Location: Grandi, Pasqualini and Bers, 2010 @ 3143cde02929 / grandi_pasqualini_bers_2010_flat.cellml

Author:
Dougal Cowan <devnull@localhost>
Date:
2011-06-03 08:27:01+12:00
Desc:
Fixed keywords
Permanent Source URI:
https://models.cellml.org/workspace/grandi_pasqualini_bers_2010/rawfile/3143cde02929e8ed8db7b3a064a06e2ffd680585/grandi_pasqualini_bers_2010_flat.cellml

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<!--
This CellML file was generated on 18/10/2010 at 13:49:35 using:

COR (0.9.31.1393)
Copyright 2002-2010 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
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		<article>
			<articleinfo>
				<title>A novel computational model of the human ventricular action potential and Ca transient
</title>
				<author>
					<firstname>Geoffrey</firstname>
					<surname>Nunns</surname>
					<affiliation>
						<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
					</affiliation>
				</author>
			</articleinfo>
			<section id="sec_status">
				<title>Model Status</title>
				<para>
				This CellML model is part of a CellML 1.1 model, this segment contains all the model equations describing cellular species. It is imported by smaller CellML models which describe different voltage protocols, and does not run as a standalone model. The units are consistent throughout.

				</para>
			</section>
			<sect1 id="sec_structure">
				<title>Model Structure</title>
				<para>
ABSTRACT: We have developed a detailed mathematical model for Ca handling and ionic currents in the human ventricular myocyte. Our aims were to: (1) simulate basic excitation-contraction coupling phenomena; (2) use realistic repolarizing K current densities; (3) reach steady-state. The model relies on the framework of the rabbit myocyte model previously developed by our group, with subsarcolemmal and junctional compartments where ion channels sense higher [Ca] vs. bulk cytosol. Ion channels and transporters have been modeled on the basis of the most recent experimental data from human ventricular myocytes. Rapidly and slowly inactivating components of I(to) have been formulated to differentiate between endocardial and epicardial myocytes. Transmural gradients of Ca handling proteins and Na pump were also simulated. The model has been validated against a wide set of experimental data including action potential duration (APD) adaptation and restitution, frequency-dependent increase in Ca transient peak and [Na](i). Interestingly, Na accumulation at fast heart rate is a major determinant of APD shortening, via outward shifts in Na pump and Na-Ca exchange currents. We investigated the effects of blocking K currents on APD and repolarization reserve: I(Ks) block does not affect the former and slightly reduces the latter; I(K1) blockade modestly increases APD and more strongly reduces repolarization reserve; I(Kr) blockers significantly prolong APD, an effect exacerbated as pacing frequency is decreased, in good agreement with experimental results in human myocytes. We conclude that this model provides a useful framework to explore excitation-contraction coupling mechanisms and repolarization abnormalities at the single myocyte level.
</para>
				<para>
The original paper reference is cited below:
</para>
				<para>
A novel computational model of the human ventricular action potential and Ca transient, Eleonora Grandi, Francesco S. Pasqualini, Donald M. Bers, 2010, <emphasis>Journal of Molecular and Cellular Cardiology</emphasis>, volume 48, 112-121.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=19835882&amp;query_hl=1&amp;itool=pubmed_docsum">PubMed ID: 19835882</ulink>
				</para>
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            <eq/>
            <ci>Vmyo</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.65</cn>
               <ci>Vcell</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vsr</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.035</cn>
               <ci>Vcell</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vsl</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.02</cn>
               <ci>Vcell</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vjunc</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.0539</cn>
               <cn cellml:units="dimensionless">0.01</cn>
               <ci>Vcell</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>SAjunc</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">20150</cn>
               <pi/>
               <cn cellml:units="dimensionless">2</cn>
               <ci>junctionLength</ci>
               <ci>junctionRadius</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>SAsl</ci>
            <apply>
               <times/>
               <pi/>
               <cn cellml:units="dimensionless">2</cn>
               <ci>cellRadius</ci>
               <ci>cellLength</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_ca_juncsl</ci>
            <cn type="e-notation" cellml:units="liters_per_msec">8.2413   <sep/>
            -13</cn>
         </apply>
         <apply>
            <eq/>
            <ci>J_ca_slmyo</ci>
            <cn type="e-notation" cellml:units="liters_per_msec">3.2743   <sep/>
            -12</cn>
         </apply>
         <apply>
            <eq/>
            <ci>J_na_juncsl</ci>
            <cn type="e-notation" cellml:units="liters_per_msec">1.8313   <sep/>
            -14</cn>
         </apply>
         <apply>
            <eq/>
            <ci>J_na_slmyo</ci>
            <cn type="e-notation" cellml:units="liters_per_msec">1.6386   <sep/>
            -12</cn>
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         <apply>
            <eq/>
            <ci>Fjunc</ci>
            <cn cellml:units="dimensionless">0.11</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Fsl</ci>
            <apply>
               <minus/>
               <cn cellml:units="dimensionless">1</cn>
               <ci>Fjunc</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Fjunc_CaL</ci>
            <cn cellml:units="dimensionless">0.9</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Fsl_CaL</ci>
            <apply>
               <minus/>
               <cn cellml:units="dimensionless">1</cn>
               <ci>Fjunc_CaL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Cli</ci>
            <cn cellml:units="mM">15</cn>
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         <apply>
            <eq/>
            <ci>Clo</ci>
            <cn cellml:units="mM">150</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Ko</ci>
            <cn cellml:units="mM">5.4</cn>
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         <apply>
            <eq/>
            <ci>Nao</ci>
            <cn cellml:units="mM">140</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Cao</ci>
            <cn cellml:units="mM">1.8</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Mgi</ci>
            <cn cellml:units="mM">1</cn>
         </apply>
         <apply>
            <eq/>
            <ci>ena_junc</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>FoRT</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Nao</ci>
                     <ci>Na_j</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ena_sl</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>FoRT</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Nao</ci>
                     <ci>Na_sl</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ek</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>FoRT</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <ci>K_i</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>eca_junc</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <divide/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>FoRT</ci>
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                  <cn cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Ca_j</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>eca_sl</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <divide/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>FoRT</ci>
                  </apply>
                  <cn cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Ca_sl</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ecl</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>FoRT</ci>
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               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cli</ci>
                     <ci>Clo</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>GNa</ci>
            <cn cellml:units="mS_per_uF">23</cn>
         </apply>
         <apply>
            <eq/>
            <ci>GNaB</ci>
            <cn type="e-notation" cellml:units="mS_per_uF">0.597   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>IbarNaK</ci>
            <apply>
               <times/>
               <cn cellml:units="uA_per_uF">1</cn>
               <cn cellml:units="dimensionless">1.8</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>KmNaip</ci>
            <cn cellml:units="mM">11</cn>
         </apply>
         <apply>
            <eq/>
            <ci>KmKo</ci>
            <cn cellml:units="mM">1.5</cn>
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         <apply>
            <eq/>
            <ci>Q10NaK</ci>
            <cn cellml:units="dimensionless">1.63</cn>
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         <apply>
            <eq/>
            <ci>Q10KmNai</ci>
            <cn cellml:units="dimensionless">1.39</cn>
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         <apply>
            <eq/>
            <ci>pNaK</ci>
            <cn cellml:units="dimensionless">0.01833</cn>
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         <apply>
            <eq/>
            <ci>gkp</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">2</cn>
               <cn cellml:units="mS_per_uF">0.001</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>GClCa</ci>
            <apply>
               <times/>
               <cn cellml:units="mS_per_uF">0.5</cn>
               <cn cellml:units="dimensionless">0.109625</cn>
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         </apply>
         <apply>
            <eq/>
            <ci>GClB</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">1</cn>
               <cn type="e-notation" cellml:units="mS_per_uF">9   <sep/>
               -3</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>KdClCa</ci>
            <cn type="e-notation" cellml:units="mM">100   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>pNa</ci>
            <apply>
               <times/>
               <cn cellml:units="cm_per_sec">0.5</cn>
               <cn type="e-notation" cellml:units="dimensionless">1.5   <sep/>
               -8</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pCa</ci>
            <apply>
               <times/>
               <cn cellml:units="cm_per_sec">0.5</cn>
               <cn type="e-notation" cellml:units="dimensionless">5.4   <sep/>
               -4</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pK</ci>
            <apply>
               <times/>
               <cn cellml:units="cm_per_sec">0.5</cn>
               <cn type="e-notation" cellml:units="dimensionless">2.7   <sep/>
               -7</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Q10CaL</ci>
            <cn cellml:units="dimensionless">1.8</cn>
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         <apply>
            <eq/>
            <ci>IbarNCX</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">1</cn>
               <cn cellml:units="uA_per_uF">4.5</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>KmCai</ci>
            <cn type="e-notation" cellml:units="mM">3.59   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>KmCao</ci>
            <cn cellml:units="mM">1.3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>KmNai</ci>
            <cn cellml:units="mM">12.29</cn>
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         <apply>
            <eq/>
            <ci>KmNao</ci>
            <cn cellml:units="mM">87.5</cn>
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         <apply>
            <eq/>
            <ci>ksat</ci>
            <cn cellml:units="dimensionless">0.32</cn>
         </apply>
         <apply>
            <eq/>
            <ci>nu</ci>
            <cn cellml:units="dimensionless">0.27</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kdact</ci>
            <cn type="e-notation" cellml:units="mM">0.15   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Q10NCX</ci>
            <cn cellml:units="dimensionless">1.57</cn>
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         <apply>
            <eq/>
            <ci>IbarSLCaP</ci>
            <cn cellml:units="uA_per_uF">0.0673</cn>
         </apply>
         <apply>
            <eq/>
            <ci>KmPCa</ci>
            <cn type="e-notation" cellml:units="mM">0.5   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>GCaB</ci>
            <cn type="e-notation" cellml:units="mS_per_uF">5.513   <sep/>
            -4</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Q10SLCaP</ci>
            <cn cellml:units="dimensionless">2.35</cn>
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         <apply>
            <eq/>
            <ci>Q10SRCaP</ci>
            <cn cellml:units="dimensionless">2.6</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Vmax_SRCaP</ci>
            <cn type="e-notation" cellml:units="mM_per_msec">5.3114   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kmf</ci>
            <cn type="e-notation" cellml:units="mM">0.246   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Kmr</ci>
            <cn cellml:units="mM">1.7</cn>
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         <apply>
            <eq/>
            <ci>hillSRCaP</ci>
            <cn cellml:units="dimensionless">1.787</cn>
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         <apply>
            <eq/>
            <ci>ks</ci>
            <cn cellml:units="per_msec">25</cn>
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         <apply>
            <eq/>
            <ci>koCa</ci>
            <cn cellml:units="per_mM2_per_msec">10</cn>
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         <apply>
            <eq/>
            <ci>kom</ci>
            <cn cellml:units="per_msec">0.06</cn>
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         <apply>
            <eq/>
            <ci>kiCa</ci>
            <cn cellml:units="per_mM_per_msec">0.5</cn>
         </apply>
         <apply>
            <eq/>
            <ci>kim</ci>
            <cn cellml:units="per_msec">0.005</cn>
         </apply>
         <apply>
            <eq/>
            <ci>ec50SR</ci>
            <cn cellml:units="mM">0.45</cn>
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         <apply>
            <eq/>
            <ci>Bmax_Naj</ci>
            <cn cellml:units="mM">7.561</cn>
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         <apply>
            <eq/>
            <ci>Bmax_Nasl</ci>
            <cn cellml:units="mM">1.65</cn>
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         <apply>
            <eq/>
            <ci>koff_na</ci>
            <cn type="e-notation" cellml:units="per_msec">1   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>kon_na</ci>
            <cn type="e-notation" cellml:units="per_mM_per_msec">0.1   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Bmax_TnClow</ci>
            <cn type="e-notation" cellml:units="mM">70   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>koff_tncl</ci>
            <cn type="e-notation" cellml:units="per_msec">19.6   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>kon_tncl</ci>
            <cn cellml:units="per_mM_per_msec">32.7</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Bmax_TnChigh</ci>
            <cn type="e-notation" cellml:units="mM">140   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>koff_tnchca</ci>
            <cn type="e-notation" cellml:units="per_msec">0.032   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>kon_tnchca</ci>
            <cn cellml:units="per_mM_per_msec">2.37</cn>
         </apply>
         <apply>
            <eq/>
            <ci>koff_tnchmg</ci>
            <cn type="e-notation" cellml:units="per_msec">3.33   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>kon_tnchmg</ci>
            <cn type="e-notation" cellml:units="per_mM_per_msec">3   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>Bmax_CaM</ci>
            <cn type="e-notation" cellml:units="mM">24   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>koff_cam</ci>
            <cn type="e-notation" cellml:units="per_msec">238   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>kon_cam</ci>
            <cn cellml:units="per_mM_per_msec">34</cn>
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         <apply>
            <eq/>
            <ci>Bmax_myosin</ci>
            <cn type="e-notation" cellml:units="mM">140   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>koff_myoca</ci>
            <cn type="e-notation" cellml:units="per_msec">0.46   <sep/>
            -3</cn>
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         <apply>
            <eq/>
            <ci>kon_myoca</ci>
            <cn cellml:units="per_mM_per_msec">13.8</cn>
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         <apply>
            <eq/>
            <ci>koff_myomg</ci>
            <cn type="e-notation" cellml:units="per_msec">0.057   <sep/>
            -3</cn>
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            <eq/>
            <ci>kon_myomg</ci>
            <cn cellml:units="per_mM_per_msec">0.0157</cn>
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         <apply>
            <eq/>
            <ci>Bmax_SR</ci>
            <apply>
               <times/>
               <cn cellml:units="mM">19</cn>
               <cn type="e-notation" cellml:units="dimensionless">0.9   <sep/>
               -3</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>koff_sr</ci>
