- Author:
- Hanne <Hanne@hanne-nielsens-macbook.local>
- Date:
- 2010-06-24 10:45:53+12:00
- Desc:
- Added new session file woth clickable SVG
- Permanent Source URI:
- https://models.cellml.org/workspace/egli_bertram_sellix_freeman_2004/rawfile/e25b94f083f6b7f727bbc81f9b71c6be061fb1ea/egli_bertram_sellix_freeman_2004.cellml
<?xml version="1.0"?>
<!-- FILE : egli_model_2004.xml
CREATED : 3rd August 2007
LAST MODIFIED : 3rd August 2007
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.1 Specification.
DESCRIPTION : This file contains a CellML description of Egli et al's 2004 mathematical model of rhythmic secretion of prolactin in rats.
CHANGES:
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xml:base="" cmeta:id="egli_model_2004" name="egli_model_2004_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by vasoactive intestinal polypeptide of suprachiasmatic nucleus origin</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This model has been curated and is known to run in OpenCell and COR to produce the results described in the publication. A PCEnv session file is also available for this model and reproduces the set of graphs in Figure 6 of the publication.
</para>
<para>This model has been verified as valid CellML with consistent units.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Prolactin (PRL) is a hormone which is synthesised and secreted by lactotrophs in the anterior lobe of the pituitary gland. It plays an important role in lactation, and also contributes to a wide range of physiological functions. Its release is inhibited by dopamine (DA), and is stimulated by oxytocin (OT). Neurons in the paraventricular nucleus of the hypothalamus are major sites of OT synthesis, and they themselves are influenced by the secretion of vasoactive intestinal polypeptide (VIP) by the suprachiasmatic nucleus (SCN). The SCN is also part of the hypothalamus, and is known for its pacemaker function, often regulating the timing of circadian rhythms in mammals.
</para>
<para>
In the paper described here, Egli <emphasis>et al.</emphasis> present a mathematical model of the mechanisms regulating the rhythmic secretion of prolactin in rats (see figure below). In this model the SCN acts as a pacemaker, controlling the activity of the hypothalamic DA and OT neurons via its rhythmic VIP secretion. In turn, the activity of these DA and OT neurons combine to determine the PRL secretory pattern.
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>model diagram</title>
</objectinfo>
<imagedata fileref="egli_2004.png"/>
</imageobject>
</mediaobject>
<caption>Schematic diagram of the network proposed to be involved in the regulation of prolactin (PRL) secretion in response to uterine cervical stimulation (CS). Vasoactive intestinal polypeptide (VIP) is secreted from the suprachiasmatic nucleus and relays the time of day to DAergic and OTergic neurosecretory cells via inhibition. x represents an additional stimulatory input which feeds into the OT neurons. DA neurons provide an inhibitory input while OT neurons provide a stimulatory input to the lactotrophs to regulate the synthesis and secretion of PRL.</caption>
</informalfigure>
<para>
The complete original paper reference is cited below:
</para>
<para>
Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by vasoactive intestinal polypeptide of suprachiasmatic nucleus origin, 2004, Marcel Egli, Richard Bertram, Michael T. Sellix, and Marc E. Freeman.
<emphasis>Endocrinology</emphasis>
, 145, 3386-3394. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15033917&query_hl=1&itool=pubmed_docsum">PubMed ID: 15033917</ulink>
</para>
<para>
The authors highlight that the original code they wrote for this model can be downloaded <ulink url="http://www.math.fsu.edu/~bertram/software/pituitary/Endo_04.ode">here</ulink>.
