<?xml version='1.0'?>
<model cmeta:id="Weinstein_2000_AE1" name="Weinstein_2000_AE1" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="Units/Units.cellml">
<units name="mM" units_ref="mM"/>
<units name="per_s" units_ref="per_s"/>
<units name="mM_per_s" units_ref="mM_per_s"/>
</import>
<import xlink:href="Weinstein_2000_AE1.cellml">
<component component_ref="AE1" name="AE1"/>
</import>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
</component>
<component name="concentrations">
<variable name="time" public_interface="in" units="second"/>
<variable initial_value="50.0" name="HCO3_int" public_interface="out" units="mM"/>
<variable initial_value="0.0" name="HCO3_ext" public_interface="out" units="mM"/>
<variable initial_value="0.0" name="Cl_int" public_interface="out" units="mM"/>
<variable initial_value="0.0" name="Cl_ext" public_interface="out" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HCO3_int</ci>
</apply>
<cn cellml:units="mM_per_s">0.0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HCO3_ext</ci>
</apply>
<cn cellml:units="mM_per_s">1.0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cl_int</ci>
</apply>
<cn cellml:units="mM_per_s">0.0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cl_ext</ci>
</apply>
<cn cellml:units="mM_per_s">0.0</cn>
</apply>
</math>
</component>
<component name="fluxes">
<variable name="J_AE1_HCO3" public_interface="in" units="mM_per_s"/>
<variable name="J_AE1_Cl" public_interface="in" units="mM_per_s"/>
<variable name="J_HCO3_influx" public_interface="in" units="mM_per_s"/>
<variable name="J_Cl_influx" public_interface="in" units="mM_per_s"/>
</component>
<connection>
<map_components component_1="concentrations" component_2="AE1"/>
<map_variables variable_1="HCO3_int" variable_2="HCO3_int"/>
<map_variables variable_1="HCO3_ext" variable_2="HCO3_ext"/>
<map_variables variable_1="Cl_int" variable_2="Cl_int"/>
<map_variables variable_1="Cl_ext" variable_2="Cl_ext"/>
</connection>
<connection>
<map_components component_1="fluxes" component_2="AE1"/>
<map_variables variable_1="J_AE1_HCO3" variable_2="J_AE1_HCO3"/>
<map_variables variable_1="J_AE1_Cl" variable_2="J_AE1_Cl"/>
<map_variables variable_1="J_HCO3_influx" variable_2="J_HCO3_influx"/>
<map_variables variable_1="J_Cl_influx" variable_2="J_Cl_influx"/>
</connection>
<connection>
<map_components component_1="concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<!--
The following RDF block contains metadata that applies to this document
as a whole, as indicated by the empty about attribute on the
<rdf:Description> element.
-->
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="">
<!--
The Model Builder Metadata. The Dublin Core "creator" element is used
to indicate the person who translated the model into CellML.
-->
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
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<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Terkildsen</vCard:Family>
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Jonna</vCard:Given>
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<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">j.terkildsen@auckland.ac.nz</rdf:value>
<rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="http://imc.org/vCard/3.0#internet"/>
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<vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<vCard:Orgname xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Auckland Bioengineering Institute</vCard:Orgname>
</vCard:ORG>
</dc:creator>
<!--
The Creation Date metadata. This is the date on which the model
was translated into CellML.
-->
<dcterms:created xmlns:dcterms="http://purl.org/dc/terms/" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2009-11-11</dcterms:W3CDTF>
</dcterms:created>
<!--
The Modification History metadata. This lists the changes that have been
made to the document, who made the changes, and when they were made.
-->
</rdf:Description>
<!--
The following metadata refers to the model itself, as indicated by the
reference to the ID "weinstein_2000_AE1", which is
declared on the <model> element.
-->
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#weinstein_2000_AE1">
<!-- A human readable name for the model. -->
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">
The Weinstein 2000 quantitative model of AE1 (Cl/HCO3 exchanger).
</dc:title>
<!-- A comment regarding the model. -->
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
This is the CellML description of the Weinstein 2000 quantitative model of AE1 (Cl/HCO3 exchanger)
</rdf:value>
<!-- The creator of the comment. -->
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Jonna Terkildsen</vCard:FN>
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</cmeta:comment>
<!-- Keyword(s) -->
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<rdf:Bag xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">renal</rdf:li>
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">ion transport</rdf:li>
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">kidney</rdf:li>
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">medullary collecting duct</rdf:li>
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<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<bqs:Pubmed_id xmlns:bqs="http://www.cellml.org/bqs/1.0#">10894785</bqs:Pubmed_id>
<bqs:JournalArticle xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">
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<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Weinstein</vCard:Family>
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">A</vCard:Given>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">M</vCard:Other>
</vCard:N>
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</dc:creator>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">
A mathematical model of the outer medullary collecting duct of the rat
</dc:title>
<dcterms:issued xmlns:dcterms="http://purl.org/dc/terms/" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2000-07</dcterms:W3CDTF>
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<bqs:Journal xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">American Journal of Physiology</dc:title>
</bqs:Journal>
<bqs:volume xmlns:bqs="http://www.cellml.org/bqs/1.0#">279</bqs:volume>
<bqs:first_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">24</bqs:first_page>
<bqs:last_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">45</bqs:last_page>
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</model>
