<?xml version='1.0'?>
<!-- This CellML file was generated from:
Weinstein, Alan M. "A mathematical model of the outer medullary collecting duct of the rat." American Journal of Physiology-Renal Physiology 279.1 (2000): F24-F45.
The results are compared with Figure 6 in:
Chang, Hangil, and Toshiro Fujita. "A numerical model of acid-base transport in rat distal tubule." American Journal of Physiology-Renal Physiology 281.2 (2001): F222-F243.-->
<model cmeta:id="Weinstein_2000_HATPase" name="Weinstein_2000_HATPase" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/">
<rdf:Description rdf:about="">
<dc:title>A kinetic model of V-type H+-ATPase (proton pump)</dc:title>
</rdf:Description>
<rdf:Description rdf:about="#Weinstein_2000_HATPase">
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>protein module</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
<import xlink:href="Units/Units.cellml">
<units name="mM" units_ref="mM"/>
<units name="mM_per_s" units_ref="mM_per_s"/>
<units name="joule_per_mmole" units_ref="joule_per_mmole"/>
<units name="mmole_per_joule" units_ref="mmole_per_joule"/>
<units name="coulomb_per_mmole" units_ref="coulomb_per_mmole"/>
<units name="joule_per_mmole_kelvin" units_ref="joule_per_mmole_kelvin"/>
</import>
<component name="H_ATPase">
<variable name="psi" public_interface="in" units="volt"/>
<variable name="H_int" public_interface="in" units="mM"/>
<variable name="H_ext" public_interface="in" units="mM"/>
<variable name="mu_H" units="joule_per_mmole"/>
<variable initial_value="4.0" name="mu_0" units="joule_per_mmole"/>
<variable initial_value="0.4" name="xi" units="mmole_per_joule"/>
<variable initial_value="96.5" name="F" units="coulomb_per_mmole"/>
<variable initial_value="0.008315" name="R" units="joule_per_mmole_kelvin"/>
<variable initial_value="300" name="T" units="kelvin"/>
<variable initial_value="-1.57" name="z" units="dimensionless"/>
<variable initial_value="1.8" name="J_Vtype_H_Max" public_interface="out" units="mM_per_s"/>
<variable name="J_Vtype_H" public_interface="out" units="mM_per_s"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="electrochemical_potential_difference_calculation">
<eq/>
<ci>mu_H</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>H_ext</ci>
<ci>H_int</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>z</ci>
<ci>F</ci>
<ci>psi</ci>
</apply>
</apply>
</apply>
<apply id="H_flux">
<eq/>
<ci>J_Vtype_H</ci>
<apply>
<divide/>
<ci>J_Vtype_H_Max</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<ci>xi</ci>
<apply>
<minus/>
<ci>mu_H</ci>
<ci>mu_0</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">A kinetic model of V-type H+-ATPase (proton pump)</dc:title>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#Weinstein_2000_HATPase">
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<bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
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<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">protein module</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
</model>
