_ref component="ultrarapid_delayed_rectifier_K_current_ui_gate"/>
         </component_ref>
         <component_ref component="rapid_delayed_rectifier_K_current">
            <component_ref component="rapid_delayed_rectifier_K_current_xr_gate"/>
         </component_ref>
         <component_ref component="slow_delayed_rectifier_K_current">
            <component_ref component="slow_delayed_rectifier_K_current_xs_gate"/>
         </component_ref>
         <component_ref component="L_type_Ca_channel">
            <component_ref component="L_type_Ca_channel_d_gate"/>
            <component_ref component="L_type_Ca_channel_f_gate"/>
            <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
         </component_ref>
         <component_ref component="sodium_potassium_pump"/>
         <component_ref component="background_currents"/>
         <component_ref component="Na_Ca_exchanger_current"/>
         <component_ref component="sarcolemmal_calcium_pump_current"/>
         <component_ref component="Ca_release_current_from_JSR">
            <component_ref component="Ca_release_current_from_JSR_u_gate"/>
            <component_ref component="Ca_release_current_from_JSR_v_gate"/>
            <component_ref component="Ca_release_current_from_JSR_w_gate"/>
         </component_ref>
         <component_ref component="transfer_current_from_NSR_to_JSR"/>
         <component_ref component="Ca_uptake_current_by_the_NSR"/>
         <component_ref component="Ca_leak_current_by_the_NSR"/>
         <component_ref component="Ca_buffers"/>
         <component_ref component="intracellular_ion_concentrations"/>
         <component_ref component="standard_ionic_concentrations"/>
      </component_ref>
   </group>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="fast_sodium_current">
         <component_ref component="fast_sodium_current_m_gate"/>
         <component_ref component="fast_sodium_current_h_gate"/>
         <component_ref component="fast_sodium_current_j_gate"/>
      </component_ref>
      <component_ref component="transient_outward_K_current">
         <component_ref component="transient_outward_K_current_oa_gate"/>
         <component_ref component="transient_outward_K_current_oi_gate"/>
      </component_ref>
      <component_ref component="ultrarapid_delayed_rectifier_K_current">
         <component_ref component="ultrarapid_delayed_rectifier_K_current_ua_gate"/>
         <component_ref component="ultrarapid_delayed_rectifier_K_current_ui_gate"/>
      </component_ref>
      <component_ref component="rapid_delayed_rectifier_K_current">
         <component_ref component="rapid_delayed_rectifier_K_current_xr_gate"/>
      </component_ref>
      <component_ref component="slow_delayed_rectifier_K_current">
         <component_ref component="slow_delayed_rectifier_K_current_xs_gate"/>
      </component_ref>
      <component_ref component="L_type_Ca_channel">
         <component_ref component="L_type_Ca_channel_d_gate"/>
         <component_ref component="L_type_Ca_channel_f_gate"/>
         <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
      </component_ref>
      <component_ref component="Ca_release_current_from_JSR">
         <component_ref component="Ca_release_current_from_JSR_u_gate"/>
         <component_ref component="Ca_release_current_from_JSR_v_gate"/>
         <component_ref component="Ca_release_current_from_JSR_w_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="membrane" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_K_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="ultrarapid_delayed_rectifier_K_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifier_K_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="slow_delayed_rectifier_K_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_release_current_from_JSR" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="transfer_current_from_NSR_to_JSR" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_uptake_current_by_the_NSR" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_leak_current_by_the_NSR" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_buffers" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="intracellular_ion_concentrations" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="fast_sodium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="transient_outward_K_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_to" variable_2="i_to"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="ultrarapid_delayed_rectifier_K_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kur" variable_2="i_Kur"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="rapid_delayed_rectifier_K_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="slow_delayed_rectifier_K_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="L_type_Ca_channel"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_potassium_pump"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="background_currents"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_B_Ca" variable_2="i_B_Ca"/>
      <map_variables variable_1="i_B_Na" variable_2="i_B_Na"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="Na_Ca_exchanger_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sarcolemmal_calcium_pump_current"/>
      <map_variables variable_1="i_CaP" variable_2="i_CaP"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="Ca_release_current_from_JSR" component_2="membrane"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
      <map_variables variable_1="Na_i" variable_2="Na_i"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="standard_ionic_concentrations"/>
      <map_variables variable_1="Na_o" variable_2="Na_o"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="background_currents"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
      <map_variables variable_1="K_i" variable_2="K_i"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="standard_ionic_concentrations"/>
      <map_variables variable_1="K_o" variable_2="K_o"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="transient_outward_K_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="background_currents"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="ultrarapid_delayed_rectifier_K_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="rapid_delayed_rectifier_K_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="slow_delayed_rectifier_K_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
