Location: Leloup, Goldbeter, 1998 @ 7e96457c1b1b / mRNAs.cellml

Author:
Mona Zhu <devnull@localhost>
Date:
2011-02-02 17:15:49+13:00
Desc:
Adding 1.1 diagram
Permanent Source URI:
https://models.cellml.org/workspace/leloup_goldbeter_1998/rawfile/7e96457c1b1b46a2d960322820ef8a0f79e552ec/mRNAs.cellml

<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" name="mRNAs">
	<!-- documentation -->
	<documentation xmlns="http://cellml.org/tmp-documentation">
		<article>
			<articleinfo>
				<title>A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins</title>
				<author>
					<firstname>Mona</firstname>
					<surname>Zhu</surname>
					<affiliation>
						<shortaffil>Auckland Bioengineering Institute, University of Auckland</shortaffil>
					</affiliation>
				</author>
			</articleinfo>
			<section id="sec_status">
				<title>Model Status</title>
				<para>This is an import for the model "leloup_1998a_1.1model.cellml". It is used to define a reoccuring structure within the model and may be used for multiple equations in the model. This file is known to run only in OpenCell in conjunction with the base file.</para>
			</section>
		</article>
	</documentation>
	
	<!-- units -->
	<units name="hour">
		<unit multiplier="3600" units="second"/>
	</units>
	<units name="per_hour">
		<unit exponent="-1" units="hour"/>
	</units>
	<units name="per_litre">
		<unit exponent="-1" units="litre"/>
	</units>
	<units name="nanomolar">
		<unit prefix="nano" units="mole"/>
		<unit units="per_litre"/>
	</units>
	<units name="nanomolar_hour">
		<unit units="nanomolar"/>
		<unit units="per_hour"/>
	</units>
	<units name="per_nanomolar_hour">
		<unit exponent="-1" units="nanomolar"/>
		<unit units="per_hour"/>
	</units>

	<!-- components -->
	<component name="interface">
		<variable initial_value="M_init" name="M" public_interface="out" units="nanomolar"/>
		<variable name="time" public_interface="in" units="hour"/>
		<variable name="v_s" public_interface="in" units="nanomolar_hour"/>
		<variable name="v_m" public_interface="in" units="nanomolar_hour"/>
		<variable name="K_I" public_interface="in" units="nanomolar"/>
		<variable name="K_m" public_interface="in" units="nanomolar"/>
		<variable name="C_N" public_interface="in" units="nanomolar"/>
		<variable name="n" public_interface="in" units="dimensionless"/>
		<variable name="k_d" public_interface="in" units="per_hour"/>
		<variable name="M_init" public_interface="in" units="nanomolar"/>
		<math xmlns="http://www.w3.org/1998/Math/MathML">
			<apply>
				<eq/>
				<apply>
					<diff/>
					<bvar>
					<ci>time</ci>
					</bvar>
					<ci>M</ci>
				</apply>
				<apply>
					<minus/>
					<apply>
						<minus/>
						<apply>
							<times/>
							<ci>v_s</ci>
							<apply>
								<divide/>
								<apply>
									<power/>
									<ci>K_I</ci>
									<ci>n</ci>
								</apply>
								<apply>
									<plus/>
									<apply>
										<power/>
										<ci>K_I</ci>
										<ci>n</ci>
									</apply>
									<apply>
										<power/>
										<ci>C_N</ci>
										<ci>n</ci>
									</apply>
								</apply>
							</apply>
						</apply>
						<apply>
							<times/>
							<ci>v_m</ci>
							<apply>
								<divide/>
								<ci>M</ci>
								<apply>
									<plus/>
									<ci>K_m</ci>
									<ci>M</ci>
								</apply>
							</apply>
						</apply>
					</apply>
					<apply>
						<times/>
						<ci>k_d</ci>
						<ci>M</ci>
					</apply>
				</apply>
			</apply>
		</math>
	</component>
	
	<!-- metadata -->
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
		<rdf:Description rdf:nodeID="n1">
			<FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Mona Zhu</FN>
		</rdf:Description>
		<rdf:Description rdf:nodeID="n8">
			<creator xmlns="http://purl.org/dc/elements/1.1/"></creator>
			<title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins</title>
			<issued xmlns="http://purl.org/dc/terms/">
				<rdf:Description rdf:nodeID="n9"/>
			</issued>
			<Journal xmlns="http://www.cellml.org/bqs/1.1#">
				<rdf:Description rdf:nodeID="n10"/>
			</Journal>
			<first_page xmlns="http://www.cellml.org/bqs/1.1#" xml:lang="en">70</first_page>
			<volume xmlns="http://www.cellml.org/bqs/1.1#" xml:lang="en">13</volume>
			<last_page xmlns="http://www.cellml.org/bqs/1.1#" xml:lang="en">87</last_page>
		</rdf:Description>
		<rdf:Description rdf:nodeID="n10">
			<title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Journal of Biological Rhythms</title>
		</rdf:Description>
		<rdf:Description rdf:nodeID="n11">
			<W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">28-12-2010</W3CDTF>
		</rdf:Description>
		<rdf:Description rdf:nodeID="n18">
			<JournalArticle xmlns="http://www.cellml.org/bqs/1.1#">
				<rdf:Description rdf:nodeID="n8"/>
			</JournalArticle>
			<Pubmed_id xmlns="http://www.cellml.org/bqs/1.1#" xml:lang="en">9486845</Pubmed_id>
		</rdf:Description>
		<rdf:Description rdf:nodeID="n21">
			<rdf:value xml:lang="en">xzhu055@aucklanduni.ac.nz</rdf:value>
			<rdf:type>
				<rdf:Description rdf:about="http://imc.org/vCard/3.0#internet"/>
			</rdf:type>
		</rdf:Description>
	</rdf:RDF>
</model>