            <cn type="e-notation" cellml:units="per_msec">60   <sep/>
            -3</cn>
         </apply>
         <apply>
            <eq/>
            <ci>kon_sr</ci>
            <cn cellml:units="per_mM_per_msec">100</cn>
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         <apply>
            <eq/>
            <ci>Bmax_SLlowsl</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn type="e-notation" cellml:units="mM">37.4   <sep/>
                  -3</cn>
                  <ci>Vmyo</ci>
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               <ci>Vsl</ci>
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         </apply>
         <apply>
            <eq/>
            <ci>Bmax_SLlowj</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn type="e-notation" cellml:units="mM">4.6   <sep/>
                     -3</cn>
                     <ci>Vmyo</ci>
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                  <ci>Vjunc</ci>
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               <cn cellml:units="dimensionless">0.1</cn>
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         </apply>
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            <ci>koff_sll</ci>
            <cn type="e-notation" cellml:units="per_msec">1300   <sep/>
            -3</cn>
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            <ci>kon_sll</ci>
            <cn cellml:units="per_mM_per_msec">100</cn>
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         <apply>
            <eq/>
            <ci>Bmax_SLhighsl</ci>
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               <divide/>
               <apply>
                  <times/>
                  <cn type="e-notation" cellml:units="mM">13.4   <sep/>
                  -3</cn>
                  <ci>Vmyo</ci>
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               <ci>Vsl</ci>
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         <apply>
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            <ci>Bmax_SLhighj</ci>
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               <times/>
               <apply>
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                  <apply>
                     <times/>
                     <cn type="e-notation" cellml:units="mM">1.65   <sep/>
                     -3</cn>
                     <ci>Vmyo</ci>
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                  <ci>Vjunc</ci>
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               <cn cellml:units="dimensionless">0.1</cn>
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            <ci>koff_slh</ci>
            <cn type="e-notation" cellml:units="per_msec">30   <sep/>
            -3</cn>
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            <ci>kon_slh</ci>
            <cn cellml:units="per_mM_per_msec">100</cn>
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         <apply>
            <eq/>
            <ci>Bmax_Csqn</ci>
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               <divide/>
               <apply>
                  <times/>
                  <cn type="e-notation" cellml:units="mM">140   <sep/>
                  -3</cn>
                  <ci>Vmyo</ci>
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               <ci>Vsr</ci>
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         <apply>
            <eq/>
            <ci>koff_csqn</ci>
            <cn cellml:units="per_msec">65</cn>
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         <apply>
            <eq/>
            <ci>kon_csqn</ci>
            <cn cellml:units="per_mM_per_msec">100</cn>
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      </math>
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      <variable name="taum" units="msec" public_interface="out"/>
      <variable name="ah" units="dimensionless" public_interface="out"/>
      <variable name="bh" units="dimensionless" public_interface="out"/>
      <variable name="tauh" units="msec" public_interface="out"/>
      <variable name="hss" units="dimensionless" public_interface="out"/>
      <variable name="aj" units="dimensionless" public_interface="out"/>
      <variable name="bj" units="dimensionless" public_interface="out"/>
      <variable name="tauj" units="msec" public_interface="out"/>
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      <variable name="m" units="dimensionless" initial_value="0.003793087414436" public_interface="out"/>
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      <variable name="I_Na_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_Na" units="uA_per_uF" public_interface="out"/>
      <variable name="V_m" units="mV" public_interface="in"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="Fjunc" units="dimensionless" public_interface="in"/>
      <variable name="Fsl" units="dimensionless" public_interface="in"/>
      <variable name="GNa" units="mS_per_uF" public_interface="in"/>
      <variable name="ena_junc" units="mV" public_interface="in"/>
      <variable name="ena_sl" units="mV" public_interface="in"/>
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            <ci>mss</ci>
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                        <apply>
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                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <cn cellml:units="mV">56.86</cn>
                                 <ci>V_m</ci>
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                           </apply>
                           <cn cellml:units="mV">9.03</cn>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>taum</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn cellml:units="msec">0.1292</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>V_m</ci>
                                 <cn cellml:units="mV">45.79</cn>
                              </apply>
                              <cn cellml:units="mV">15.54</cn>
                           </apply>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="msec">0.06487</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <ci>V_m</ci>
                                 <cn cellml:units="mV">4.823</cn>
                              </apply>
                              <cn cellml:units="mV">51.12</cn>
                           </apply>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ah</ci>
            <piecewise>
               <piece>
                  <cn cellml:units="dimensionless">0</cn>
                  <apply>
                     <geq/>
                     <ci>V_m</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="mV">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.057</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V_m</ci>
                                 <cn cellml:units="mV">80</cn>
                              </apply>
                           </apply>
                           <cn cellml:units="mV">6.8</cn>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>bh</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <cn cellml:units="dimensionless">0.77</cn>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.13</cn>
                        <apply>
                           <plus/>
                           <cn cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <plus/>
                                       <ci>V_m</ci>
                                       <cn cellml:units="mV">10.66</cn>
                                    </apply>
                                 </apply>
                                 <cn cellml:units="mV">11.1</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <geq/>
                     <ci>V_m</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="mV">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">2.7</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_mV">0.079</cn>
                              <ci>V_m</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn type="e-notation" cellml:units="dimensionless">3.1   <sep/>
                        5</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_mV">0.3485</cn>
                              <ci>V_m</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>tauh</ci>
            <apply>
               <divide/>
               <cn cellml:units="msec">1</cn>
               <apply>
                  <plus/>
                  <ci>ah</ci>
                  <ci>bh</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>hss</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V_m</ci>
                              <cn cellml:units="mV">71.55</cn>
                           </apply>
                           <cn cellml:units="mV">7.43</cn>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>aj</ci>
            <piecewise>
               <piece>
                  <cn cellml:units="dimensionless">0</cn>
                  <apply>
                     <geq/>
                     <ci>V_m</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="mV">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn type="e-notation" cellml:units="per_mV">2.5428   <sep/>
                                 4</cn>
                              </apply>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <cn cellml:units="per_mV">0.2444</cn>
                                    <ci>V_m</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <cn type="e-notation" cellml:units="per_mV">6.948   <sep/>
                              -6</cn>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <apply>
                                       <minus/>
                                       <cn cellml:units="per_mV">0.04391</cn>
                                    </apply>
                                    <ci>V_m</ci>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V_m</ci>
                           <cn cellml:units="mV">37.78</cn>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_mV">0.311</cn>
                              <apply>
                                 <plus/>
                                 <ci>V_m</ci>
                                 <cn cellml:units="mV">79.23</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>bj</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.6</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_mV">0.057</cn>
                              <ci>V_m</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_mV">0.1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V_m</ci>
                                 <cn cellml:units="mV">32</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <geq/>
                     <ci>V_m</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="mV">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.02424</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_mV">0.01052</cn>
                              </apply>
                              <ci>V_m</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_mV">0.1378</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V_m</ci>
                                 <cn cellml:units="mV">40.14</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>tauj</ci>
            <apply>
               <divide/>
               <cn cellml:units="msec">1</cn>
               <apply>
                  <plus/>
                  <ci>aj</ci>
                  <ci>bj</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>jss</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V_m</ci>
                              <cn cellml:units="mV">71.55</cn>
                           </apply>
                           <cn cellml:units="mV">7.43</cn>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>mss</ci>
                  <ci>m</ci>
               </apply>
               <ci>taum</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>hss</ci>
                  <ci>h</ci>
               </apply>
               <ci>tauh</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>j</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>jss</ci>
                  <ci>j</ci>
               </apply>
               <ci>tauj</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Na_junc</ci>
            <apply>
               <times/>
               <ci>Fjunc</ci>
               <ci>GNa</ci>
               <apply>
                  <power/>
                  <ci>m</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
               <ci>h</ci>
               <ci>j</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ena_junc</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Na_sl</ci>
            <apply>
               <times/>
               <ci>Fsl</ci>
               <ci>GNa</ci>
               <apply>
                  <power/>
                  <ci>m</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
               <ci>h</ci>
               <ci>j</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ena_sl</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Na</ci>
            <apply>
               <plus/>
               <ci>I_Na_junc</ci>
               <ci>I_Na_sl</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_NaBK">
      <variable name="I_nabk_junc" units="uA_per_uF" public_interface="out"/>
      <variable name="I_nabk_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_nabk" units="uA_per_uF" public_interface="out"/>
      <variable name="V_m" units="mV" public_interface="in"/>
      <variable name="Fjunc" units="dimensionless" public_interface="in"/>
      <variable name="Fsl" units="dimensionless" public_interface="in"/>
      <variable name="GNaB" units="mS_per_uF" public_interface="in"/>
      <variable name="ena_junc" units="mV" public_interface="in"/>
      <variable name="ena_sl" units="mV" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_nabk_junc</ci>
            <apply>
               <times/>
               <ci>Fjunc</ci>
               <ci>GNaB</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ena_junc</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_nabk_sl</ci>
            <apply>
               <times/>
               <ci>Fsl</ci>
               <ci>GNaB</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ena_sl</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_nabk</ci>
            <apply>
               <plus/>
               <ci>I_nabk_junc</ci>
               <ci>I_nabk_sl</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_NaK">
      <variable name="sigma" units="dimensionless" public_interface="out"/>
      <variable name="fnak" units="dimensionless" public_interface="out"/>
      <variable name="I_nak_junc" units="uA_per_uF" public_interface="out"/>
      <variable name="I_nak_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_nak" units="uA_per_uF" public_interface="out"/>
      <variable name="V_m" units="mV" public_interface="in"/>
      <variable name="Nao" units="mM" public_interface="in"/>
      <variable name="Ko" units="mM" public_interface="in"/>
      <variable name="FoRT" units="per_mV" public_interface="in"/>
      <variable name="Fjunc" units="dimensionless" public_interface="in"/>
      <variable name="Fsl" units="dimensionless" public_interface="in"/>
      <variable name="IbarNaK" units="uA_per_uF" public_interface="in"/>
      <variable name="KmKo" units="mM" public_interface="in"/>
      <variable name="KmNaip" units="mM" public_interface="in"/>
      <variable name="Na_j" units="mM" public_interface="in"/>
      <variable name="Na_sl" units="mM" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>sigma</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Nao</ci>
                        <cn cellml:units="mM">67.3</cn>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
               <cn cellml:units="dimensionless">7</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>fnak</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.1245</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn cellml:units="dimensionless">0.1</cn>
                           </apply>
                           <ci>V_m</ci>
                           <ci>FoRT</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.0365</cn>
                     <ci>sigma</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>V_m</ci>
                           </apply>
                           <ci>FoRT</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_nak_junc</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Fjunc</ci>
                     <ci>IbarNaK</ci>
                     <ci>fnak</ci>
                     <ci>Ko</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>KmNaip</ci>
                           <ci>Na_j</ci>
                        </apply>
                        <cn cellml:units="dimensionless">4</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ko</ci>
                  <ci>KmKo</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_nak_sl</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Fsl</ci>
                     <ci>IbarNaK</ci>
                     <ci>fnak</ci>
                     <ci>Ko</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>KmNaip</ci>
                           <ci>Na_sl</ci>
                        </apply>
                        <cn cellml:units="dimensionless">4</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ko</ci>
                  <ci>KmKo</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_nak</ci>
            <apply>
               <plus/>
               <ci>I_nak_junc</ci>
               <ci>I_nak_sl</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_Kr">
      <variable name="gkr" units="mS_per_uF" public_interface="out"/>
      <variable name="xrss" units="dimensionless" public_interface="out"/>
      <variable name="tauxr" units="msec" public_interface="out"/>
      <variable name="x_kr" units="dimensionless" initial_value="0.0210022533039071" public_interface="out"/>
      <variable name="rkr" units="dimensionless" public_interface="out"/>
      <variable name="I_kr" units="uA_per_uF" public_interface="out"/>
