<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 28/07/2017 at 15:29:20 using:
COR (0.9.31.1409)
Copyright 2002-2017 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
<model name="varela_2016" cmeta:id="varela_2016" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millisecond">
<unit units="second" prefix="milli"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_millisecond">
<unit units="millisecond" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_millivolt">
<unit units="millivolt" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_millivolt_millisecond">
<unit units="millivolt" exponent="-1"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millimolar_per_millisecond">
<unit units="millimolar"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millisecond_per_millimolar">
<unit units="millisecond"/>
<unit units="millimolar" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="picoA">
<unit units="ampere" prefix="pico"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="picoA_per_picoF">
<unit units="ampere" prefix="pico"/>
<unit units="farad" prefix="pico" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="nanoS_per_picoF">
<unit units="siemens" prefix="nano"/>
<unit units="farad" prefix="pico" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="picoF">
<unit units="farad" prefix="pico"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="micrometre_3">
<unit units="metre" prefix="micro" exponent="3"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_micrometre_3">
<unit units="metre" prefix="micro" exponent="-3"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="mm2">
<unit units="metre" prefix="milli" exponent="2"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="joule_per_mole_kelvin">
<unit units="joule"/>
<unit units="mole" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
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<units xmlns="http://www.cellml.org/cellml/1.0#" name="coulomb_per_millimole">
<unit units="coulomb"/>
<unit units="mole" prefix="milli" exponent="-1"/>
</units>
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<component xmlns="http://www.cellml.org/cellml/1.0#" name="membrane">
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<variable name="R" units="joule_per_mole_kelvin" initial_value="8.3143" public_interface="out"/>
<variable name="T" units="kelvin" initial_value="310" public_interface="out"/>
<variable name="F" units="coulomb_per_millimole" initial_value="96.4867" public_interface="out"/>
<variable name="Cm" units="picoF" initial_value="100" public_interface="out"/>
<variable name="i_st" units="picoA"/>
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<variable name="i_Na" units="picoA" public_interface="in"/>
<variable name="i_K1" units="picoA" public_interface="in"/>
<variable name="i_to" units="picoA" public_interface="in"/>
<variable name="i_Kur" units="picoA" public_interface="in"/>
<variable name="i_Kr" units="picoA" public_interface="in"/>
<variable name="i_Ks" units="picoA" public_interface="in"/>
<variable name="i_Ca_L" units="picoA" public_interface="in"/>
<variable name="i_CaP" units="picoA" public_interface="in"/>
<variable name="i_NaK" units="picoA" public_interface="in"/>
<variable name="i_NaCa" units="picoA" public_interface="in"/>
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<variable name="i_B_Ca" units="picoA" public_interface="in"/>
<variable name="i_B_Cl" units="picoA" public_interface="in"/>
<variable name="i_K_Ach" units="picoA" public_interface="in"/>
<variable name="stim_start" units="millisecond" initial_value="50"/>
<variable name="stim_end" units="millisecond" initial_value="50000"/>
<variable name="stim_period" units="millisecond" initial_value="1000"/>
<variable name="stim_duration" units="millisecond" initial_value="2"/>
<variable name="stim_amplitude" units="picoA" initial_value="-2000"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<piece>
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<and/>
<apply>
<geq/>
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<ci>stim_start</ci>
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<apply>
<leq/>
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<ci>stim_end</ci>
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<leq/>
<apply>
<minus/>
<apply>
<minus/>
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<times/>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
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<ci>stim_period</ci>
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<ci>stim_period</ci>
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<diff/>
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<ci>V</ci>
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<divide/>
<apply>
<minus/>
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<plus/>
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<ci>i_Ca_L</ci>
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<ci>i_K_Ach</ci>
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</apply>
</math>
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<variable name="E_Na" units="millivolt" public_interface="out"/>
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<variable name="Cm" units="picoF" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="Na_o" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="m" units="dimensionless" private_interface="in"/>
<variable name="h" units="dimensionless" private_interface="in"/>
<variable name="j" units="dimensionless" private_interface="in"/>
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<times/>
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<eq/>
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<times/>
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<divide/>
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<times/>
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<ci>T</ci>
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<apply>
<ln/>
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<divide/>
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<ci>Na_i</ci>
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</apply>
</apply>
</apply>
</math>
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<variable name="alpha_m" units="per_millisecond"/>
<variable name="beta_m" units="per_millisecond"/>
<variable name="m_inf" units="dimensionless"/>
<variable name="tau_m" units="millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
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<exp/>
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<divide/>
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<minus/>
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<divide/>
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<plus/>
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<eq/>
<apply>
<diff/>
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<divide/>
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<minus/>
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<variable name="alpha_h" units="per_millisecond"/>
<variable name="beta_h" units="per_millisecond"/>
<variable name="h_inf" units="dimensionless"/>
<variable name="tau_h" units="millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<piecewise>
