- Author:
- jlaw060 <jlaw060@bioeng203.bioeng.auckland.ac.nz>
- Date:
- 2009-06-26 13:31:35+12:00
- Desc:
- fixed image links in documentation
- Permanent Source URI:
- https://models.cellml.org/workspace/faville_pullan_sanders_koh_lloyd_smith_2009/rawfile/56686c8920e1429a456a5602b4cc67f6537cf5a0/faville_pacemaker_unit_2008.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model
name="faville_pacemaker_unit_2008"
cmeta:id="faville_pacemaker_unit_2008"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:xlink="http://www.w3.org/1999/xlink"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" >
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
This CellML model describes the pacemaker unit of the Faville et al. 2008 model. This model is imported by the bulk cytoplasm model from the same publication 10 times.
</rdf:value>
<dc:creator rdf:parseType="Resource">
<vCard:FN>Catherine Lloyd</vCard:FN>
</dc:creator>
</cmeta:comment>
<units name="millivolt">
<unit prefix="milli" units="volt" />
</units>
<units name="per_millivolt">
<unit units="millivolt" exponent="-1" />
</units>
<units name="per_second_per_millivolt">
<unit units="second" exponent="-1" />
<unit units="millivolt" exponent="-1" />
</units>
<units name="micromolar">
<unit prefix="micro" units="mole" />
<unit units="litre" exponent="-1" />
</units>
<units name="per_micromolar">
<unit units="micromolar" exponent="-1" />
</units>
<units name="per_micromolar2">
<unit units="micromolar" exponent="-2" />
</units>
<units name="picofarad">
<unit prefix="pico" units="farad" />
</units>
<units name="picosiemens">
<unit prefix="pico" units="siemens" />
</units>
<units name="picoampere">
<unit prefix="pico" units="ampere" />
</units>
<units name="femtoampere">
<unit prefix="femto" units="ampere" />
</units>
<units name="micromolar_per_coulomb">
<unit units="micromolar" />
<unit units="coulomb" exponent="-1" />
</units>
<units name="femtocoulomb_per_zeptomole">
<unit prefix="femto" units="coulomb" />
<unit prefix="zepto" units="mole" exponent="-1" />
</units>
<units name="attojoule_per_zeptomole_kelvin">
<unit prefix="atto" units="joule"/>
<unit prefix="zepto" units="mole" exponent="-1" />
<unit units="kelvin" exponent="-1" />
</units>
<units name="first_order_rate_constant">
<unit units="second" exponent="-1" />
</units>
<units name="per_second_squared">
<unit units="second" exponent="-2" />
</units>
<units name="flux">
<unit units="micromolar" />
<unit units="second" exponent="-1" />
</units>
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
In order to facilitate the import of this pacemaker unit model by the bulk cytoplasm model I will encapsulate the current model in a top component called "pacemaker_unit_model".
</rdf:value>
<dc:creator rdf:parseType="Resource">
<vCard:FN>Catherine Lloyd</vCard:FN>
</dc:creator>
</cmeta:comment>
<component name="pacemaker_unit_model" cmeta:id="pacemaker_unit_model">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="pacemaker_unit_model">
<dc:title>pacemaker_unit_model</dc:title>
<dcterms:alternative>top component which encapsulates the entire pacemaker unit model</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="I_ion_PU" public_interface="out" private_interface="in" units="picoampere" />
<variable name="CS1" public_interface="out" private_interface="in" units="micromolar" />
<variable name="CS2" public_interface="out" private_interface="in" units="micromolar" />
<variable name="n_PU" public_interface="in" private_interface="out" units="dimensionless" />
<variable name="JS2Cy" public_interface="in" private_interface="out" units="flux" />
<variable name="JS1S2" public_interface="in" private_interface="out" units="flux" />
<variable name="Vm" public_interface="in" private_interface="out" units="millivolt" />
<variable name="time" public_interface="in" private_interface="out" units="second" />
</component>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="PU_membrane" />
<map_variables variable_1="I_ion_PU" variable_2="I_ion_PU" />
</connection>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="CS2" />
<map_variables variable_1="CS2" variable_2="CS2" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="JS2Cy" variable_2="JS2Cy" />
<map_variables variable_1="JS1S2" variable_2="JS1S2" />
</connection>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="CS1" />
<map_variables variable_1="CS1" variable_2="CS1" />
<map_variables variable_1="JS1S2" variable_2="JS1S2" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="model_parameters" />
<map_variables variable_1="n_PU" variable_2="n_PU" />
</connection>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="I_NaP" />
<map_variables variable_1="Vm" variable_2="Vm" />
</connection>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="I_Na" />
<map_variables variable_1="Vm" variable_2="Vm" />
</connection>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="I_Ca" />
<map_variables variable_1="Vm" variable_2="Vm" />
</connection>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="I_NSCC_Ca" />
<map_variables variable_1="Vm" variable_2="Vm" />
</connection>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="I_NSCC_Na" />
<map_variables variable_1="Vm" variable_2="Vm" />
</connection>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="JIPR" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="CER" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="CMT" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="pacemaker_unit_model" component_2="NS1" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
Calcium flux which occurs between the pacemaker unit(s) and the bulk cytosol. The value of mu_S2Cy is imported from the "model_parameters" component of the main model.