      <variable name="V_m" units="mV" public_interface="in"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="Ko" units="mM" public_interface="in"/>
      <variable name="ek" units="mV" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>gkr</ci>
            <apply>
               <times/>
               <cn cellml:units="mS_per_uF">0.035</cn>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn cellml:units="mM">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>xrss</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V_m</ci>
                              <cn cellml:units="mV">10</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="mV">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauxr</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">550</cn>
                        <apply>
                           <plus/>
                           <cn cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <minus/>
                                       <cn cellml:units="mV">22</cn>
                                    </apply>
                                    <ci>V_m</ci>
                                 </apply>
                                 <cn cellml:units="mV">9</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <cn cellml:units="msec">6</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>V_m</ci>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="mV">11</cn>
                              </apply>
                           </apply>
                           <cn cellml:units="mV">9</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn cellml:units="msec">230</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>V_m</ci>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="mV">40</cn>
                              </apply>
                           </apply>
                           <cn cellml:units="mV">20</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>x_kr</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xrss</ci>
                  <ci>x_kr</ci>
               </apply>
               <ci>tauxr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>rkr</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V_m</ci>
                           <cn cellml:units="mV">74</cn>
                        </apply>
                        <cn cellml:units="mV">24</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_kr</ci>
            <apply>
               <times/>
               <ci>gkr</ci>
               <ci>x_kr</ci>
               <ci>rkr</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ek</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_Kp">
      <variable name="kp_kp" units="dimensionless" public_interface="out"/>
      <variable name="I_kp_junc" units="uA_per_uF" public_interface="out"/>
      <variable name="I_kp_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_kp" units="uA_per_uF" public_interface="out"/>
      <variable name="V_m" units="mV" public_interface="in"/>
      <variable name="Fjunc" units="dimensionless" public_interface="in"/>
      <variable name="Fsl" units="dimensionless" public_interface="in"/>
      <variable name="ek" units="mV" public_interface="in"/>
      <variable name="gkp" units="mS_per_uF" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>kp_kp</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">7.488</cn>
                        <apply>
                           <divide/>
                           <ci>V_m</ci>
                           <cn cellml:units="mV">5.98</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_kp_junc</ci>
            <apply>
               <times/>
               <ci>Fjunc</ci>
               <ci>gkp</ci>
               <ci>kp_kp</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ek</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_kp_sl</ci>
            <apply>
               <times/>
               <ci>Fsl</ci>
               <ci>gkp</ci>
               <ci>kp_kp</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ek</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_kp</ci>
            <apply>
               <plus/>
               <ci>I_kp_junc</ci>
               <ci>I_kp_sl</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_Ks">
      <variable name="eks" units="mV" public_interface="out"/>
      <variable name="gks_junc" units="mS_per_uF" public_interface="out"/>
      <variable name="gks_sl" units="mS_per_uF" public_interface="out"/>
      <variable name="xsss" units="dimensionless" public_interface="out"/>
      <variable name="tauxs" units="msec" public_interface="out"/>
      <variable name="x_ks" units="dimensionless" initial_value="0.00428016666258923" public_interface="out"/>
      <variable name="I_ks_junc" units="uA_per_uF" public_interface="out"/>
      <variable name="I_ks_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_ks" units="uA_per_uF" public_interface="out"/>
      <variable name="V_m" units="mV" public_interface="in"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="FoRT" units="per_mV" public_interface="in"/>
      <variable name="Ko" units="mM" public_interface="in"/>
      <variable name="Nao" units="mM" public_interface="in"/>
      <variable name="pNaK" units="dimensionless" public_interface="in"/>
      <variable name="Fjunc" units="dimensionless" public_interface="in"/>
      <variable name="Fsl" units="dimensionless" public_interface="in"/>
      <variable name="K_i" units="mM" public_interface="in"/>
      <variable name="Na_i" units="mM" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>eks</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>FoRT</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <apply>
                           <times/>
                           <ci>pNaK</ci>
                           <ci>Nao</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>K_i</ci>
                        <apply>
                           <times/>
                           <ci>pNaK</ci>
                           <ci>Na_i</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gks_junc</ci>
            <cn cellml:units="mS_per_uF">0.0035</cn>
         </apply>
         <apply>
            <eq/>
            <ci>gks_sl</ci>
            <cn cellml:units="mS_per_uF">0.0035</cn>
         </apply>
         <apply>
            <eq/>
            <ci>xsss</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V_m</ci>
                              <cn cellml:units="mV">3.8</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="mV">14.25</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauxs</ci>
            <apply>
               <divide/>
               <cn cellml:units="msec">990.1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V_m</ci>
                              <cn cellml:units="mV">2.436</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="mV">14.12</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>x_ks</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xsss</ci>
                  <ci>x_ks</ci>
               </apply>
               <ci>tauxs</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ks_junc</ci>
            <apply>
               <times/>
               <ci>Fjunc</ci>
               <ci>gks_junc</ci>
               <apply>
                  <power/>
                  <ci>x_ks</ci>
                  <cn cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>eks</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ks_sl</ci>
            <apply>
               <times/>
               <ci>Fsl</ci>
               <ci>gks_sl</ci>
               <apply>
                  <power/>
                  <ci>x_ks</ci>
                  <cn cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>eks</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ks</ci>
            <apply>
               <plus/>
               <ci>I_ks_junc</ci>
               <ci>I_ks_sl</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_to">
      <variable name="GtoSlow" units="mS_per_uF" public_interface="out"/>
      <variable name="GtoFast" units="mS_per_uF" public_interface="out"/>
      <variable name="xtoss" units="dimensionless" public_interface="out"/>
      <variable name="ytoss" units="dimensionless" public_interface="out"/>
      <variable name="tauxtos" units="msec" public_interface="out"/>
      <variable name="tauytos" units="msec" public_interface="out"/>
      <variable name="x_to_s" units="dimensionless" initial_value="0.000440445885642567" public_interface="out"/>
      <variable name="y_to_s" units="dimensionless" initial_value="0.785115828275182" public_interface="out"/>
      <variable name="I_tos" units="uA_per_uF" public_interface="out"/>
      <variable name="tauxtof" units="msec" public_interface="out"/>
      <variable name="tauytof" units="msec" public_interface="out"/>
      <variable name="x_to_f" units="dimensionless" initial_value="0.000440438103758954" public_interface="out"/>
      <variable name="y_to_f" units="dimensionless" initial_value="0.999995844038706" public_interface="out"/>
      <variable name="I_tof" units="uA_per_uF" public_interface="out"/>
      <variable name="I_to" units="uA_per_uF" public_interface="out"/>
      <variable name="V_m" units="mV" public_interface="in"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="epi" units="dimensionless" public_interface="in"/>
      <variable name="ek" units="mV" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>GtoSlow</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn cellml:units="mS_per_uF">1</cn>
                     <cn cellml:units="dimensionless">0.13</cn>
                     <cn cellml:units="dimensionless">0.12</cn>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>epi</ci>
                     <cn cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <cn cellml:units="mS_per_uF">0.13</cn>
                     <cn cellml:units="dimensionless">0.3</cn>
                     <cn cellml:units="dimensionless">0.964</cn>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>GtoFast</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn cellml:units="mS_per_uF">1</cn>
                     <cn cellml:units="dimensionless">0.13</cn>
                     <cn cellml:units="dimensionless">0.88</cn>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>epi</ci>
                     <cn cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <cn cellml:units="mS_per_uF">0.13</cn>
                     <cn cellml:units="dimensionless">0.3</cn>
                     <cn cellml:units="dimensionless">0.036</cn>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>xtoss</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V_m</ci>
                              <cn cellml:units="mV">19</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="mV">13</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ytoss</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V_m</ci>
                           <cn cellml:units="mV">19.5</cn>
                        </apply>
                        <cn cellml:units="mV">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauxtos</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn cellml:units="msec">9</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V_m</ci>
                              <cn cellml:units="mV">3</cn>
                           </apply>
                           <cn cellml:units="mV">15</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn cellml:units="msec">0.5</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauytos</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn cellml:units="msec">800</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V_m</ci>
                              <cn cellml:units="mV">60</cn>
                           </apply>
                           <cn cellml:units="mV">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn cellml:units="msec">30</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>x_to_s</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xtoss</ci>
                  <ci>x_to_s</ci>
               </apply>
               <ci>tauxtos</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y_to_s</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ytoss</ci>
                  <ci>y_to_s</ci>
               </apply>
               <ci>tauytos</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_tos</ci>
            <apply>
               <times/>
               <ci>GtoSlow</ci>
               <ci>x_to_s</ci>
               <ci>y_to_s</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ek</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauxtof</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn cellml:units="msec">8.5</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>V_m</ci>
                                 <cn cellml:units="mV">45</cn>
                              </apply>
                              <cn cellml:units="mV">50</cn>
                           </apply>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn cellml:units="msec">0.5</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauytof</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn cellml:units="msec">85</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <plus/>
                                 <ci>V_m</ci>
                                 <cn cellml:units="mV">40</cn>
                              </apply>
                              <cn cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="mV2">220</cn>
                     </apply>
                  </apply>
               </apply>
               <cn cellml:units="msec">7</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>x_to_f</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xtoss</ci>
                  <ci>x_to_f</ci>
               </apply>
               <ci>tauxtof</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y_to_f</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ytoss</ci>
                  <ci>y_to_f</ci>
               </apply>
               <ci>tauytof</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_tof</ci>
            <apply>
               <times/>
               <ci>GtoFast</ci>
               <ci>x_to_f</ci>
               <ci>y_to_f</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ek</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_to</ci>
            <apply>
               <plus/>
               <ci>I_tos</ci>
               <ci>I_tof</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_Ki">
      <variable name="aki" units="dimensionless" public_interface="out"/>
      <variable name="bki" units="dimensionless" public_interface="out"/>
      <variable name="kiss" units="dimensionless" public_interface="out"/>
      <variable name="I_ki" units="uA_per_uF" public_interface="out"/>
      <variable name="V_m" units="mV" public_interface="in"/>
      <variable name="ek" units="mV" public_interface="in"/>
      <variable name="Ko" units="mM" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>aki</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1.02</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_mV">0.2385</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V_m</ci>
                              <ci>ek</ci>
                           </apply>
                           <cn cellml:units="mV">59.215</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>bki</ci>
            <apply>
               <divide/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.49124</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn cellml:units="per_mV">0.08032</cn>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V_m</ci>
                                 <cn cellml:units="mV">5.476</cn>
                              </apply>
                              <ci>ek</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_mV">0.06175</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V_m</ci>
                              <ci>ek</ci>
                           </apply>
                           <cn cellml:units="mV">594.31</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn cellml:units="per_mV">0.5143</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>V_m</ci>
                              <ci>ek</ci>
                           </apply>
                           <cn cellml:units="mV">4.753</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kiss</ci>
            <apply>
               <divide/>
               <ci>aki</ci>
               <apply>
                  <plus/>
                  <ci>aki</ci>
                  <ci>bki</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ki</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">1</cn>
               <cn cellml:units="mS_per_uF">0.35</cn>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn cellml:units="mM">5.4</cn>
                  </apply>
               </apply>
               <ci>kiss</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ek</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_ClCa">
      <variable name="I_ClCa_junc" units="uA_per_uF" public_interface="out"/>
      <variable name="I_ClCa_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_ClCa" units="uA_per_uF" public_interface="out"/>
      <variable name="I_Clbk" units="uA_per_uF" public_interface="out"/>
      <variable name="V_m" units="mV" public_interface="in"/>
      <variable name="ecl" units="mV" public_interface="in"/>
      <variable name="Fjunc" units="dimensionless" public_interface="in"/>
      <variable name="Fsl" units="dimensionless" public_interface="in"/>
      <variable name="GClCa" units="mS_per_uF" public_interface="in"/>
      <variable name="GClB" units="mS_per_uF" public_interface="in"/>
      <variable name="KdClCa" units="mM" public_interface="in"/>
      <variable name="Ca_sl" units="mM" public_interface="in"/>
      <variable name="Ca_j" units="mM" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_ClCa_junc</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Fjunc</ci>
                     <ci>GClCa</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>KdClCa</ci>
