- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2008-06-30 03:03:35+12:00
- Desc:
- committing version01 of dougherty_wright_yew_2005
- Permanent Source URI:
- https://models.cellml.org/workspace/dougherty_wright_yew_2005/rawfile/b423e1cea98934bef90717fcb5aa3211ee3213cc/dougherty_wright_yew_2005.cellml
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<!--
This CellML file was generated on 25/06/2008 at 9:39:31 at a.m. using:
COR (0.9.31.979)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.CellML.org/
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<title>Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons</title>
<author>
<firstname>Geoffrey</firstname>
<surname>Nunns</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This model runs in both PCEnv and COR. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Abstract: We develop a mechanistic mathematical model of the G-protein coupled signaling pathway responsible for generating current responses in frog olfactory receptor neurons. The model incorporates descriptions of ligand-receptor interaction, intracellular transduction events involving the second messenger cAMP, effector ion-channel activity, and calcium-mediated feedback steps. We parameterized the model with respect to suction pipette current recordings from single cells stimulated with multiple odor concentrations. The proposed model accurately predicts the receptor-current response of the neuron to brief and prolonged odorant exposure and is able to produce the adaptation observed under repeated or sustained stimulation.
</para>
<para>
<informalfigure float="0" id="fig_reaction_diagram">
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<title>model diagram</title>
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<caption>Schematic diagram of the Dougherty et al model.</caption>
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</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.pnas.org/cgi/content/full/102/30/10415">Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons</ulink>, Daniel P. Dougherty, Geraldine A. Wright, Alice C. Yew, 2005, <ulink url="http://www.pnas.org/">
<emphasis>Proceeding of the National Academy of Sciences</emphasis>
</ulink>, 102, 10415- 10420. (<ulink url="http://www.pnas.org/cgi/reprint/102/30/10415">PDF</ulink> versions of the article are available for Journal Members on the PNAS website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16027364 &dopt=Abstract">PubMed ID: 16027364 </ulink>
</para>
</sect1>
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<variable units="uM" public_interface="in" name="hmc_2"/>
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<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_ClCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>clmax</ci>
<apply>
<power/>
<ci>Ca</ci>
<ci>n_2</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca</ci>
<ci>n_2</ci>
</apply>
<apply>
<power/>
<ci>hmc_2</ci>
<ci>n_2</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>V_Cl</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="I_NCX">
<variable units="nanoampere" public_interface="out" name="I_NCX"/>
<variable units="uM_per_second" public_interface="out" private_interface="in" name="J_NCX"/>
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<variable units="per_second" public_interface="in" private_interface="out" name="ef"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_NCX</ci>
<apply>
<times/>
<ci>F_vol</ci>
<ci>J_NCX</ci>
</apply>
</apply>
</math>
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<component name="J_NCX">
<variable units="uM_per_second" public_interface="out" name="J_NCX"/>
<variable units="uM" public_interface="in" name="Ca"/>
<variable units="per_second" public_interface="in" name="ef"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_NCX</ci>
<apply>
<times/>
<ci>ef</ci>
<ci>Ca</ci>
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</apply>
</math>
</component>
<component name="I_other">
<variable units="nanoampere" public_interface="out" name="I_other"/>
<variable units="nanosiemens" public_interface="in" name="gl"/>
<variable units="millivolt" public_interface="in" name="V_l"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_other</ci>
<apply>
<times/>
<ci>gl</ci>
<apply>
<minus/>
<ci>V_l</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</math>
</component>
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<relationship_ref relationship="encapsulation"/>
<component_ref component="aG">
<component_ref component="k_G"/>
<component_ref component="r_G"/>
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<component_ref component="cAMP">
<component_ref component="synth"/>
<component_ref component="degrad"/>
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<component_ref component="Ca">
<component_ref component="cc_1"/>
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<connection>
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<connection>
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<connection>
<map_components component_2="Ca" component_1="environment"/>
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<connection>
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<connection>
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<connection>
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<connection>
<map_components component_2="O_stim" component_1="environment"/>
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<connection>
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<connection>
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<map_variables variable_2="degrad" variable_1="degrad"/>
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<connection>
<map_components component_2="CaCaM" component_1="aCaMK"/>
<map_variables variable_2="CaCaM" variable_1="CaCaM"/>
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<connection>
<map_components component_2="Ca" component_1="I_NCX"/>
<map_variables variable_2="Ca" variable_1="Ca"/>
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<connection>
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<connection>
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<connection>
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<map_variables variable_2="k_2" variable_1="k_2"/>
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<connection>
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<map_variables variable_2="r_G" variable_1="r_G"/>
<map_variables variable_2="r_2" variable_1="r_2"/>
