- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2007-06-18 02:45:29+12:00
- Desc:
- committing version01 of lenbury_pacheenburawana_1991
- Permanent Source URI:
- https://models.cellml.org/workspace/lenbury_pacheenburawana_1991/rawfile/336323c75831d18c07366e067c142cfa50bb9f33/lenbury_pacheenburawana_1991.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : lenbury_model_1991.xml
CREATED : 18th June 2007
LAST MODIFIED : 18th June 2007
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.1 Specification.
DESCRIPTION : This file contains a CellML description of Lenbury and Pacheenburawana's 1991 mathematical model of plasma cortisol secretion fluctuations.
CHANGES:
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<article>
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<title>Modelling insulin kinetics in response to oral glucose administration</title>
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<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
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<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Biological systems often display periodicity and oscillatory behaviour. Several studies have described the fluctuations in plasma corticosteroid levels in humans. Through these investigations it has become clear that although many hormones cycle smoothly through circadian rhythms, on a shorter timescale their levels can experience much sharper changes; especially during the latter half of sleep. These secretory bursts during the early morning sleep period are a biological reality rather than a sampling artifact.
</para>
<para>
The corticotropin-releasing hormone (CRH) is synthesised in the hypothalamus and is carried to the anterior pituitary gland where it stimulates cells to produce adrenocorticotrophic hormone (ACTH). In turn, ACTH stimulates the synthesis and secretion of cortisol (F). Cortisol exerts a negative feedback effect on the ACTH secretion in the pituitary and also suppresses CRH synthesis in the hypothalamus. In addition, there is also a negative feedback effect of ACTH on the secretion of CRH. Therefore the entire process can be thought of as a self-regulating system, as summarised in the figure below).
</para>
<para>
The current CellML file describes a mathematical model of this self-regulating system, published by Lenbury <emphasis>et al.</emphasis> (1991). The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T2K-49NH733-50&_user=140507&_coverDate=12%2F31%2F1991&_rdoc=5&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%234921%231991%23999739997%23460273%23FLP%23display%23Volume)&_cdi=4921&_sort=d&_docanchor=&view=c&_ct=6&_acct=C000011498&_version=1&_urlVersion=0&_userid=140507&md5=4e4ae6ba90b2352dec19f3fd2a7f05ee">Modelling fluctuation phenomena in the plasma cortisol secretion system in normal man.</ulink>, Yongwimon Lenbury and Pariwatana Pacheenburawana, 1991, <ulink url="http://www.sciencedirect.com/science/journal/03032647">
<emphasis>BioSystems</emphasis>
</ulink>, 26, 117-125. (A PDF version of the article is available to journal subscribers on the <emphasis>BioSystems</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=1668715&query_hl=1&itool=pubmed_docsum">PubMed ID: 1668715</ulink>
</para>
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<caption>Schematic diagram of the self-regulatory system for corticol secretion. CRH represents corticotropin-releasing hormone, ACTH is adrenocorticotropic hormone, and F represents cortisol. The red lines represent positive feedback pathways, while the blue lines represent negative feedback loops.</caption>
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Modelling fluctuation phenomena in the plasma cortisol secretion system in normal man
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Modelling fluctuation phenomena in the plasma cortisol secretion system in normal man
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