Location: Mlcek, Neumann, Kittnar, Novak, 2001 @ e73eb840cbf4 / mlcek_neumann_kittnar_novak_2001.cellml

Author:
pmr2.import <nobody@models.cellml.org>
Date:
2009-06-17 15:11:48+12:00
Desc:
committing version02 of mlcek_neumann_kittnar_novak_2001
Permanent Source URI:
https://models.cellml.org/workspace/mlcek_neumann_kittnar_novak_2001/rawfile/e73eb840cbf4e13e8260319c21753b76ed6b25b5/mlcek_neumann_kittnar_novak_2001.cellml

<?xml version='1.0' encoding='utf-8'?>
<!--  FILE :  mlcek_model_2001_version02.xml

CREATED :  23rd May 2007

LAST MODIFIED : 23rd May 2007

AUTHOR :  Catherine Lloyd
          The Bioengineering Institute
          The University of Auckland
          
MODEL STATUS :  This model conforms to the CellML 1.1 Specification.

DESCRIPTION :  This file contains a CellML description of Mlcek et al's
               mathematical model of the electromechanical heart contractile
               system.

CHANGES:  
   
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Mathematical Model of the Electromechanical Heart Contractile System</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
Computational modelling in molecular cardiology has recently focused on simulating subsets of myocardial excitation-contraction processes.  As people try to improve their understanding of myocardial function, there is an increasing interest in excitation-contraction coupling and mechanical events in cardiac muscle.  It is hoped that these computer simulations will also help explain the pathophysiological mechanisms of heart failure.
</para>

<para>
In their 2001 paper, Mlcek, Neumann, Kittnar and Novak concentrate on the molecular level of electromechanical events in cardiac muscle.  They introduce an actomyosin subsystem accompanied by a simple regulatory subsystem involving calcium binding to troponin C (see <xref linkend="fig_reaction_diagram"/> below).  They performed many simulations to prove the stability of their model and they then used the simulation results to help interpret experimental and clinical data.     
</para>

<para>
The complete original paper reference is cited below:
</para>

<para>
<ulink url="http://www.biomed.cas.cz/physiolres/2001/issue4/mlcek.htm">Mathematical Model of the Electromechanical Heart Contractile System - Regulatory Subsystem Physiological Considerations</ulink>, M. Mlcek, J. Neumann, O. Kittnar and V. Novak, 2001, <ulink url="http://www.biomed.cas.cz/physiolres/">
            <emphasis>Physiological Research</emphasis>
          </ulink>, 50, 425-432. (A PDF version of the article is also available on the Physiological Research journal website.)  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=11551150&amp;dopt=Abstract">PubMed ID: 11551150</ulink> 
</para>

<para>
The raw CellML descriptions of the model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>.
</para>

<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>reaction_diagram</title>
    </objectinfo>
    <imagedata fileref="mlcek_2001.png"/>
  </imageobject>
</mediaobject>
<caption>Diagram of the regulatory subsystem scheme and the actomyosin subsystem scheme.</caption>
</informalfigure>

</sect1>
</article>
</documentation>


  
  
   
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    <dcterms:alternative>Actomyosin</dcterms:alternative>
    <dc:title>AM</dc:title>
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  <rdf:Description rdf:about="rdf:#dce481ed-c2d2-464c-832e-928ff8d7ca14">
    <vCard:Orgname>The University of Auckland</vCard:Orgname>
    <vCard:Orgunit>The Bioengineering Institute</vCard:Orgunit>
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  <rdf:Description rdf:about="rdf:#66a06fd7-7f8f-48c5-8a68-1e936956a74f">
    <rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
    <vCard:N rdf:resource="rdf:#e7959ab6-0340-4477-9c28-73df8b090e3c"/>
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</rdf:RDF>
</model>