</rdf:value>
<dc:creator rdf:parseType="Resource">
<vCard:FN>Catherine Lloyd</vCard:FN>
</dc:creator>
</cmeta:comment>
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
Pacemaker unit equations.
</rdf:value>
<dc:creator rdf:parseType="Resource">
<vCard:FN>Catherine Lloyd</vCard:FN>
</dc:creator>
</cmeta:comment>
<component name="PU_membrane">
<variable name="I_iCa" public_interface="out" units="picoampere" />
<variable name="I_iNa" public_interface="out" units="picoampere" />
<variable name="I_ion_PU" public_interface="out" units="picoampere" />
<variable name="alpha_scale" public_interface="in" units="dimensionless" />
<variable name="I_Ca" public_interface="in" units="picoampere" />
<variable name="I_Na" public_interface="in" units="picoampere" />
<variable name="I_NaP" public_interface="in" units="picoampere" />
<variable name="I_NSCC_Ca" public_interface="in" units="picoampere" />
<variable name="I_PM" public_interface="in" units="picoampere" />
<variable name="I_NSCC_Na" public_interface="in" units="picoampere" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="1" >
<apply><eq />
<ci> I_iCa </ci>
<apply><times />
<ci> alpha_scale </ci>
<apply><plus />
<ci> I_Ca </ci>
<ci> I_NSCC_Ca </ci>
<ci> I_PM </ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="2" >
<apply><eq />
<ci> I_iNa </ci>
<apply><times />
<ci> alpha_scale </ci>
<apply><plus />
<ci> I_NSCC_Na </ci>
<ci> I_Na </ci>
<ci> I_NaP </ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="3" >
<apply><eq />
<ci> I_ion_PU </ci>
<apply><plus />
<ci> I_iCa </ci>
<ci> I_iNa </ci>
</apply>
</apply>
</math>
</component>
<component name="I_Ca" cmeta:id="I_Ca">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="I_Ca">
<dc:title>I_Ca</dc:title>
<dcterms:alternative>inward calcium current</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="I_Ca" public_interface="out" units="picoampere" />
<variable name="gCa_" initial_value="0.074" units="picosiemens" />
<variable name="kCa" initial_value="0.013" units="per_millivolt" />
<variable name="gCa" units="picosiemens" />
<variable name="ECa_PU" units="millivolt" />
<variable name="Vm" public_interface="in" units="millivolt" />
<variable name="T" public_interface="in" units="kelvin" />
<variable name="R" public_interface="in" units="attojoule_per_zeptomole_kelvin" />
<variable name="F" public_interface="in" units="femtocoulomb_per_zeptomole" />
<variable name="CO" public_interface="in" units="micromolar" />
<variable name="CS1" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="4">
<apply><eq />
<ci> I_Ca </ci>
<apply><times />
<ci> gCa </ci>
<apply><minus />
<ci> Vm </ci>
<ci> ECa_PU </ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="5" >
<apply><eq />
<ci> gCa </ci>
<apply><times />
<ci> gCa_ </ci>
<apply><exp />
<apply><times />
<ci> kCa </ci>
<ci> Vm </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="6" >
<apply><eq />
<ci> ECa_PU </ci>
<apply><times />
<apply><divide />
<apply><times />
<ci> R </ci>
<ci> T </ci>
</apply>
<apply><times />
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci> F </ci>
</apply>
</apply>
<apply><ln />
<apply><divide />
<ci> CO </ci>
<ci> CS1 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="I_NSCC_Ca" cmeta:id="I_NSCC_Ca">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="I_NSCC_Ca">
<dc:title>I_NSCC_Ca</dc:title>
<dcterms:alternative>non-selective calcium conductance</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="I_NSCC_Ca" public_interface="out" units="picoampere" />
<variable name="gNSCC_Ca_" initial_value="0.10" units="picosiemens" />
<variable name="gNSCC_Ca" units="picosiemens" />
<variable name="hNSCC" public_interface="in" units="dimensionless" />
<variable name="Vm" public_interface="in" units="millivolt" />
<variable name="ENSCC" public_interface="in" units="millivolt" />
<variable name="KNSCC" public_interface="in" units="micromolar" />
<variable name="CS1" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="7" >
<apply><eq />
<ci> gNSCC_Ca </ci>
<apply><times />
<ci> gNSCC_Ca_ </ci>
<apply><divide />
<apply><power />
<ci> KNSCC </ci>
<ci> hNSCC </ci>
</apply>
<apply><plus />
<apply><power />
<ci> KNSCC </ci>
<ci> hNSCC </ci>
</apply>
<apply><power />
<ci> CS1 </ci>
<ci> hNSCC </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="8" >
<apply><eq />
<ci> I_NSCC_Ca </ci>
<apply><times />
<ci> gNSCC_Ca </ci>
<apply><minus />
<ci> Vm </ci>
