- Author:
- Tommy Yu <tommy.yu@auckland.ac.nz>
- Date:
- 2010-08-25 18:18:46+12:00
- Desc:
- xml:base fix
- Permanent Source URI:
- https://models.cellml.org/workspace/guyton_antidiuretic_hormone_2008/rawfile/248aa91939ca186a4a29f8ba0c3bdfdf6d8a7a52/antidiuretic_hormone.cellml
<?xml version="1.0" encoding="utf-8"?>
<model
name="antidiuretic_hormone_model"
cmeta:id="antidiuretic_hormone_model"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:xlink="http://www.w3.org/1999/xlink">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#antidiuretic_hormone_model">
<rdf:value>
Antidiuretic Hormone and its control functions.
This section calculates the control of antidiuretic hormone secretion and also
calculates multiplier factors for control of other aspects of circulatory function
by antidiuretic hormone. The major factors that are considered to affect the rate
of antidiuretic hormone secretion are (1) a feedback effect of osmotic concentration
in the extracellular fluids as determined from the concentration of sodium (CNA),
and (2) a feedback effect of arterial pressure (PA).
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- ============================================= Import the required units from the Units file ==================================================== -->
<import xlink:href="units.cellml">
<units name="minute" units_ref="minute"/>
<units name="per_minute" units_ref="per_minute"/>
<units name="beats_per_minute" units_ref="beats_per_minute"/>
<units name="beats_per_minute_per_mmHg" units_ref="beats_per_minute_per_mmHg"/>
<units name="minute_per_L" units_ref="minute_per_L"/>
<units name="mmHg" units_ref="mmHg"/>
<units name="per_mmHg" units_ref="per_mmHg"/>
<units name="mmHg_per_mL" units_ref="mmHg_per_mL"/>
<units name="mmHg_L" units_ref="mmHg_L"/>
<units name="per_mmHg2" units_ref="per_mmHg2"/>
<units name="mmHg3" units_ref="mmHg3"/>
<units name="monovalent_mEq" units_ref="monovalent_mEq"/>
<units name="monovalent_mEq_per_minute" units_ref="monovalent_mEq_per_minute"/>
<units name="monovalent_mEq_per_litre" units_ref="monovalent_mEq_per_litre"/>
<units name="mOsm" units_ref="mOsm"/>
<units name="mOsm_per_litre" units_ref="mOsm_per_litre"/>
<units name="mOsm_per_minute" units_ref="mOsm_per_minute"/>
<units name="monovalent_mEq_per_litre_per_minute" units_ref="monovalent_mEq_per_litre_per_minute"/>
<units name="litre2_per_monovalent_mEq_per_minute" units_ref="litre2_per_monovalent_mEq_per_minute"/>
<units name="L_per_minute" units_ref="L_per_minute"/>
<units name="per_mmHg_per_minute" units_ref="per_mmHg_per_minute"/>
<units name="mL" units_ref="mL"/>
<units name="gram_per_L" units_ref="gram_per_L"/>
<units name="L_mmHg_per_gram" units_ref="L_mmHg_per_gram"/>
<units name="L2_mmHg_per_gram2" units_ref="L2_mmHg_per_gram2"/>
<units name="mmHg_minute_per_L" units_ref="mmHg_minute_per_L"/>
<units name="mmHg_L_per_minute" units_ref="mmHg_L_per_minute"/>
<units name="gram_per_minute" units_ref="gram_per_minute"/>
<units name="mL_per_L" units_ref="mL_per_L"/>
<units name="mL_per_L_per_mmHg" units_ref="mL_per_L_per_mmHg"/>
<units name="mL_per_L_per_minute" units_ref="mL_per_L_per_minute"/>
<units name="mL_per_minute_per_mmHg" units_ref="mL_per_minute_per_mmHg"/>
<units name="L_mL_per_minute_per_mmHg" units_ref="L_mL_per_minute_per_mmHg"/>
<units name="L_per_mL" units_ref="L_per_mL"/>
<units name="L_per_mmHg" units_ref="L_per_mmHg"/>
<units name="mL_per_minute" units_ref="mL_per_minute"/>
<units name="L_per_minute_per_mmHg" units_ref="L_per_minute_per_mmHg"/>
<units name="L_per_minute_per_mmHg2" units_ref="L_per_minute_per_mmHg2"/>
</import>
<!-- ===================================== Import all Parameters and State Variables from the Parameter file ============================================== -->
<import xlink:href="parameters.cellml">
<component component_ref="parameter_values" name="parameter_values"/>
<component component_ref="state_variables" name="state_variables"/>
</import>
<!-- ======================================== ANTI-DIURETIC HORMONE TOP-LEVEL COMPONENT ============================================= -->
<component name="antidiuretic_hormone"
cmeta:id="antidiuretic_hormone">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#antidiuretic_hormone">
<rdf:value>
Encapsulation grouping component containing all the components in the Anti-Diuretic Hormone Model.