</para>
</sect1>
</article>
</documentation>
<units name="hour">
<unit multiplier="3600.0" units="second"/>
</units>
<units name="first_order_rate_constant">
<unit exponent="-1" units="hour"/>
</units>
<units name="nanog_ml">
<unit prefix="nano" units="gram"/>
<unit exponent="-1" prefix="milli" units="litre"/>
</units>
<units name="picog_ml">
<unit prefix="pico" units="gram"/>
<unit exponent="-1" prefix="milli" units="litre"/>
</units>
<units name="nanog_ml_hr">
<unit prefix="nano" units="gram"/>
<unit exponent="-1" prefix="milli" units="litre"/>
<unit exponent="-1" units="hour"/>
</units>
<units name="picog_ml_hr">
<unit prefix="pico" units="gram"/>
<unit exponent="-1" prefix="milli" units="litre"/>
<unit exponent="-1" units="hour"/>
</units>
<component name="environment">
<variable cmeta:id="environment_time" name="time" public_interface="out" units="hour"/>
</component>
<component cmeta:id="PRL" name="PRL">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="PRL">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">PRL</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">prolactin</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="PRL_PRL" initial_value="20.0" name="PRL" units="nanog_ml"/>
<variable initial_value="300.0" name="kD" units="nanog_ml"/>
<variable initial_value="9.0" name="kO" units="picog_ml"/>
<variable initial_value="300000.0" name="rP" units="nanog_ml_hr"/>
<variable initial_value="0.5" name="qP" units="first_order_rate_constant"/>
<variable name="OT" public_interface="in" units="picog_ml"/>
<variable name="DA" public_interface="in" units="nanog_ml"/>
<variable name="time" public_interface="in" units="hour"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci> PRL </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> rP </ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanog_ml"> 1.0 </cn>
<apply>
<plus/>
<ci> kD </ci>
<ci> DA </ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci> OT </ci>
<apply>
<plus/>
<ci> kO </ci>
<ci> OT </ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> qP </ci>
<ci> PRL </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="DA" name="DA">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="DA">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">DA</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">dopamine</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="DA_DA" initial_value="20000.0" name="DA" public_interface="out" units="nanog_ml"/>
<variable cmeta:id="DA_vD" name="vD" units="nanog_ml_hr"/>
<variable initial_value="10000.0" name="vDbar" units="nanog_ml_hr"/>
<variable initial_value="20000.0" name="DA_infinity" units="nanog_ml"/>
<variable initial_value="0.2" name="qD" units="first_order_rate_constant"/>
<variable name="time" public_interface="in" units="hour"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci> DA </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> qD </ci>
<apply>
<minus/>
<ci> DA_infinity </ci>
<ci> DA </ci>
</apply>
</apply>
<ci> vD </ci>
</apply>
</apply>
<apply>
<eq/>
<ci> vD </ci>
<piecewise>
<piece>
<ci> vDbar </ci>
<apply>
<and/>
<apply>
<geq/>
<ci> time </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="hour"> 2.0 </cn>
</apply>
<apply>
<leq/>
<ci> time </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="hour"> 4.0 </cn>
</apply>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanog_ml_hr"> 0.0 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component cmeta:id="OT" name="OT">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="OT">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">OT</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">oxytocin</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="OT_OT" initial_value="25.0" name="OT" public_interface="out" units="picog_ml"/>
<variable initial_value="50.0" name="kx" units="picog_ml"/>
<variable name="vO" units="picog_ml_hr"/>
<variable initial_value="500.0" name="vObar" units="picog_ml_hr"/>
<variable initial_value="1100.0" name="rO" units="picog_ml_hr"/>
<variable initial_value="1.0" name="qO" units="first_order_rate_constant"/>
<variable name="x" public_interface="in" units="picog_ml"/>
<variable name="time" public_interface="in" units="hour"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci> OT </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> rO </ci>
<apply>
<divide/>
<ci> x </ci>
<apply>
<plus/>
<ci> kx </ci>
<ci> x </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> qO </ci>
<ci> OT </ci>
</apply>
<ci> vO </ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci> vO </ci>
<piecewise>
<piece>
<ci> vObar </ci>
<apply>
<and/>
<apply>
<geq/>
<ci> time </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="hour"> 2.0 </cn>
</apply>
<apply>
<leq/>
<ci> time </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="hour"> 4.0 </cn>
</apply>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="picog_ml_hr"> 0.0 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component cmeta:id="x" name="x">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="x">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">x</dc:title>
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">stimulus</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="x_x" name="x" public_interface="out" units="picog_ml"/>