<ci> ENSCC </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="I_NSCC_Na" cmeta:id="I_NSCC_Na">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="I_NSCC_Na">
<dc:title>I_NSCC_Na</dc:title>
<dcterms:alternative>non-selective sodium conductance</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="I_NSCC_Na" public_interface="out" units="picoampere" />
<variable name="gNSCC_Na_" initial_value="160.0" units="picosiemens" />
<variable name="gNSCC_Na" units="picosiemens" />
<variable name="hNSCC" public_interface="in" units="dimensionless" />
<variable name="Vm" public_interface="in" units="millivolt" />
<variable name="ENSCC" public_interface="in" units="millivolt" />
<variable name="KNSCC" public_interface="in" units="micromolar" />
<variable name="CS1" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="9" >
<apply><eq />
<ci> gNSCC_Na </ci>
<apply><times />
<ci> gNSCC_Na_ </ci>
<apply><divide />
<apply><power />
<ci> KNSCC </ci>
<ci> hNSCC </ci>
</apply>
<apply><plus />
<apply><power />
<ci> KNSCC </ci>
<ci> hNSCC </ci>
</apply>
<apply><power />
<ci> CS1 </ci>
<ci> hNSCC </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="10" >
<apply><eq />
<ci> I_NSCC_Na </ci>
<apply><times />
<ci> gNSCC_Na </ci>
<apply><minus />
<ci> Vm </ci>
<ci> ENSCC </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="I_PM" cmeta:id="I_PM">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="I_PM">
<dc:title>I_PM</dc:title>
<dcterms:alternative>plasma membrane Ca2+-ATPase current</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="I_PM" public_interface="out" units="picoampere" />
<variable name="gPM" initial_value="675.0" units="femtoampere" />
<variable name="KPM" initial_value="1.0" units="micromolar" />
<variable name="CS1" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="11" >
<apply><eq />
<ci> I_PM </ci>
<apply><times />
<ci> gPM </ci>
<apply><divide />
<apply><power />
<ci> CS1 </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply><plus />
<apply><power />
<ci> KPM </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply><power />
<ci> CS1 </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="I_Na" cmeta:id="I_Na">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="I_Na">
<dc:title>I_Na</dc:title>
<dcterms:alternative>inward sodium current</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="I_Na" public_interface="out" units="picoampere" />
<variable name="gNa" initial_value="13.5" units="picosiemens" />
<variable name="ENa_PU" units="millivolt" />
<variable name="Vm" public_interface="in" units="millivolt" />
<variable name="T" public_interface="in" units="kelvin" />
<variable name="R" public_interface="in" units="attojoule_per_zeptomole_kelvin" />
<variable name="F" public_interface="in" units="femtocoulomb_per_zeptomole" />
<variable name="NO" public_interface="in" units="micromolar" />
<variable name="NS1" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="12" >
<apply><eq />
<ci> I_Na </ci>
<apply><times />
<ci> gNa </ci>
<apply><minus />
<ci> Vm </ci>
<ci> ENa_PU </ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="13" >
<apply><eq />
<ci> ENa_PU </ci>
<apply><times />
<apply><divide />
<apply><times />
<ci> R </ci>
<ci> T </ci>
</apply>
<ci> F </ci>
</apply>
<apply><ln />
<apply><divide />
<ci> NO </ci>
<ci> NS1 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="I_NaP" cmeta:id="I_NaP">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="I_NaP">
<dc:title>I_NaP</dc:title>
<dcterms:alternative>outward sodium pump</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="I_NaP" public_interface="out" units="picoampere" />
<variable name="gNaP" initial_value="187.5" units="picosiemens" />
<variable name="KNaP" initial_value="1.0E4" units="micromolar" />
<variable name="hNaP" initial_value="4.0" units="dimensionless" />
<variable name="ENaP" initial_value="10.0" units="millivolt" />
<variable name="NS1" public_interface="in" units="micromolar" />
<variable name="Vm" public_interface="in" units="millivolt" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="14">
<apply><eq />
<ci> I_NaP </ci>
<apply><times />
<ci> gNaP </ci>
<apply><divide />
<apply><power />
<ci> NS1 </ci>
<ci> hNaP </ci>
</apply>
<apply><plus />
<apply><power />
<ci> KNaP </ci>
<ci> hNaP </ci>
</apply>
<apply><power />
<ci> NS1 </ci>
<ci> hNaP </ci>
</apply>
</apply>
</apply>
<apply><minus />
<ci> ENaP </ci>
<ci> Vm </ci>
</apply>
</apply>
</apply>
</math>
</component>
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
Calcium fluxes which occur within the pacemaker unit.
