Kinetic Model for the Sensory Control of Sporulation in Physarum polycephalum
Catherine
Lloyd
Bioengineering Institute, University of Auckland
Model Status
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
Model Structure
Complementation is the production of a wildtype phenotype when two recessive mutant alleles are combined in the same genotype. In fungi complementation can arise when two mutant cells form to produce a heterokaryon. In such heterokaryons two nuclear populations mix, providing the biochemical basis for the complementation effect.
In the Marwan 2003 publication described here, the author uses the photosensory control of sporulation in the protist Physarum polycephalum as an example of how complementation in a heterokaryon can create a wildtype phenotype. Marwan also investigates how such a process can depend on the time-dependent physiological state adopted after pathway activation by one of the mutant fusion partners.
The kinetic model of this process can be seen in below. Two inputs, light of the far-red wavelength and glucose, control the devlopmental switch network through formation of the sporulation signal S. Photoreceptor and glucose sensor dependent pathways are integrated by a mechanism which behaves like a logic AND gate. Transcription of gene S is repressed by the product of gene V, while the transcription of gene V is reiprocally repressed by the product of gene S.
The model has been described here in CellML (the raw CellML description of the Marwan 2003 model can be downloaded in various formats as described in ).
The complete original paper reference is cited below:
Theory of Time-Resolved Somatic Complementation and Its Use to Explore the Sporulation Control Network in Physarum polycephalum
, Wolfgang Marwan, 2003,
Genetics
, 164, 105-115. (Full text (HTML) and PDF versions of the article are available on the Genetics website.) PubMed ID: 12750324
reaction diagram
Schematic diagram of the kinetic model for the sensory control of sporulation in Physarum polycephalum.
Pfr
inactive Phytochrome
Pr
active Phytochrome
Xi
inactive X-signal
Xa
active X-signal
prepreS
pre-pre-sporulation signal S
preS
pre-sporulation signal S
S
sporulation signal S
V
Ya
enzyme catalyst
Wolfgang
Marwan
2004-02-09
2003-05
Genetics
c.lloyd@auckland.ac.nz
Catherine Lloyd
keyword
sporulation control
signal transduction
This is the CellML description of Marwan's 2003 mathematical model of sporulation control in Physarum polycephalum.
The University of Auckland
The Bioengineering Institute
12750324
Catherine
Lloyd
May
The University of Auckland, Bioengineering Institute
Theory of Time-Resolved Somatic Complementation and Its Use to Explore the Sporulation Control Network in Physarum polycephalum
164
105
115
Marwan's 2003 mathematical model of sporulation control in Physarum polycephalum.
Physarum polycephalum