                        <ci>Ca_j</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ecl</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ClCa_sl</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Fsl</ci>
                     <ci>GClCa</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>KdClCa</ci>
                        <ci>Ca_sl</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ecl</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ClCa</ci>
            <apply>
               <plus/>
               <ci>I_ClCa_junc</ci>
               <ci>I_ClCa_sl</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Clbk</ci>
            <apply>
               <times/>
               <ci>GClB</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>ecl</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_Ca">
      <variable name="fss" units="dimensionless" public_interface="out"/>
      <variable name="dss" units="dimensionless" public_interface="out"/>
      <variable name="taud" units="msec" public_interface="out"/>
      <variable name="tauf" units="msec" public_interface="out"/>
      <variable name="d" units="dimensionless" initial_value="2.92407183949469e-6" public_interface="out"/>
      <variable name="f" units="dimensionless" initial_value="0.995135796703515" public_interface="out"/>
      <variable name="f_Ca_Bj" units="dimensionless" initial_value="0.0246760872105795" public_interface="out"/>
      <variable name="f_Ca_Bsl" units="dimensionless" initial_value="0.0152723084239416" public_interface="out"/>
      <variable name="fcaCaMSL" units="dimensionless" public_interface="out"/>
      <variable name="fcaCaj" units="dimensionless" public_interface="out"/>
      <variable name="ibarca_j" units="uA_per_uF" public_interface="out"/>
      <variable name="ibarca_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="ibark" units="uA_per_uF" public_interface="out"/>
      <variable name="ibarna_j" units="uA_per_uF" public_interface="out"/>
      <variable name="ibarna_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_Ca_junc" units="uA_per_uF" public_interface="out"/>
      <variable name="I_Ca_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_Ca" units="uA_per_uF" public_interface="out"/>
      <variable name="I_CaK" units="uA_per_uF" public_interface="out"/>
      <variable name="I_CaNa_junc" units="uA_per_uF" public_interface="out"/>
      <variable name="I_CaNa_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_CaNa" units="uA_per_uF" public_interface="out"/>
      <variable name="I_Catot" units="uA_per_uF" public_interface="out"/>
      <variable name="V_m" units="mV" public_interface="in"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="FoRT" units="per_mV" public_interface="in"/>
      <variable name="Frdy" units="coulomb_per_mole" public_interface="in"/>
      <variable name="Fjunc_CaL" units="dimensionless" public_interface="in"/>
      <variable name="Fsl_CaL" units="dimensionless" public_interface="in"/>
      <variable name="Q10CaL" units="dimensionless" public_interface="in"/>
      <variable name="Qpow" units="dimensionless" public_interface="in"/>
      <variable name="pCa" units="cm_per_sec" public_interface="in"/>
      <variable name="pK" units="cm_per_sec" public_interface="in"/>
      <variable name="pNa" units="cm_per_sec" public_interface="in"/>
      <variable name="Cao" units="mM" public_interface="in"/>
      <variable name="Nao" units="mM" public_interface="in"/>
      <variable name="Ko" units="mM" public_interface="in"/>
      <variable name="Ca_j" units="mM" public_interface="in"/>
      <variable name="Ca_sl" units="mM" public_interface="in"/>
      <variable name="Na_j" units="mM" public_interface="in"/>
      <variable name="Na_sl" units="mM" public_interface="in"/>
      <variable name="K_i" units="mM" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>fss</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V_m</ci>
                              <cn cellml:units="mV">35</cn>
                           </apply>
                           <cn cellml:units="mV">9</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">0.6</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <cn cellml:units="mV">50</cn>
                              <ci>V_m</ci>
                           </apply>
                           <cn cellml:units="mV">20</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dss</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V_m</ci>
                              <cn cellml:units="mV">5</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="mV">6</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>taud</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="msec">1</cn>
                  <ci>dss</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V_m</ci>
                                 <cn cellml:units="mV">5</cn>
                              </apply>
                           </apply>
                           <cn cellml:units="mV">6</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="per_mV">0.035</cn>
                  <apply>
                     <plus/>
                     <ci>V_m</ci>
                     <cn cellml:units="mV">5</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauf</ci>
            <apply>
               <divide/>
               <cn cellml:units="msec">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.0197</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="per_mV">0.0337</cn>
                                 <apply>
                                    <plus/>
                                    <ci>V_m</ci>
                                    <cn cellml:units="mV">14.5</cn>
                                 </apply>
                              </apply>
                              <cn cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">0.02</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>dss</ci>
                  <ci>d</ci>
               </apply>
               <ci>taud</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>fss</ci>
                  <ci>f</ci>
               </apply>
               <ci>tauf</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f_Ca_Bj</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_msec">1.7</cn>
                        <ci>Ca_j</ci>
                     </apply>
                     <cn cellml:units="mM">1</cn>
                  </apply>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>f_Ca_Bj</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn type="e-notation" cellml:units="per_msec">11.9   <sep/>
                  -3</cn>
                  <ci>f_Ca_Bj</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f_Ca_Bsl</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_msec">1.7</cn>
                        <ci>Ca_sl</ci>
                     </apply>
                     <cn cellml:units="mM">1</cn>
                  </apply>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>f_Ca_Bsl</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn type="e-notation" cellml:units="per_msec">11.9   <sep/>
                  -3</cn>
                  <ci>f_Ca_Bsl</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>fcaCaMSL</ci>
            <cn cellml:units="dimensionless">0</cn>
         </apply>
         <apply>
            <eq/>
            <ci>fcaCaj</ci>
            <cn cellml:units="dimensionless">0</cn>
         </apply>
         <apply>
            <eq/>
            <ci>ibarca_j</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>pCa</ci>
                  <cn cellml:units="correction_factor">4</cn>
                  <ci>V_m</ci>
                  <ci>Frdy</ci>
                  <ci>FoRT</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.341</cn>
                        <ci>Ca_j</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="dimensionless">2</cn>
                              <ci>V_m</ci>
                              <ci>FoRT</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.341</cn>
                        <ci>Cao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">2</cn>
                        <ci>V_m</ci>
                        <ci>FoRT</ci>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ibarca_sl</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>pCa</ci>
                  <cn cellml:units="correction_factor">4</cn>
                  <ci>V_m</ci>
                  <ci>Frdy</ci>
                  <ci>FoRT</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.341</cn>
                        <ci>Ca_sl</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="dimensionless">2</cn>
                              <ci>V_m</ci>
                              <ci>FoRT</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.341</cn>
                        <ci>Cao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">2</cn>
                        <ci>V_m</ci>
                        <ci>FoRT</ci>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ibark</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>pK</ci>
                  <ci>V_m</ci>
                  <ci>Frdy</ci>
                  <ci>FoRT</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn cellml:units="correction_factor">0.75</cn>
                        <ci>K_i</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <ci>V_m</ci>
                              <ci>FoRT</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn cellml:units="correction_factor">0.75</cn>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <ci>V_m</ci>
                        <ci>FoRT</ci>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ibarna_j</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>pNa</ci>
                  <ci>V_m</ci>
                  <ci>Frdy</ci>
                  <ci>FoRT</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn cellml:units="correction_factor">0.75</cn>
                        <ci>Na_j</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <ci>V_m</ci>
                              <ci>FoRT</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn cellml:units="correction_factor">0.75</cn>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <ci>V_m</ci>
                        <ci>FoRT</ci>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ibarna_sl</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>pNa</ci>
                  <ci>V_m</ci>
                  <ci>Frdy</ci>
                  <ci>FoRT</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn cellml:units="correction_factor">0.75</cn>
                        <ci>Na_sl</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <ci>V_m</ci>
                              <ci>FoRT</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn cellml:units="correction_factor">0.75</cn>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <ci>V_m</ci>
                        <ci>FoRT</ci>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Ca_junc</ci>
            <apply>
               <times/>
               <ci>Fjunc_CaL</ci>
               <ci>ibarca_j</ci>
               <ci>d</ci>
               <ci>f</ci>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>f_Ca_Bj</ci>
                  </apply>
                  <ci>fcaCaj</ci>
               </apply>
               <apply>
                  <power/>
                  <ci>Q10CaL</ci>
                  <ci>Qpow</ci>
               </apply>
               <cn cellml:units="dimensionless">0.45</cn>
               <cn cellml:units="dimensionless">1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Ca_sl</ci>
            <apply>
               <times/>
               <ci>Fsl_CaL</ci>
               <ci>ibarca_sl</ci>
               <ci>d</ci>
               <ci>f</ci>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>f_Ca_Bsl</ci>
                  </apply>
                  <ci>fcaCaMSL</ci>
               </apply>
               <apply>
                  <power/>
                  <ci>Q10CaL</ci>
                  <ci>Qpow</ci>
               </apply>
               <cn cellml:units="dimensionless">0.45</cn>
               <cn cellml:units="dimensionless">1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Ca</ci>
            <apply>
               <plus/>
               <ci>I_Ca_junc</ci>
               <ci>I_Ca_sl</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaK</ci>
            <apply>
               <times/>
               <ci>ibark</ci>
               <ci>d</ci>
               <ci>f</ci>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>Fjunc_CaL</ci>
                     <apply>
                        <plus/>
                        <ci>fcaCaj</ci>
                        <apply>
                           <minus/>
                           <cn cellml:units="dimensionless">1</cn>
                           <ci>f_Ca_Bj</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Fsl_CaL</ci>
                     <apply>
                        <plus/>
                        <ci>fcaCaMSL</ci>
                        <apply>
                           <minus/>
                           <cn cellml:units="dimensionless">1</cn>
                           <ci>f_Ca_Bsl</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <ci>Q10CaL</ci>
                  <ci>Qpow</ci>
               </apply>
               <cn cellml:units="dimensionless">0.45</cn>
               <cn cellml:units="dimensionless">1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaNa_junc</ci>
            <apply>
               <times/>
               <ci>Fjunc_CaL</ci>
               <ci>ibarna_j</ci>
               <ci>d</ci>
               <ci>f</ci>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>f_Ca_Bj</ci>
                  </apply>
                  <ci>fcaCaj</ci>
               </apply>
               <apply>
                  <power/>
                  <ci>Q10CaL</ci>
                  <ci>Qpow</ci>
               </apply>
               <cn cellml:units="dimensionless">0.45</cn>
               <cn cellml:units="dimensionless">1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaNa_sl</ci>
            <apply>
               <times/>
               <ci>Fsl_CaL</ci>
               <ci>ibarna_sl</ci>
               <ci>d</ci>
               <ci>f</ci>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>f_Ca_Bsl</ci>
                  </apply>
                  <ci>fcaCaMSL</ci>
               </apply>
               <apply>
                  <power/>
                  <ci>Q10CaL</ci>
                  <ci>Qpow</ci>
               </apply>
               <cn cellml:units="dimensionless">0.45</cn>
               <cn cellml:units="dimensionless">1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaNa</ci>
            <apply>
               <plus/>
               <ci>I_CaNa_junc</ci>
               <ci>I_CaNa_sl</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Catot</ci>
            <apply>
               <plus/>
               <ci>I_Ca</ci>
               <ci>I_CaK</ci>
               <ci>I_CaNa</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_NCX">
      <variable name="Ka_junc" units="dimensionless" public_interface="out"/>
      <variable name="Ka_sl" units="dimensionless" public_interface="out"/>
      <variable name="s1_junc" units="mM4" public_interface="out"/>
      <variable name="s1_sl" units="mM4" public_interface="out"/>
      <variable name="s2_junc" units="mM4" public_interface="out"/>
      <variable name="s3_junc" units="mM4" public_interface="out"/>
      <variable name="s2_sl" units="mM4" public_interface="out"/>
      <variable name="s3_sl" units="mM4" public_interface="out"/>
      <variable name="I_ncx_junc" units="uA_per_uF" public_interface="out"/>
      <variable name="I_ncx_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_ncx" units="uA_per_uF" public_interface="out"/>
      <variable name="V_m" units="mV" public_interface="in"/>
      <variable name="Cao" units="mM" public_interface="in"/>
      <variable name="Nao" units="mM" public_interface="in"/>
      <variable name="FoRT" units="per_mV" public_interface="in"/>
      <variable name="ksat" units="dimensionless" public_interface="in"/>
      <variable name="Kdact" units="mM" public_interface="in"/>
      <variable name="KmCai" units="mM" public_interface="in"/>
      <variable name="KmCao" units="mM" public_interface="in"/>
      <variable name="KmNai" units="mM" public_interface="in"/>
      <variable name="KmNao" units="mM" public_interface="in"/>
      <variable name="nu" units="dimensionless" public_interface="in"/>
      <variable name="Fjunc" units="dimensionless" public_interface="in"/>
      <variable name="Fsl" units="dimensionless" public_interface="in"/>
      <variable name="IbarNCX" units="uA_per_uF" public_interface="in"/>
      <variable name="Q10NCX" units="dimensionless" public_interface="in"/>
      <variable name="Qpow" units="dimensionless" public_interface="in"/>
      <variable name="Ca_sl" units="mM" public_interface="in"/>
      <variable name="Ca_j" units="mM" public_interface="in"/>
      <variable name="Na_j" units="mM" public_interface="in"/>
      <variable name="Na_sl" units="mM" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Ka_junc</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>Kdact</ci>
                        <ci>Ca_j</ci>
                     </apply>
                     <cn cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ka_sl</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>Kdact</ci>
                        <ci>Ca_sl</ci>
                     </apply>
                     <cn cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>s1_junc</ci>
            <apply>
               <times/>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <ci>nu</ci>
                     <ci>V_m</ci>
                     <ci>FoRT</ci>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <ci>Na_j</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
               <ci>Cao</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>s1_sl</ci>
            <apply>
               <times/>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <ci>nu</ci>
                     <ci>V_m</ci>