<piece>
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<plus/>
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<times/>
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<eq/>
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<diff/>
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<divide/>
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<minus/>
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<variable name="beta_j" units="per_millisecond"/>
<variable name="j_inf" units="dimensionless"/>
<variable name="tau_j" units="millisecond"/>
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<variable name="time" units="millisecond" public_interface="in"/>
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<times/>
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<times/>
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<minus/>
<cn type="e-notation" cellml:units="per_millivolt">2.535 <sep/>
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<plus/>
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<times/>
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<plus/>
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<eq/>
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<divide/>
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<plus/>
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<ci>beta_j</ci>
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<eq/>
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<eq/>
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<diff/>
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<apply>
<divide/>
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<minus/>
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</apply>
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</component>
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<variable name="Cm" units="picoF" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="K_i" units="millimolar" public_interface="in"/>
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<component xmlns="http://www.cellml.org/cellml/1.0#" name="transient_outward_K_current">
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<variable name="E_K" units="millivolt" public_interface="in"/>
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<variable name="oi" units="dimensionless" private_interface="in"/>
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<ci>i_to</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_to</ci>
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<power/>
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<ci>E_K</ci>
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<variable name="time" units="millisecond" public_interface="in"/>
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<eq/>
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<apply>
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<apply>
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<apply>
<divide/>
<apply>
<minus/>
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<cn cellml:units="millivolt">20</cn>
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<exp/>
<apply>
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<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">12</cn>
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<apply>
<minus/>
<cn cellml:units="millivolt">11.5</cn>
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<cn cellml:units="dimensionless">3</cn>
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<eq/>
<apply>
<diff/>
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<ci>time</ci>
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<ci>oa</ci>
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<apply>
<minus/>
<ci>oa_infinity</ci>
<ci>oa</ci>
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<ci>tau_oa</ci>
</apply>
</apply>
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<variable name="beta_oi" units="per_millisecond"/>
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<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>alpha_oi</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">95.2</cn>
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<cn cellml:units="millivolt">5.85</cn>
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<eq/>
<ci>beta_oi</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">9.54</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">48</cn>
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<apply>
<minus/>
<cn cellml:units="millivolt">20</cn>
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<apply>
<eq/>
<ci>tau_oi</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>alpha_oi</ci>
<ci>beta_oi</ci>
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<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
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<eq/>
<ci>oi_infinity</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">31</cn>
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<cn cellml:units="millivolt">6.45</cn>
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</apply>
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<apply>
<minus/>
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<eq/>
<apply>
<diff/>
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<ci>time</ci>
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<ci>oi</ci>
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<divide/>
<apply>
<minus/>
<ci>oi_infinity</ci>
<ci>oi</ci>
</apply>
<ci>tau_oi</ci>
</apply>
</apply>
</math>
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<variable name="i_Kur" units="picoA" public_interface="out"/>
<variable name="g_Kur" units="nanoS_per_picoF" initial_value="0.0115" public_interface="out"/>
<variable name="Cm" units="picoF" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="ua" units="dimensionless" private_interface="in"/>
<variable name="ui" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kur</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_Kur</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">3</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">14</cn>
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<apply>
<minus/>
<cn cellml:units="millivolt">6</cn>
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<power/>
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<cn cellml:units="dimensionless">3</cn>
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<ci>ui</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
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</apply>
</apply>
</math>
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<variable name="ua" units="dimensionless" initial_value="0.05869" public_interface="out"/>
<variable name="alpha_ua" units="per_millisecond"/>
<variable name="beta_ua" units="per_millisecond"/>
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<variable name="ua_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_ua</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">1.47</cn>
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<plus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">33.2</cn>
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<apply>