</rdf:value>
<dc:creator rdf:parseType="Resource">
<vCard:FN>Catherine Lloyd</vCard:FN>
</dc:creator>
</cmeta:comment>
<component name="JSERCA" cmeta:id="JSERCA">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="JSERCA">
<dc:title>JSERCA</dc:title>
<dcterms:alternative>SERCA pump</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="JSERCA" public_interface="out" units="flux" />
<variable name="VSERCA" initial_value="1.0E5" units="first_order_rate_constant" />
<variable name="A2" initial_value="6E-4" units="dimensionless" />
<variable name="A4" initial_value="3.57" units="per_micromolar" />
<variable name="A5" initial_value="2.7E-5" units="per_micromolar" />
<variable name="A6" initial_value="2.31E-5" units="per_micromolar2" />
<variable name="CER" public_interface="in" units="micromolar" />
<variable name="CS1" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="15">
<apply><eq />
<ci> JSERCA </ci>
<apply><divide />
<apply><times />
<ci> VSERCA </ci>
<apply><minus />
<ci> CS1 </ci>
<apply><times />
<ci> A2 </ci>
<ci> CER </ci>
</apply>
</apply>
</apply>
<apply><plus />
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply><times />
<ci> A4 </ci>
<ci> CS1 </ci>
</apply>
<apply><times />
<ci> A5 </ci>
<ci> CER </ci>
</apply>
<apply><times />
<ci> A6 </ci>
<ci> CS1 </ci>
<ci> CER </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="JMCU" cmeta:id="JMCU">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="JMCU">
<dc:title>JMCU</dc:title>
<dcterms:alternative>mitochondrial Ca2+ uniporter</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="JMCU" public_interface="out" units="flux" />
<variable name="VMCU" initial_value="800.0" units="flux" />
<variable name="KMCU" initial_value="10.0" units="micromolar" />
<variable name="epsilon_INH" units="dimensionless" />
<variable name="KINH" initial_value="10.0" units="micromolar" />
<variable name="hINH" initial_value="4.0" units="dimensionless" />
<variable name="CS2" public_interface="in" units="micromolar" />
<variable name="CMT" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="16">
<apply><eq />
<ci> JMCU </ci>
<apply><times />
<ci> VMCU </ci>
<apply><divide />
<apply><power />
<ci> CS2 </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply><plus />
<apply><power />
<ci> KMCU </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply><power />
<ci> CS2 </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
<ci> epsilon_INH </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="17" >
<apply><eq />
<ci> epsilon_INH </ci>
<apply><divide />
<apply><power />
<ci> KINH </ci>
<ci> hINH </ci>
</apply>
<apply><plus />
<apply><power />
<ci> KINH </ci>
<ci> hINH </ci>
</apply>
<apply><power />
<ci> CMT </ci>
<ci> hINH </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="JNCX" cmeta:id="JNCX">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="JNCX">
<dc:title>JNCX</dc:title>
<dcterms:alternative>mitochondrial Na+/Ca2+ exchanger</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="JNCX" public_interface="out" units="flux" />
<variable name="VNCX" initial_value="3.0" units="flux" />
<variable name="KNCX" initial_value="0.3" units="micromolar" />
<variable name="CMT" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="18">
<apply><eq />
<ci> JNCX </ci>
<apply><times />
<ci> VNCX </ci>
<apply><divide />
<ci> CMT </ci>
<apply><plus />
<ci> CMT </ci>
<ci> KNCX </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="JIPR" cmeta:id="JIPR">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="JIPR">
<dc:title>JIPR</dc:title>
<dcterms:alternative>IP3R Ca2+ flux</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="JIPR" public_interface="out" units="flux" />
<variable name="kIPR" initial_value="2000.0" units="first_order_rate_constant" />
<variable name="k_1" initial_value="6.4" units="flux" />
<variable name="k1" initial_value="0.0" units="first_order_rate_constant" />
<variable name="k2" initial_value="4.0" units="first_order_rate_constant" />
<variable name="r2" initial_value="250.0" units="first_order_rate_constant" />
<variable name="r_2" initial_value="0.0" units="flux" />
<variable name="r4" initial_value="750.0" units="first_order_rate_constant" />
<variable name="R1" initial_value="36.0" units="micromolar" />
<variable name="R3" initial_value="300.0" units="micromolar" />
<variable name="phi1" units="first_order_rate_constant" />
<variable name="phi_1" units="flux" />
<variable name="phi2" units="first_order_rate_constant" />
<variable name="phi3" units="first_order_rate_constant" />
<variable name="H" initial_value="0.200" units="dimensionless" />
<variable name="g_beta" initial_value="1500.0" units="first_order_rate_constant" />
<variable name="h_beta" initial_value="4.0" units="dimensionless" />
