Modelling the calcium-calcineurin signalling network in cardiac myocytes
Catherine
Lloyd
Auckland Bioengineering Institute, The University of Auckland
Model Status
This CellML model runs in both PCEnv and COR to recreate the published results. The units have been checked and they are consistent.
Model Structure
ABSTRACT: Understanding of processes in which calcium signaling is involved is of fundamental importance in systems biology and has many applications in medicine. In this paper we have studied the particular case of the complex calcium-calcineurin-MCIP-NFAT signaling network in cardiac myocytes, the understanding of which is critical for treatment of pathologic hypertrophy and heart failure. By including some most recent experimental
In 2006, Shin et al. published a paper which modelled the dual role of MCIP in cardiac hypertrophy. In the study described here, Cui and Kaandorp have extended this model to include more recent and extensive experimental data. They used Cellerator, an open source software, to automatically generate the equations, and the model was subsequently translated into CellML to facilitate future model exchange, reuse and implementation.
model diagram
A schematic diagram of the Ca2+-calcineurin-MCIP-NFAT signalling networks in cardiac myocytes described by the model. Abbreviations: calmodulin (CaM); calcineurin (CaN); activated calcineurin (CaN*); nuclear factor of activated T-cells (NFAT); phosphorylated NFAT (NFATP); modulatory calcineurin-interacting protein (MCIP); phosphorylated MCIP on serine 112 (MCIPP); phosphorylated MCIP on both serine 112 and serine 108 (MCIPPP); big mitogen-activated protein kinase 1 (BMK1); glycogen synthase 3
The original book chapter reference is cited below:
Simulating Complex Calcium-Calcineurin Signaling Network, Jiangjun Cui and Jaap A. Kaandorp, 2008,
Lecture Notes in Computer Science, 5013, 110-119, PubMed ID: 16445978.
BMK1
big mitogen-activated protein kinase 1
MRNA
MCIP mRNA
NFATc
cytosolic NFAT
NFATn
nuclear NFAT
NFATpc
cytosolic NFATp
NFATpn
nuclear NFATp
GSK3betac
cytosolic glycogen synthase 3-beta
GSK3betan
nuclear glycogen synthase 3-beta
CaNc
cytosolic inactive calcineurin
CaNc_star
cytosolic activated calcineurin
CaNn_star
nuclear activated calcineurin
CaNn
nuclear inactive calcineurin
CaM
calmodulin
CaMCa
calcium-calmodulin complex
MCIP
modulatory calcineurin-interacting protein
MCIPp
phosphorylated MCIP on serine 112
MCIPpp
phosphorylated MCIP on both serine 112 and serine 108
Comp1
complex formed by MCIP and calcineurin
Comp2
complex formed by MCIPPP and 14-3-3
Comp3
complex formed by NFATP and 14-3-3
P1433
14-3-3 protein
Jiangjun
Cui
Jaap
Kaandorp
A
The University of Auckland, Auckland Bioengineering Institute
The University of Auckland
Auckland Bioengineering Institute
Lecture Notes in Computer Science
keyword
cardiac
cardiac mycocyte
signal transduction
Simulating Complex Calcium-Calcineurin Signaling Network
5013
16445978
110
119
This CellML model runs in both PCEnv and COR to recreate the published results. The units have been checked and they are consistent.
2008-05-14T00:00:00+00:00
Catherine Lloyd
c.lloyd@auckland.ac.nz
2008-06-00 00:00
Catherine
Lloyd
May