Location: Cronwright, Rohwer, Prior, 2002 @ a4fb5c1b092f / cronwright_rohwer_prior_2002.cellml

Author:

pmr2.import <nobody@models.cellml.org>

Date:

2009-06-17 13:24:33+12:00

Desc:

committing version02 of cronwright_rohwer_prior_2002

Permanent Source URI:

https://models.cellml.org/workspace/cronwright_rohwer_prior_2002/rawfile/a4fb5c1b092f40116bc7036c76e2286ee4696753/cronwright_rohwer_prior_2002.cellml

<?xml version='1.0' encoding='utf-8'?>
<!--  FILE :  cronwright_model_2002.xml

CREATED :  22nd January 2004

LAST MODIFIED : 22nd January 2004

AUTHOR :  Catherine Lloyd
          Bioengineering Institute
          The University of Auckland
          
MODEL STATUS :  This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.

DESCRIPTION :  This file contains a CellML description of Cronwright et al.'s 2002 metabolic control analysis of glycerol synthesis in Saccharomyces cerevisiae.

CHANGES:  
  
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="cronwright_rohwer_prior_2002_version01" name="cronwright_rohwer_prior_2002_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Metabolic Control Analysis of Glycerol Synthesis in Saccharomyces cerevisiae</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This model is able to be solved but its output has not been checked against the publication.
</para>
<para>
ValidateCellML verifies this model as valid CellML but detects a unit inconsistency.
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
Glycerol is a major by-product of ethanol fermentation by <emphasis>Saccharomyces cerevisiae</emphasis>, and it is a valuable product in the wine, beer and ethanol production industries.  For this reason, several attempts have been made to manufacture an industrial strain of <emphasis>S. cerevisiae</emphasis> that is capable of producing larger than normal amounts of glycerol.  These attempts have generally employed one of three potential strategies:
</para>
<itemizedlist>
  <listitem>
            <para>altered growth conditions;</para>
          </listitem>
  <listitem>
            <para>use of improved wine-producing <emphasis>S. cerevisiae</emphasis> strains by classical selective breeding techniques; and</para>
          </listitem>
  <listitem>
            <para>use of improved strains by genetic modification and molecular manipulation.</para>
          </listitem>
</itemizedlist>  

<para>
These strategies have proven to be successful, to a degree.  More glycerol is synthesised, but in addition, there are increased quantities of other by-products such as acetaldehyde and acetate.  For the wine making industry in particular, these products are undesirable.
</para>

<para>
In order to gain a better understanding of the glycerol synthesis pathway, Cronwright <emphasis>et al.</emphasis> (2002) have devloped a detailed kinetic model of the reactions involved (see <xref linkend="fig_reaction_diagram"/> below).  The model provides insight into the roles of, and the extents to which, the redox balance, substrate availability, modifier concentrations, and intrinsic enzyme capabilities control the amount of glycerol produced.  Model simulation results may also provide some insight into the inherent capacities of the pathway and therefore facilitate a more knowledgable approach to controlled glycerol syntheisi by <emphasis>S. cerevisiae</emphasis>.   
</para>

<para>
The model has been described here in CellML (the raw CellML description of the Cronwright <emphasis>et al.</emphasis> 2002 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>).     
</para>

<para>
The complete original paper reference is cited below:
</para>

<para>
Metabolic Control Analysis of Glycerol Synthesis in <emphasis>Saccharomyces cerevisiae</emphasis>
          , Garth R. Cronwright, Johann M. Rohwer, and Bernard A. Prior, 2002, 
            <emphasis>Applied and Environmental Microbiology</emphasis>
          , 68, 4448-4456.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=12200299&amp;dopt=Abstract">PubMed ID: 12200299</ulink>
</para>

<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>reaction diagram</title>
    </objectinfo>
    <imagedata fileref="cronwright_2002.png"/>
  </imageobject>
</mediaobject>
<caption>Schematic diagram of the glycerol synthesis pathway in <emphasis>Saccharomyces cerevisiae</emphasis>.</caption>
</informalfigure>

</sect1>
</article>
</documentation>
  
  
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