<minus/>
<cn cellml:units="millivolt">30.63</cn>
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<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">27.6</cn>
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<apply>
<minus/>
<cn cellml:units="millivolt">30.65</cn>
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<eq/>
<ci>beta_ua</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">0.42</cn>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">26.64</cn>
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<cn cellml:units="millivolt">2.49</cn>
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<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">44.41</cn>
</apply>
<cn cellml:units="millivolt">20.36</cn>
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</apply>
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<eq/>
<ci>tau_ua</ci>
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<power/>
<apply>
<plus/>
<ci>alpha_ua</ci>
<ci>beta_ua</ci>
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<minus/>
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<eq/>
<ci>ua_infinity</ci>
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<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
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<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">2.81</cn>
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<apply>
<minus/>
<cn cellml:units="millivolt">9.49</cn>
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<divide/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
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<cn cellml:units="dimensionless">3</cn>
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<eq/>
<apply>
<diff/>
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<ci>ua</ci>
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<divide/>
<apply>
<minus/>
<ci>ua_infinity</ci>
<ci>ua</ci>
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<ci>tau_ua</ci>
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<variable name="ui" units="dimensionless" initial_value="9.987e-1" public_interface="out"/>
<variable name="alpha_ui" units="per_millisecond"/>
<variable name="beta_ui" units="per_millisecond"/>
<variable name="tau_ui" units="millisecond"/>
<variable name="ui_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
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<eq/>
<ci>alpha_ui</ci>
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<divide/>
<cn cellml:units="per_millisecond">1</cn>
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<cn cellml:units="dimensionless">21</cn>
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<exp/>
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<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">185</cn>
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<minus/>
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<eq/>
<ci>beta_ui</ci>
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<times/>
<cn cellml:units="per_millisecond">1</cn>
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<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">158</cn>
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<cn cellml:units="millivolt">16</cn>
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<eq/>
<ci>tau_ui</ci>
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<power/>
<apply>
<plus/>
<ci>alpha_ui</ci>
<ci>beta_ui</ci>
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<eq/>
<ci>ui_infinity</ci>
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<power/>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
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<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">99.45</cn>
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<cn cellml:units="millivolt">27.48</cn>
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<minus/>
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<eq/>
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<diff/>
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<ci>ui</ci>
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<divide/>
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<minus/>
<ci>ui_infinity</ci>
<ci>ui</ci>
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<ci>tau_ui</ci>
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<variable name="i_Kr" units="picoA" public_interface="out"/>
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<eq/>
<ci>i_Kr</ci>
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<times/>
<ci>Cm</ci>
<ci>g_Kr</ci>
<ci>xr</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
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<apply>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
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<plus/>
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<divide/>
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<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">26</cn>
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<cn cellml:units="millivolt">20.4</cn>
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</apply>
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</apply>
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<variable name="tau_xr" units="millisecond"/>
<variable name="xr_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
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<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.04</cn>
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<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">248</cn>
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<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">248</cn>
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<apply>
<minus/>
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<ci>beta_xr</ci>
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<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.028</cn>
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<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">163</cn>
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<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">163</cn>
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<cn cellml:units="millivolt">21</cn>
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<cn cellml:units="dimensionless">1</cn>
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<apply>
<eq/>
<ci>tau_xr</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>alpha_xr</ci>
<ci>beta_xr</ci>
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<apply>
<minus/>
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<eq/>
<ci>xr_infinity</ci>
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<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">7.654</cn>
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<apply>
<minus/>
<cn cellml:units="millivolt">5.377</cn>
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</apply>
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<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
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<apply>
<eq/>
<apply>
<diff/>
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<ci>time</ci>
