Location: Dougherty, Wright, Yew, 2005 @ ef3815f4d017 / dougherty_wright_yew_2005.cellml

Author:
Catherine Lloyd <c.lloyd@auckland.ac.nz>
Date:
2010-08-06 05:05:01+12:00
Desc:
Minor changes to metadata.
Permanent Source URI:
https://models.cellml.org/workspace/dougherty_wright_yew_2005/rawfile/ef3815f4d017b9666f0c9a47778c44b022de9e5a/dougherty_wright_yew_2005.cellml

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COR (0.9.31.979)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.CellML.org/
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				<title>Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons</title>
				<author>
					<firstname>Geoffrey</firstname>
					<surname>Nunns</surname>
					<affiliation>
						<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
					</affiliation>
				</author>
			</articleinfo>
			<section id="sec_status">
				<title>Model Status</title>
				<para>
            This model runs in both OpenCell and COR and the units are consistent. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.   
          </para>
			</section>
			<sect1 id="sec_structure">
				<title>Model Structure</title>
				<para>
Abstract: We develop a mechanistic mathematical model of the G-protein coupled signaling pathway responsible for generating current responses in frog olfactory receptor neurons. The model incorporates descriptions of ligand-receptor interaction, intracellular transduction events involving the second messenger cAMP, effector ion-channel activity, and calcium-mediated feedback steps. We parameterized the model with respect to suction pipette current recordings from single cells stimulated with multiple odor concentrations. The proposed model accurately predicts the receptor-current response of the neuron to brief and prolonged odorant exposure and is able to produce the adaptation observed under repeated or sustained stimulation. 
</para>

<para>
<informalfigure float="0" id="fig_reaction_diagram">
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<caption>Schematic diagram of the Dougherty et al model.</caption>
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</para>

				<para>
The complete original paper reference is cited below:
</para>
				<para>
					Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons, Daniel P. Dougherty, Geraldine A. Wright, Alice C. Yew, 2005, 
						<emphasis>Proceeding of the National Academy of Sciences</emphasis>
					, 102, 10415- 10420. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=16027364  &amp;dopt=Abstract">PubMed ID: 16027364  </ulink>
				</para>
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    <dc:title>Proceedings of the National Academy of Sciences</dc:title>
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    <rdf:value>This model runs in both PCEnv and COR. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.</rdf:value>
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    <rdf:value>Fixed &quot;not exactly equivalent but dimensionally equivalent&quot; errors.</rdf:value>
    <cmeta:modifier rdf:resource="rdf:#422857d6-735f-46b7-afd7-ae6b6c228004"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#164401d0-fef7-43af-bf8c-a47fb7a73421">
    <vCard:FN>Geoff Nunns</vCard:FN>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#8078a259-dcff-4723-80e8-a1de74ac4858">
    <dcterms:W3CDTF>2008-06-25T00:00:00+00:00</dcterms:W3CDTF>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#cd16a728-b0f4-4a27-b6bd-c4d6e52ede72">
    <vCard:Given>Alice</vCard:Given>
    <vCard:Family>Yew</vCard:Family>
    <vCard:Other>C</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#422857d6-735f-46b7-afd7-ae6b6c228004">
    <vCard:N rdf:resource="rdf:#086a028d-4be2-4694-abce-581ff52bf5a6"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#9cab8f27-d34a-4f72-b8f1-b4af961ced38">
    <vCard:Orgname>The University of Auckland</vCard:Orgname>
    <vCard:Orgunit>Auckland Bioengineering Institute</vCard:Orgunit>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#687584b2-d93e-4cdc-a097-a7b14ad83963">
    <vCard:FN>Geoff Nunns</vCard:FN>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#13d4ae94-8e32-4d1c-8c3f-da78a8a86469">
    <dcterms:W3CDTF>2005-05-25 00:00</dcterms:W3CDTF>
  </rdf:Description>
  <rdf:Description rdf:about="#dougherty_wright_yew_2005">
    <bqs:reference rdf:resource="rdf:#e76eba0b-15da-4ec3-88c8-10669f4724b3"/>
<bqs:reference rdf:parseType="Resource">

  <dc:subject rdf:parseType="Resource">
    <bqs:subject_type>keyword</bqs:subject_type>
    <rdf:value>
      <rdf:Bag>
        <rdf:li>calcium dynamics</rdf:li>
        <rdf:li>signal transduction</rdf:li>
      </rdf:Bag>
    </rdf:value>
  </dc:subject>
</bqs:reference>
    <cmeta:comment rdf:resource="rdf:#514ea0ef-e1c3-44cd-b481-d9f8ab0979cf"/>
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  <rdf:Description rdf:about="rdf:#3a5bd4a6-dc9b-483f-a24f-9144a576d6bd">
    <vCard:Given>Daniel</vCard:Given>
    <vCard:Family>Dougherty</vCard:Family>
    <vCard:Other>P</vCard:Other>
  </rdf:Description>
</rdf:RDF>
</model>