- Author:
- Hanne <Hanne@hanne-nielsens-macbook.local>
- Date:
- 2010-08-12 10:28:57+12:00
- Desc:
- Made ai and svg, added xul and clickable session file
- Permanent Source URI:
- https://models.cellml.org/workspace/terkildsen_niederer_crampin_hunter_smith_2008/rawfile/cebc92eb074b5acf345f88c53ca883169675bca3/Pandit_et_al_2001_endo.cellml
<?xml version="1.0" encoding="utf-8"?>
<model name="pandit_et_al_2001_endo" cmeta:id="pandit_et_al_2001_endo" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units name="per_second">
<unit units="second" exponent="-1"/>
</units>
<units name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units name="per_millivolt">
<unit units="volt" prefix="milli" exponent="-1"/>
</units>
<units name="per_millivolt2">
<unit units="volt" prefix="milli" exponent="-2"/>
</units>
<units name="microS">
<unit units="siemens" prefix="micro"/>
</units>
<units name="microF">
<unit units="farad" prefix="micro"/>
</units>
<units name="nanoA">
<unit units="ampere" prefix="nano"/>
</units>
<units name="nanoA_per_millimolar_4">
<unit units="ampere" prefix="nano"/>
<unit units="millimolar" exponent="-4"/>
</units>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="per_millimolar_per_second">
<unit units="millimolar" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units name="millimolar_per_second">
<unit units="millimolar"/>
<unit units="second" exponent="-1"/>
</units>
<units name="millimolar3_per_second">
<unit units="millimolar" exponent="-3"/>
<unit units="second" exponent="-1"/>
</units>
<units name="millimolar4_per_second">
<unit units="millimolar" exponent="-4"/>
<unit units="second" exponent="-1"/>
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<units name="millimolar_4">
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</units>
<units name="millijoule_per_mole_kelvin">
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<unit units="mole" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units name="coulomb_per_mole">
<unit units="coulomb"/>
<unit units="mole" exponent="-1"/>
</units>
<units name="micro_litre">
<unit units="litre" prefix="micro"/>
</units>
<component name="environment">
<variable name="time" units="second" public_interface="out"/>
</component>
<component name="membrane">
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<variable name="T" units="kelvin" initial_value="295" public_interface="out"/>
<variable name="F" units="coulomb_per_mole" initial_value="96487" public_interface="out"/>
<variable name="Cm" units="microF" initial_value="0.0001"/>
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<variable name="i_Ca_L" units="nanoA" public_interface="in"/>
<variable name="i_t" units="nanoA" public_interface="in"/>
<variable name="i_ss" units="nanoA" public_interface="in"/>
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<variable name="i_K1" units="nanoA" public_interface="in"/>
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<variable name="i_NaK" units="nanoA" public_interface="in"/>
<variable name="i_NaCa" units="nanoA" public_interface="in"/>
<variable name="i_Ca_P" units="nanoA" public_interface="in"/>
<variable name="i_Stim" units="nanoA" public_interface="out"/>
<variable name="stim_period" units="second"/>
<variable name="stim_duration" units="second" initial_value="5e-3"/>
<variable name="stim_amplitude" units="nanoA" initial_value="-0.6"/>
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<and/>
<apply>
<geq/>
<apply>
<minus/>
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<times/>
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<floor/>
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<divide/>
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<apply>
<plus/>
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</apply>
</piece>
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<eq/>
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<diff/>
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<divide/>
<apply>
<minus/>
<apply>
<plus/>
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<ci>i_Ca_L</ci>
<ci>i_t</ci>
<ci>i_ss</ci>
<ci>i_f</ci>
<ci>i_K1</ci>
<ci>i_B</ci>
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<ci>i_Ca_P</ci>
<ci>i_Stim</ci>
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</apply>
<ci>Cm</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_current">
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<variable name="E_Na" units="millivolt" public_interface="out"/>
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<variable name="g_Na_endo" units="microS"/>
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<variable name="Na_o" units="millimolar" public_interface="in"/>
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<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
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<variable name="h" units="dimensionless" private_interface="in"/>
<variable name="j" units="dimensionless" private_interface="in"/>
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<times/>
<apply>
<divide/>
<apply>
<times/>
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<ci>T</ci>
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<divide/>
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</apply>
</apply>
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<times/>
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<power/>
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</apply>
</apply>
</math>
</component>
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<variable name="m_infinity" units="dimensionless"/>
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<divide/>
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<plus/>
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<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
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<minus/>
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</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_m</ci>