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    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Richard</vCard:Other>
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    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Rafael</vCard:Given>
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    <dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#b2f216b5-d815-4132-b519-ed2c9ae4d171"/>
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    <vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine Lloyd</vCard:FN>
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  <rdf:Description rdf:about="rdf:#62d3c703-8a13-4d22-91f7-6be9a591923e">
    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2006-09-27T00:00:00+00:00</dcterms:W3CDTF>
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    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#e1c2f6ea-42d2-4d09-aaeb-fee67b33c31b"/>
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    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">1998-07</dcterms:W3CDTF>
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    <dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#9d60f44e-c05e-45f9-80b1-944bac04cba7"/>
    <rdf:value>This model has been validated by Penny Noble of Oxford University (v02 created from v01,) and is known to run in COR and PCEnv. A PCEnv session is also associated with this file.</rdf:value>
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    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#4b99bfb1-b157-4c60-80ad-9423ec5fcdf0"/>
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    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lloyd</vCard:Family>
    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">May</vCard:Other>
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    <rdf:value>This is the CellML description of Courtemanche et al's mathematical 
model of the ionic mechanisms underlying human atrial action potential           properties.</rdf:value>
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    <rdf:value>fixed e-notation errors, 
updated curation status,
removed reference link in documentation</rdf:value>
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    <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Ionic mechanisms underlying human atrial action potential                        properties: insights from a mathematical model</dc:title>
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    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">James</vCard:Given>
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    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Richard</vCard:Other>
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    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">James</vCard:Given>
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    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Penny</vCard:Given>
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    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">J</vCard:Other>
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    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2003-06-04</dcterms:W3CDTF>
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    <ns7:endingValue xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">5000</ns7:endingValue>
    <ns7:nonstandard-pointDensity xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">100000</ns7:nonstandard-pointDensity>
    <ns7:maximumStepSize xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">0.1</ns7:maximumStepSize>
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    <vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#e541a07c-bc0b-404d-b573-f1486f8a3b7f"/>
    <vCard:EMAIL xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#58b98bb9-4079-434c-9ff3-2d40caac4142"/>
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#51c690e7-176f-4a4a-8671-ec016bf11100"/>
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  <rdf:Description rdf:about="rdf:#$59O35">
    <ns7:boundIntervals xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" rdf:resource="rdf:#$69O35"/>
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  <rdf:Description rdf:about="rdf:#799f6ee1-e426-4f15-98eb-61ff3f925287">
    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2009-06-08T13:24:53+12:00</dcterms:W3CDTF>
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  <rdf:Description rdf:about="rdf:#9c41a790-c147-4542-b56d-c97a8490104f">
    <dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#b40aadf2-77e6-4a22-b3df-285f7206db1f"/>
    <rdf:value>Corrected equations: alpha_j_calculation and beta_j_calculation in 
          fast_sodium_current_j_gate, oa_infinity_calculation in 
          transient_outward_K_current_oa_gate, alpha_ui_calculation in 
          ultrarapid_delayed_rectifier_K_current_ui_gate, i_Ca_L_calculation in 
          L_type_Ca_channel, and i_rel_calculation in 
          Ca_release_current_from_JSR.</rdf:value>
    <cmeta:modifier rdf:resource="rdf:#f4ad66df-9c4c-44b3-a9f2-270a2b534ee4"/>
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  <rdf:Description rdf:about="rdf:#565c4fe6-cd24-4422-8007-cd8d49b1fbbe">
    <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#f88cd459-f20f-4770-bb46-99fd2982e76e"/>
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  <rdf:Description rdf:about="rdf:#a5211371-ffaf-4811-b369-9fdbfad03924">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Stanley</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Nattel</vCard:Family>
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  <rdf:Description rdf:about="rdf:#8286b7a5-3770-4c4b-b95c-dadd88acdda7">
    <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2003-03-28</dcterms:W3CDTF>
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  <rdf:Description rdf:about="rdf:#7c3e37c4-120f-44bb-91d1-978af4d66308">
    <dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#0e132f6d-817a-4e7c-a4a8-642806e4844d"/>
    <rdf:value>Added cmeta:id's to several variables to allow creation of a PCEnv session file.</rdf:value>
    <cmeta:modifier rdf:resource="rdf:#73a6806b-b868-4470-8743-7e38e1785664"/>
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</rdf:RDF>
</model>