The inputs and outputs of the Anti-Diuretic Hormone Model must be passed by this component.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<variable name="time" units="minute" private_interface="out" public_interface="in"/>
<!-- Inputs from components in other models -->
<variable name="CNA" units="monovalent_mEq_per_litre" private_interface="out" public_interface="in"/>
<variable name="PA1" units="mmHg" private_interface="out" public_interface="in"/>
<!-- Outputs to components in other models -->
<variable name="ADHMK" units="dimensionless" private_interface="in" public_interface="out"/>
<variable name="ADHMV" units="dimensionless" private_interface="in" public_interface="out"/>
<variable name="ADHC" units="dimensionless" private_interface="in" public_interface="out"/>
</component>
<!-- OUTPUT CONNECTIONS -->
<connection>
<map_components component_1="antidiuretic_hormone" component_2="ADH_effect_on_kidney"/>
<map_variables variable_1="ADHMK" variable_2="ADHMK"/>
</connection>
<connection>
<map_components component_1="antidiuretic_hormone" component_2="ADH_effect_on_nonrenal_vascular_resistance"/>
<map_variables variable_1="ADHMV" variable_2="ADHMV"/>
</connection>
<connection>
<map_components component_1="antidiuretic_hormone" component_2="ADH_in_blood"/>
<map_variables variable_1="ADHC" variable_2="ADHC"/>
</connection>
<!-- ======================================== OSMOTIC CONTROL OF ANTIDIURETIC HORMONE SECRETION ============================================= -->
<component name="osmotic_control_of_ADH_secretion"
cmeta:id="osmotic_control_of_ADH_secretion">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#osmotic_control_of_ADH_secretion">
<rdf:value>
AD1, AD2, and AD3:
Calculation of a multiplier factor (ADHNA) that determines the effect of the
concentration of sodium in the extracellular fluid (CNA) on the secretion of ADH.
The lower limit of CNA at which the normal stimulating effect of changes in CNA
will affect antidiuretic hormone secretion is equal to CNR. The mathematical
steps in Blocks AD1, AD2, and AD3 provide curve shaping effects for the relationship
between CNA and ADHNA.
AD8:
The effect of sodium concentration on ADH secretion (ADHNA) is not allowed
to go below zero.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#AD1_to_AD3">
<rdf:value>
AD1, AD2, and AD3:
Calculation of a multiplier factor (ADHNA) that determines the effect of the
concentration of sodium in the extracellular fluid (CNA) on the secretion of ADH.
The lower limit of CNA at which the normal stimulating effect of changes in CNA
will affect antidiuretic hormone secretion is equal to CNR. The mathematical
steps in Blocks AD1, AD2, and AD3 provide curve shaping effects for the relationship
between CNA and ADHNA.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#AD8">
<rdf:value>
AD8:
The effect of sodium concentration on ADH secretion (ADHNA) is not allowed
to go below zero.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="CNA" units="monovalent_mEq_per_litre" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable name="ADHNA" units="dimensionless" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="CNR" units="monovalent_mEq_per_litre" private_interface="none" public_interface="in"/>
<!-- Internal variables -->
<variable name="ADHNA1" units="dimensionless" private_interface="none" public_interface="none"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="AD1_to_AD3">
<eq/>
<ci>ADHNA1</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>CNA</ci>
<ci>CNR</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="monovalent_mEq_per_litre">142</cn>
<ci>CNR</ci>
</apply>
</apply>
</apply>
<apply id="AD8">
<eq/>
<ci>ADHNA</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">0</cn>
<apply>
<lt/>
<ci>ADHNA1</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<ci>ADHNA1</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="osmotic_control_of_ADH_secretion" component_2="antidiuretic_hormone"/>
<map_variables variable_1="CNA" variable_2="CNA"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="osmotic_control_of_ADH_secretion" component_2="parameter_values"/>
<map_variables variable_1="CNR" variable_2="CNR"/>
</connection>
<!-- ======================================== PRESSURE CONTROL OF ANTIDIURETIC HORMONE SECRETION ============================================= -->
<component name="pressure_control_of_ADH_secretion"
cmeta:id="pressure_control_of_ADH_secretion">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#pressure_control_of_ADH_secretion">
<rdf:value>
AD4, AD5, AD6, and AD7:
Calculation of the effect of low levels of arterial pressure to cause secretion
of antidiuretic hormone. The mathematical steps in these blocks provide appropriate
curve shaping. Zero effect of pressure on ADH secretion occurs whenever the arterial
pressure is greater than 85 mm Hg. The factor ADHPAM is the sensitivity control for
the overall effect. The output of this set of blocks is ADHPR.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#AD4">
<rdf:value>
AD4, AD5, AD6, and AD7:
Calculation of the effect of low levels of arterial pressure to cause secretion
of antidiuretic hormone. The mathematical steps in these blocks provide appropriate
curve shaping. Zero effect of pressure on ADH secretion occurs whenever the arterial
pressure is greater than 85 mm Hg. The factor ADHPAM is the sensitivity control for
the overall effect. The output of this set of blocks is ADHPR.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#AD5_to_AD7">
<rdf:value>
AD4, AD5, AD6, and AD7:
Calculation of the effect of low levels of arterial pressure to cause secretion
of antidiuretic hormone. The mathematical steps in these blocks provide appropriate
curve shaping. Zero effect of pressure on ADH secretion occurs whenever the arterial
pressure is greater than 85 mm Hg. The factor ADHPAM is the sensitivity control for
the overall effect. The output of this set of blocks is ADHPR.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="PA1" units="mmHg" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable name="ADHPR" units="dimensionless" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="ADHPUL" units="mmHg" private_interface="none" public_interface="in"/>
<variable name="ADHPAM" units="per_mmHg2" private_interface="none" public_interface="in"/>
<!-- Internal variables -->
<variable name="ADHPA" units="mmHg" private_interface="none" public_interface="none"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="AD4">
<eq/>
<ci>ADHPA</ci>
<piecewise>
<piece>
<ci>ADHPUL</ci>
<apply>
<gt/>
<ci>PA1</ci>
<ci>ADHPUL</ci>
</apply>
</piece>
<otherwise>
<ci>PA1</ci>
</otherwise>
</piecewise>
</apply>
<apply id="AD5_to_AD7">
<eq/>
<ci>ADHPR</ci>
<apply>
<times/>
<apply>
<power/>
<apply>
<minus/>
<ci>ADHPUL</ci>
<ci>ADHPA</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>ADHPAM</ci>
</apply>
</apply>
</math>
</component>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="pressure_control_of_ADH_secretion" component_2="antidiuretic_hormone"/>
<map_variables variable_1="PA1" variable_2="PA1"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="pressure_control_of_ADH_secretion" component_2="parameter_values"/>
<map_variables variable_1="ADHPUL" variable_2="ADHPUL"/>
<map_variables variable_1="ADHPAM" variable_2="ADHPAM"/>
</connection>
<!-- ======================================== TOTAL ANTIDIURETIC HORMONE SECRETION ============================================= -->
<component name="total_ADH_secretion"
cmeta:id="total_ADH_secretion">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#total_ADH_secretion">
<rdf:value>
AD9:
Calculation of the net rate of ADH entry into the body fluids (ADH) by adding
the partial effect of ADHNA for osmotic control of ADH secretion plus the partial
effect ADHPR for pressure control of secretion, plus ADHINF for any rate of
infusion of ADH.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#AD9">
<rdf:value>
AD9:
Calculation of the net rate of ADH entry into the body fluids (ADH) by adding
the partial effect of ADHNA for osmotic control of ADH secretion plus the partial
effect ADHPR for pressure control of secretion, plus ADHINF for any rate of
infusion of ADH.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="ADHNA" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="ADHPR" units="dimensionless" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable name="ADH" units="dimensionless" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="ADHINF" units="dimensionless" private_interface="none" public_interface="in"/>
<!-- Internal variables -->
<variable name="ADH1" units="dimensionless" private_interface="none" public_interface="none"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="AD9">
<eq/>
<ci>ADH1</ci>
<apply>
<plus/>
<ci>ADHNA</ci>
<ci>ADHPR</ci>
<ci>ADHINF</ci>
</apply>
</apply>
<apply id="AD9_extended">
<eq/>
<ci>ADH</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">0</cn>
<apply>
<lt/>
<ci>ADH1</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<ci>ADH1</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="total_ADH_secretion" component_2="osmotic_control_of_ADH_secretion"/>
<map_variables variable_1="ADHNA" variable_2="ADHNA"/>
</connection>
<connection>
<map_components component_1="total_ADH_secretion" component_2="pressure_control_of_ADH_secretion"/>
<map_variables variable_1="ADHPR" variable_2="ADHPR"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="total_ADH_secretion" component_2="parameter_values"/>
<map_variables variable_1="ADHINF" variable_2="ADHINF"/>
</connection>
<!-- ======================================== ANTIDIURETIC HORMONE IN BLOOD ============================================= -->
<component name="ADH_in_blood"
cmeta:id="ADH_in_blood">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#ADH_in_blood">
<rdf:value>
AD10, AD11, AD12, and AD13:
Calculation of instantaneous antidiuretic hormone concentration in the blood (ADHC)
by integrating in Block 12 the rate of hormone entry into the fluids (ADH) with
respect to time. A time constant for the integration (Block 11) is equal to ADHTC.