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<divide/>
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<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
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<plus/>
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<minus/>
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<exp/>
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<times/>
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<minus/>
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<plus/>
<ci>V</ci>
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<times/>
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<divide/>
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<minus/>
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</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
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<divide/>
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<minus/>
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<ci>tau_m</ci>
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</apply>
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</component>
<component name="sodium_current_h_gate">
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<variable name="h_infinity" units="dimensionless"/>
<variable name="tau_h" units="second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
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</apply>
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<apply>
<eq/>
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<times/>
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<plus/>
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<exp/>
<apply>
<divide/>
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<minus/>
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<plus/>
<ci>V</ci>
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<cn cellml:units="millivolt">11.1</cn>
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</apply>
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<apply>
<geq/>
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<minus/>
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<plus/>
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<exp/>
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<divide/>
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<minus/>
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<plus/>
<ci>V</ci>
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<apply>
<times/>
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<exp/>
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<times/>
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<apply>
<times/>
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<exp/>
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<times/>
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<eq/>
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<diff/>
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<divide/>
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<minus/>
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<divide/>
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<plus/>
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<divide/>
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<exp/>
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<times/>
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<minus/>
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<geq/>
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<minus/>
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<divide/>
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<plus/>
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<plus/>
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<minus/>
<apply>
<times/>
<apply>
<minus/>
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<exp/>
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<times/>
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<exp/>
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<times/>
<apply>
<minus/>
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<ci>V</ci>
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<divide/>
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<times/>
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<exp/>
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<times/>
<apply>
<minus/>
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<ci>V</ci>
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<times/>
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<minus/>
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<plus/>
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<eq/>
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<diff/>
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<divide/>
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<minus/>
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<variable name="time" units="second" public_interface="in" private_interface="out"/>
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<variable name="Ca_ss" units="millimolar" public_interface="in" private_interface="out"/>
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<variable name="f_12" units="dimensionless" private_interface="in"/>
<variable name="Ca_inact" units="dimensionless" private_interface="in"/>
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<plus/>
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<times/>
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<plus/>
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<divide/>
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<minus/>
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<divide/>
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<apply>
<minus/>
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</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_d_gate">
