- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2007-08-27 01:28:42+12:00
- Desc:
- committing version01 of karagiannis_popel_2006
- Permanent Source URI:
- https://models.cellml.org/workspace/karagiannis_popel_2006/rawfile/e54f2a53d45d8e0fb028a5ff7db8d4212b50b8db/karagiannis_popel_2006.cellml
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This CellML file was generated on 20/06/2007 at 12:39:18 at a.m. using:
COR (0.9.31.649)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
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http://www.CellML.org/
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<title>Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
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<title>Model Status</title>
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This version of the model has been checked and it runs in PCEnv.
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<title>Model Structure</title>
<para>
The formation of new biological vessels requires the coordinated assembly of a proliferating syncytium of endothelial cells (EC) at different developmental stages. Angiogenesis may also be an essential mechanism of blood vessel remodelling which occurs during a diverse range of physiological processes; including tissue regeneration following injury and new vessel formation during muscle exercise. It can also occur under pathological conditions such as atherosclerosis and the vascularisation of cancerous tumours.
</para>
<para>
Matrix metalloproteinases (MMPs) are a family of enzymes responsible for the proteolytic processing of extracellular matrix (ECM) structural proteins. During angiogenesis MMPs are expressed by a single endothelial cell at the tip of the new vessel. These enzymes manifest a proteolytic activity that allows the cells of the new vessle to penetrate the ECM. In the mathematical model presented here, Karagiannis and Popel investigate the proteolytic potential of such a tip endothelial cell. The model authors suggest this model provides a foundation for future quantitative studies of angiogenesis in ECMs of different compositions. The model is described in more detail in the figure below:
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WMD-4GJVBHT-2&_user=140507&_coverDate=01%2F07%2F2006&_rdoc=12&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236932%232006%23997619998%23612742%23FLA%23display%23Volume)&_cdi=6932&_sort=d&_docanchor=&view=c&_ct=21&_acct=C000011498&_version=1&_urlVersion=0&_userid=140507&md5=d5addc907496eab847175a55928184d0">Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model</ulink>, Emmanouil D. Karagiannis and Aleksander S. Popel, 2006, <ulink url="http://www.elsevier.com/wps/find/journaldescription.cws_home/622904/description#description">
<emphasis>The Journal of Theoretical Biology</emphasis>
</ulink>, 238, 124-145. (<ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WMD-4GJVBHT-2&_user=140507&_coverDate=01%2F07%2F2006&_rdoc=12&_fmt=full&_orig=browse&_srch=doc-info(%23toc%236932%232006%23997619998%23612742%23FLA%23display%23Volume)&_cdi=6932&_sort=d&_docanchor=&view=c&_ct=21&_acct=C000011498&_version=1&_urlVersion=0&_userid=140507&md5=fc173e34bcf3e139ae316b2c34b309ef">Full text</ulink> and PDF versions of the article are available to subscribers on The Journal of Theoretical Biology website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16005020&dopt=Abstract">PubMed ID: 16005020</ulink>
</para>
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<caption>A schematic diagram of the signalling pathway.</caption>
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