                     <ci>FoRT</ci>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <ci>Na_sl</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
               <ci>Cao</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>s2_junc</ci>
            <apply>
               <times/>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>nu</ci>
                        <cn cellml:units="dimensionless">1</cn>
                     </apply>
                     <ci>V_m</ci>
                     <ci>FoRT</ci>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <ci>Nao</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
               <ci>Ca_j</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>s3_junc</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>KmCai</ci>
                  <apply>
                     <power/>
                     <ci>Nao</ci>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Na_j</ci>
                           <ci>KmNai</ci>
                        </apply>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <ci>KmNao</ci>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
                  <ci>Ca_j</ci>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>Ca_j</ci>
                        <ci>KmCai</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>KmCao</ci>
                  <apply>
                     <power/>
                     <ci>Na_j</ci>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <ci>Na_j</ci>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
                  <ci>Cao</ci>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <ci>Nao</ci>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
                  <ci>Ca_j</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>s2_sl</ci>
            <apply>
               <times/>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>nu</ci>
                        <cn cellml:units="dimensionless">1</cn>
                     </apply>
                     <ci>V_m</ci>
                     <ci>FoRT</ci>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <ci>Nao</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
               <ci>Ca_sl</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>s3_sl</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>KmCai</ci>
                  <apply>
                     <power/>
                     <ci>Nao</ci>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Na_sl</ci>
                           <ci>KmNai</ci>
                        </apply>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <ci>KmNao</ci>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
                  <ci>Ca_sl</ci>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>Ca_sl</ci>
                        <ci>KmCai</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>KmCao</ci>
                  <apply>
                     <power/>
                     <ci>Na_sl</ci>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <ci>Na_sl</ci>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
                  <ci>Cao</ci>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <ci>Nao</ci>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
                  <ci>Ca_sl</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ncx_junc</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Fjunc</ci>
                     <ci>IbarNCX</ci>
                     <apply>
                        <power/>
                        <ci>Q10NCX</ci>
                        <ci>Qpow</ci>
                     </apply>
                     <ci>Ka_junc</ci>
                     <apply>
                        <minus/>
                        <ci>s1_junc</ci>
                        <ci>s2_junc</ci>
                     </apply>
                  </apply>
                  <ci>s3_junc</ci>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <ci>ksat</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>nu</ci>
                              <cn cellml:units="dimensionless">1</cn>
                           </apply>
                           <ci>V_m</ci>
                           <ci>FoRT</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ncx_sl</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Fsl</ci>
                     <ci>IbarNCX</ci>
                     <apply>
                        <power/>
                        <ci>Q10NCX</ci>
                        <ci>Qpow</ci>
                     </apply>
                     <ci>Ka_sl</ci>
                     <apply>
                        <minus/>
                        <ci>s1_sl</ci>
                        <ci>s2_sl</ci>
                     </apply>
                  </apply>
                  <ci>s3_sl</ci>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <ci>ksat</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>nu</ci>
                              <cn cellml:units="dimensionless">1</cn>
                           </apply>
                           <ci>V_m</ci>
                           <ci>FoRT</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ncx</ci>
            <apply>
               <plus/>
               <ci>I_ncx_junc</ci>
               <ci>I_ncx_sl</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_PCa">
      <variable name="I_pca_junc" units="uA_per_uF" public_interface="out"/>
      <variable name="I_pca_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_pca" units="uA_per_uF" public_interface="out"/>
      <variable name="IbarSLCaP" units="uA_per_uF" public_interface="in"/>
      <variable name="KmPCa" units="mM" public_interface="in"/>
      <variable name="Fjunc" units="dimensionless" public_interface="in"/>
      <variable name="Fsl" units="dimensionless" public_interface="in"/>
      <variable name="Q10SLCaP" units="dimensionless" public_interface="in"/>
      <variable name="Qpow" units="dimensionless" public_interface="in"/>
      <variable name="Ca_sl" units="mM" public_interface="in"/>
      <variable name="Ca_j" units="mM" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_pca_junc</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Fjunc</ci>
                  <apply>
                     <power/>
                     <ci>Q10SLCaP</ci>
                     <ci>Qpow</ci>
                  </apply>
                  <ci>IbarSLCaP</ci>
                  <apply>
                     <power/>
                     <ci>Ca_j</ci>
                     <cn cellml:units="dimensionless">1.6</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <power/>
                     <ci>KmPCa</ci>
                     <cn cellml:units="dimensionless">1.6</cn>
                  </apply>
                  <apply>
                     <power/>
                     <ci>Ca_j</ci>
                     <cn cellml:units="dimensionless">1.6</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_pca_sl</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Fsl</ci>
                  <apply>
                     <power/>
                     <ci>Q10SLCaP</ci>
                     <ci>Qpow</ci>
                  </apply>
                  <ci>IbarSLCaP</ci>
                  <apply>
                     <power/>
                     <ci>Ca_sl</ci>
                     <cn cellml:units="dimensionless">1.6</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <power/>
                     <ci>KmPCa</ci>
                     <cn cellml:units="dimensionless">1.6</cn>
                  </apply>
                  <apply>
                     <power/>
                     <ci>Ca_sl</ci>
                     <cn cellml:units="dimensionless">1.6</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_pca</ci>
            <apply>
               <plus/>
               <ci>I_pca_junc</ci>
               <ci>I_pca_sl</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="I_CaBK">
      <variable name="I_cabk_junc" units="uA_per_uF" public_interface="out"/>
      <variable name="I_cabk_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_cabk" units="uA_per_uF" public_interface="out"/>
      <variable name="V_m" units="mV" public_interface="in"/>
      <variable name="Fjunc" units="dimensionless" public_interface="in"/>
      <variable name="Fsl" units="dimensionless" public_interface="in"/>
      <variable name="GCaB" units="mS_per_uF" public_interface="in"/>
      <variable name="eca_junc" units="mV" public_interface="in"/>
      <variable name="eca_sl" units="mV" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_cabk_junc</ci>
            <apply>
               <times/>
               <ci>Fjunc</ci>
               <ci>GCaB</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>eca_junc</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_cabk_sl</ci>
            <apply>
               <times/>
               <ci>Fsl</ci>
               <ci>GCaB</ci>
               <apply>
                  <minus/>
                  <ci>V_m</ci>
                  <ci>eca_sl</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_cabk</ci>
            <apply>
               <plus/>
               <ci>I_cabk_junc</ci>
               <ci>I_cabk_sl</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="SR_Fluxes">
      <variable name="MaxSR" units="dimensionless" public_interface="out"/>
      <variable name="MinSR" units="dimensionless" public_interface="out"/>
      <variable name="kCaSR" units="dimensionless" public_interface="out"/>
      <variable name="koSRCa" units="per_mM2_per_msec" public_interface="out"/>
      <variable name="kiSRCa" units="per_mM_per_msec" public_interface="out"/>
      <variable name="RI" units="mM" public_interface="out"/>
      <variable name="Ry_Rr" units="mM" initial_value="0.890806040818203" public_interface="out"/>
      <variable name="Ry_Ro" units="mM" initial_value="7.40481128853622e-7" public_interface="out"/>
      <variable name="Ry_Ri" units="mM" initial_value="9.07666168960848e-8" public_interface="out"/>
      <variable name="J_SRCarel" units="mM_per_msec" public_interface="out"/>
      <variable name="J_serca" units="mM_per_msec" public_interface="out"/>
      <variable name="J_SRleak" units="mM_per_msec" public_interface="out"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="ec50SR" units="mM" public_interface="in"/>
      <variable name="koCa" units="per_mM2_per_msec" public_interface="in"/>
      <variable name="kiCa" units="per_mM_per_msec" public_interface="in"/>
      <variable name="kim" units="per_msec" public_interface="in"/>
      <variable name="kom" units="per_msec" public_interface="in"/>
      <variable name="ks" units="per_msec" public_interface="in"/>
      <variable name="Kmf" units="mM" public_interface="in"/>
      <variable name="Kmr" units="mM" public_interface="in"/>
      <variable name="Q10SRCaP" units="dimensionless" public_interface="in"/>
      <variable name="Qpow" units="dimensionless" public_interface="in"/>
      <variable name="Vmax_SRCaP" units="mM_per_msec" public_interface="in"/>
      <variable name="hillSRCaP" units="dimensionless" public_interface="in"/>
      <variable name="Ca_sr" units="mM" public_interface="in"/>
      <variable name="Ca_j" units="mM" public_interface="in"/>
      <variable name="Ca_i" units="mM" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>MaxSR</ci>
            <cn cellml:units="dimensionless">15</cn>
         </apply>
         <apply>
            <eq/>
            <ci>MinSR</ci>
            <cn cellml:units="dimensionless">1</cn>
         </apply>
         <apply>
            <eq/>
            <ci>kCaSR</ci>
            <apply>
               <minus/>
               <ci>MaxSR</ci>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>MaxSR</ci>
                     <ci>MinSR</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>ec50SR</ci>
                           <ci>Ca_sr</ci>
                        </apply>
                        <cn cellml:units="dimensionless">2.5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>koSRCa</ci>
            <apply>
               <divide/>
               <ci>koCa</ci>
               <ci>kCaSR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kiSRCa</ci>
            <apply>
               <times/>
               <ci>kiCa</ci>
               <ci>kCaSR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>RI</ci>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <cn cellml:units="mM">1</cn>
                     <ci>Ry_Rr</ci>
                  </apply>
                  <ci>Ry_Ro</ci>
               </apply>
               <ci>Ry_Ri</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ry_Rr</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kim</ci>
                     <ci>RI</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kiSRCa</ci>
                     <ci>Ca_j</ci>
                     <ci>Ry_Rr</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>koSRCa</ci>
                     <apply>
                        <power/>
                        <ci>Ca_j</ci>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                     <ci>Ry_Rr</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kom</ci>
                     <ci>Ry_Ro</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ry_Ro</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>koSRCa</ci>
                     <apply>
                        <power/>
                        <ci>Ca_j</ci>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                     <ci>Ry_Rr</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kom</ci>
                     <ci>Ry_Ro</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kiSRCa</ci>
                     <ci>Ca_j</ci>
                     <ci>Ry_Ro</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kim</ci>
                     <ci>Ry_Ri</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ry_Ri</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kiSRCa</ci>
                     <ci>Ca_j</ci>
                     <ci>Ry_Ro</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kim</ci>
                     <ci>Ry_Ri</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kom</ci>
                     <ci>Ry_Ri</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>koSRCa</ci>
                     <apply>
                        <power/>
                        <ci>Ca_j</ci>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                     <ci>RI</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_SRCarel</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>ks</ci>
                     <ci>Ry_Ro</ci>
                  </apply>
                  <cn cellml:units="mM">1</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>Ca_sr</ci>
                  <ci>Ca_j</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_serca</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <ci>Q10SRCaP</ci>
                     <ci>Qpow</ci>
                  </apply>
                  <ci>Vmax_SRCaP</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Ca_i</ci>
                           <ci>Kmf</ci>
                        </apply>
                        <ci>hillSRCaP</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Ca_sr</ci>
                           <ci>Kmr</ci>
                        </apply>
                        <ci>hillSRCaP</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>Ca_i</ci>
                        <ci>Kmf</ci>
                     </apply>
                     <ci>hillSRCaP</ci>
                  </apply>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>Ca_sr</ci>
                        <ci>Kmr</ci>
                     </apply>
                     <ci>hillSRCaP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_SRleak</ci>
            <apply>
               <times/>
               <cn type="e-notation" cellml:units="per_msec">5.348   <sep/>
               -6</cn>
               <apply>
                  <minus/>
                  <ci>Ca_sr</ci>
                  <ci>Ca_j</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Na_Buffers">
      <variable name="Na_Bj" units="mM" initial_value="3.4543773303328" public_interface="out"/>
      <variable name="Na_Bsl" units="mM" initial_value="0.753740951477775" public_interface="out"/>
      <variable name="dNa_Bj_dt" units="mM_per_msec" public_interface="out"/>
      <variable name="dNa_Bsl_dt" units="mM_per_msec" public_interface="out"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="kon_na" units="per_mM_per_msec" public_interface="in"/>
      <variable name="koff_na" units="per_msec" public_interface="in"/>
      <variable name="Bmax_Naj" units="mM" public_interface="in"/>
      <variable name="Bmax_Nasl" units="mM" public_interface="in"/>
      <variable name="Na_j" units="mM" public_interface="in"/>
      <variable name="Na_sl" units="mM" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Na_Bj</ci>
            </apply>
            <ci>dNa_Bj_dt</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNa_Bj_dt</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_na</ci>
                  <ci>Na_j</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_Naj</ci>
                     <ci>Na_Bj</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_na</ci>
                  <ci>Na_Bj</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Na_Bsl</ci>
            </apply>
            <ci>dNa_Bsl_dt</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dNa_Bsl_dt</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_na</ci>
                  <ci>Na_sl</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_Nasl</ci>
                     <ci>Na_Bsl</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_na</ci>
                  <ci>Na_Bsl</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Cytosolic_Ca_Buffers">
      <variable name="Tn_CL" units="mM" initial_value="0.00893455096919132" public_interface="out"/>
      <variable name="Tn_CHc" units="mM" initial_value="0.117412025936615" public_interface="out"/>
      <variable name="Tn_CHm" units="mM" initial_value="0.0106160166692932" public_interface="out"/>
      <variable name="CaM" units="mM" initial_value="0.000295573424135051" public_interface="out"/>
      <variable name="Myo_c" units="mM" initial_value="0.00192322252438022" public_interface="out"/>