<variable name="g_alpha" initial_value="0.85" units="first_order_rate_constant" />
<variable name="K_beta" initial_value="0.35" units="micromolar" />
<variable name="alpha_zeta" units="first_order_rate_constant" />
<variable name="beta_zeta" units="first_order_rate_constant" />
<variable name="zeta" initial_value="0.300" units="dimensionless" />
<variable name="K_phi3_act" initial_value="0.1" units="micromolar" />
<variable name="K_phi3_inh" initial_value="0.5" units="micromolar" />
<variable name="h_phi3_act" initial_value="3.0" units="dimensionless" />
<variable name="h_phi3_inh" initial_value="3.0" units="dimensionless" />
<variable name="g_phi3" initial_value="4.5" units="first_order_rate_constant" />
<variable name="CER" public_interface="in" units="micromolar" />
<variable name="CS2" public_interface="in" units="micromolar" />
<variable name="P" public_interface="in" units="micromolar" />
<variable name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="19">
<apply><eq />
<apply><diff />
<bvar><ci>time</ci></bvar>
<ci> H </ci>
</apply>
<apply><minus />
<apply><times />
<ci> phi3 </ci>
<apply><minus />
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci> H </ci>
</apply>
</apply>
<apply><times />
<apply><divide />
<apply><times />
<ci> P </ci>
<ci> phi1 </ci>
<ci> phi2 </ci>
</apply>
<apply><plus />
<apply><times />
<ci> P </ci>
<ci> phi1 </ci>
</apply>
<ci> phi_1 </ci>
</apply>
</apply>
<ci> H </ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="20" >
<apply><eq />
<ci> JIPR </ci>
<apply><times />
<ci> kIPR </ci>
<apply><power />
<apply><divide />
<apply><times />
<ci> P </ci>
<ci> phi1 </ci>
<ci> H </ci>
</apply>
<apply><plus />
<apply><times />
<ci> P </ci>
<ci> phi1 </ci>
</apply>
<ci> phi_1 </ci>
</apply>
</apply>
<cn cellml:units="dimensionless"> 4.0 </cn>
</apply>
<apply><minus />
<ci> CER </ci>
<ci> CS2 </ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="21" >
<apply><eq />
<ci> phi1 </ci>
<apply><divide />
<apply><plus />
<apply><times />
<ci> k1 </ci>
<ci> R1 </ci>
</apply>
<apply><times />
<ci> r2 </ci>
<ci> CS2 </ci>
</apply>
</apply>
<apply><plus />
<ci> R1 </ci>
<ci> CS2 </ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="22" >
<apply><eq />
<ci> phi_1 </ci>
<apply><divide />
<apply><times />
<apply><plus />
<ci> k_1 </ci>
<ci> r_2 </ci>
</apply>
<ci> R3 </ci>
</apply>
<apply><plus />
<ci> R3 </ci>
<ci> CS2 </ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="23" >
<apply><eq />
<ci> phi2 </ci>
<apply><divide />
<apply><plus />
<apply><times />
<ci> k2 </ci>
<ci> R3 </ci>
</apply>
<apply><times />
<ci> r4 </ci>
<ci> CS2 </ci>
</apply>
</apply>
<apply><plus />
<ci> R3 </ci>
<ci> CS2 </ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="24" >
<apply><eq />
<ci> phi3 </ci>
<apply><divide />
<apply><times />
<ci> g_phi3 </ci>
<ci> zeta </ci>
</apply>
<apply><times />
<apply><plus />
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply><power />
<apply><divide />
<ci> K_phi3_act </ci>
<ci> CS2 </ci>
</apply>
<ci> h_phi3_act </ci>
</apply>
</apply>
<apply><plus />
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply><power />
<apply><divide />
<ci> CS2 </ci>
<ci> K_phi3_inh </ci>
</apply>
<ci> h_phi3_inh </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="25" >
<apply><eq />
<ci> alpha_zeta </ci>
<ci> g_alpha </ci>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="26" >
<apply><eq />
<ci> beta_zeta </ci>
<apply><divide />
<ci> g_beta </ci>
<apply><plus />
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply><power />
<apply><divide />
<ci> K_beta </ci>
<ci> CS2 </ci>
</apply>
<ci> h_beta </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="27" >
<apply><eq />
<apply><diff />
<bvar><ci>time</ci></bvar>
<ci> zeta </ci>
</apply>
<apply><minus />
<apply><times />
<ci> alpha_zeta </ci>
<apply><minus />
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci> zeta </ci>
</apply>
</apply>
<apply><times />
<ci> beta_zeta </ci>
<ci> zeta </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="CS1" cmeta:id="CS1">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="CS1">
<dc:title>CS1</dc:title>
<dcterms:alternative>calcium concentration in cytoplasmic subspace 1</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="CS1" initial_value="0.120" public_interface="out" units="micromolar" />
<variable name="lambda_MT_S1" units="dimensionless" />
<variable name="lambda_ER_S1" units="dimensionless" />
<variable name="JS1S2" public_interface="in" units="flux" />
<variable name="JNCX" public_interface="in" units="flux" />
<variable name="JSERCA" public_interface="in" units="flux" />
<variable name="I_iCa" public_interface="in" units="picoampere" />
<variable name="delta_SPU" public_interface="in" units="micromolar_per_coulomb" />