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<ci>xr</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>xr_infinity</ci>
<ci>xr</ci>
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<ci>tau_xr</ci>
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<variable name="E_K" units="millivolt" public_interface="in"/>
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<ci>Cm</ci>
<ci>g_Ks</ci>
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<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
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<variable name="V" units="millivolt" public_interface="in"/>
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<ci>alpha_xs</ci>
<piecewise>
<piece>
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<lt/>
<apply>
<abs/>
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<plus/>
<ci>V</ci>
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<cn type="e-notation" cellml:units="millivolt">1 <sep/>
-10</cn>
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<plus/>
<ci>V</ci>
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<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28.5</cn>
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<apply>
<minus/>
<cn cellml:units="millivolt">115</cn>
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</apply>
</apply>
</apply>
</apply>
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<eq/>
<ci>beta_xs</ci>
<piecewise>
<piece>
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<apply>
<abs/>
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<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28.5</cn>
</apply>
</apply>
<cn type="e-notation" cellml:units="millivolt">1 <sep/>
-10</cn>
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<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.00023</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28.5</cn>
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</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28.5</cn>
</apply>
<cn cellml:units="millivolt">3.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
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<apply>
<eq/>
<ci>tau_xs</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>alpha_xs</ci>
<ci>beta_xs</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>xs_infinity</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">13</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">12</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xs</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>xs_infinity</ci>
<ci>xs</ci>
</apply>
<ci>tau_xs</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_K_Ach">
<variable name="i_K_Ach" units="picoA" public_interface="out"/>
<variable name="g_K_Ach" units="nanoS_per_picoF" initial_value="0.0045"/>
<variable name="Cm" units="picoF" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="xa" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K_Ach</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_K_Ach</ci>
<ci>xa</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.078</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn cellml:units="millivolt">65</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_K_Ach_xa_gate">
<variable name="xa" units="dimensionless" initial_value="1e-5" public_interface="out"/>
<variable name="tau_xa" units="millisecond"/>
<variable name="xa_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>tau_xa</ci>
<apply>
<plus/>
<cn cellml:units="per_millisecond">360</cn>
<apply>
<times/>
<cn cellml:units="per_millisecond">130</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">130</cn>
</apply>
</apply>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>xa_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">93</cn>
</apply>
<ci>V</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">15.2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xa</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>xa_infinity</ci>
<ci>xa</ci>
</apply>
<ci>tau_xa</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="L_type_Ca_channel">
<variable name="i_Ca_L" units="picoA" public_interface="out"/>
<variable name="g_Ca_L" units="nanoS_per_picoF" initial_value="0.58"/>
<variable name="Cm" units="picoF" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="Ca_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="d" units="dimensionless" private_interface="in"/>
<variable name="f" units="dimensionless" private_interface="in"/>
<variable name="f_Ca" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ca_L</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f_Ca</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">60</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="L_type_Ca_channel_d_gate">
<variable name="d" units="dimensionless" initial_value="4.757e-6" public_interface="out"/>
<variable name="d_infinity" units="dimensionless"/>
<variable name="tau_d" units="millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_infinity</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">2</cn>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d</ci>
<piecewise>
<piece>
<cn cellml:units="millisecond">0.763</cn>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn type="e-notation" cellml:units="millivolt">1 <sep/>
-10</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">6.24</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.035</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">6.24</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_infinity</ci>
<ci>d</ci>
</apply>
<ci>tau_d</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="L_type_Ca_channel_f_gate">
<variable name="f" units="dimensionless" initial_value="0.9999" public_interface="out"/>
<variable name="f_infinity" units="dimensionless"/>
<variable name="tau_f" units="millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">34</cn>
</apply>
<cn cellml:units="millivolt">6.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">400</cn>
<apply>
<plus/>
<cn cellml:units="millisecond">1</cn>
<apply>
<times/>
<cn cellml:units="millisecond">4.5</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">9</cn>
</apply>
<cn cellml:units="per_millivolt">0.0265</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_infinity</ci>
<ci>f</ci>
</apply>
<ci>tau_f</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="L_type_Ca_channel_f_Ca_gate">
<variable name="f_Ca" units="dimensionless" initial_value="0.7484" public_interface="out"/>
<variable name="f_Ca_infinity" units="dimensionless"/>
<variable name="tau_f_Ca" units="millisecond"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_Ca_infinity</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.29</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.8</cn>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_i</ci>
<cn type="e-notation" cellml:units="millimolar">1.2 <sep/>
-4</cn>
</apply>
<cn type="e-notation" cellml:units="millimolar">6 <sep/>
-5</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_Ca</ci>
<cn cellml:units="millisecond">2</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_Ca</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_Ca_infinity</ci>
<ci>f_Ca</ci>
</apply>