      <variable name="Myo_m" units="mM" initial_value="0.137560495022823" public_interface="out"/>
      <variable name="SRB" units="mM" initial_value="0.00217360235649355" public_interface="out"/>
      <variable name="J_CaB_cytosol" units="mM_per_msec" public_interface="out"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="Bmax_TnClow" units="mM" public_interface="in"/>
      <variable name="Bmax_CaM" units="mM" public_interface="in"/>
      <variable name="Bmax_TnChigh" units="mM" public_interface="in"/>
      <variable name="Bmax_myosin" units="mM" public_interface="in"/>
      <variable name="Bmax_SR" units="mM" public_interface="in"/>
      <variable name="kon_cam" units="per_mM_per_msec" public_interface="in"/>
      <variable name="koff_cam" units="per_msec" public_interface="in"/>
      <variable name="kon_tncl" units="per_mM_per_msec" public_interface="in"/>
      <variable name="koff_tncl" units="per_msec" public_interface="in"/>
      <variable name="kon_tnchca" units="per_mM_per_msec" public_interface="in"/>
      <variable name="koff_tnchca" units="per_msec" public_interface="in"/>
      <variable name="kon_tnchmg" units="per_mM_per_msec" public_interface="in"/>
      <variable name="koff_tnchmg" units="per_msec" public_interface="in"/>
      <variable name="kon_myomg" units="per_mM_per_msec" public_interface="in"/>
      <variable name="koff_myomg" units="per_msec" public_interface="in"/>
      <variable name="kon_myoca" units="per_mM_per_msec" public_interface="in"/>
      <variable name="koff_myoca" units="per_msec" public_interface="in"/>
      <variable name="kon_sr" units="per_mM_per_msec" public_interface="in"/>
      <variable name="koff_sr" units="per_msec" public_interface="in"/>
      <variable name="Mgi" units="mM" public_interface="in"/>
      <variable name="Ca_i" units="mM" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Tn_CL</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_tncl</ci>
                  <ci>Ca_i</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_TnClow</ci>
                     <ci>Tn_CL</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_tncl</ci>
                  <ci>Tn_CL</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Tn_CHc</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_tnchca</ci>
                  <ci>Ca_i</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <ci>Bmax_TnChigh</ci>
                        <ci>Tn_CHc</ci>
                     </apply>
                     <ci>Tn_CHm</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_tnchca</ci>
                  <ci>Tn_CHc</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Tn_CHm</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_tnchmg</ci>
                  <ci>Mgi</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <ci>Bmax_TnChigh</ci>
                        <ci>Tn_CHc</ci>
                     </apply>
                     <ci>Tn_CHm</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_tnchmg</ci>
                  <ci>Tn_CHm</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CaM</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_cam</ci>
                  <ci>Ca_i</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_CaM</ci>
                     <ci>CaM</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_cam</ci>
                  <ci>CaM</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Myo_c</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_myoca</ci>
                  <ci>Ca_i</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <ci>Bmax_myosin</ci>
                        <ci>Myo_c</ci>
                     </apply>
                     <ci>Myo_m</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_myoca</ci>
                  <ci>Myo_c</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Myo_m</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_myomg</ci>
                  <ci>Mgi</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <ci>Bmax_myosin</ci>
                        <ci>Myo_c</ci>
                     </apply>
                     <ci>Myo_m</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_myomg</ci>
                  <ci>Myo_m</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>SRB</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_sr</ci>
                  <ci>Ca_i</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_SR</ci>
                     <ci>SRB</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_sr</ci>
                  <ci>SRB</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_CaB_cytosol</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <plus/>
                                       <apply>
                                          <minus/>
                                          <apply>
                                             <plus/>
                                             <apply>
                                                <minus/>
                                                <apply>
                                                   <times/>
                                                   <ci>kon_tncl</ci>
                                                   <ci>Ca_i</ci>
                                                   <apply>
                                                      <minus/>
                                                      <ci>Bmax_TnClow</ci>
                                                      <ci>Tn_CL</ci>
                                                   </apply>
                                                </apply>
                                                <apply>
                                                   <times/>
                                                   <ci>koff_tncl</ci>
                                                   <ci>Tn_CL</ci>
                                                </apply>
                                             </apply>
                                             <apply>
                                                <times/>
                                                <ci>kon_tnchca</ci>
                                                <ci>Ca_i</ci>
                                                <apply>
                                                   <minus/>
                                                   <apply>
                                                      <minus/>
                                                      <ci>Bmax_TnChigh</ci>
                                                      <ci>Tn_CHc</ci>
                                                   </apply>
                                                   <ci>Tn_CHm</ci>
                                                </apply>
                                             </apply>
                                          </apply>
                                          <apply>
                                             <times/>
                                             <ci>koff_tnchca</ci>
                                             <ci>Tn_CHc</ci>
                                          </apply>
                                       </apply>
                                       <apply>
                                          <times/>
                                          <ci>kon_tnchmg</ci>
                                          <ci>Mgi</ci>
                                          <apply>
                                             <minus/>
                                             <apply>
                                                <minus/>
                                                <ci>Bmax_TnChigh</ci>
                                                <ci>Tn_CHc</ci>
                                             </apply>
                                             <ci>Tn_CHm</ci>
                                          </apply>
                                       </apply>
                                    </apply>
                                    <apply>
                                       <times/>
                                       <ci>koff_tnchmg</ci>
                                       <ci>Tn_CHm</ci>
                                    </apply>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>kon_cam</ci>
                                    <ci>Ca_i</ci>
                                    <apply>
                                       <minus/>
                                       <ci>Bmax_CaM</ci>
                                       <ci>CaM</ci>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>koff_cam</ci>
                                 <ci>CaM</ci>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <ci>kon_myoca</ci>
                              <ci>Ca_i</ci>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>Bmax_myosin</ci>
                                    <ci>Myo_c</ci>
                                 </apply>
                                 <ci>Myo_m</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>koff_myoca</ci>
                           <ci>Myo_c</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>kon_myomg</ci>
                        <ci>Mgi</ci>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>Bmax_myosin</ci>
                              <ci>Myo_c</ci>
                           </apply>
                           <ci>Myo_m</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>koff_myomg</ci>
                     <ci>Myo_m</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kon_sr</ci>
                     <ci>Ca_i</ci>
                     <apply>
                        <minus/>
                        <ci>Bmax_SR</ci>
                        <ci>SRB</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>koff_sr</ci>
                     <ci>SRB</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Junctional_and_SL_Ca_Buffers">
      <variable name="SLL_j" units="mM" initial_value="0.00740524521680039" public_interface="out"/>
      <variable name="SLL_sl" units="mM" initial_value="0.00990339304377132" public_interface="out"/>
      <variable name="SLH_j" units="mM" initial_value="0.0735890020284214" public_interface="out"/>
      <variable name="SLH_sl" units="mM" initial_value="0.114583623436917" public_interface="out"/>
      <variable name="J_CaB_junction" units="mM_per_msec" public_interface="out"/>
      <variable name="J_CaB_sl" units="mM_per_msec" public_interface="out"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="Bmax_SLlowj" units="mM" public_interface="in"/>
      <variable name="Bmax_SLlowsl" units="mM" public_interface="in"/>
      <variable name="Bmax_SLhighj" units="mM" public_interface="in"/>
      <variable name="Bmax_SLhighsl" units="mM" public_interface="in"/>
      <variable name="kon_sll" units="per_mM_per_msec" public_interface="in"/>
      <variable name="koff_sll" units="per_msec" public_interface="in"/>
      <variable name="kon_slh" units="per_mM_per_msec" public_interface="in"/>
      <variable name="koff_slh" units="per_msec" public_interface="in"/>
      <variable name="Ca_j" units="mM" public_interface="in"/>
      <variable name="Ca_sl" units="mM" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>SLL_j</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_sll</ci>
                  <ci>Ca_j</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_SLlowj</ci>
                     <ci>SLL_j</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_sll</ci>
                  <ci>SLL_j</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>SLL_sl</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_sll</ci>
                  <ci>Ca_sl</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_SLlowsl</ci>
                     <ci>SLL_sl</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_sll</ci>
                  <ci>SLL_sl</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>SLH_j</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_slh</ci>
                  <ci>Ca_j</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_SLhighj</ci>
                     <ci>SLH_j</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_slh</ci>
                  <ci>SLH_j</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>SLH_sl</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_slh</ci>
                  <ci>Ca_sl</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_SLhighsl</ci>
                     <ci>SLH_sl</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_slh</ci>
                  <ci>SLH_sl</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_CaB_junction</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kon_sll</ci>
                     <ci>Ca_j</ci>
                     <apply>
                        <minus/>
                        <ci>Bmax_SLlowj</ci>
                        <ci>SLL_j</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>koff_sll</ci>
                     <ci>SLL_j</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kon_slh</ci>
                     <ci>Ca_j</ci>
                     <apply>
                        <minus/>
                        <ci>Bmax_SLhighj</ci>
                        <ci>SLH_j</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>koff_slh</ci>
                     <ci>SLH_j</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_CaB_sl</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kon_sll</ci>
                     <ci>Ca_sl</ci>
                     <apply>
                        <minus/>
                        <ci>Bmax_SLlowsl</ci>
                        <ci>SLL_sl</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>koff_sll</ci>
                     <ci>SLL_sl</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kon_slh</ci>
                     <ci>Ca_sl</ci>
                     <apply>
                        <minus/>
                        <ci>Bmax_SLhighsl</ci>
                        <ci>SLH_sl</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>koff_slh</ci>
                     <ci>SLH_sl</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="SR_Ca_Concentrations">
      <variable name="Csqn_b" units="mM" initial_value="1.19723145924432" public_interface="out"/>
      <variable name="Ca_sr" units="mM" initial_value="0.554760499828172" public_interface="out"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="Bmax_Csqn" units="mM" public_interface="in"/>
      <variable name="kon_csqn" units="per_mM_per_msec" public_interface="in"/>
      <variable name="koff_csqn" units="per_msec" public_interface="in"/>
      <variable name="Vmyo" units="liter" public_interface="in"/>
      <variable name="Vsr" units="liter" public_interface="in"/>
      <variable name="J_serca" units="mM_per_msec" public_interface="in"/>
      <variable name="J_SRleak" units="mM_per_msec" public_interface="in"/>
      <variable name="J_SRCarel" units="mM_per_msec" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Csqn_b</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_csqn</ci>
                  <ci>Ca_sr</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_Csqn</ci>
                     <ci>Csqn_b</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_csqn</ci>
                  <ci>Csqn_b</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_sr</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <ci>J_serca</ci>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>J_SRleak</ci>
                           <ci>Vmyo</ci>
                        </apply>
                        <ci>Vsr</ci>
                     </apply>
                     <ci>J_SRCarel</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kon_csqn</ci>
                     <ci>Ca_sr</ci>
                     <apply>
                        <minus/>
                        <ci>Bmax_Csqn</ci>
                        <ci>Csqn_b</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>koff_csqn</ci>
                     <ci>Csqn_b</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Na_Concentrations">
      <variable name="I_Na_tot_junc" units="uA_per_uF" public_interface="out"/>
      <variable name="I_Na_tot_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="I_Na_tot_sl2" units="uA_per_uF" public_interface="out"/>
      <variable name="I_Na_tot_junc2" units="uA_per_uF" public_interface="out"/>
      <variable name="Na_j" units="mM" initial_value="8.40537012592918" public_interface="out"/>
      <variable name="Na_sl" units="mM" initial_value="8.40491910001025" public_interface="out"/>
      <variable name="Na_i" units="mM" initial_value="8.40513364344858" public_interface="out"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="Cmem" units="farad" public_interface="in"/>
      <variable name="Frdy" units="coulomb_per_mole" public_interface="in"/>
      <variable name="J_na_juncsl" units="liters_per_msec" public_interface="in"/>
      <variable name="J_na_slmyo" units="liters_per_msec" public_interface="in"/>
      <variable name="Vjunc" units="liter" public_interface="in"/>
      <variable name="Vsl" units="liter" public_interface="in"/>
      <variable name="Vmyo" units="liter" public_interface="in"/>
      <variable name="I_Na_junc" units="uA_per_uF" public_interface="in"/>
      <variable name="I_nabk_junc" units="uA_per_uF" public_interface="in"/>
      <variable name="I_ncx_junc" units="uA_per_uF" public_interface="in"/>
      <variable name="I_nak_junc" units="uA_per_uF" public_interface="in"/>
      <variable name="I_CaNa_junc" units="uA_per_uF" public_interface="in"/>
      <variable name="I_Na_sl" units="uA_per_uF" public_interface="in"/>
      <variable name="I_nabk_sl" units="uA_per_uF" public_interface="in"/>
      <variable name="I_ncx_sl" units="uA_per_uF" public_interface="in"/>
      <variable name="I_nak_sl" units="uA_per_uF" public_interface="in"/>
      <variable name="I_CaNa_sl" units="uA_per_uF" public_interface="in"/>
      <variable name="dNa_Bj_dt" units="mM_per_msec" public_interface="in"/>
      <variable name="dNa_Bsl_dt" units="mM_per_msec" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_Na_tot_junc</ci>