<variable name="gamma_S1" public_interface="in" units="dimensionless" />
<variable name="gamma_MT" public_interface="in" units="dimensionless" />
<variable name="gamma_ER" public_interface="in" units="dimensionless" />
<variable name="alpha_scale" public_interface="in" units="dimensionless" />
<variable name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="28">
<apply><eq />
<apply><diff />
<bvar><ci>time</ci></bvar>
<ci> CS1 </ci>
</apply>
<apply><minus />
<apply><plus />
<ci> JS1S2 </ci>
<apply><times />
<ci> lambda_MT_S1 </ci>
<ci> JNCX </ci>
</apply>
</apply>
<apply><plus />
<apply><times />
<apply><divide />
<ci> delta_SPU </ci>
<apply><times />
<ci> alpha_scale </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
<ci> I_iCa </ci>
</apply>
<apply><times />
<ci> lambda_ER_S1 </ci>
<ci> JSERCA </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="29" >
<apply><eq />
<ci> lambda_MT_S1 </ci>
<apply><divide />
<ci> gamma_MT </ci>
<ci> gamma_S1 </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="30" >
<apply><eq />
<ci> lambda_ER_S1 </ci>
<apply><divide />
<ci> gamma_ER </ci>
<ci> gamma_S1 </ci>
</apply>
</apply>
</math>
</component>
<component name="CS2" cmeta:id="CS2">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="CS2">
<dc:title>CS2</dc:title>
<dcterms:alternative>calcium concentration in cytoplasmic subspace 2</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="CS2" initial_value="0.023" public_interface="out" units="micromolar" />
<variable name="lambda_MT_S2" units="dimensionless" />
<variable name="lambda_ER_S2" units="dimensionless" />
<variable name="lambda_S1_S2" units="dimensionless" />
<variable name="JS1S2" public_interface="in" units="flux" />
<variable name="JS2Cy" public_interface="in" units="flux" />
<variable name="JMCU" public_interface="in" units="flux" />
<variable name="JIPR" public_interface="in" units="flux" />
<variable name="gamma_S1" public_interface="in" units="dimensionless" />
<variable name="gamma_S2" public_interface="in" units="dimensionless" />
<variable name="gamma_MT" public_interface="in" units="dimensionless" />
<variable name="gamma_ER" public_interface="in" units="dimensionless" />
<variable name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="31">
<apply><eq />
<apply><diff />
<bvar><ci>time</ci></bvar>
<ci> CS2 </ci>
</apply>
<apply><minus />
<apply><plus />
<ci> JS2Cy </ci>
<apply><times />
<ci> lambda_ER_S2 </ci>
<ci> JIPR </ci>
</apply>
</apply>
<apply><plus />
<apply><times />
<ci> lambda_S1_S2 </ci>
<ci> JS1S2 </ci>
</apply>
<apply><times />
<ci> lambda_MT_S2 </ci>
<ci> JMCU </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="32" >
<apply><eq />
<ci> lambda_MT_S2 </ci>
<apply><divide />
<ci> gamma_MT </ci>
<ci> gamma_S2 </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="33" >
<apply><eq />
<ci> lambda_ER_S2 </ci>
<apply><divide />
<ci> gamma_ER </ci>
<ci> gamma_S2 </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="34" >
<apply><eq />
<ci> lambda_S1_S2 </ci>
<apply><divide />
<ci> gamma_S1 </ci>
<ci> gamma_S2 </ci>
</apply>
</apply>
</math>
</component>
<component name="CER" cmeta:id="CER">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="CER">
<dc:title>CER</dc:title>
<dcterms:alternative>calcium concentration in the endoplasmic reticulum</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="CER" initial_value="200.0" public_interface="out" units="micromolar" />
<variable name="JSERCA" public_interface="in" units="flux" />
<variable name="JIPR" public_interface="in" units="flux" />
<variable name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="35">
<apply><eq />
<apply><diff />
<bvar><ci>time</ci></bvar>
<ci> CER </ci>
</apply>
<apply><minus />
<ci> JSERCA </ci>
<ci> JIPR </ci>
</apply>
</apply>
</math>
</component>
<component name="CMT" cmeta:id="CMT">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="CMT">
<dc:title>CMT</dc:title>
<dcterms:alternative>calcium concentration in the mitochondria</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="CMT" initial_value="0.200" public_interface="out" units="micromolar" />
<variable name="fm" units="dimensionless" />
<variable name="Km" initial_value="0.01" units="micromolar" />
<variable name="Bm" initial_value="100.0" units="micromolar" />
<variable name="JMCU" public_interface="in" units="flux" />
<variable name="JNCX" public_interface="in" units="flux" />
<variable name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="36">
<apply><eq />
<apply><diff />
<bvar><ci>time</ci></bvar>
<ci> CMT </ci>
</apply>
<apply><times />
<ci> fm </ci>
<apply><minus />
<ci> JMCU </ci>
<ci> JNCX </ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="37" >
<apply><eq />
<ci> fm </ci>