<ci>tau_f_Ca</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="sodium_potassium_pump">
<variable name="i_NaK" units="picoA" public_interface="out"/>
<variable name="Km_Na_i" units="millimolar" initial_value="10"/>
<variable name="Km_K_o" units="millimolar" initial_value="1.5"/>
<variable name="i_NaK_max" units="picoA_per_picoF" initial_value="0.6"/>
<variable name="Cm" units="picoF" public_interface="in"/>
<variable name="f_NaK" units="dimensionless"/>
<variable name="sigma" units="dimensionless"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="Na_o" units="millimolar" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">7</cn>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Na_o</ci>
<cn cellml:units="millimolar">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_NaK</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>F</ci>
</apply>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Cm</ci>
<ci>i_NaK_max</ci>
<ci>f_NaK</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Na_i</ci>
<ci>Na_i</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<ci>K_o</ci>
</apply>
<apply>
<plus/>
<ci>K_o</ci>
<ci>Km_K_o</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="background_currents">
<variable name="i_B_Na" units="picoA" public_interface="out"/>
<variable name="i_B_Ca" units="picoA" public_interface="out"/>
<variable name="i_B_Cl" units="picoA" public_interface="out"/>
<variable name="g_B_Na" units="nanoS_per_picoF" initial_value="1e-5"/>
<variable name="g_B_Ca" units="nanoS_per_picoF" initial_value="1e-5"/>
<variable name="g_B_Cl" units="nanoS_per_picoF" initial_value="8e-4"/>
<variable name="Cm" units="picoF" public_interface="in"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="E_Na" units="millivolt" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="Ca_o" units="millimolar" public_interface="in"/>
<variable name="Cl_i" units="millimolar" public_interface="in"/>
<variable name="Cl_o" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_B_Na</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_B_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B_Ca</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_B_Ca</ci>
<apply>
<minus/>
<ci>V</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B_Cl</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_B_Cl</ci>
<apply>
<minus/>
<ci>V</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cl_i</ci>
<ci>Cl_o</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Na_Ca_exchanger_current">
<variable name="i_NaCa" units="picoA" public_interface="out"/>
<variable name="I_NaCa_max" units="picoA_per_picoF" initial_value="1600"/>
<variable name="Cm" units="picoF" public_interface="in"/>
<variable name="K_mNa" units="millimolar" initial_value="87.5"/>
<variable name="K_mCa" units="millimolar" initial_value="1.38"/>
<variable name="K_sat" units="dimensionless" initial_value="0.1"/>
<variable name="gamma" units="dimensionless" initial_value="0.35"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="Na_o" units="millimolar" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="Ca_o" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Cm</ci>
<ci>I_NaCa_max</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>gamma</ci>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<power/>
<ci>K_mNa</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>K_mCa</ci>
<ci>Ca_o</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>K_sat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="sarcolemmal_calcium_pump_current">
<variable name="i_CaP" units="picoA" public_interface="out"/>
<variable name="i_CaP_max" units="picoA_per_picoF" initial_value="0.275"/>
<variable name="Cm" units="picoF" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_CaP</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Cm</ci>
<ci>i_CaP_max</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="millimolar">0.0005</cn>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Ca_release_current_from_JSR">
<variable name="i_rel" units="millimolar_per_millisecond" public_interface="out"/>
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<variable name="Ca_i" units="millimolar" public_interface="in"/>
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3</cn>
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<apply>
<times/>
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<minus/>
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<times/>
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<times/>
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<eq/>
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<apply>
<times/>
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<power/>
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<ci>v</ci>
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<minus/>
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<ci>Ca_i</ci>
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</apply>
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<variable name="tau_u" units="millisecond"/>
<variable name="u_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="Fn" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<apply>
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<apply>
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<minus/>
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<eq/>
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<divide/>
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<variable name="tau_v" units="millisecond"/>
<variable name="v_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
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<minus/>
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<minus/>
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<cn type="e-notation" cellml:units="dimensionless">13.67 <sep/>
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<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
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<apply>
<eq/>
<apply>
<diff/>
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<apply>
<divide/>
<apply>
<minus/>
<ci>v_infinity</ci>
<ci>v</ci>
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<ci>tau_v</ci>
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</apply>
</math>
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<variable name="w_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>tau_w</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millisecond">6</cn>
<cn cellml:units="dimensionless">0.2</cn>
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<cn cellml:units="dimensionless">1.3</cn>
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<apply>
<lt/>
<apply>
<abs/>
<apply>
<minus/>
<ci>V</ci>
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</apply>
</apply>
<cn type="e-notation" cellml:units="millivolt">1 <sep/>
-10</cn>
</apply>
</piece>
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<divide/>
<apply>
<times/>
<cn cellml:units="millisecond">6</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">7.9</cn>
</apply>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.3</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">7.9</cn>
