Model Mathematics

Component: environment

Component: Casp8

J_f0=k_f0Casp8Bid J_Casp8=-uCasp8 J_0=k_10Casp8Bid-k_00Casp8Bid r_20NO=k_20NOFeLnNOCasp8 ddtimeCasp8=-J_0+J_f0+J_Casp8-r_19NO-r_20NO ddtimeCasp8Bid=J_0-J_f0

Component: Apaf_1

J_Apaf_1=P_Apaf_1-uApaf_1 J_1=k_11CytcApaf_1-k_01CytcApaf_1 ddtimeApaf_1=-J_1+J_Apaf_1

Component: CytcApaf_1

J_1b=k_11bCytcApaf_1p-k_01bApop ddtimeCytcApaf_1=J_1-7J_1b

Component: Cytc

J_Cytc=-uCytc PTPC_act=PTPC_0-PTPC ddtimeCytc=J_14-J_1+J_Cytc+k_1PTPC_actCytc_mito

Component: Cytc_mito

J_Cytc_mito=P_Cytc_mito-uCytc_mito J_14=k14Bax_2Cytc_mito ddtimeCytc_mito=-J_14+J_Cytc_mito

Component: Bax_2

J_Bax_2=-uBax_2 ddtimeBax_2=J_12b+J_Bax_2

Component: tBid_mito

J_tBid_mito=-utBid_mito J_12a=k12atBid_mitoBax ddtimetBid_mito=J_11-J_12a+J_tBid_mito

Component: tBid

J_11=k11tBid J_tBid=-utBid ddtimetBid=J_f0+J_f8-J_11+J_12b+J_tBid

Component: tBidBax

J_tBidBax=-utBidBax J_12b=k12btBidBaxBax ddtimetBidBax=J_12a-J_12b+J_tBidBax

Component: Bax

P_Bax=P_oBax1+p534p534+p53_thresh4 J_Bax=P_Bax-u_BaxBax J_13=k13Bcl_2Bax ddtimeBax=-J_12a-J_12b-J_13+J_Bax

Component: Bcl_2

P_Bcl_2=P_oBcl_2p53_thresh4p534+p53_thresh4 J_9=k_19Casp3Bcl_2-k_09Casp3Bcl_2 J_Bcl_2=P_Bcl_2-u_Bcl_2Bcl_2 ddtimeBcl_2=-J_9-J_13+J_Bcl_2

Component: Casp3Bcl_2

J_f9=k_f9Casp3Bcl_2 ddtimeCasp3Bcl_2=J_9-J_f9

Component: Casp3Bid

J_8=k_18Casp3Bid-k_08Casp3Bid J_f8=k_f8Casp3Bid ddtimeCasp3Bid=J_8-J_f8

Component: Bid

J_Bid=P_Bid-uBid ddtimeBid=-J_0-J_8+J_Bid

Component: Casp3

J_Casp3=-uCasp3 J_7=k_17Casp3IAP-k_07Casp3IAP ddtimeCasp3IAP=J_7 ddtimeCasp3=J_f6+J_f6b-J_7-J_8+J_f8-J_9+J_f9+J_Casp3-r_22NO

Component: Apop

ddtimeApop=J_1b-J_2+J_4b

Component: Pro9

J_Pro9=P_Pro9-uPro9 J_2=k_12ApopPro9-k_02ApopPro9 J_3=k_13ApopPro9Pro9-k_03ApopPro9_2 ddtimePro9=-J_2-J_3+J_Pro9 ddtimeApopPro9=J_2-J_3

Component: ApopPro9_2

J_f3=k_f3ApopPro9_2 ddtimeApopPro9_2=J_3-J_f3

Component: ApopCasp9_2Pro3

J_6b=k_16bApopCasp9_2Pro3-k_06bApopCasp9_2Pro3 J_f6b=k_f6bApopCasp9_2Pro3 ddtimeApopCasp9_2Pro3=J_6b-J_f6b

Component: Casp9Pro3

J_f6=k_f6Casp9Pro3 ddtimeCasp9Pro3=J_6-J_f6

Component: Pro3

J_6=k_16Casp9Pro3-k_06Casp9Pro3 J_Pro3=P_Pro3-uPro3 ddtimePro3=-J_6-J_6b+J_Pro3

Component: IAP

J_5=k_15Casp9IAP-k_05Casp9IAP J_5b=k_15bApopCasp9IAP-k_05bApopCasp9IAP J_5c=k_15cApopCasp9_2IAP-k_05cApopCasp9_2IAP J_IAP=P_IAP-uIAP ddtimeCasp9IAP=J_5 ddtimeApopCasp9IAP=J_5b ddtimeApopCasp9_2IAP=J_5c ddtimeIAP=-J_5-J_5b-J_5c-J_7+J_IAP

Component: ApopCasp9

J_4=k_14ApopCasp9_2-k_04ApopCasp9Casp9 J_4b=k_14bApopCasp9-k_04bApopCasp9 ddtimeApopCasp9=J_4-J_4b-J_5b

Component: Casp9

J_Casp9=-uCasp9 ddtimeCasp9=J_4+J_4b-J_5-J_6+J_f6+J_Casp9-r_21NO

Component: ApopCasp9_2

ddtimeApopCasp9_2=J_f3-J_4-J_5c-J_6b+J_f6b

Component: NO

r_1NO=k_1NO r_4NO=k_4NONOO_2m r_12aNO=k_12aNONO2O_2 r_12bNOp=k_12bNOpNO_2NO r_12bNOm=k_12bNOmN2O3 r_14NO=k_14NOGSNO r_15NO=k_15NOCcOXNO r_16NO=k_16NOFeLnNO ddtimeNO=r_1NO-r_4NO-2r_12aNO-r_12bNOp+r_12bNOm+r_14NO-r_15NO-r_16NO ddtimeCcOX=-r_15NO ddtimeNO_2=2r_12aNO-r_12bNOp+r_12bNOm

Component: O_2m

r_2NO=k_2NO r_5NO=k_5NOSODO_2m r_10NO=k_10NOGSNO2O_2m ddtimeO_2m=r_2NO-r_4NO-r_5NO-r_10NO

Component: ONOO_m

r_6NO=k_6NOONOO_mGSH r_7NO=k_7NOONOO_mGPX r_8NO=k_8NOONOO_mCO_2 r_9NO=k_9NOONOO_mCyt_c r_18NO=k_18NOONOO_mPTPC ddtimeONOO_m=r_4NO-r_6NO-r_7NO-r_8NO-r_9NO-r_18NO

Component: GSH

GSSG=GSH_0-GSH-GSNO2 r_11NO=k_11NON2O3GSH r_m=v_mGSSGk_m+GSSG r_17NO=k_17NOFeLnNOGSH ddtimeGSH=-r_6NO-r_11NO+2r_m-r_17NO

Component: GSNO

ddtimeGSNO=r_6NO-2r_10NO+r_11NO-r_14NO+r_17NO

Component: N2O3

r_13NO=k_13NON2O3 ddtimeN2O3=-r_11NO+r_12bNOp-r_12bNOm-r_13NO-r_19NO

Component: FeLn

r_21NO=k_21NOFeLnNOCasp9 r_22NO=k_22NOFeLnNOCasp3 ddtimeFeLn=-r_16NO+r_17NO+r_20NO+r_21NO+r_22NO ddtimeFeLnNO=r_16NO-r_17NO-r_20NO-r_21NO-r_22NO

Component: PTPC

r_19NO=k_19NON2O3Casp8 ddtimePTPC=-r_19NO

Component: model_constant