<?xml version='1.0'?>
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<import xlink:href="Units/Units.cellml">
<units name="mM" units_ref="mM"/>
<units name="per_s" units_ref="per_s"/>
<units name="mM_per_s" units_ref="mM_per_s"/>
</import>
<import xlink:href="Weinstein_1995_NHE3.cellml">
<component component_ref="NHE3" name="NHE3"/>
</import>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
</component>
<component name="concentrations">
<variable initial_value="1.0" name="Na_ext" public_interface="out" units="mM"/>
<variable initial_value="0.0" name="Na_int" public_interface="out" units="mM"/>
<variable initial_value="2.51189e-4" name="H_ext" public_interface="out" units="mM"/>
<variable initial_value="1.0e-3" name="H_int" public_interface="out" units="mM"/>
<variable initial_value="0.0" name="NH4_ext" public_interface="out" units="mM"/>
<variable initial_value="0.0" name="NH4_int" public_interface="out" units="mM"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_ext</ci>
</apply>
<cn cellml:units="mM_per_s">100</cn>
</apply>
</math>
</component>
<component name="fluxes">
<variable name="J_NHE3_Na" public_interface="in" units="mM_per_s"/>
<variable name="J_NHE3_H" public_interface="in" units="mM_per_s"/>
<variable name="J_NHE3_NH4" public_interface="in" units="mM_per_s"/>
<variable name="J_NHE3_Na_Max" public_interface="in" units="mM_per_s"/>
<variable name="Na_ext" public_interface="in" units="mM"/>
<variable name="plot" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>plot</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Na_ext</ci>
</apply>
<apply>
<divide/>
<ci>J_NHE3_Na</ci>
<ci>J_NHE3_Na_Max</ci>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="concentrations" component_2="NHE3"/>
<map_variables variable_1="Na_ext" variable_2="Na_ext"/>
<map_variables variable_1="Na_int" variable_2="Na_int"/>
<map_variables variable_1="H_ext" variable_2="H_ext"/>
<map_variables variable_1="H_int" variable_2="H_int"/>
<map_variables variable_1="NH4_ext" variable_2="NH4_ext"/>
<map_variables variable_1="NH4_int" variable_2="NH4_int"/>
</connection>
<connection>
<map_components component_1="fluxes" component_2="NHE3"/>
<map_variables variable_1="J_NHE3_Na" variable_2="J_NHE3_Na"/>
<map_variables variable_1="J_NHE3_H" variable_2="J_NHE3_H"/>
<map_variables variable_1="J_NHE3_NH4" variable_2="J_NHE3_NH4"/>
<map_variables variable_1="J_NHE3_Na_Max" variable_2="J_NHE3_Na_Max"/>
</connection>
<connection>
<map_components component_1="fluxes" component_2="concentrations"/>
<map_variables variable_1="Na_ext" variable_2="Na_ext"/>
</connection>
<connection>
<map_components component_1="concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
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<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Terkildsen</vCard:Family>
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Jonna</vCard:Given>
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<vCard:EMAIL xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">j.terkildsen@auckland.ac.nz</rdf:value>
<rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="http://imc.org/vCard/3.0#internet"/>
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<vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<vCard:Orgname xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Auckland Bioengineering Institute</vCard:Orgname>
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</dc:creator>
<dcterms:created xmlns:dcterms="http://purl.org/dc/terms/" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2009-05-27</dcterms:W3CDTF>
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<bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
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<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">Na/H antiporter</rdf:li>
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">ion transport</rdf:li>
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">kidney</rdf:li>
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">proximal tubule</rdf:li>
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">renal</rdf:li>
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<bqs:Pubmed_id xmlns:bqs="http://www.cellml.org/bqs/1.0#">7658195</bqs:Pubmed_id>
<bqs:JournalArticle xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
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<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Weinstein</vCard:Family>
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<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">M</vCard:Other>
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<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">
A kinetically defined Na+/H+ antiporter within a mathematical model of the rat proximal tubule
</dc:title>
<bqs:Journal xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">The Journal of General Physiology</dc:title>
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<bqs:volume xmlns:bqs="http://www.cellml.org/bqs/1.0#">105</bqs:volume>
<bqs:first_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">617</bqs:first_page>
<bqs:last_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">641</bqs:last_page>
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</model>