</apply>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="per_millivolt">1</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">7.9</cn>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
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<apply>
<eq/>
<ci>w_infinity</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>w</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>w_infinity</ci>
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<ci>tau_w</ci>
</apply>
</apply>
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<component xmlns="http://www.cellml.org/cellml/1.0#" name="transfer_current_from_NSR_to_JSR">
<variable name="i_tr" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="tau_tr" units="millisecond" initial_value="180"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="Ca_rel" units="millimolar" public_interface="in"/>
<variable name="Ca_up" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_up</ci>
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</apply>
<ci>tau_tr</ci>
</apply>
</apply>
</math>
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<variable name="I_up_max" units="millimolar_per_millisecond" initial_value="0.0035" public_interface="out"/>
<variable name="i_up" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="K_up" units="millimolar" initial_value="6e-4"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_up</ci>
<apply>
<divide/>
<ci>I_up_max</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_up</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Ca_leak_current_by_the_NSR">
<variable name="i_up_leak" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="Ca_up_max" units="millimolar" initial_value="27"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="Ca_up" units="millimolar" public_interface="in"/>
<variable name="I_up_max" units="millimolar_per_millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_up_leak</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>I_up_max</ci>
<ci>Ca_up</ci>
</apply>
<ci>Ca_up_max</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Ca_buffers">
<variable name="CMDN_max" units="millimolar" initial_value="0.045" public_interface="out"/>
<variable name="TRPN_max" units="millimolar" initial_value="0.35" public_interface="out"/>
<variable name="CSQN_max" units="millimolar" initial_value="10" public_interface="out"/>
<variable name="Ca_CMDN" units="millimolar" initial_value="1.856e-3" public_interface="out"/>
<variable name="Ca_TRPN" units="millimolar" initial_value="7.022e-3" public_interface="out"/>
<variable name="Ca_CSQN" units="millimolar" initial_value="6.432" public_interface="out"/>
<variable name="var_CMDN" units="millimolar" public_interface="out"/>
<variable name="var_TRPN" units="millimolar" public_interface="out"/>
<variable name="var_CSQN" units="millimolar" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="Ca_rel" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>var_CMDN</ci>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">200</cn>
<ci>Ca_i</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_CMDN</ci>
<ci>CMDN_max</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.476</cn>
<ci>Ca_CMDN</ci>
</apply>
<ci>CMDN_max</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>var_TRPN</ci>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">78.4</cn>
<ci>Ca_i</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_TRPN</ci>
<ci>TRPN_max</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.392</cn>
<ci>Ca_TRPN</ci>
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<ci>TRPN_max</ci>
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</apply>
</apply>
<apply>
<eq/>
<ci>var_CSQN</ci>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.48</cn>
<ci>Ca_rel</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_CSQN</ci>
<ci>CSQN_max</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4</cn>
<ci>Ca_CSQN</ci>
</apply>
<ci>CSQN_max</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_CMDN</ci>
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<apply>
<times/>
<ci>var_CMDN</ci>
<ci>CMDN_max</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_TRPN</ci>
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<apply>
<times/>
<ci>var_TRPN</ci>
<ci>TRPN_max</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>Ca_CSQN</ci>
</apply>
<apply>
<times/>
<ci>var_CSQN</ci>
<ci>CSQN_max</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="intracellular_ion_concentrations">
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<variable name="V_up" units="micrometre_3"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
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<variable name="i_K_Ach" units="picoA" public_interface="in"/>
<variable name="i_NaCa" units="picoA" public_interface="in"/>
<variable name="i_B_Na" units="picoA" public_interface="in"/>
<variable name="i_Na" units="picoA" public_interface="in"/>
<variable name="i_K1" units="picoA" public_interface="in"/>
<variable name="i_to" units="picoA" public_interface="in"/>
<variable name="i_Kur" units="picoA" public_interface="in"/>
<variable name="i_Kr" units="picoA" public_interface="in"/>
<variable name="i_Ks" units="picoA" public_interface="in"/>
<variable name="i_CaP" units="picoA" public_interface="in"/>
<variable name="i_Ca_L" units="picoA" public_interface="in"/>
<variable name="i_B_Ca" units="picoA" public_interface="in"/>
<variable name="i_B_Cl" units="picoA" public_interface="in"/>
<variable name="i_up" units="millimolar_per_millisecond" public_interface="in"/>
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<variable name="i_tr" units="millimolar_per_millisecond" public_interface="in"/>
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<variable name="CMDN_max" units="millimolar" public_interface="in"/>
<variable name="TRPN_max" units="millimolar" public_interface="in"/>
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<variable name="var_TRPN" units="millimolar" public_interface="in"/>
<variable name="var_CSQN" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_i</ci>
<apply>
<times/>
<ci>V_cell</ci>
<cn cellml:units="dimensionless">0.68</cn>
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</apply>
<apply>
<eq/>
<ci>V_rel</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0048</cn>
<ci>V_cell</ci>
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<apply>
<eq/>
<ci>V_up</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0552</cn>
<ci>V_cell</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
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<ci>Na_i</ci>
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<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>i_NaK</ci>
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<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaCa</ci>
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<ci>i_B_Na</ci>
<ci>i_Na</ci>
</apply>
</apply>
<apply>
<times/>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
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<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaK</ci>
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<apply>
<plus/>
<ci>i_K1</ci>
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<ci>i_Kur</ci>
<ci>i_Kr</ci>
<ci>i_Ks</ci>
<ci>i_K_Ach</ci>
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</apply>
