Model Status
This CellML model runs in both OpenCell and COR to reproduce the published results. The units have been checked and they are consistent.
Model Structure
ABSTRACT: A quantitative kinetic model is proposed to simulate the ATP-induced intracellular Ca(2+) oscillations. The quantitative effect of ATP concentration upon the oscillations was successfully simulated. Our simulation results support previous experimental explanations that the Ca(2+) oscillations are mainly due to interaction of Ca(2+) release from the endoplasmic reticulum (ER) and the ATP-dependent Ca(2+) pump back into the ER, and the oscillations are prolonged by extracellular Ca(2+) entry that maintains the constant Ca(2+) supplies to its intracellular stores. The model is also able to simulate the sudden disappearance phenomenon of the Ca(2+) oscillations observed in some cell types by taking into account of the biphasic characteristic of the Ca(2+) release from the endoplasmic reticulum (ER). Moreover, the model simulation results for the Ca(2+) oscillations characteristics such as duration, peak [Ca(2+)](cyt), and average interval, etc., lead to prediction of some possible factors responsible for the variations of Ca(2+) oscillations in different types of cells.
The original paper is cited below:
A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations. J. Wang, X. Huang and W. Huang, 2006, Journal of Theoretical Biology, 245, 510-519. PubMed ID: 17188305
Diagram of model
A schematic diagram of the pathway described by the mathematical model.
Liu
Wei
wliu052@aucklanduni.ac.nz
The University of Auckland
2009-09-29
The Wang et al. 2006 model of ATP-induced intracellular calcium oscillations
This is the CellML description of Wang et al.'s mathematical model of ATP-induced intracellular calcium oscillations
Catherine Lloyd
keyword
calcium dynamics
17188305
Wang
J
Huang
X
Huang
W
A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations
2006-04-07
Journal of Theoretical Biology
245
510
519