- Author:
- Catherine Lloyd <c.lloyd@auckland.ac.nz>
- Date:
- 2010-07-13 23:17:54+12:00
- Desc:
- Fixed broken RDF.
- Permanent Source URI:
- https://models.cellml.org/workspace/wodarz_hamer_2007/rawfile/08f678e9ea1cbe5ffc05795898e005df7b23802b/wodarz_hamer_2007_c.cellml
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<title>Infection dynamics in HIV-specific CD4 T cells: Does a CD4 T cell boost benefit the host or the virus?</title>
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<title>Model Status</title>
<para>
This CellML model is known to run in both PCEnv and COR to recreate the published results. The units have been checked and they are consistent. The published paper contains four different mathematical models. This particular CellML model represents the third model - which includes a description of the infectious spread of the virus amongst CD4+ T cells and incorporates alternative target cells which are do not react against HIV, such as T cells with other specificities and antigen presenting cells.
</para>
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<title>Model Structure</title>
<para>
ABSTRACT: Recent experimental data have shown that HIV-specific CD4 T cells provide a very important target for HIV replication. We use mathematical models to explore the effect of specific CD4 T cell infection on the dynamics of virus spread and immune responses. Infected CD4 T cells can provide antigen for their own stimulation. We show that such autocatalytic cell division can significantly enhance virus spread, and can also provide an additional reservoir for virus persistence during anti-viral drug therapy. In addition, the initial number of HIV-specific CD4 T cells is an important determinant of acute infection dynamics. A high initial number of HIV-specific CD4 T cells can lead to a sudden and fast drop of the population of HIV-specific CD4 T cells which results quickly in their extinction. On the other hand, a low initial number of HIV-specific CD4 T cells can lead to a prolonged persistence of HIV-specific CD4 T cell help at higher levels. The model suggests that boosting the population of HIV-specific CD4 T cells can increase the amount of virus-induced immune impairment, lead to less efficient anti-viral effector responses, and thus speed up disease progression, especially if effector responses such as CTL have not been sufficiently boosted at the same time.
</para>
<para>
The original paper reference is cited below:
</para>
<para>
Infection dynamics in HIV-specific CD4 T cells: Does a CD4 T cell boost benefit the host or the virus?, Dominik Wodarz and Dean H. Hamer, 2007, <emphasis>Mathematical Biosciences</emphasis> <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/17379260">PubMed ID: 17379260</ulink>
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xml:lang="en">Lloyd</Family></rdf:Description><rdf:Description rdf:about="rdf:#33c3f504-7089-4b22-8031-675562787f68"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Mathematical Biosciences</title></rdf:Description><rdf:Description rdf:about="rdf:#9856135a-29c0-42f1-bd4f-ad4a892aa517"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2007-00-00 00:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#59c34b4a-cb08-47a3-bbe2-39adf1535c82"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#86850c8b-28a9-46d1-a871-02474a480f58"/></N></rdf:Description><rdf:Description rdf:about="rdf:#1f646c74-a9d3-4440-aee2-df4ff83440b9"><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#28151b71-89ca-430e-b694-aad3d25baa20"/></creator><rdf:value xml:lang="en">the model runs in PCenv to partially recreate the published results - the CD4 T cell pattern matched the figure 2 result - but I'm not sure about the virus load. It may be the same but in the published paper the graph in figure 2 has a log scale on the y axis.</rdf:value></rdf:Description><rdf:Description rdf:about="#T"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">susceptible non-specific target T cells</alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">T</title></rdf:Description><rdf:Description rdf:about="#wodarz_2007"><cmeta:comment><rdf:Description rdf:about="rdf:#e6d3c4fe-503e-4373-9ec5-13ae68f17c35"/></cmeta:comment><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#7729b1d3-3f31-4c31-b338-47a7a4811622"/></reference><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#4373bfae-0cc1-46f5-be9a-3166ab412226"/></reference><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">
Wodarz and Hamer's 2007 mathematical model of infection dynamics in HIV-specific CD4+ T cells.
</title></rdf:Description><rdf:Description rdf:about="rdf:#e6d3c4fe-503e-4373-9ec5-13ae68f17c35"><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#53d09b11-f44f-4104-8891-7b81bbcbf4f0"/></creator><rdf:value xml:lang="en">This is a CellML description of Wodarz and Hamer's 2007 mathematical model of infection dynamics in HIV-specific CD4+ T cells.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#cb614922-ff31-466f-9afc-780ce64b219c"><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#6df09b06-a716-40b5-b22b-175f7504cc31"/></modified><cmeta:modifier><rdf:Description rdf:about="rdf:#c50ff037-eb3e-434d-bc1e-cb92ac1bf079"/></cmeta:modifier><rdf:value xml:lang="en">added units</rdf:value></rdf:Description><rdf:Description rdf:about="#v"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">free virus particles</alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">v</title></rdf:Description><rdf:Description rdf:about="rdf:#12e62c9d-73d0-4120-946b-3c4253e860cc"><Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">The Bioengineering Institute</Orgunit><Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">The University of Auckland</Orgname></rdf:Description><rdf:Description rdf:about="rdf:#53d09b11-f44f-4104-8891-7b81bbcbf4f0"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine Lloyd</FN></rdf:Description><rdf:Description rdf:about="#x"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">uninfected HIV-specific CD4+ T cells</alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">x</title></rdf:Description><rdf:Description rdf:about="rdf:#c50ff037-eb3e-434d-bc1e-cb92ac1bf079"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#522ead91-9968-4c08-afe2-37e6da03d974"/></N></rdf:Description><rdf:Description rdf:about="rdf:#7729b1d3-3f31-4c31-b338-47a7a4811622"><subject xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#b12990d9-4bc2-4373-b890-704d61f14835"/></subject></rdf:Description><rdf:Description rdf:about="rdf:#fb2aefcc-3530-4cf3-abf2-d0d44eb981b7"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family></rdf:Description><rdf:Description rdf:about="rdf:#3a880a16-d6f1-454d-bc68-e422361b17b5"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2007-07-16T00:00:00+00:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#7d95d4ea-cc4a-4658-a13e-5e77bb0a0e4a"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#c2f75c17-6482-42d2-946c-55024c2a629c"/></N></rdf:Description><rdf:Description rdf:about="rdf:#4373bfae-0cc1-46f5-be9a-3166ab412226"><JournalArticle xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#a0de449c-1e5e-4440-b960-9569c1b5b9ef"/></JournalArticle><Pubmed_id xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">17379260</Pubmed_id></rdf:Description><rdf:Description rdf:about="I"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">infected non-specific target T cells</alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">I</title></rdf:Description></rdf:RDF></model>