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<variable name="d_infinity" units="dimensionless"/>
<variable name="tau_d" units="second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
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<eq/>
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<divide/>
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<plus/>
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<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
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<apply>
<minus/>
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</apply>
</apply>
</apply>
</apply>
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<apply>
<eq/>
<ci>tau_d</ci>
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<plus/>
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<times/>
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<exp/>
<apply>
<times/>
<apply>
<minus/>
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<apply>
<power/>
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<plus/>
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<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt2">0.002</cn>
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<apply>
<power/>
<apply>
<minus/>
<ci>V</ci>
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</apply>
</apply>
</apply>
<cn cellml:units="second">0.00025</cn>
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<eq/>
<apply>
<diff/>
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<apply>
<divide/>
<apply>
<minus/>
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<eq/>
<ci>f_11_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">26.7</cn>
</apply>
<cn cellml:units="millivolt">5.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_11</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="second">0.105</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45</cn>
</apply>
<cn cellml:units="millivolt">12</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
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</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="second">0.04</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="second">0.015</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.0017</cn>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_11</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>f_11_infinity</ci>
<ci>f_11</ci>
</apply>
<ci>tau_f_11</ci>
</apply>
</apply>
</math>
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<component name="L_type_Ca_channel_f_12_gate">
<variable name="f_12" units="dimensionless" initial_value="0.9999529" public_interface="out"/>
<variable name="f_12_infinity" units="dimensionless"/>
<variable name="tau_f_12" units="second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_12_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">26.7</cn>
</apply>
<cn cellml:units="millivolt">5.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_12</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="second">0.041</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">47</cn>
</apply>
<cn cellml:units="millivolt">12</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="second">0.08</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">55</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="second">0.015</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.0017</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_12</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>f_12_infinity</ci>
<ci>f_12</ci>
</apply>
<ci>tau_f_12</ci>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_Ca_inact_gate">
<variable name="Ca_inact" units="dimensionless" initial_value="0.9913102" public_interface="out"/>
<variable name="tau_Ca_inact" units="second" initial_value="0.009"/>
<variable name="Ca_inact_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="Ca_ss" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Ca_inact_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_ss</ci>
<cn cellml:units="millimolar">0.01</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_inact</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_inact_infinity</ci>
<ci>Ca_inact</ci>
</apply>
<ci>tau_Ca_inact</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current">
<variable name="i_t" units="nanoA" public_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="out"/>
<variable name="g_t" units="microS" initial_value="0.035"/>
<variable name="g_t_endo" units="microS"/>
<variable name="a_endo" units="dimensionless" initial_value="0.583"/>
<variable name="b_endo" units="dimensionless" initial_value="0.417"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="R" units="millijoule_per_mole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="K_i" units="millimolar" public_interface="in"/>
<variable name="r" units="dimensionless" private_interface="in"/>
<variable name="s" units="dimensionless" private_interface="in"/>
<variable name="s_slow" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_t_endo</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4647</cn>
<ci>g_t</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_t</ci>
<apply>
<times/>
<ci>g_t_endo</ci>
<ci>r</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>a_endo</ci>
<ci>s</ci>
</apply>
<apply>
<times/>
<ci>b_endo</ci>
<ci>s_slow</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current_r_gate">
<variable name="r" units="dimensionless" initial_value="0.002191519" public_interface="out"/>
<variable name="tau_r" units="second"/>
<variable name="r_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10.6</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">11.42</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r</ci>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">45.16</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.03577</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">98.9</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_infinity</ci>