<variable name="time" public_interface="in" units="hour"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> x </ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="picog_ml"> 51.0 </cn>
<apply>
<and/>
<apply>
<geq/>
<ci> time </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="hour"> 2.0 </cn>
</apply>
<apply>
<leq/>
<ci> time </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="hour"> 4.0 </cn>
</apply>
</apply>
</piece>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="picog_ml"> 51.0 </cn>
<apply>
<and/>
<apply>
<geq/>
<ci> time </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="hour"> 16.0 </cn>
</apply>
<apply>
<leq/>
<ci> time </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="hour"> 18.0 </cn>
</apply>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="picog_ml"> 1.0 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<connection>
<map_components component_1="PRL" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="DA" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="OT" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="x" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="PRL" component_2="OT"/>
<map_variables variable_1="OT" variable_2="OT"/>
</connection>
<connection>
<map_components component_1="PRL" component_2="DA"/>
<map_variables variable_1="DA" variable_2="DA"/>
</connection>
<connection>
<map_components component_1="OT" component_2="x"/>
<map_variables variable_1="x" variable_2="x"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Seq rdf:about="rdf:#ae6026c8-7c0e-411b-8033-8002dd6eacfe">
<rdf:li rdf:resource="rdf:#eefc5760-47f7-4b46-97a5-7950293f3ad8"/>
<rdf:li rdf:resource="rdf:#f80ff12a-f237-41a1-9896-404b1d7c7514"/>
<rdf:li rdf:resource="rdf:#2e72c786-ff87-4ab7-8dd3-77ba6c79b517"/>
<rdf:li rdf:resource="rdf:#6b567af1-363d-4693-92f7-a0f029b24782"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#ae6026c8-7c0e-411b-8033-8002dd6eacfe"/>
<rdf:Bag rdf:about="rdf:#94ad8e11-f8fc-4631-9186-f941c421ef91">
<rdf:li>endocrine</rdf:li>
<rdf:li>prolactin</rdf:li>
<rdf:li>oxytocin</rdf:li>
<rdf:li>dopamine</rdf:li>
</rdf:Bag>
<rdf:Description rdf:about="rdf:#94ad8e11-f8fc-4631-9186-f941c421ef91"/>
<rdf:Description rdf:about="rdf:#60197827-50b6-4a59-b8b8-bcc2d43d607e">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Endocrinology</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d2b6eebf-b3b4-41cd-b33f-a3d0e3cbc4c0">
<vCard:Orgname xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">The University of Auckland</vCard:Orgname>
<vCard:Orgunit xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">The Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#657bc821-bd30-41cd-842e-aa1f03d2c0c7">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lloyd</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b8d31a82-b2b7-4d58-93c2-afc1fbb38c4f">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#5e37423f-e188-467e-997b-ac0f06920f58"/>
<rdf:value>Using COR I have added the correct units and have checked for consistency. The model still runs to give the published results, but now the units are more real.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#89e97588-8c0b-4b0d-9efc-f452958f8848">
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#8aef4a2b-9b5b-43f7-a65b-598aad50c4f9"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5e37423f-e188-467e-997b-ac0f06920f58">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9c7bd641-cd6e-4270-816d-02a28603c519">
<dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#9a413d3c-fdfa-41ef-9614-0e499a9f3b93"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b4abb276-a6db-45ea-9ca8-619fc6e9501c">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Marc</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Freeman</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">E</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher xmlns:dc="http://purl.org/dc/elements/1.1/">The University of Auckland, Bioengineering Institute</dc:publisher>
<cmeta:comment rdf:resource="rdf:#b8d31a82-b2b7-4d58-93c2-afc1fbb38c4f"/>
<dcterms:created xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#97aa43bc-99c3-4fff-b456-28d5c7102f46"/>
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#a188993f-029e-4b2c-8226-6a59a9272d93"/>
<cmeta:modification rdf:resource="rdf:#0039b938-168c-4d47-8284-a220567de7a0"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#21bb0faa-9c41-47ee-b54d-b2c00f42c89b">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Marcel</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Egli</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8aef4a2b-9b5b-43f7-a65b-598aad50c4f9">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lloyd</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f80ff12a-f237-41a1-9896-404b1d7c7514">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#ec5f1312-d77c-4d6f-90c0-2037fe70f28d"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a188993f-029e-4b2c-8226-6a59a9272d93">
<vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#d2b6eebf-b3b4-41cd-b33f-a3d0e3cbc4c0"/>
