Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm
Catherine
Lloyd
Auckland Bioengineering Institute, The University of Auckland
Model Status
This CellML model is known to run in both OpenCell and COR to replicate the published results. The units have been checked and they are consistent.
Model Structure
ABSTRACT: A mechanism for generating circadian rhythms has been of major interest in recent years. After the discovery of per and tim, a model with a simple feedback loop involving per and tim has been proposed. However, it is recognized that the simple feedback model cannot account for phenotypes generated by various mutants. A recent report by Glossop, Lyons and Hardin [Science286, 766 (1999)] on Drosophila suggests involvement of another feedback loop by dClk that is interlocked with per-tim feedback loop. In order to examine whether interlocked feedback loops can be a basic mechanism for circadian rhythms, a mathematical model was created and examined. Through extensive simulation and mathematical analysis, it was revealed that the interlocked feedback model accounts for the observations that are not explained by the simple feedback model. Moreover, the interlocked feedback model has robust properties in oscillations.
The original paper reference is cited below:
Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm, Hiroki R. Ueda, Masatoshi Hagiwara, and Hiroaki Kitano, 2001, Journal of Theoretical Biology, 210, 401-406. PubMed ID: 11403560
reaction diagram
The interlocked feedback model of Drosophila circadian rhythm.
Per_m
Per mRNA
Per_c
cytosolic Per protein
Tim_m
Tim mRNA
Tim_c
cytosolic Tim protein
PT_c
cytosolic Per-Tim protein complex
PT_n
nuclear Per-Tim protein complex
Clk_m
Clk mRNA
Clk_c
cytosolic Clk protein
Cyc_c
cytosolic Cyc protein
CC_c
cytosolic Clk-Cyc protein complex
CC_n
nuclear Clk-Cyc protein complex
circadian rhythms
signal transduction
oscillator
circadian rhythm
drosophila
2001-06-21
11403560
Hiroki
Ueda
R
The University of Auckland
Auckland Bioengineering Institute
Hiroaki
Kitano
Catherine
Lloyd
May
Catherine Lloyd
Catherine
Lloyd
May
This CellML model is known to run in both PCEnv and COR to replicate the published results. The units have been checked and they are consistent.
1000
10000
0.1
2008-10-14T15:10:39+13:00
Masatoshi
Hagiwara
keyword
The University of Auckland, Auckland Bioengineering Institute
Added simulation metadata and cmeta:id's to some variables
Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm
210
401
406
2008-10-20T14:24:23+13:00
c.lloyd@auckland.ac.nz
Added initial conditions to all the substrates (these were based on the values used in the corresponding SBML model in the BioModels database), and fixed a typo in the equation for dPTc/dt such that the first term in this equation now reads V1*Perc*Timc rather than V1*Perc*PTc.
James
Lawson
Richard
Journal of Theoretical Biology
This is the CellML description of Ueda et al.'s mathematical model of circadian rhythms in Drosophila.
Ueda et al.'s mathematical model of circadian rhythms in Drosophila.
Drosophila
2003-09-23T00:00:00+00:00
Catherine Lloyd