<ci>r</ci>
</apply>
<ci>tau_r</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current_s_gate">
<variable name="s" units="dimensionless" initial_value="0.9842542" public_interface="out"/>
<variable name="tau_s_endo" units="second"/>
<variable name="s_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45.3</cn>
</apply>
<cn cellml:units="millivolt">6.8841</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_endo</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="second">0.55</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">70</cn>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.049</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>s_infinity</ci>
<ci>s</ci>
</apply>
<ci>tau_s_endo</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current_s_slow_gate">
<variable name="s_slow" units="dimensionless" initial_value="0.6421196" public_interface="out"/>
<variable name="tau_s_slow_endo" units="second"/>
<variable name="s_slow_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_slow_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45.3</cn>
</apply>
<cn cellml:units="millivolt">6.8841</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_slow_endo</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="second">3.3</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">70</cn>
</apply>
</apply>
<cn cellml:units="millivolt">30</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">70</cn>
</apply>
</apply>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.049</cn>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s_slow</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>s_slow_infinity</ci>
<ci>s_slow</ci>
</apply>
<ci>tau_s_slow_endo</ci>
</apply>
</apply>
</math>
</component>
<component name="steady_state_outward_K_current">
<variable name="i_ss" units="nanoA" public_interface="out"/>
<variable name="g_ss" units="microS" initial_value="0.007"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="r_ss" units="dimensionless" private_interface="in"/>
<variable name="s_ss" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_ss</ci>
<apply>
<times/>
<ci>g_ss</ci>
<ci>r_ss</ci>
<ci>s_ss</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="steady_state_outward_K_current_r_ss_gate">
<variable name="r_ss" units="dimensionless" initial_value="0.002907171" public_interface="out"/>
<variable name="tau_r_ss" units="second"/>
<variable name="r_ss_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_ss_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">11.5</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">11.82</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r_ss</ci>
<apply>
<divide/>
<cn cellml:units="second">10</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">45.16</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.03577</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">98.9</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">38</cn>
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</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>r_ss</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>r_ss_infinity</ci>
<ci>r_ss</ci>
</apply>
<ci>tau_r_ss</ci>
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</apply>
</math>
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<component name="steady_state_outward_K_current_s_ss_gate">
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<variable name="tau_s_ss" units="second"/>
<variable name="s_ss_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_ss_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">87.5</cn>
</apply>
<cn cellml:units="millivolt">10.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_ss</ci>
<cn cellml:units="second">2.1</cn>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s_ss</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>s_ss_infinity</ci>
<ci>s_ss</ci>
</apply>
<ci>tau_s_ss</ci>
</apply>
</apply>
</math>
</component>
<component name="inward_rectifier">
<variable name="i_K1" units="nanoA" public_interface="out"/>
<variable name="g_K1" units="microS" initial_value="0.024"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="R" units="millijoule_per_mole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="K_i" units="millimolar" public_interface="in"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="nanoA">48</cn>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">37</cn>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">37</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="nanoA">10</cn>
</apply>
<cn cellml:units="dimensionless">0.001</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="millivolt">76.77</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>g_K1</ci>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="millivolt">1.73</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.613</cn>
<ci>F</ci>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="millivolt">1.73</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>K_o</ci>
<cn cellml:units="millimolar">0.9988</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millimolar">0.124</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="hyperpolarisation_activated_current">
<variable name="i_f" units="nanoA" public_interface="out"/>
<variable name="i_f_Na" units="nanoA" public_interface="out"/>
<variable name="i_f_K" units="nanoA" public_interface="out"/>
<variable name="g_f" units="microS" initial_value="0.00145"/>
<variable name="f_Na" units="dimensionless" initial_value="0.2"/>
<variable name="f_K" units="dimensionless"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="E_Na" units="millivolt" public_interface="in"/>
<variable name="y" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_K</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>f_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f_Na</ci>
<apply>
<times/>