<apply><divide />
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply><plus />
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply><divide />
<apply><times />
<ci> Km </ci>
<ci> Bm </ci>
</apply>
<apply><power />
<apply><plus />
<ci> Km </ci>
<ci> CMT </ci>
</apply>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="NS1" cmeta:id="NS1">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="NS1">
<dc:title>NS1</dc:title>
<dcterms:alternative>sodium concentration in cytoplasmic subspace 1</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="NS1" initial_value="1.01E4" public_interface="out" units="micromolar" />
<variable name="alpha_scale" public_interface="in" units="dimensionless" />
<variable name="delta_SPU" public_interface="in" units="micromolar_per_coulomb" />
<variable name="I_iNa" public_interface="in" units="picoampere" />
<variable name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="38">
<apply><eq />
<apply><diff />
<bvar><ci>time</ci></bvar>
<ci> NS1 </ci>
</apply>
<apply><times />
<apply><minus />
<apply><divide />
<ci> delta_SPU </ci>
<apply><times />
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci> alpha_scale </ci>
</apply>
</apply>
</apply>
<ci> I_iNa </ci>
</apply>
</apply>
</math>
</component>
<component name="model_parameters">
<variable name="R" public_interface="out" initial_value="8.314E-3" units="attojoule_per_zeptomole_kelvin" />
<variable name="F" public_interface="out" initial_value="0.09649" units="femtocoulomb_per_zeptomole" />
<variable name="T" public_interface="out" initial_value="310.16" units="kelvin" />
<variable name="NO" public_interface="out" initial_value="140.0E3" units="micromolar" />
<variable name="CO" public_interface="out" initial_value="1.8E3" units="micromolar" />
<variable name="KO" public_interface="out" initial_value="5400.0" units="micromolar" />
<variable name="Ki" public_interface="out" initial_value="145E3" units="micromolar" />
<variable name="P" public_interface="out" initial_value="1.0" units="micromolar" />
<variable name="delta_SPU" public_interface="out" initial_value="18.5" units="micromolar_per_coulomb" />
<variable name="gamma_S1" public_interface="out" initial_value="100.0" units="dimensionless" />
<variable name="gamma_S2" public_interface="out" initial_value="1.0" units="dimensionless" />
<variable name="gamma_MT" public_interface="out" initial_value="200.0" units="dimensionless" />
<variable name="gamma_ER" public_interface="out" initial_value="20.0" units="dimensionless" />
<variable name="KNSCC" public_interface="out" initial_value="0.12" units="micromolar" />
<variable name="ENSCC" public_interface="out" initial_value="0.0" units="millivolt" />
<variable name="hNSCC" public_interface="out" initial_value="3.0" units="dimensionless" />
<variable name="alpha_scale" public_interface="out" units="dimensionless" />
<variable name="n_PU" public_interface="in" units="dimensionless" />
<variable name="n_PU_base" initial_value="50.0" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="39">
<apply><eq />
<ci> alpha_scale </ci>
<apply><divide />
<ci> n_PU_base </ci>
<ci> n_PU </ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation" />
<component_ref component="pacemaker_unit_model">
<component_ref component="PU_membrane" />
<component_ref component="I_Ca" />
<component_ref component="I_Na" />
<component_ref component="I_NSCC_Ca" />
<component_ref component="I_NSCC_Na" />
<component_ref component="I_PM" />
<component_ref component="I_NaP" />
<component_ref component="JSERCA" />
<component_ref component="JMCU" />
<component_ref component="JIPR" />
<component_ref component="JNCX" />
<component_ref component="CS1" />
<component_ref component="CS2" />
<component_ref component="CER" />
<component_ref component="CMT" />
<component_ref component="NS1" />
<component_ref component="model_parameters" />
</component_ref>
</group>
<connection>
<map_components component_1="PU_membrane" component_2="I_Ca"/>
<map_variables variable_1="I_Ca" variable_2="I_Ca"/>
</connection>
<connection>
<map_components component_1="PU_membrane" component_2="I_NaP"/>
<map_variables variable_1="I_NaP" variable_2="I_NaP"/>
</connection>
<connection>
<map_components component_1="PU_membrane" component_2="I_Na"/>
<map_variables variable_1="I_Na" variable_2="I_Na"/>
</connection>
<connection>
<map_components component_1="PU_membrane" component_2="I_NSCC_Na"/>
<map_variables variable_1="I_NSCC_Na" variable_2="I_NSCC_Na"/>
</connection>
<connection>
<map_components component_1="PU_membrane" component_2="I_NSCC_Ca"/>
<map_variables variable_1="I_NSCC_Ca" variable_2="I_NSCC_Ca"/>
</connection>
<connection>
<map_components component_1="PU_membrane" component_2="I_PM"/>
<map_variables variable_1="I_PM" variable_2="I_PM"/>
