Adult Rat Left Ventricular Myocyte Model, 2001
Catherine
Lloyd
Bioengineering Institute, University of Auckland
Model Status
This CellML version of the model represents the epicardial cell. The model has been checked in COR, PCEnv and JSim and it runs in all three to recreate the published results. The units have been checked and are consistent. Thank you to Frank Sachse for his helpful feedback and careful code checking.
Model Structure
Over the past decade electrophysiological studies have revealed transmural heterogeneity, or differences in the action potential waveforms recorded in cells isolated from the epicardial and the endocardial tissues in the left ventricles of mammalian hearts.
The adult rat has been widely used as an experimental model to investigate the electrical heterogeneity in the left ventricle under normal conditions and pathophysiological states. From this biophysical, experimental data, derived from patch clamp experiments, Sandeep V. Pandit, Robert B. Clark, Wayne R. Giles and Semahat S. Demir have developed a mathematical model of action potential heterogeneity in adult rat left ventricular myocytes (see the figure below). The mathematical models for the epicardial and endocardial cells of the rat left ventricle are based on the classical formulation of Hodgkin and Huxley (please see the CellML version of The Hodgkin-Huxley Squid Axon Model, 1952 for more details), and are therefore similar to previous computational work carried out by this research group (see Demir et al. Sinoatrial Node Model 1994 and Demir et al. Sinoatrial Node Model 1999). The endocardial cell model is based on the epicardial formulation with only slight modifications in certain parameters and equations.
The complete original paper reference is cited below:
A Mathematical Model of Action Potential Heterogeneity in Adult Rat Left Ventricular Myocytes, , Sandeep V. Pandit, Robert B. Clark, Wayne R. Giles and Semahat S. Demir, 2001,
Biophysical Journal
, 81, 3029-3051. (Full text and PDF versions of the article are available for Journal Members on the Biophysical Journal website.) PubMed ID: 11720973
fluid compartment model of the rat epicardial/endocardial ventricular cell
A fluid compartment model of the rat epicardial/endocardial ventricular cell.
Department of Physiology, Anatomy & Genetics, University of Oxford
James Lawson
W
Giles
R
unknown
unknown
Biophysical Journal
2007-01-16T00:00:00+00:00
James
Lawson
Richard
Catherine Lloyd
This model has been curated by Penny Noble of Oxford University
penny.noble@dpag.ox.ac.uk
Catherine
Lloyd
May
Penny
Noble
J
100000
0.001
2006-01-01
Several variables were given cmeta:id's to allow creation of a PCEnv session file.
2007-01-16T14:20:00+13:00
2007-06-22T14:17:56+12:00
This file contains a CellML description of Pandit et al.'s 2001 model of action potential heterogeneity in adult rat left ventricular myocytes. This variant describes the ENDOCARDIAL cell.
S
Demir
S
A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes
81 6
3029
3051
unknown
unknown
unknown
unknown
2001-12-01 00:00
Oxford University
Department of Physiology, Anatomy & Genetics
R
Clark
B
unknown
Penny
Noble
J
S
Pandit
V
Added two differential equations to calculate HTRPNCa and LTRPNCa (the last two equations on page 3047 of the original paper). In doing so fixed the model to recreate the published results. Frank Sachse has checked this model in JSim and it also runs in this tool.
11720973
This version was created by Penny Noble of Oxford University and represents the EPICARDIAL CELL VARIANT. The model has been checked in COR, PCEnv and JSim and it runs in all three to recreate the published results. The units have been checked and are consistent. Thank you to Frank Sachse for his helpful feedback and careful code checking.
2007-11-01T12:18:01+13:00