<map_variables variable_2="aG" variable_1="aG"/>
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<connection>
<map_components component_2="parameters" component_1="cAMP"/>
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<map_variables variable_2="kinh" variable_1="kinh"/>
<map_variables variable_2="ninh" variable_1="ninh"/>
<map_variables variable_2="pd" variable_1="pd"/>
</connection>
<connection>
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<connection>
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<map_variables variable_2="cc_2" variable_1="cc_2"/>
<map_variables variable_2="cc1lin" variable_1="cc1lin"/>
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<connection>
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<map_variables variable_2="Ca" variable_1="Ca"/>
<map_variables variable_2="cc_1" variable_1="cc_1"/>
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<connection>
<map_components component_2="CaCaM" component_1="Ca"/>
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<map_variables variable_2="CaCaM" variable_1="CaCaM"/>
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<connection>
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<connection>
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<connection>
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<map_variables variable_2="ck1lin" variable_1="ck1lin"/>
<map_variables variable_2="CaCaM" variable_1="CaCaM"/>
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<connection>
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<connection>
<map_components component_2="I_CNG" component_1="Ca"/>
<map_variables variable_2="I_CNG" variable_1="I_CNG"/>
</connection>
<connection>
<map_components component_2="parameters" component_1="I_other"/>
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<map_variables variable_2="gl" variable_1="gl"/>
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<connection>
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<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="I_other" variable_1="I_other"/>
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<connection>
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<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="I_CNG" variable_1="I_CNG"/>
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<connection>
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<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="I_ClCa" variable_1="I_ClCa"/>
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<connection>
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<connection>
<map_components component_2="parameters" component_1="I_CNG"/>
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<map_variables variable_2="V_cng" variable_1="V_cng"/>
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<map_variables variable_2="hmc_1" variable_1="hmc_1"/>
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<map_variables variable_2="kinhcng" variable_1="kinhcng"/>
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<connection>
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<connection>
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<connection>
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<map_variables variable_2="inhmax" variable_1="inhmax"/>
<map_variables variable_2="ninhcng" variable_1="ninhcng"/>
<map_variables variable_2="CaCaM" variable_1="CaCaM"/>
<map_variables variable_2="kinhcng" variable_1="kinhcng"/>
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<connection>
<map_components component_2="parameters" component_1="I_ClCa"/>
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<map_variables variable_2="hmc_2" variable_1="hmc_2"/>
<map_variables variable_2="V_Cl" variable_1="V_Cl"/>
<map_variables variable_2="clmax" variable_1="clmax"/>
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<connection>
<map_components component_2="Ca" component_1="I_ClCa"/>
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<connection>
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<map_variables variable_2="ef" variable_1="ef"/>
<map_variables variable_2="F_vol" variable_1="F_vol"/>
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<connection>
<map_components component_2="J_NCX" component_1="I_NCX"/>
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<map_variables variable_2="J_NCX" variable_1="J_NCX"/>
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<connection>
<map_components component_2="aG" component_1="cAMP"/>
<map_variables variable_2="aG" variable_1="aG"/>
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<connection>
<map_components component_2="aCaMK" component_1="cAMP"/>
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<connection>
<map_components component_2="bLR" component_1="O_stim"/>
<map_variables variable_2="O_stim" variable_1="O_stim"/>
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<vCard:Given>Geraldine</vCard:Given>
<vCard:Family>Wright</vCard:Family>
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<rdf:Description rdf:about="rdf:#aab22817-18a9-4ecf-ba8a-6cfc28a6ee88">
<vCard:FN>Geoff Nunns</vCard:FN>
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<vCard:Given>Alice</vCard:Given>
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<dc:title>Proceedings of the National Academy of Sciences</dc:title>
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<dcterms:W3CDTF>2005-05-25 00:00</dcterms:W3CDTF>
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<dcterms:W3CDTF>2008-06-25T00:00:00+12:00</dcterms:W3CDTF>
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<vCard:Given>Geoffrey</vCard:Given>
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<vCard:Other>Rogan</vCard:Other>
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<bqs:last_page>10420</bqs:last_page>
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<bqs:Pubmed_id>16027364</bqs:Pubmed_id>
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<rdf:value>This model runs in both PCEnv and COR. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.</rdf:value>
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<vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
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<vCard:FN>Geoff Nunns</vCard:FN>
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<rdf:value>This model runs in both PCEnv and COR. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.</rdf:value>
</rdf:Description>
</rdf:RDF>
</model>