Block 13 damps the response of this integration to prevent oscillation when very
long iteration intervals are used in providing long-term solutions for the model.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#AD10_to_AD13">
<rdf:value>
AD10, AD11, AD12, and AD13:
Calculation of instantaneous antidiuretic hormone concentration in the blood (ADHC)
by integrating in Block 12 the rate of hormone entry into the fluids (ADH) with
respect to time. A time constant for the integration (Block 11) is equal to ADHTC.
Block 13 damps the response of this integration to prevent oscillation when very
long iteration intervals are used in providing long-term solutions for the model.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="ADH" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="ADHC_init" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="time" units="minute" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable name="ADHC" initial_value="ADHC_init" units="dimensionless" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="ADHTC" units="minute" private_interface="none" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="AD10_to_AD13">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ADHC</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ADH</ci>
<ci>ADHC</ci>
</apply>
<ci>ADHTC</ci>
</apply>
</apply>
</math>
</component>
<!-- STATE VARIABLES INITIAL VALUE -->
<connection>
<map_components component_1="ADH_in_blood" component_2="state_variables"/>
<map_variables variable_1="ADHC_init" variable_2="ADHC_init"/>
</connection>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="ADH_in_blood" component_2="total_ADH_secretion"/>
<map_variables variable_1="ADH" variable_2="ADH"/>
</connection>
<connection>
<map_components component_1="ADH_in_blood" component_2="antidiuretic_hormone"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="ADH_in_blood" component_2="parameter_values"/>
<map_variables variable_1="ADHTC" variable_2="ADHTC"/>
</connection>
<!-- ==================================== ANTIDIURETIC HORMONE EFFECT ON NONRENAL VASCULAR RESISTANCE ======================================== -->
<component name="ADH_effect_on_nonrenal_vascular_resistance"
cmeta:id="ADH_effect_on_nonrenal_vascular_resistance">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#ADH_effect_on_nonrenal_vascular_resistance">
<rdf:value>
AD14 and AD15:
Calculation from the instantaneous concentration of ADH in the plasma (ADHC)
of a multiplier factor (ADHMV) to describe the effect of antidiuretic hormone
in causing contraction of many of the blood vessels of the body. Block 15 sets
a lower limit for ADHMV equal to ADHVLL, and the upper limit is ADHVUL.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#AD14">
<rdf:value>
AD14:
Calculation from the instantaneous concentration of ADH in the plasma (ADHC)
of a multiplier factor (ADHMV) to describe the effect of antidiuretic hormone
in causing contraction of many of the blood vessels of the body.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#AD15">
<rdf:value>
AD15:
Block 15 sets a lower limit for ADHMV equal to ADHVLL, and the upper limit is ADHVUL.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="ADHC" units="dimensionless" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable cmeta:id="ADH_effect_on_nonrenal_vascular_resistance_ADHMV"
name="ADHMV" units="dimensionless" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="ADHVUL" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="ADHVLL" units="dimensionless" private_interface="none" public_interface="in"/>
<!-- Internal variables -->
<variable name="ADHMV1" units="dimensionless" private_interface="none" public_interface="none"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="AD14">
<eq/>
<ci>ADHMV1</ci>
<apply>
<minus/>
<ci>ADHVUL</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>ADHVUL</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<ci>ADHVLL</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>ADHVLL</ci>
<ci>ADHVUL</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>ADHC</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply id="AD15">
<eq/>
<ci>ADHMV</ci>
