- Author:
- Catherine Lloyd <c.lloyd@auckland.ac.nz>
- Date:
- 2010-05-26 02:37:12+12:00
- Desc:
- Fixed documentation. Model will require further curation.
- Permanent Source URI:
- https://models.cellml.org/workspace/starbuck_wiley_lauffenburger_1990/rawfile/ca6874b72e100d7479c90d3bb81eeeb5d072df35/starbuck_wiley_lauffenburger_1990.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE :starbuck_model_1990.xml
CREATED : 28th November 2003
LAST MODIFIED : 21st April 2005
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/01/2002 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Starbuck et al.'s 1990 model of epidermal growth factor binding and trafficking dynamics in fibroblasts: relationship to cell proliferation.
CHANGES:
21/04/2005 - PJV - Changed unit dimension to correct inconsistancy
-->
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Epidermal Growth Factor Binding and Trafficking Dynamics in Fibroblasts</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: We provide a mathematical model, with accompanying quantitative experimental data, for binding and trafficking properties of the epidermal growth factor (EGF) receptor on B82 fibroblasts, and propose a theoretical dependence of cell proliferation rate on these properties. The signal for cell proliferation is generated by intrinsic EGF-receptor (EGFR) tyrosine kinase activation via EGF binding at the cell surface, and terminated by receptor/growth factor complex internalization and degradation. Our model consists of kinetic equations which describe the binding, internalization, and recycling of EGF and EGFR, along with a simple expression relation the dependence of cell cycle progression on EGFR dynamics. We show that, with key model parameters determined independently from EGF/fibroblast binding and internalization experiments, our model successfully predicts, as a first step, kinetic data for EGF binding to and internalization by B82 cells at 37 degrees Celcius.
</para>
<para>
The original paper reference is cited below:
</para>
<para>
Epidermal Growth Factor Binding and Trafficking Dynamics in Fibroblasts: Relationship to Cell Proliferation, Cindy Starbuck, H. Steven Wiley, and Douglas A. Lauffenburger, 1990, <emphasis>Chemical Engineering Science</emphasis>, 45, 2367-2373. (No PubMed ID)
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
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<title>reaction diagram</title>
</objectinfo>
<imagedata fileref="starbuck_1990.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the processes which take place in the response of mammalian cells to epidermal growth factor.</caption>
</informalfigure>
</sect1>
</article>
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This is the CellML description of Starbuck et al.'s 1990 model of
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<vCard:Given>Catherine</vCard:Given>
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<vCard:Given>Douglas</vCard:Given>
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Epidermal Growth Factor Binding and Trafficking Dynamics in
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The University of Auckland, Auckland Bioengineering Institute
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<vCard:Given>H</vCard:Given>
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Starbuck et al.'s 1990 model of epidermal growth factor binding and
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