<vCard:EMAIL xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#8f90ceb0-3c62-42a1-b5dc-7ff01b1ce3ca"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#657bc821-bd30-41cd-842e-aa1f03d2c0c7"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2e72c786-ff87-4ab7-8dd3-77ba6c79b517">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#d8aeee2e-aa39-4a83-bfb4-2186cb4580b3"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d8aeee2e-aa39-4a83-bfb4-2186cb4580b3">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Michael</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Sellix</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">T</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$AvI52">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$BvI52"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f7b71ade-69a5-4431-9427-619c5eb8824d">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-09-02T11:52:39+12:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#6b567af1-363d-4693-92f7-a0f029b24782">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#b4abb276-a6db-45ea-9ca8-619fc6e9501c"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#14fa76f4-984f-4bac-8b50-2dc4fbbcdbd7">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#bc4fd6d7-86e3-466e-b302-0c37453559c7"/>
<rdf:value>This is a CellML description of Egli et al's 2004 mathematical model of rhythmic secretion of prolactin in rats.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c418270f-7b6b-4c4d-be76-9a8498a37e1c">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#ae6026c8-7c0e-411b-8033-8002dd6eacfe"/>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by vasoactive intestinal polypeptide of suprachiasmatic nucleus origin</dc:title>
<bqs:volume xmlns:bqs="http://www.cellml.org/bqs/1.0#">145</bqs:volume>
<bqs:first_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">3386</bqs:first_page>
<bqs:Journal xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#60197827-50b6-4a59-b8b8-bcc2d43d607e"/>
<dcterms:issued xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#26a18c78-b9bd-4b09-a1d1-04a1af92825b"/>
<bqs:last_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">3394</bqs:last_page>
</rdf:Description>
<rdf:Description rdf:about="rdf:#26a18c78-b9bd-4b09-a1d1-04a1af92825b">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2004-07-00 00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8f90ceb0-3c62-42a1-b5dc-7ff01b1ce3ca">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>c.lloyd@auckland.ac.nz</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#eefc5760-47f7-4b46-97a5-7950293f3ad8">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#21bb0faa-9c41-47ee-b54d-b2c00f42c89b"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0039b938-168c-4d47-8284-a220567de7a0">
<dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#f7b71ade-69a5-4431-9427-619c5eb8824d"/>
<rdf:value>Using COR I have added the correct units and have checked for consistency. The model still runs to give the published results, but now the units are more real.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#89e97588-8c0b-4b0d-9efc-f452958f8848"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$zvI52">
<ns7:boundIntervals xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" rdf:resource="rdf:#$AvI52"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#97aa43bc-99c3-4fff-b456-28d5c7102f46">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-08-07T00:00:00+00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="#egli_model_2004">
<ns7:simulation xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" rdf:resource="rdf:#$zvI52"/>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Egli et al's 2004 mathematical model of rhythmic secretion of prolactin in rats.</dc:title>
<cmeta:comment rdf:resource="rdf:#14fa76f4-984f-4bac-8b50-2dc4fbbcdbd7"/>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#9c7bd641-cd6e-4270-816d-02a28603c519"/>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#ee6def1b-f5e1-4323-a149-894fb7fce99b"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ec5f1312-d77c-4d6f-90c0-2037fe70f28d">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Richard</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Bertram</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ee6def1b-f5e1-4323-a149-894fb7fce99b">
<bqs:Pubmed_id xmlns:bqs="http://www.cellml.org/bqs/1.0#">15033917</bqs:Pubmed_id>
<bqs:JournalArticle xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#c418270f-7b6b-4c4d-be76-9a8498a37e1c"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#bc4fd6d7-86e3-466e-b302-0c37453559c7">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine Lloyd</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9a413d3c-fdfa-41ef-9614-0e499a9f3b93">
<bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
<rdf:value rdf:resource="rdf:#94ad8e11-f8fc-4631-9186-f941c421ef91"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$BvI52">
<ns7:endingValue xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">24</ns7:endingValue>
<ns7:nonstandard-pointDensity xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">100000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">0.01</ns7:maximumStepSize>
</rdf:Description>
</rdf:RDF>
</model>
