Penny
Noble
DPAG, University of Oxford
Model Status
This CellML version of the model has been checked in COR and OpenCell. The units are consistent and the model runs to recreate the published results.
Model Structure
In the paper described here, Philip Stewart and colleagues present a details of their newly developed model for the human Purkinje cell including validation against experimental data. Ionic mechanisms underlying the heterogeneity between
the Purkinje fibre and ventricular action potentials in humans and other species
were analysed. The newly developed Purkinje fibre cell model adds a new member
to the family of human cardiac cell models developed previously for the sino-atrial
node, atrial and ventricular cells, which can be incorporated into an anatomical
model of human heart with details of its electrophysiological heterogeneity and
anatomical complexity.
The original paper reference is cited below:
Mathematical models of the electrical action potential of Purkinje fibre cells, Philip Stewart, Oleg V. Aslanidi, Denis Noble, Penelope J. Noble, Mark R. Boyett, and Henggui Zhang, 2009, Philosophical Transactions of the Royal Society, 367, 2225-2255.
PubMed ID: 19414454
A schematic diagram describing the ion movement across the cell surface membrane and the sarcoplasmic reticulum, which are described by the Stewart et al. 2009 mathematical model of the human Purkinje fibres.
OVAslanidi1003000100000keywordDNoblePurkinje fibreHumanpenny.noble@dpag.ox.ac.ukPJNoble36722552225
Mathematical models of the electrical action potential of Purkinje fibre cells
DPAGUniversity of OxfordPhilosophical Transactions of the Royal Society Aelectrophysiologycardiacpurkinje cellPStewartMRBoyettPennyJNoble19414454HZhang2009-06-13