</connection>
<connection>
<map_components component_1="PU_membrane" component_2="CS1"/>
<map_variables variable_1="I_iCa" variable_2="I_iCa"/>
</connection>
<connection>
<map_components component_1="PU_membrane" component_2="NS1"/>
<map_variables variable_1="I_iNa" variable_2="I_iNa"/>
</connection>
<connection>
<map_components component_1="PU_membrane" component_2="model_parameters"/>
<map_variables variable_1="alpha_scale" variable_2="alpha_scale" />
</connection>
<connection>
<map_components component_1="JSERCA" component_2="CS1" />
<map_variables variable_1="CS1" variable_2="CS1" />
<map_variables variable_1="JSERCA" variable_2="JSERCA" />
</connection>
<connection>
<map_components component_1="JNCX" component_2="CS1" />
<map_variables variable_1="JNCX" variable_2="JNCX" />
</connection>
<connection>
<map_components component_1="I_PM" component_2="CS1" />
<map_variables variable_1="CS1" variable_2="CS1" />
</connection>
<connection>
<map_components component_1="I_NSCC_Ca" component_2="CS1" />
<map_variables variable_1="CS1" variable_2="CS1" />
</connection>
<connection>
<map_components component_1="I_NSCC_Na" component_2="CS1" />
<map_variables variable_1="CS1" variable_2="CS1" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="CS1" />
<map_variables variable_1="delta_SPU" variable_2="delta_SPU" />
<map_variables variable_1="gamma_MT" variable_2="gamma_MT" />
<map_variables variable_1="gamma_S1" variable_2="gamma_S1" />
<map_variables variable_1="gamma_ER" variable_2="gamma_ER" />
<map_variables variable_1="alpha_scale" variable_2="alpha_scale" />
</connection>
<connection>
<map_components component_1="JMCU" component_2="CS2" />
<map_variables variable_1="CS2" variable_2="CS2" />
<map_variables variable_1="JMCU" variable_2="JMCU" />
</connection>
<connection>
<map_components component_1="JIPR" component_2="CS2" />
<map_variables variable_1="CS2" variable_2="CS2" />
<map_variables variable_1="JIPR" variable_2="JIPR" />
</connection>
<connection>
<map_components component_1="JIPR" component_2="model_parameters" />
<map_variables variable_1="P" variable_2="P" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="CS2" />
<map_variables variable_1="gamma_MT" variable_2="gamma_MT" />
<map_variables variable_1="gamma_S1" variable_2="gamma_S1" />
<map_variables variable_1="gamma_S2" variable_2="gamma_S2" />
<map_variables variable_1="gamma_ER" variable_2="gamma_ER" />
</connection>
<connection>
<map_components component_1="JSERCA" component_2="CER" />
<map_variables variable_1="CER" variable_2="CER" />
<map_variables variable_1="JSERCA" variable_2="JSERCA" />
</connection>
<connection>
<map_components component_1="JIPR" component_2="CER" />
<map_variables variable_1="CER" variable_2="CER" />
<map_variables variable_1="JIPR" variable_2="JIPR" />
</connection>
<connection>
<map_components component_1="JNCX" component_2="CMT" />
<map_variables variable_1="CMT" variable_2="CMT" />
<map_variables variable_1="JNCX" variable_2="JNCX" />
</connection>
<connection>
<map_components component_1="JMCU" component_2="CMT" />
<map_variables variable_1="CMT" variable_2="CMT" />
<map_variables variable_1="JMCU" variable_2="JMCU" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="NS1" />
<map_variables variable_1="delta_SPU" variable_2="delta_SPU" />
<map_variables variable_1="alpha_scale" variable_2="alpha_scale" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="I_NSCC_Ca" />
<map_variables variable_1="hNSCC" variable_2="hNSCC" />
<map_variables variable_1="ENSCC" variable_2="ENSCC" />
<map_variables variable_1="KNSCC" variable_2="KNSCC" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="I_NSCC_Na" />
<map_variables variable_1="hNSCC" variable_2="hNSCC" />
<map_variables variable_1="ENSCC" variable_2="ENSCC" />
<map_variables variable_1="KNSCC" variable_2="KNSCC" />
</connection>
<connection>
<map_components component_1="I_Ca" component_2="CS1" />
<map_variables variable_1="CS1" variable_2="CS1" />
</connection>
<connection>
<map_components component_1="I_Ca" component_2="model_parameters"/>
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="T" variable_2="T" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="CO" variable_2="CO" />
</connection>
<connection>
<map_components component_1="I_Na" component_2="model_parameters"/>
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="T" variable_2="T" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="NO" variable_2="NO" />
</connection>
<connection>
<map_components component_1="I_NaP" component_2="NS1" />
<map_variables variable_1="NS1" variable_2="NS1" />
</connection>
<connection>
<map_components component_1="I_Na" component_2="NS1" />
<map_variables variable_1="NS1" variable_2="NS1" />
</connection>
</model>