<apply>
<times/>
<ci>V_i</ci>
<ci>F</ci>
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</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cl_i</ci>
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<apply>
<divide/>
<ci>i_B_Cl</ci>
<apply>
<times/>
<ci>V_i</ci>
<ci>F</ci>
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</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
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<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
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<apply>
<plus/>
<ci>i_CaP</ci>
<ci>i_Ca_L</ci>
<ci>i_B_Ca</ci>
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<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V_i</ci>
<ci>F</ci>
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</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>V_up</ci>
<apply>
<minus/>
<ci>i_up_leak</ci>
<ci>i_up</ci>
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</apply>
<apply>
<times/>
<ci>i_rel</ci>
<ci>V_rel</ci>
</apply>
</apply>
<ci>V_i</ci>
</apply>
</apply>
<apply>
<times/>
<ci>TRPN_max</ci>
<ci>var_TRPN</ci>
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</apply>
<apply>
<times/>
<ci>CMDN_max</ci>
<ci>var_CMDN</ci>
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</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_up</ci>
</apply>
<apply>
<minus/>
<ci>i_up</ci>
<apply>
<plus/>
<ci>i_up_leak</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>i_tr</ci>
<ci>V_rel</ci>
</apply>
<ci>V_up</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_rel</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>i_tr</ci>
<ci>i_rel</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">31</cn>
<ci>var_CSQN</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="standard_ionic_concentrations">
<variable name="Na_o" units="millimolar" initial_value="140" public_interface="out"/>
<variable name="Ca_o" units="millimolar" initial_value="1.8" public_interface="out"/>
<variable name="K_o" units="millimolar" initial_value="5.4" public_interface="out"/>
<variable name="Cl_o" units="millimolar" initial_value="132" public_interface="out"/>
</component>
<group xmlns="http://www.cellml.org/cellml/1.0#">
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
<component_ref component="fast_sodium_current_j_gate"/>
</component_ref>
<component_ref component="time_independent_potassium_current"/>
<component_ref component="transient_outward_K_current">
<component_ref component="transient_outward_K_current_oa_gate"/>
<component_ref component="transient_outward_K_current_oi_gate"/>
</component_ref>
<component_ref component="ultrarapid_delayed_rectifier_K_current">
<component_ref component="ultrarapid_delayed_rectifier_K_current_ua_gate"/>
<component_ref component="ultrarapid_delayed_rectifier_K_current_ui_gate"/>
</component_ref>
<component_ref component="rapid_delayed_rectifier_K_current">
<component_ref component="rapid_delayed_rectifier_K_current_xr_gate"/>
</component_ref>
<component_ref component="slow_delayed_rectifier_K_current">
<component_ref component="slow_delayed_rectifier_K_current_xs_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_gate"/>
<component_ref component="L_type_Ca_channel_f_Ca_gate"/>
</component_ref>
<component_ref component="sodium_potassium_pump"/>
<component_ref component="background_currents"/>
<component_ref component="Na_Ca_exchanger_current"/>
<component_ref component="sarcolemmal_calcium_pump_current"/>
<component_ref component="i_K_Ach">
<component_ref component="i_K_Ach_xa_gate"/>
</component_ref>
<component_ref component="Ca_release_current_from_JSR">
<component_ref component="Ca_release_current_from_JSR_u_gate"/>
<component_ref component="Ca_release_current_from_JSR_v_gate"/>
<component_ref component="Ca_release_current_from_JSR_w_gate"/>
</component_ref>
<component_ref component="transfer_current_from_NSR_to_JSR"/>
<component_ref component="Ca_uptake_current_by_the_NSR"/>
<component_ref component="Ca_leak_current_by_the_NSR"/>
<component_ref component="Ca_buffers"/>
<component_ref component="intracellular_ion_concentrations"/>
<component_ref component="standard_ionic_concentrations"/>
</component_ref>
</group>
<group xmlns="http://www.cellml.org/cellml/1.0#">
<relationship_ref relationship="encapsulation"/>
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
<component_ref component="fast_sodium_current_j_gate"/>
</component_ref>
<component_ref component="transient_outward_K_current">
<component_ref component="transient_outward_K_current_oa_gate"/>
<component_ref component="transient_outward_K_current_oi_gate"/>
</component_ref>
<component_ref component="ultrarapid_delayed_rectifier_K_current">
<component_ref component="ultrarapid_delayed_rectifier_K_current_ua_gate"/>
<component_ref component="ultrarapid_delayed_rectifier_K_current_ui_gate"/>
</component_ref>
<component_ref component="rapid_delayed_rectifier_K_current">
<component_ref component="rapid_delayed_rectifier_K_current_xr_gate"/>
</component_ref>
<component_ref component="i_K_Ach">
<component_ref component="i_K_Ach_xa_gate"/>
</component_ref>
<component_ref component="slow_delayed_rectifier_K_current">
<component_ref component="slow_delayed_rectifier_K_current_xs_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_gate"/>
<component_ref component="L_type_Ca_channel_f_Ca_gate"/>
</component_ref>
<component_ref component="Ca_release_current_from_JSR">
<component_ref component="Ca_release_current_from_JSR_u_gate"/>
<component_ref component="Ca_release_current_from_JSR_v_gate"/>
<component_ref component="Ca_release_current_from_JSR_w_gate"/>
</component_ref>
</group>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="fast_sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="transient_outward_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ultrarapid_delayed_rectifier_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="rapid_delayed_rectifier_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="slow_delayed_rectifier_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="L_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_K_Ach" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Ca_release_current_from_JSR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="transfer_current_from_NSR_to_JSR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Ca_uptake_current_by_the_NSR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Ca_leak_current_by_the_NSR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Ca_buffers" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="intracellular_ion_concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="fast_sodium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="time_independent_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="transient_outward_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_to" variable_2="i_to"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="ultrarapid_delayed_rectifier_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kur" variable_2="i_Kur"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="i_K_Ach"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K_Ach" variable_2="i_K_Ach"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="rapid_delayed_rectifier_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="slow_delayed_rectifier_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="L_type_Ca_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="background_currents"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_B_Ca" variable_2="i_B_Ca"/>