            <apply>
               <plus/>
               <ci>I_Na_junc</ci>
               <ci>I_nabk_junc</ci>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">3</cn>
                  <ci>I_ncx_junc</ci>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">3</cn>
                  <ci>I_nak_junc</ci>
               </apply>
               <ci>I_CaNa_junc</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Na_tot_sl</ci>
            <apply>
               <plus/>
               <ci>I_Na_sl</ci>
               <ci>I_nabk_sl</ci>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">3</cn>
                  <ci>I_ncx_sl</ci>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">3</cn>
                  <ci>I_nak_sl</ci>
               </apply>
               <ci>I_CaNa_sl</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Na_tot_sl2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">3</cn>
                  <ci>I_ncx_sl</ci>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">3</cn>
                  <ci>I_nak_sl</ci>
               </apply>
               <ci>I_CaNa_sl</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Na_tot_junc2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">3</cn>
                  <ci>I_ncx_junc</ci>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">3</cn>
                  <ci>I_nak_junc</ci>
               </apply>
               <ci>I_CaNa_junc</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Na_j</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>I_Na_tot_junc</ci>
                        </apply>
                        <ci>Cmem</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Vjunc</ci>
                        <ci>Frdy</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <ci>J_na_juncsl</ci>
                        <ci>Vjunc</ci>
                     </apply>
                     <apply>
                        <minus/>
                        <ci>Na_sl</ci>
                        <ci>Na_j</ci>
                     </apply>
                  </apply>
               </apply>
               <ci>dNa_Bj_dt</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Na_sl</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>I_Na_tot_sl</ci>
                        </apply>
                        <ci>Cmem</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Vsl</ci>
                        <ci>Frdy</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <ci>J_na_juncsl</ci>
                        <ci>Vsl</ci>
                     </apply>
                     <apply>
                        <minus/>
                        <ci>Na_j</ci>
                        <ci>Na_sl</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <ci>J_na_slmyo</ci>
                        <ci>Vsl</ci>
                     </apply>
                     <apply>
                        <minus/>
                        <ci>Na_i</ci>
                        <ci>Na_sl</ci>
                     </apply>
                  </apply>
               </apply>
               <ci>dNa_Bsl_dt</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Na_i</ci>
            </apply>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <ci>J_na_slmyo</ci>
                  <ci>Vmyo</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>Na_sl</ci>
                  <ci>Na_i</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="K_Concentration">
      <variable name="I_K_tot" units="uA_per_uF" public_interface="out"/>
      <variable name="K_i" units="mM" initial_value="120" public_interface="out"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="I_to" units="uA_per_uF" public_interface="in"/>
      <variable name="I_kr" units="uA_per_uF" public_interface="in"/>
      <variable name="I_ks" units="uA_per_uF" public_interface="in"/>
      <variable name="I_ki" units="uA_per_uF" public_interface="in"/>
      <variable name="I_nak" units="uA_per_uF" public_interface="in"/>
      <variable name="I_CaK" units="uA_per_uF" public_interface="in"/>
      <variable name="I_kp" units="uA_per_uF" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_K_tot</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>I_to</ci>
                     <ci>I_kr</ci>
                     <ci>I_ks</ci>
                     <ci>I_ki</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">2</cn>
                     <ci>I_nak</ci>
                  </apply>
               </apply>
               <ci>I_CaK</ci>
               <ci>I_kp</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>K_i</ci>
            </apply>
            <cn cellml:units="mM_per_msec">0</cn>
         </apply>
      </math>
   </component>
   <component name="Ca_Concentrations">
      <variable name="I_Ca_tot_junc" units="uA_per_uF" public_interface="out"/>
      <variable name="I_Ca_tot_sl" units="uA_per_uF" public_interface="out"/>
      <variable name="Ca_j" units="mM" initial_value="0.000175882395147342" public_interface="out"/>
      <variable name="Ca_sl" units="mM" initial_value="0.000106779509977354" public_interface="out"/>
      <variable name="Ca_i" units="mM" initial_value="8.72509677797499e-5" public_interface="out"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="I_Ca_junc" units="uA_per_uF" public_interface="in"/>
      <variable name="I_cabk_junc" units="uA_per_uF" public_interface="in"/>
      <variable name="I_pca_junc" units="uA_per_uF" public_interface="in"/>
      <variable name="I_ncx_junc" units="uA_per_uF" public_interface="in"/>
      <variable name="I_Ca_sl" units="uA_per_uF" public_interface="in"/>
      <variable name="I_cabk_sl" units="uA_per_uF" public_interface="in"/>
      <variable name="I_pca_sl" units="uA_per_uF" public_interface="in"/>
      <variable name="I_ncx_sl" units="uA_per_uF" public_interface="in"/>
      <variable name="Cmem" units="farad" public_interface="in"/>
      <variable name="Vjunc" units="liter" public_interface="in"/>
      <variable name="Vsl" units="liter" public_interface="in"/>
      <variable name="Vsr" units="liter" public_interface="in"/>
      <variable name="Vmyo" units="liter" public_interface="in"/>
      <variable name="Frdy" units="coulomb_per_mole" public_interface="in"/>
      <variable name="J_CaB_junction" units="mM_per_msec" public_interface="in"/>
      <variable name="J_SRCarel" units="mM_per_msec" public_interface="in"/>
      <variable name="J_ca_juncsl" units="liters_per_msec" public_interface="in"/>
      <variable name="J_CaB_sl" units="mM_per_msec" public_interface="in"/>
      <variable name="J_ca_slmyo" units="liters_per_msec" public_interface="in"/>
      <variable name="J_serca" units="mM_per_msec" public_interface="in"/>
      <variable name="J_SRleak" units="mM_per_msec" public_interface="in"/>
      <variable name="J_CaB_cytosol" units="mM_per_msec" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_Ca_tot_junc</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>I_Ca_junc</ci>
                  <ci>I_cabk_junc</ci>
                  <ci>I_pca_junc</ci>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">2</cn>
                  <ci>I_ncx_junc</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Ca_tot_sl</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>I_Ca_sl</ci>
                  <ci>I_cabk_sl</ci>
                  <ci>I_pca_sl</ci>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">2</cn>
                  <ci>I_ncx_sl</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_j</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>I_Ca_tot_junc</ci>
                           </apply>
                           <ci>Cmem</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Vjunc</ci>
                           <cn cellml:units="dimensionless">2</cn>
                           <ci>Frdy</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <ci>J_ca_juncsl</ci>
                           <ci>Vjunc</ci>
                        </apply>
                        <apply>
                           <minus/>
                           <ci>Ca_sl</ci>
                           <ci>Ca_j</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>J_CaB_junction</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>J_SRCarel</ci>
                     <ci>Vsr</ci>
                  </apply>
                  <ci>Vjunc</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>J_SRleak</ci>
                     <ci>Vmyo</ci>
                  </apply>
                  <ci>Vjunc</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_sl</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>I_Ca_tot_sl</ci>
                        </apply>
                        <ci>Cmem</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Vsl</ci>
                        <cn cellml:units="dimensionless">2</cn>
                        <ci>Frdy</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <ci>J_ca_juncsl</ci>
                        <ci>Vsl</ci>
                     </apply>
                     <apply>
                        <minus/>
                        <ci>Ca_j</ci>
                        <ci>Ca_sl</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <ci>J_ca_slmyo</ci>
                        <ci>Vsl</ci>
                     </apply>
                     <apply>
                        <minus/>
                        <ci>Ca_i</ci>
                        <ci>Ca_sl</ci>
                     </apply>
                  </apply>
               </apply>
               <ci>J_CaB_sl</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_i</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>J_serca</ci>
                        </apply>
                        <ci>Vsr</ci>
                     </apply>
                     <ci>Vmyo</ci>
                  </apply>
                  <ci>J_CaB_cytosol</ci>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>J_ca_slmyo</ci>
                     <ci>Vmyo</ci>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>Ca_sl</ci>
                     <ci>Ca_i</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="membrane_potential">
      <variable name="I_Na_tot" units="uA_per_uF"/>
      <variable name="I_Cl_tot" units="uA_per_uF"/>
      <variable name="I_Ca_tot" units="uA_per_uF"/>
      <variable name="I_tot" units="uA_per_uF"/>
      <variable name="V_m" units="mV" initial_value="-81.4552030512661" public_interface="out"/>
      <variable name="time" units="msec" public_interface="in"/>
      <variable name="I_Na_tot_junc" units="uA_per_uF" public_interface="in"/>
      <variable name="I_Na_tot_sl" units="uA_per_uF" public_interface="in"/>
      <variable name="I_ClCa" units="uA_per_uF" public_interface="in"/>
      <variable name="I_Clbk" units="uA_per_uF" public_interface="in"/>
      <variable name="I_Ca_tot_junc" units="uA_per_uF" public_interface="in"/>
      <variable name="I_Ca_tot_sl" units="uA_per_uF" public_interface="in"/>
      <variable name="I_K_tot" units="uA_per_uF" public_interface="in"/>
      <variable name="i_Stim" units="uA_per_uF"/>
      <variable name="stim_start" units="msec" initial_value="10"/>
      <variable name="stim_period" units="msec" initial_value="1000"/>
      <variable name="stim_duration" units="msec" initial_value="5"/>
      <variable name="stim_amplitude" units="uA_per_uF" initial_value="9.5"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Stim</ci>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <ci>stim_amplitude</ci>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <geq/>
                        <apply>
                           <minus/>
                           <ci>time</ci>
                           <apply>
                              <times/>
                              <apply>
                                 <floor/>
                                 <apply>
                                    <divide/>
                                    <ci>time</ci>
                                    <ci>stim_period</ci>
                                 </apply>
                              </apply>
                              <ci>stim_period</ci>
                           </apply>
                        </apply>
                        <ci>stim_start</ci>
                     </apply>
                     <apply>
                        <leq/>
                        <apply>
                           <minus/>
                           <ci>time</ci>
                           <apply>
                              <times/>
                              <apply>
                                 <floor/>
                                 <apply>
                                    <divide/>
                                    <ci>time</ci>
                                    <ci>stim_period</ci>
                                 </apply>
                              </apply>
                              <ci>stim_period</ci>
                           </apply>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>stim_start</ci>
                           <ci>stim_duration</ci>
                        </apply>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="uA_per_uF">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>I_Na_tot</ci>
            <apply>
               <plus/>
               <ci>I_Na_tot_junc</ci>
               <ci>I_Na_tot_sl</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Cl_tot</ci>
            <apply>
               <plus/>
               <ci>I_ClCa</ci>
               <ci>I_Clbk</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_Ca_tot</ci>
            <apply>
               <plus/>
               <ci>I_Ca_tot_junc</ci>
               <ci>I_Ca_tot_sl</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_tot</ci>
            <apply>
               <plus/>
               <ci>I_Na_tot</ci>
               <ci>I_Cl_tot</ci>
               <ci>I_Ca_tot</ci>
               <ci>I_K_tot</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>V_m</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>I_tot</ci>
                  <ci>i_Stim</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="interface">
         <component_ref component="parameters"/>
         <component_ref component="I_Na"/>
         <component_ref component="I_NaBK"/>
         <component_ref component="I_NaK"/>
         <component_ref component="I_Kr"/>
         <component_ref component="I_Kp"/>
         <component_ref component="I_Ks"/>
         <component_ref component="I_to"/>
         <component_ref component="I_Ki"/>
         <component_ref component="I_ClCa"/>
         <component_ref component="I_Ca"/>
         <component_ref component="I_NCX"/>
         <component_ref component="I_PCa"/>
         <component_ref component="I_CaBK"/>
         <component_ref component="SR_Fluxes"/>
         <component_ref component="Na_Buffers"/>
         <component_ref component="Cytosolic_Ca_Buffers"/>
         <component_ref component="Junctional_and_SL_Ca_Buffers"/>
         <component_ref component="SR_Ca_Concentrations"/>
         <component_ref component="Na_Concentrations"/>
         <component_ref component="K_Concentration"/>
         <component_ref component="Ca_Concentrations"/>
         <component_ref component="membrane_potential"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="interface" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="interface" component_2="membrane_potential"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
   </connection>
   <connection>
      <map_components component_1="I_Na" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="I_Na" component_2="parameters"/>
      <map_variables variable_1="Fjunc" variable_2="Fjunc"/>
      <map_variables variable_1="Fsl" variable_2="Fsl"/>
      <map_variables variable_1="GNa" variable_2="GNa"/>
      <map_variables variable_1="ena_junc" variable_2="ena_junc"/>
      <map_variables variable_1="ena_sl" variable_2="ena_sl"/>
   </connection>
   <connection>
      <map_components component_1="I_Na" component_2="membrane_potential"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
   </connection>
   <connection>
      <map_components component_1="I_NaBK" component_2="parameters"/>
      <map_variables variable_1="Fjunc" variable_2="Fjunc"/>
      <map_variables variable_1="Fsl" variable_2="Fsl"/>
      <map_variables variable_1="GNaB" variable_2="GNaB"/>
      <map_variables variable_1="ena_junc" variable_2="ena_junc"/>
      <map_variables variable_1="ena_sl" variable_2="ena_sl"/>
   </connection>
   <connection>
      <map_components component_1="I_NaBK" component_2="membrane_potential"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
   </connection>
   <connection>
      <map_components component_1="I_NaK" component_2="parameters"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="FoRT" variable_2="FoRT"/>
      <map_variables variable_1="Fjunc" variable_2="Fjunc"/>
      <map_variables variable_1="Fsl" variable_2="Fsl"/>
      <map_variables variable_1="IbarNaK" variable_2="IbarNaK"/>
      <map_variables variable_1="KmKo" variable_2="KmKo"/>
      <map_variables variable_1="KmNaip" variable_2="KmNaip"/>
   </connection>
   <connection>
      <map_components component_1="I_NaK" component_2="Na_Concentrations"/>
      <map_variables variable_1="Na_j" variable_2="Na_j"/>
      <map_variables variable_1="Na_sl" variable_2="Na_sl"/>
      <map_variables variable_1="I_nak_junc" variable_2="I_nak_junc"/>
      <map_variables variable_1="I_nak_sl" variable_2="I_nak_sl"/>
   </connection>
   <connection>
      <map_components component_1="I_NaK" component_2="membrane_potential"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
   </connection>
   <connection>
      <map_components component_1="I_Kr" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="I_Kr" component_2="parameters"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="ek" variable_2="ek"/>
   </connection>
   <connection>
      <map_components component_1="I_Kr" component_2="membrane_potential"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
   </connection>
   <connection>
      <map_components component_1="I_Kp" component_2="parameters"/>
      <map_variables variable_1="Fjunc" variable_2="Fjunc"/>