<ci>g_f</ci>
<ci>y</ci>
<ci>f_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f_K</ci>
<apply>
<times/>
<ci>g_f</ci>
<ci>y</ci>
<ci>f_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f</ci>
<apply>
<plus/>
<ci>i_f_Na</ci>
<ci>i_f_K</ci>
</apply>
</apply>
</math>
</component>
<component name="hyperpolarisation_activated_current_y_gate">
<variable name="y" units="dimensionless" initial_value="0.003578708" public_interface="out"/>
<variable name="tau_y" units="second"/>
<variable name="y_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">138.6</cn>
</apply>
<cn cellml:units="millivolt">10.48</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y</ci>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.11885</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">80</cn>
</apply>
<cn cellml:units="millivolt">28.37</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5623</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">80</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">14.19</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_infinity</ci>
<ci>y</ci>
</apply>
<ci>tau_y</ci>
</apply>
</apply>
</math>
</component>
<component name="background_currents">
<variable name="i_B" units="nanoA" public_interface="out"/>
<variable name="i_B_Na" units="nanoA" public_interface="out"/>
<variable name="i_B_Ca" units="nanoA" public_interface="out"/>
<variable name="i_B_K" units="nanoA" public_interface="out"/>
<variable name="g_B_Na" units="microS" initial_value="0.00008015"/>
<variable name="g_B_Ca" units="microS" initial_value="0.0000324"/>
<variable name="g_B_K" units="microS" initial_value="0.000138"/>
<variable name="E_Ca" units="millivolt" initial_value="65"/>
<variable name="E_Na" units="millivolt" public_interface="in"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="Ca_o" units="millimolar" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="R" units="millijoule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_B_Na</ci>
<apply>
<times/>
<ci>g_B_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B_Ca</ci>
<apply>
<times/>
<ci>g_B_Ca</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B_K</ci>
<apply>
<times/>
<ci>g_B_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B</ci>
<apply>
<plus/>
<ci>i_B_Na</ci>
<ci>i_B_Ca</ci>
<ci>i_B_K</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump">
<variable name="i_NaK" units="nanoA" public_interface="out"/>
<variable name="i_NaK_max" units="nanoA" initial_value="0.08"/>
<variable name="K_m_K" units="millimolar" initial_value="1.5"/>
<variable name="K_m_Na" units="millimolar" initial_value="10"/>
<variable name="sigma" units="dimensionless"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="Na_o" units="millimolar" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="R" units="millijoule_per_mole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Na_o</ci>
<cn cellml:units="millimolar">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<cn cellml:units="dimensionless">7</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>i_NaK_max</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>K_o</ci>
</apply>
<apply>
<plus/>
<ci>K_o</ci>
<ci>K_m_K</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>K_m_Na</ci>
<ci>Na_i</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sarcolemmal_calcium_pump_current">
<variable name="i_Ca_P" units="nanoA" public_interface="out"/>
<variable name="i_Ca_P_max" units="nanoA" initial_value="0.004"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ca_P</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>i_Ca_P_max</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.0004</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_Ca_ion_exchanger_current">
<variable name="i_NaCa" units="nanoA" public_interface="out"/>
<variable name="K_NaCa" units="nanoA_per_millimolar_4" initial_value="0.000009984"/>
<variable name="d_NaCa" units="millimolar_4" initial_value="0.0001"/>
<variable name="gamma_NaCa" units="dimensionless" initial_value="0.5"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="Na_o" units="millimolar" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="Ca_o" units="millimolar" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K_NaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.03743</cn>
<ci>V</ci>
<ci>gamma_NaCa</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.03743</cn>
<ci>V</ci>
<apply>
<minus/>
<ci>gamma_NaCa</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>d_NaCa</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SR_Ca_release_channel">
<variable name="J_rel" units="millimolar_per_second" public_interface="out"/>
<variable name="v1" units="per_second" initial_value="1.8e3"/>
<variable name="k_a_plus" units="millimolar4_per_second" initial_value="12.15e12"/>
<variable name="k_a_minus" units="per_second" initial_value="576"/>
<variable name="k_b_plus" units="millimolar3_per_second" initial_value="4.05e9"/>
<variable name="k_b_minus" units="per_second" initial_value="1930"/>
<variable name="k_c_plus" units="per_second" initial_value="100"/>
<variable name="k_c_minus" units="per_second" initial_value="0.8"/>
<variable name="P_O1" units="dimensionless" initial_value="0.0004327548"/>
<variable name="P_O2" units="dimensionless" initial_value="0.000000000606254"/>
<variable name="P_C1" units="dimensionless" initial_value="0.6348229"/>
<variable name="P_C2" units="dimensionless" initial_value="0.3647471"/>
<variable name="n" units="dimensionless" initial_value="4"/>
<variable name="m" units="dimensionless" initial_value="3"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="Ca_ss" units="millimolar" public_interface="in"/>
<variable name="Ca_JSR" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_C1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>k_a_plus</ci>
</apply>
<apply>
<power/>
<ci>Ca_ss</ci>
<ci>n</ci>
</apply>
<ci>P_C1</ci>
</apply>
<apply>
<times/>
<ci>k_a_minus</ci>