<piecewise>
<piece>
<ci>ADHVLL</ci>
<apply>
<lt/>
<ci>ADHMV1</ci>
<ci>ADHVLL</ci>
</apply>
</piece>
<otherwise>
<ci>ADHMV1</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="ADH_effect_on_nonrenal_vascular_resistance" component_2="ADH_in_blood"/>
<map_variables variable_1="ADHC" variable_2="ADHC"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="ADH_effect_on_nonrenal_vascular_resistance" component_2="parameter_values"/>
<map_variables variable_1="ADHVUL" variable_2="ADHVUL"/>
<map_variables variable_1="ADHVLL" variable_2="ADHVLL"/>
</connection>
<!-- ======================================== ANTIDIURETIC HORMONE EFFECT ON KIDNEY ============================================= -->
<component name="ADH_effect_on_kidney"
cmeta:id="ADH_effect_on_kidney">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#ADH_effect_on_kidney">
<rdf:value>
AD16 and AD17:
Calculation from the plasma concentration of ADH (ADHC) of a multiplier factor (ADHMK)
to describe the effect of the ADH in affecting the kidney. Block 17 gives a lower limit
to ADHMK equal to ADHKLL, and Block 16 gives an upper limit equal to AMKUL.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#AD16">
<rdf:value>
AD16:
Calculation from the plasma concentration of ADH (ADHC) of a multiplier factor (ADHMK)
to describe the effect of the ADH in affecting the kidney.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#AD17">
<rdf:value>
AD17:
Block 17 gives a lower limit to ADHMK equal to ADHKLL, and Block 16 gives an upper limit equal to AMKUL.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="ADHC" units="dimensionless" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable cmeta:id="ADH_effect_on_kidney_ADHMK"
name="ADHMK" units="dimensionless" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="ADHKLL" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="ADHKUL" units="dimensionless" private_interface="none" public_interface="in"/>
<!-- Internal variables -->
<variable name="ADHMK1" units="dimensionless" private_interface="none" public_interface="none"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="AD16">
<eq/>
<ci>ADHMK1</ci>
<apply>
<minus/>
<ci>ADHKUL</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>ADHKUL</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<ci>ADHKLL</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>ADHKLL</ci>
<ci>ADHKUL</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>ADHC</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply id="AD17">
<eq/>
<ci>ADHMK</ci>
<piecewise>
<piece>
<ci>ADHKLL</ci>
<apply>
<lt/>
<ci>ADHMK1</ci>
<ci>ADHKLL</ci>
</apply>
</piece>
<otherwise>
<ci>ADHMK1</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="ADH_effect_on_kidney" component_2="ADH_in_blood"/>
<map_variables variable_1="ADHC" variable_2="ADHC"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="ADH_effect_on_kidney" component_2="parameter_values"/>
<map_variables variable_1="ADHKLL" variable_2="ADHKLL"/>
<map_variables variable_1="ADHKUL" variable_2="ADHKUL"/>
</connection>
<!-- ============================================================ GROUPING =============================================================== -->
<group>
<relationship_ref relationship="containment"/>
<component_ref component="antidiuretic_hormone">
<component_ref component="osmotic_control_of_ADH_secretion"/>
<component_ref component="pressure_control_of_ADH_secretion"/>
<component_ref component="total_ADH_secretion"/>
<component_ref component="ADH_in_blood"/>
<component_ref component="ADH_effect_on_nonrenal_vascular_resistance"/>
<component_ref component="ADH_effect_on_kidney"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="antidiuretic_hormone">
<component_ref component="parameter_values"/>
<component_ref component="state_variables"/>
<component_ref component="osmotic_control_of_ADH_secretion"/>
<component_ref component="pressure_control_of_ADH_secretion"/>
<component_ref component="total_ADH_secretion"/>
<component_ref component="ADH_in_blood"/>
<component_ref component="ADH_effect_on_nonrenal_vascular_resistance"/>
<component_ref component="ADH_effect_on_kidney"/>
</component_ref>
</group>
</model>
