- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2006-07-09 07:22:07+12:00
- Desc:
- committing version01 of goldbeter_1995
- Permanent Source URI:
- https://models.cellml.org/workspace/goldbeter_1995/rawfile/212aab103ef507ffa9c3c07ddba158705cb4eb4c/goldbeter_1995.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : goldbeter_model_1995.xml
CREATED : 30th October 2003
LAST MODIFIED : 3rd November 2003
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Albert Goldbeter's
1995 model for circadian oscillations in the Drosophila period protein (PER).
CHANGES:
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="goldbeter_1995_version01" name="goldbeter_1995_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A Model For Circadian PER Oscillations In Drosophila</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Studies of the period (<emphasis>per</emphasis>) gene in <emphasis>Drosophila</emphasis> have led to a better understanding of the molecular mechanisms underlying circadian rhythms. The PER protein shares characteristics with some transcription factors, which suggests how PER can regulate the periodic expression of several other genes. <emphasis>per</emphasis> mRNA varies on a circadian cycle, and PER protein also cycles in a circadian manner, but with a several hour delay after the mRNA cycle. This suggests that the mechanism of circadian oscillations involves a negative feedback of the PER protein on transcription of the <emphasis>per</emphasis> gene. Post-translational phosphorylation of the PER protein appears to be involved in the regulation of the oscillations, as PER is phosphorylated in a circadian manner.
</para>
<para>
In the publication described here, Albert Goldbeter presents a mathematical model for circadian oscillations in the <emphasis>Drosophila</emphasis> PER protein and its mRNA. The model is based on the multiple phosphorylation of PER and on the inhibition of <emphasis>per</emphasis> transcription by a phosphorylated version of the protein (see <xref linkend="fig_reaction diagram"/> below). Model simulations support the idea that multiple PER phosphorylation introduces time delays which reinforce the capability of negative feedback to produce oscillations.
</para>
<para>
The principal prediction from the model is that there are two different ways in which calcium waves propagate in acinar cells: at low agonist concentration the wave is propagated by the diffusion of Ca<superscript>2+</superscript> between release sites. At higher agonist concentrations the basal region of the cell responds later than the apical region, creating a wave which is independent of Ca<superscript>2+</superscript> diffusion.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://journals.royalsociety.org/content/102024/?p=d560208aa5024204b2cec07eb9280d9d&pi=0">A Model for Circadian Oscillations in the Drosophila Period Protein (PER)</ulink>, Albert Goldbeter, 1995, <ulink url="http://journals.royalsociety.org/content/d5j58746110h3g4x/">
<emphasis>Proceedings of the Royal Society of London, Series B, Biological Sciences</emphasis>
</ulink>, 261, 319-324. (A PDF version of the article is available on the <emphasis>Proceedings of the Royal Society of London, Series B, Biological Sciences</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8587874&dopt=Abstract">PubMed ID: 8587874</ulink>
</para>
<para>
The raw CellML description of the Goldbeter 1995 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>.
</para>
<informalfigure float="0" id="fig_reaction diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>reaction diagram</title>
</objectinfo>
<imagedata fileref="reaction_diagram.gif"/>
</imageobject>
</mediaobject>
<caption>Scheme of the model for circadian oscillations in PER protein and <emphasis>per</emphasis> mRNA.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<dc:title>
A model for circadian oscillations in the Drosophila period protein
(PER)
</dc:title>
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Proceedings of the Royal Society of London series B
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<dc:title>
Albert Goldbeter's 1995 model for circadian oscillations in the
Drosophila period protein (PER).
</dc:title>
<cmeta:species>Drosophila</cmeta:species>
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<dcterms:W3CDTF>2003-10-30</dcterms:W3CDTF>
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<dcterms:W3CDTF>1995-09-22</dcterms:W3CDTF>
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<vCard:Given>Catherine</vCard:Given>
<vCard:Family>Lloyd</vCard:Family>
<vCard:Other>May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#81c17b21-b38d-4446-bf3b-2daba4d927b7">
<vCard:Given>Albert</vCard:Given>
<vCard:Family>Goldbeter</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9ed64af0-0d21-4399-aa64-b7884a48fe5b">
<dc:creator rdf:resource="rdf:#de6cd0b0-562a-46ce-98ca-d927a0851dd1"/>
<rdf:value>
This is the CellML description of Albert Goldbeter's 1995 model for
circadian oscillations in the Drosophila period protein (PER).
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#dca6adc6-35fd-42a8-882d-4451b65ed3a1">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>The Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d2de4e53-5b0d-4311-807f-3ce01d6803e5">
<bqs:Pubmed_id>8587874</bqs:Pubmed_id>
<bqs:JournalArticle rdf:resource="rdf:#96f4ffdd-d740-4eb9-9a76-5d8eededf995"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#de6cd0b0-562a-46ce-98ca-d927a0851dd1">
<vCard:FN>Catherine Lloyd</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#54dedfa6-9e78-453b-ad6a-a4ac24ed6a06">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>cell cycle</rdf:value>
</rdf:Description>
</rdf:RDF>
</model>