<ci>P_O1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_O1</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>k_a_plus</ci>
<apply>
<power/>
<ci>Ca_ss</ci>
<ci>n</ci>
</apply>
<ci>P_C1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>k_a_minus</ci>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_b_plus</ci>
<apply>
<power/>
<ci>Ca_ss</ci>
<ci>m</ci>
</apply>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_c_plus</ci>
<ci>P_O1</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>k_b_minus</ci>
<ci>P_O2</ci>
</apply>
<apply>
<times/>
<ci>k_c_minus</ci>
<ci>P_C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_O2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_b_plus</ci>
<apply>
<power/>
<ci>Ca_ss</ci>
<ci>m</ci>
</apply>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_b_minus</ci>
<ci>P_O2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_C2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_c_plus</ci>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_c_minus</ci>
<ci>P_C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_rel</ci>
<apply>
<times/>
<ci>v1</ci>
<apply>
<plus/>
<ci>P_O1</ci>
<ci>P_O2</ci>
</apply>
<apply>
<minus/>
<ci>Ca_JSR</ci>
<ci>Ca_ss</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SERCA2a_pump">
<variable name="J_up" units="millimolar_per_second" public_interface="out"/>
<variable name="K_fb" units="millimolar" initial_value="0.000168"/>
<variable name="K_rb" units="millimolar" initial_value="3.29"/>
<variable name="fb" units="dimensionless"/>
<variable name="rb" units="dimensionless"/>
<variable name="Vmaxf" units="millimolar_per_second" initial_value="0.04"/>
<variable name="Vmaxr" units="millimolar_per_second" initial_value="0.9"/>
<variable name="K_SR" units="dimensionless" initial_value="1"/>
<variable name="N_fb" units="dimensionless" initial_value="1.2"/>
<variable name="N_rb" units="dimensionless" initial_value="1"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="Ca_NSR" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>fb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_i</ci>
<ci>K_fb</ci>
</apply>
<ci>N_fb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>rb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_NSR</ci>
<ci>K_rb</ci>
</apply>
<ci>N_rb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_up</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K_SR</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Vmaxf</ci>
<ci>fb</ci>
</apply>
<apply>
<times/>
<ci>Vmaxr</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fb</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_and_SR_Ca_fluxes">
<variable name="J_tr" units="millimolar_per_second" public_interface="out"/>
<variable name="J_xfer" units="millimolar_per_second" public_interface="out"/>
<variable name="J_trpn" units="millimolar_per_second" public_interface="out"/>
<variable name="tau_tr" units="second" initial_value="0.0005747"/>
<variable name="tau_xfer" units="second" initial_value="0.0267"/>
<variable name="HTRPNCa" units="millimolar" initial_value="1.394301e-1"/>
<variable name="LTRPNCa" units="millimolar" initial_value="5.1619e-3"/>
<variable name="J_HTRPNCa" units="millimolar_per_second"/>
<variable name="J_LTRPNCa" units="millimolar_per_second"/>
<variable name="HTRPN_tot" units="millimolar" initial_value="0.14"/>
<variable name="LTRPN_tot" units="millimolar" initial_value="0.07"/>
<variable name="k_htrpn_plus" units="per_millimolar_per_second" initial_value="200000"/>
<variable name="k_htrpn_minus" units="per_second" initial_value="0.066"/>
<variable name="k_ltrpn_plus" units="per_millimolar_per_second" initial_value="40000"/>
<variable name="k_ltrpn_minus" units="per_second" initial_value="40"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="Ca_ss" units="millimolar" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="Ca_NSR" units="millimolar" public_interface="in"/>
<variable name="Ca_JSR" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_NSR</ci>
<ci>Ca_JSR</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_xfer</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_ss</ci>
<ci>Ca_i</ci>
</apply>
<ci>tau_xfer</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_HTRPNCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_htrpn_plus</ci>
<ci>Ca_i</ci>
<apply>
<minus/>
<ci>HTRPN_tot</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_htrpn_minus</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPNCa</ci>
</apply>
<ci>J_HTRPNCa</ci>
</apply>
<apply>
<eq/>
<ci>J_LTRPNCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_ltrpn_plus</ci>
<ci>Ca_i</ci>
<apply>
<minus/>
<ci>LTRPN_tot</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_ltrpn_minus</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPNCa</ci>
</apply>
<ci>J_LTRPNCa</ci>
</apply>
<apply>
<eq/>
<ci>J_trpn</ci>
<apply>
<plus/>
<ci>J_HTRPNCa</ci>
<ci>J_LTRPNCa</ci>
</apply>
</apply>
</math>
</component>
<component name="intracellular_ion_concentrations">
<variable name="Na_i" units="millimolar" initial_value="10.73519" public_interface="out"/>
<variable name="Ca_i" units="millimolar" initial_value="0.00007901351" public_interface="out"/>
<variable name="K_i" units="millimolar" initial_value="139.2751" public_interface="out"/>
<variable name="Ca_ss" units="millimolar" initial_value="0.00008737212" public_interface="out"/>
<variable name="Ca_JSR" units="millimolar" initial_value="0.06607948" public_interface="out"/>
<variable name="Ca_NSR" units="millimolar" initial_value="0.06600742" public_interface="out"/>
<variable name="V_myo" units="micro_litre" initial_value="9.36e-6"/>
<variable name="V_JSR" units="micro_litre" initial_value="0.056e-6"/>
<variable name="V_NSR" units="micro_litre" initial_value="0.504e-6"/>
<variable name="V_SS" units="micro_litre" initial_value="1.2e-9"/>
<variable name="K_mCMDN" units="millimolar" initial_value="0.00238"/>
<variable name="K_mCSQN" units="millimolar" initial_value="0.8"/>