      <map_variables variable_1="Fsl" variable_2="Fsl"/>
      <map_variables variable_1="ek" variable_2="ek"/>
      <map_variables variable_1="gkp" variable_2="gkp"/>
   </connection>
   <connection>
      <map_components component_1="I_Kp" component_2="membrane_potential"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
   </connection>
   <connection>
      <map_components component_1="I_Ks" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="I_Ks" component_2="parameters"/>
      <map_variables variable_1="FoRT" variable_2="FoRT"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="pNaK" variable_2="pNaK"/>
      <map_variables variable_1="Fjunc" variable_2="Fjunc"/>
      <map_variables variable_1="Fsl" variable_2="Fsl"/>
   </connection>
   <connection>
      <map_components component_1="I_Ks" component_2="Na_Concentrations"/>
      <map_variables variable_1="Na_i" variable_2="Na_i"/>
   </connection>
   <connection>
      <map_components component_1="I_Ks" component_2="K_Concentration"/>
      <map_variables variable_1="K_i" variable_2="K_i"/>
      <map_variables variable_1="I_ks" variable_2="I_ks"/>
   </connection>
   <connection>
      <map_components component_1="I_Ks" component_2="membrane_potential"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
   </connection>
   <connection>
      <map_components component_1="I_to" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="I_to" component_2="parameters"/>
      <map_variables variable_1="epi" variable_2="epi"/>
      <map_variables variable_1="ek" variable_2="ek"/>
   </connection>
   <connection>
      <map_components component_1="I_to" component_2="membrane_potential"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
   </connection>
   <connection>
      <map_components component_1="I_Ki" component_2="parameters"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="ek" variable_2="ek"/>
   </connection>
   <connection>
      <map_components component_1="I_Ki" component_2="membrane_potential"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
   </connection>
   <connection>
      <map_components component_1="I_ClCa" component_2="parameters"/>
      <map_variables variable_1="ecl" variable_2="ecl"/>
      <map_variables variable_1="Fjunc" variable_2="Fjunc"/>
      <map_variables variable_1="Fsl" variable_2="Fsl"/>
      <map_variables variable_1="GClCa" variable_2="GClCa"/>
      <map_variables variable_1="GClB" variable_2="GClB"/>
      <map_variables variable_1="KdClCa" variable_2="KdClCa"/>
   </connection>
   <connection>
      <map_components component_1="I_ClCa" component_2="Ca_Concentrations"/>
      <map_variables variable_1="Ca_sl" variable_2="Ca_sl"/>
      <map_variables variable_1="Ca_j" variable_2="Ca_j"/>
   </connection>
   <connection>
      <map_components component_1="I_ClCa" component_2="membrane_potential"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
      <map_variables variable_1="I_ClCa" variable_2="I_ClCa"/>
      <map_variables variable_1="I_Clbk" variable_2="I_Clbk"/>
   </connection>
   <connection>
      <map_components component_1="I_Ca" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="I_Ca" component_2="parameters"/>
      <map_variables variable_1="FoRT" variable_2="FoRT"/>
      <map_variables variable_1="Frdy" variable_2="Frdy"/>
      <map_variables variable_1="Fjunc_CaL" variable_2="Fjunc_CaL"/>
      <map_variables variable_1="Fsl_CaL" variable_2="Fsl_CaL"/>
      <map_variables variable_1="Q10CaL" variable_2="Q10CaL"/>
      <map_variables variable_1="Qpow" variable_2="Qpow"/>
      <map_variables variable_1="pCa" variable_2="pCa"/>
      <map_variables variable_1="pK" variable_2="pK"/>
      <map_variables variable_1="pNa" variable_2="pNa"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
   </connection>
   <connection>
      <map_components component_1="I_Ca" component_2="Na_Concentrations"/>
      <map_variables variable_1="Na_j" variable_2="Na_j"/>
      <map_variables variable_1="Na_sl" variable_2="Na_sl"/>
      <map_variables variable_1="I_CaNa_junc" variable_2="I_CaNa_junc"/>
      <map_variables variable_1="I_CaNa_sl" variable_2="I_CaNa_sl"/>
   </connection>
   <connection>
      <map_components component_1="I_Ca" component_2="Ca_Concentrations"/>
      <map_variables variable_1="Ca_j" variable_2="Ca_j"/>
      <map_variables variable_1="Ca_sl" variable_2="Ca_sl"/>
      <map_variables variable_1="I_Ca_junc" variable_2="I_Ca_junc"/>
      <map_variables variable_1="I_Ca_sl" variable_2="I_Ca_sl"/>
   </connection>
   <connection>
      <map_components component_1="I_Ca" component_2="K_Concentration"/>
      <map_variables variable_1="K_i" variable_2="K_i"/>
      <map_variables variable_1="I_CaK" variable_2="I_CaK"/>
   </connection>
   <connection>
      <map_components component_1="I_Ca" component_2="membrane_potential"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
   </connection>
   <connection>
      <map_components component_1="I_NCX" component_2="parameters"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="FoRT" variable_2="FoRT"/>
      <map_variables variable_1="ksat" variable_2="ksat"/>
      <map_variables variable_1="Kdact" variable_2="Kdact"/>
      <map_variables variable_1="KmCai" variable_2="KmCai"/>
      <map_variables variable_1="KmCao" variable_2="KmCao"/>
      <map_variables variable_1="KmNai" variable_2="KmNai"/>
      <map_variables variable_1="KmNao" variable_2="KmNao"/>
      <map_variables variable_1="nu" variable_2="nu"/>
      <map_variables variable_1="Fjunc" variable_2="Fjunc"/>
      <map_variables variable_1="Fsl" variable_2="Fsl"/>
      <map_variables variable_1="IbarNCX" variable_2="IbarNCX"/>
      <map_variables variable_1="Q10NCX" variable_2="Q10NCX"/>
      <map_variables variable_1="Qpow" variable_2="Qpow"/>
   </connection>
   <connection>
      <map_components component_1="I_NCX" component_2="Ca_Concentrations"/>
      <map_variables variable_1="Ca_sl" variable_2="Ca_sl"/>
      <map_variables variable_1="Ca_j" variable_2="Ca_j"/>
      <map_variables variable_1="I_ncx_sl" variable_2="I_ncx_sl"/>
      <map_variables variable_1="I_ncx_junc" variable_2="I_ncx_junc"/>
   </connection>
   <connection>
      <map_components component_1="I_NCX" component_2="Na_Concentrations"/>
      <map_variables variable_1="Na_j" variable_2="Na_j"/>
      <map_variables variable_1="Na_sl" variable_2="Na_sl"/>
      <map_variables variable_1="I_ncx_junc" variable_2="I_ncx_junc"/>
      <map_variables variable_1="I_ncx_sl" variable_2="I_ncx_sl"/>
   </connection>
   <connection>
      <map_components component_1="I_NCX" component_2="membrane_potential"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
   </connection>
   <connection>
      <map_components component_1="I_PCa" component_2="parameters"/>
      <map_variables variable_1="IbarSLCaP" variable_2="IbarSLCaP"/>
      <map_variables variable_1="KmPCa" variable_2="KmPCa"/>
      <map_variables variable_1="Fjunc" variable_2="Fjunc"/>
      <map_variables variable_1="Fsl" variable_2="Fsl"/>
      <map_variables variable_1="Q10SLCaP" variable_2="Q10SLCaP"/>
      <map_variables variable_1="Qpow" variable_2="Qpow"/>
   </connection>
   <connection>
      <map_components component_1="I_PCa" component_2="Ca_Concentrations"/>
      <map_variables variable_1="Ca_sl" variable_2="Ca_sl"/>
      <map_variables variable_1="Ca_j" variable_2="Ca_j"/>
      <map_variables variable_1="I_pca_junc" variable_2="I_pca_junc"/>
      <map_variables variable_1="I_pca_sl" variable_2="I_pca_sl"/>
   </connection>
   <connection>
      <map_components component_1="I_CaBK" component_2="parameters"/>
      <map_variables variable_1="Fjunc" variable_2="Fjunc"/>
      <map_variables variable_1="Fsl" variable_2="Fsl"/>
      <map_variables variable_1="GCaB" variable_2="GCaB"/>
      <map_variables variable_1="eca_junc" variable_2="eca_junc"/>
      <map_variables variable_1="eca_sl" variable_2="eca_sl"/>
   </connection>
   <connection>
      <map_components component_1="I_CaBK" component_2="membrane_potential"/>
      <map_variables variable_1="V_m" variable_2="V_m"/>
   </connection>
   <connection>
      <map_components component_1="SR_Fluxes" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="SR_Fluxes" component_2="parameters"/>
      <map_variables variable_1="ec50SR" variable_2="ec50SR"/>
      <map_variables variable_1="koCa" variable_2="koCa"/>
      <map_variables variable_1="kiCa" variable_2="kiCa"/>
      <map_variables variable_1="kim" variable_2="kim"/>
      <map_variables variable_1="kom" variable_2="kom"/>
      <map_variables variable_1="ks" variable_2="ks"/>
      <map_variables variable_1="Kmf" variable_2="Kmf"/>
      <map_variables variable_1="Kmr" variable_2="Kmr"/>
      <map_variables variable_1="Q10SRCaP" variable_2="Q10SRCaP"/>
      <map_variables variable_1="Qpow" variable_2="Qpow"/>
      <map_variables variable_1="Vmax_SRCaP" variable_2="Vmax_SRCaP"/>
      <map_variables variable_1="hillSRCaP" variable_2="hillSRCaP"/>
   </connection>
   <connection>
      <map_components component_1="SR_Fluxes" component_2="Ca_Concentrations"/>
      <map_variables variable_1="Ca_j" variable_2="Ca_j"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
      <map_variables variable_1="J_SRCarel" variable_2="J_SRCarel"/>
      <map_variables variable_1="J_serca" variable_2="J_serca"/>
      <map_variables variable_1="J_SRleak" variable_2="J_SRleak"/>
   </connection>
   <connection>
      <map_components component_1="SR_Fluxes" component_2="SR_Ca_Concentrations"/>
      <map_variables variable_1="Ca_sr" variable_2="Ca_sr"/>
      <map_variables variable_1="J_serca" variable_2="J_serca"/>
      <map_variables variable_1="J_SRleak" variable_2="J_SRleak"/>
      <map_variables variable_1="J_SRCarel" variable_2="J_SRCarel"/>
   </connection>
   <connection>
      <map_components component_1="Na_Buffers" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Na_Buffers" component_2="parameters"/>
      <map_variables variable_1="kon_na" variable_2="kon_na"/>
      <map_variables variable_1="koff_na" variable_2="koff_na"/>
      <map_variables variable_1="Bmax_Naj" variable_2="Bmax_Naj"/>
      <map_variables variable_1="Bmax_Nasl" variable_2="Bmax_Nasl"/>
   </connection>
   <connection>
      <map_components component_1="Na_Buffers" component_2="Na_Concentrations"/>
      <map_variables variable_1="Na_j" variable_2="Na_j"/>
      <map_variables variable_1="Na_sl" variable_2="Na_sl"/>
      <map_variables variable_1="dNa_Bsl_dt" variable_2="dNa_Bsl_dt"/>
      <map_variables variable_1="dNa_Bj_dt" variable_2="dNa_Bj_dt"/>
   </connection>
   <connection>
      <map_components component_1="Cytosolic_Ca_Buffers" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Cytosolic_Ca_Buffers" component_2="parameters"/>
      <map_variables variable_1="Bmax_TnClow" variable_2="Bmax_TnClow"/>
      <map_variables variable_1="Bmax_CaM" variable_2="Bmax_CaM"/>
      <map_variables variable_1="Bmax_TnChigh" variable_2="Bmax_TnChigh"/>
      <map_variables variable_1="Bmax_myosin" variable_2="Bmax_myosin"/>
      <map_variables variable_1="Bmax_SR" variable_2="Bmax_SR"/>
      <map_variables variable_1="kon_cam" variable_2="kon_cam"/>
      <map_variables variable_1="koff_cam" variable_2="koff_cam"/>
      <map_variables variable_1="kon_tncl" variable_2="kon_tncl"/>
      <map_variables variable_1="koff_tncl" variable_2="koff_tncl"/>
      <map_variables variable_1="kon_tnchca" variable_2="kon_tnchca"/>
      <map_variables variable_1="koff_tnchca" variable_2="koff_tnchca"/>
      <map_variables variable_1="kon_tnchmg" variable_2="kon_tnchmg"/>
      <map_variables variable_1="koff_tnchmg" variable_2="koff_tnchmg"/>
      <map_variables variable_1="kon_myomg" variable_2="kon_myomg"/>
      <map_variables variable_1="koff_myomg" variable_2="koff_myomg"/>
      <map_variables variable_1="kon_myoca" variable_2="kon_myoca"/>
      <map_variables variable_1="koff_myoca" variable_2="koff_myoca"/>
      <map_variables variable_1="kon_sr" variable_2="kon_sr"/>
      <map_variables variable_1="koff_sr" variable_2="koff_sr"/>
      <map_variables variable_1="Mgi" variable_2="Mgi"/>
   </connection>
   <connection>
      <map_components component_1="Cytosolic_Ca_Buffers" component_2="Ca_Concentrations"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
      <map_variables variable_1="J_CaB_cytosol" variable_2="J_CaB_cytosol"/>
   </connection>
   <connection>
      <map_components component_1="Junctional_and_SL_Ca_Buffers" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Junctional_and_SL_Ca_Buffers" component_2="parameters"/>
      <map_variables variable_1="Bmax_SLlowj" variable_2="Bmax_SLlowj"/>
      <map_variables variable_1="Bmax_SLlowsl" variable_2="Bmax_SLlowsl"/>
      <map_variables variable_1="Bmax_SLhighj" variable_2="Bmax_SLhighj"/>
      <map_variables variable_1="Bmax_SLhighsl" variable_2="Bmax_SLhighsl"/>
      <map_variables variable_1="kon_sll" variable_2="kon_sll"/>
      <map_variables variable_1="koff_sll" variable_2="koff_sll"/>
      <map_variables variable_1="kon_slh" variable_2="kon_slh"/>
      <map_variables variable_1="koff_slh" variable_2="koff_slh"/>
   </connection>
   <connection>
      <map_components component_1="Junctional_and_SL_Ca_Buffers" component_2="Ca_Concentrations"/>
      <map_variables variable_1="Ca_j" variable_2="Ca_j"/>
      <map_variables variable_1="Ca_sl" variable_2="Ca_sl"/>
      <map_variables variable_1="J_CaB_sl" variable_2="J_CaB_sl"/>
      <map_variables variable_1="J_CaB_junction" variable_2="J_CaB_junction"/>
   </connection>
   <connection>
      <map_components component_1="SR_Ca_Concentrations" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="SR_Ca_Concentrations" component_2="parameters"/>
      <map_variables variable_1="Bmax_Csqn" variable_2="Bmax_Csqn"/>
      <map_variables variable_1="kon_csqn" variable_2="kon_csqn"/>
      <map_variables variable_1="koff_csqn" variable_2="koff_csqn"/>
      <map_variables variable_1="Vmyo" variable_2="Vmyo"/>
      <map_variables variable_1="Vsr" variable_2="Vsr"/>
   </connection>
   <connection>
      <map_components component_1="Na_Concentrations" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Na_Concentrations" component_2="parameters"/>
      <map_variables variable_1="Cmem" variable_2="Cmem"/>
      <map_variables variable_1="Frdy" variable_2="Frdy"/>
      <map_variables variable_1="J_na_juncsl" variable_2="J_na_juncsl"/>
      <map_variables variable_1="J_na_slmyo" variable_2="J_na_slmyo"/>
      <map_variables variable_1="Vjunc" variable_2="Vjunc"/>
      <map_variables variable_1="Vsl" variable_2="Vsl"/>
      <map_variables variable_1="Vmyo" variable_2="Vmyo"/>
      <map_variables variable_1="Na_j" variable_2="Na_j"/>
      <map_variables variable_1="Na_sl" variable_2="Na_sl"/>
   </connection>
   <connection>
      <map_components component_1="Na_Concentrations" component_2="I_Na"/>
      <map_variables variable_1="I_Na_junc" variable_2="I_Na_junc"/>
      <map_variables variable_1="I_Na_sl" variable_2="I_Na_sl"/>
   </connection>
   <connection>
      <map_components component_1="Na_Concentrations" component_2="I_NaBK"/>
      <map_variables variable_1="I_nabk_junc" variable_2="I_nabk_junc"/>
      <map_variables variable_1="I_nabk_sl" variable_2="I_nabk_sl"/>
   </connection>
   <connection>
      <map_components component_1="K_Concentration" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="K_Concentration" component_2="parameters"/>
      <map_variables variable_1="K_i" variable_2="K_i"/>
   </connection>
   <connection>
      <map_components component_1="K_Concentration" component_2="I_to"/>
      <map_variables variable_1="I_to" variable_2="I_to"/>
   </connection>
   <connection>
      <map_components component_1="K_Concentration" component_2="I_Ki"/>
      <map_variables variable_1="I_ki" variable_2="I_ki"/>
   </connection>
   <connection>
      <map_components component_1="K_Concentration" component_2="I_Kr"/>
      <map_variables variable_1="I_kr" variable_2="I_kr"/>
   </connection>
   <connection>
      <map_components component_1="K_Concentration" component_2="I_NaK"/>
      <map_variables variable_1="I_nak" variable_2="I_nak"/>
   </connection>
   <connection>
      <map_components component_1="K_Concentration" component_2="I_Kp"/>
      <map_variables variable_1="I_kp" variable_2="I_kp"/>
   </connection>
   <connection>
      <map_components component_1="Ca_Concentrations" component_2="interface"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_Concentrations" component_2="parameters"/>
      <map_variables variable_1="Cmem" variable_2="Cmem"/>
      <map_variables variable_1="Vjunc" variable_2="Vjunc"/>
      <map_variables variable_1="Vsl" variable_2="Vsl"/>
      <map_variables variable_1="Vsr" variable_2="Vsr"/>
      <map_variables variable_1="Vmyo" variable_2="Vmyo"/>
      <map_variables variable_1="Frdy" variable_2="Frdy"/>
      <map_variables variable_1="J_ca_juncsl" variable_2="J_ca_juncsl"/>
      <map_variables variable_1="J_ca_slmyo" variable_2="J_ca_slmyo"/>
      <map_variables variable_1="Ca_j" variable_2="Ca_j"/>
      <map_variables variable_1="Ca_sl" variable_2="Ca_sl"/>
   </connection>
   <connection>
      <map_components component_1="Ca_Concentrations" component_2="I_CaBK"/>
      <map_variables variable_1="I_cabk_sl" variable_2="I_cabk_sl"/>
      <map_variables variable_1="I_cabk_junc" variable_2="I_cabk_junc"/>
   </connection>
   <connection>
      <map_components component_1="membrane_potential" component_2="Na_Concentrations"/>
      <map_variables variable_1="I_Na_tot_junc" variable_2="I_Na_tot_junc"/>
      <map_variables variable_1="I_Na_tot_sl" variable_2="I_Na_tot_sl"/>
   </connection>
   <connection>
      <map_components component_1="membrane_potential" component_2="K_Concentration"/>
      <map_variables variable_1="I_K_tot" variable_2="I_K_tot"/>
   </connection>
   <connection>
      <map_components component_1="membrane_potential" component_2="Ca_Concentrations"/>
      <map_variables variable_1="I_Ca_tot_junc" variable_2="I_Ca_tot_junc"/>
      <map_variables variable_1="I_Ca_tot_sl" variable_2="I_Ca_tot_sl"/>
   </connection>
</model>