<variable name="K_mEGTA" units="millimolar" initial_value="0.00015"/>
<variable name="CMDN_tot" units="millimolar" initial_value="0.05"/>
<variable name="CSQN_tot" units="millimolar" initial_value="15"/>
<variable name="EGTA_tot" units="millimolar" initial_value="10"/>
<variable name="beta_i" units="dimensionless"/>
<variable name="beta_SS" units="dimensionless"/>
<variable name="beta_JSR" units="dimensionless"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="i_Stim" units="nanoA" public_interface="in"/>
<variable name="i_Na" units="nanoA" public_interface="in"/>
<variable name="i_Ca_L" units="nanoA" public_interface="in"/>
<variable name="i_B_Na" units="nanoA" public_interface="in"/>
<variable name="i_NaCa" units="nanoA" public_interface="in"/>
<variable name="i_NaK" units="nanoA" public_interface="in"/>
<variable name="i_f_Na" units="nanoA" public_interface="in"/>
<variable name="i_f_K" units="nanoA" public_interface="in"/>
<variable name="i_B_K" units="nanoA" public_interface="in"/>
<variable name="i_K1" units="nanoA" public_interface="in"/>
<variable name="i_t" units="nanoA" public_interface="in"/>
<variable name="i_ss" units="nanoA" public_interface="in"/>
<variable name="i_Ca_P" units="nanoA" public_interface="in"/>
<variable name="i_B_Ca" units="nanoA" public_interface="in"/>
<variable name="J_up" units="millimolar_per_second" public_interface="in"/>
<variable name="J_rel" units="millimolar_per_second" public_interface="in"/>
<variable name="J_xfer" units="millimolar_per_second" public_interface="in"/>
<variable name="J_trpn" units="millimolar_per_second" public_interface="in"/>
<variable name="J_tr" units="millimolar_per_second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>beta_i</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDN_tot</ci>
<ci>K_mCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>K_mCMDN</ci>
<ci>Ca_i</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>EGTA_tot</ci>
<ci>K_mEGTA</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>K_mEGTA</ci>
<ci>Ca_i</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_SS</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDN_tot</ci>
<ci>K_mCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>K_mCMDN</ci>
<ci>Ca_ss</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_JSR</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CSQN_tot</ci>
<ci>K_mCSQN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>K_mCSQN</ci>
<ci>Ca_JSR</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<ci>beta_i</ci>
<apply>
<minus/>
<ci>J_xfer</ci>
<apply>
<plus/>
<ci>J_up</ci>
<ci>J_trpn</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<minus/>
<ci>i_B_Ca</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
<ci>i_Ca_P</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_B_Na</ci>
<apply>
<times/>
<ci>i_NaCa</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times/>
<ci>i_NaK</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>i_f_Na</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Stim</ci>
<ci>i_ss</ci>
<ci>i_B_K</ci>
<ci>i_t</ci>
<ci>i_K1</ci>
<ci>i_f_K</ci>
<apply>
<times/>
<ci>i_NaK</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_ss</ci>
</apply>
<apply>
<times/>
<ci>beta_SS</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_rel</ci>
<ci>V_JSR</ci>
</apply>
<ci>V_SS</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>J_xfer</ci>
<ci>V_myo</ci>
</apply>
<ci>V_SS</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>i_Ca_L</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V_SS</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_JSR</ci>
</apply>
<apply>
<times/>
<ci>beta_JSR</ci>
<apply>
<minus/>
<ci>J_tr</ci>
<ci>J_rel</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_NSR</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_up</ci>
<ci>V_myo</ci>
</apply>
<ci>V_NSR</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>J_tr</ci>
<ci>V_JSR</ci>
</apply>
<ci>V_NSR</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="standard_ionic_concentrations">
<variable name="Na_o" units="millimolar" initial_value="140" public_interface="out"/>
<variable name="Ca_o" units="millimolar" initial_value="1.2" public_interface="out"/>
<variable name="K_o" units="millimolar" initial_value="5.4" public_interface="out"/>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="sodium_current">
<component_ref component="sodium_current_m_gate"/>
<component_ref component="sodium_current_h_gate"/>
<component_ref component="sodium_current_j_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_11_gate"/>
<component_ref component="L_type_Ca_channel_f_12_gate"/>
<component_ref component="L_type_Ca_channel_Ca_inact_gate"/>
</component_ref>
<component_ref component="Ca_independent_transient_outward_K_current">
<component_ref component="Ca_independent_transient_outward_K_current_r_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_slow_gate"/>
</component_ref>
<component_ref component="steady_state_outward_K_current">
<component_ref component="steady_state_outward_K_current_r_ss_gate"/>
<component_ref component="steady_state_outward_K_current_s_ss_gate"/>
</component_ref>
<component_ref component="inward_rectifier"/>
<component_ref component="hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate"/>
</component_ref>
<component_ref component="background_currents"/>
<component_ref component="sodium_potassium_pump"/>
<component_ref component="sarcolemmal_calcium_pump_current"/>
<component_ref component="Na_Ca_ion_exchanger_current"/>
<component_ref component="SR_Ca_release_channel"/>
<component_ref component="SERCA2a_pump"/>
<component_ref component="intracellular_and_SR_Ca_fluxes"/>
<component_ref component="intracellular_ion_concentrations"/>
<component_ref component="standard_ionic_concentrations"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="sodium_current">
<component_ref component="sodium_current_m_gate"/>
<component_ref component="sodium_current_h_gate"/>
<component_ref component="sodium_current_j_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_11_gate"/>
<component_ref component="L_type_Ca_channel_f_12_gate"/>
<component_ref component="L_type_Ca_channel_Ca_inact_gate"/>
</component_ref>
<component_ref component="Ca_independent_transient_outward_K_current">
<component_ref component="Ca_independent_transient_outward_K_current_r_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_slow_gate"/>
</component_ref>
<component_ref component="steady_state_outward_K_current">
<component_ref component="steady_state_outward_K_current_r_ss_gate"/>
<component_ref component="steady_state_outward_K_current_s_ss_gate"/>
</component_ref>
<component_ref component="hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sarcolemmal_calcium_pump_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Na_Ca_ion_exchanger_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="SR_Ca_release_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="SERCA2a_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="intracellular_and_SR_Ca_fluxes" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_Ca_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Ca_independent_transient_outward_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_t" variable_2="i_t"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="steady_state_outward_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_ss" variable_2="i_ss"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="inward_rectifier"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="hyperpolarisation_activated_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_f" variable_2="i_f"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_currents"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_B" variable_2="i_B"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sarcolemmal_calcium_pump_current"/>
<map_variables variable_1="i_Ca_P" variable_2="i_Ca_P"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_ion_exchanger_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_Stim" variable_2="i_Stim"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="background_currents"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="hyperpolarisation_activated_current"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="background_currents" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_t" variable_2="i_t"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="steady_state_outward_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="inward_rectifier"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="hyperpolarisation_activated_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="background_currents"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_ss" variable_2="i_ss"/>
</connection>
<connection>
<map_components component_1="inward_rectifier" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection>
<map_components component_1="inward_rectifier" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_f_Na" variable_2="i_f_Na"/>
<map_variables variable_1="i_f_K" variable_2="i_f_K"/>
</connection>
<connection>
<map_components component_1="background_currents" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_B_Na" variable_2="i_B_Na"/>
<map_variables variable_1="i_B_K" variable_2="i_B_K"/>
<map_variables variable_1="i_B_Ca" variable_2="i_B_Ca"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="sarcolemmal_calcium_pump_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Ca_P" variable_2="i_Ca_P"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="Na_Ca_ion_exchanger_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="Na_Ca_ion_exchanger_current" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="SR_Ca_release_channel" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="J_rel" variable_2="J_rel"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
<map_variables variable_1="Ca_JSR" variable_2="Ca_JSR"/>
</connection>
<connection>
<map_components component_1="SERCA2a_pump" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="J_up" variable_2="J_up"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_NSR" variable_2="Ca_NSR"/>
</connection>
<connection>
<map_components component_1="intracellular_and_SR_Ca_fluxes" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="J_tr" variable_2="J_tr"/>
<map_variables variable_1="J_xfer" variable_2="J_xfer"/>
<map_variables variable_1="J_trpn" variable_2="J_trpn"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_NSR" variable_2="Ca_NSR"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
<map_variables variable_1="Ca_JSR" variable_2="Ca_JSR"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_j_gate"/>
<map_variables variable_1="j" variable_2="j"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_d_gate"/>
<map_variables variable_1="d" variable_2="d"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_11_gate"/>
<map_variables variable_1="f_11" variable_2="f_11"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_12_gate"/>
<map_variables variable_1="f_12" variable_2="f_12"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_Ca_inact_gate"/>
<map_variables variable_1="Ca_inact" variable_2="Ca_inact"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_r_gate"/>
<map_variables variable_1="r" variable_2="r"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_s_gate"/>
<map_variables variable_1="s" variable_2="s"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_s_slow_gate"/>
<map_variables variable_1="s_slow" variable_2="s_slow"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="steady_state_outward_K_current_r_ss_gate"/>
<map_variables variable_1="r_ss" variable_2="r_ss"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="steady_state_outward_K_current_s_ss_gate"/>
<map_variables variable_1="s_ss" variable_2="s_ss"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="hyperpolarisation_activated_current_y_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
</model>