<map_variables variable_1="i_B_Na" variable_2="i_B_Na"/>
<map_variables variable_1="i_B_Cl" variable_2="i_B_Cl"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="Na_Ca_exchanger_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="sarcolemmal_calcium_pump_current"/>
<map_variables variable_1="i_CaP" variable_2="i_CaP"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Ca_release_current_from_JSR" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="membrane" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="fast_sodium_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="fast_sodium_current" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="fast_sodium_current" component_2="background_currents"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="time_independent_potassium_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="time_independent_potassium_current" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="time_independent_potassium_current" component_2="transient_outward_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="time_independent_potassium_current" component_2="i_K_Ach"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="time_independent_potassium_current" component_2="background_currents"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="time_independent_potassium_current" component_2="ultrarapid_delayed_rectifier_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="time_independent_potassium_current" component_2="rapid_delayed_rectifier_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="time_independent_potassium_current" component_2="slow_delayed_rectifier_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ultrarapid_delayed_rectifier_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Kur" variable_2="i_Kur"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="rapid_delayed_rectifier_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="slow_delayed_rectifier_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_K_Ach" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_K_Ach" variable_2="i_K_Ach"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="intracellular_ion_concentrations" component_2="transient_outward_K_current"/>
<map_variables variable_1="i_to" variable_2="i_to"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="L_type_Ca_channel" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="L_type_Ca_channel" component_2="Ca_release_current_from_JSR"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="sodium_potassium_pump" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="sodium_potassium_pump" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="background_currents" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Cl_i" variable_2="Cl_i"/>
<map_variables variable_1="i_B_Ca" variable_2="i_B_Ca"/>
<map_variables variable_1="i_B_Na" variable_2="i_B_Na"/>
<map_variables variable_1="i_B_Cl" variable_2="i_B_Cl"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="background_currents" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Cl_o" variable_2="Cl_o"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Na_Ca_exchanger_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Na_Ca_exchanger_current" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Na_Ca_exchanger_current" component_2="Ca_release_current_from_JSR"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="sarcolemmal_calcium_pump_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_CaP" variable_2="i_CaP"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="intracellular_ion_concentrations" component_2="Ca_release_current_from_JSR"/>
<map_variables variable_1="i_rel" variable_2="i_rel"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_rel" variable_2="Ca_rel"/>
<map_variables variable_1="V_rel" variable_2="V_rel"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="intracellular_ion_concentrations" component_2="transfer_current_from_NSR_to_JSR"/>
<map_variables variable_1="i_tr" variable_2="i_tr"/>
<map_variables variable_1="Ca_up" variable_2="Ca_up"/>
<map_variables variable_1="Ca_rel" variable_2="Ca_rel"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="intracellular_ion_concentrations" component_2="Ca_uptake_current_by_the_NSR"/>
<map_variables variable_1="i_up" variable_2="i_up"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Ca_leak_current_by_the_NSR" component_2="Ca_uptake_current_by_the_NSR"/>
<map_variables variable_1="I_up_max" variable_2="I_up_max"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Ca_leak_current_by_the_NSR" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_up_leak" variable_2="i_up_leak"/>
<map_variables variable_1="Ca_up" variable_2="Ca_up"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Ca_buffers" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="CMDN_max" variable_2="CMDN_max"/>
<map_variables variable_1="TRPN_max" variable_2="TRPN_max"/>
<map_variables variable_1="var_CMDN" variable_2="var_CMDN"/>
<map_variables variable_1="var_TRPN" variable_2="var_TRPN"/>
<map_variables variable_1="var_CSQN" variable_2="var_CSQN"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_rel" variable_2="Ca_rel"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_j_gate"/>
<map_variables variable_1="j" variable_2="j"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_d_gate"/>
<map_variables variable_1="d" variable_2="d"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_gate"/>
<map_variables variable_1="f" variable_2="f"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_Ca_gate"/>
<map_variables variable_1="f_Ca" variable_2="f_Ca"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="transient_outward_K_current" component_2="transient_outward_K_current_oa_gate"/>
<map_variables variable_1="oa" variable_2="oa"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="transient_outward_K_current" component_2="transient_outward_K_current_oi_gate"/>
<map_variables variable_1="oi" variable_2="oi"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_K_Ach" component_2="i_K_Ach_xa_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="xa" variable_2="xa"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ultrarapid_delayed_rectifier_K_current" component_2="ultrarapid_delayed_rectifier_K_current_ua_gate"/>
<map_variables variable_1="ua" variable_2="ua"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ultrarapid_delayed_rectifier_K_current" component_2="ultrarapid_delayed_rectifier_K_current_ui_gate"/>
<map_variables variable_1="ui" variable_2="ui"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="rapid_delayed_rectifier_K_current" component_2="rapid_delayed_rectifier_K_current_xr_gate"/>
<map_variables variable_1="xr" variable_2="xr"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="slow_delayed_rectifier_K_current" component_2="slow_delayed_rectifier_K_current_xs_gate"/>
<map_variables variable_1="xs" variable_2="xs"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Ca_release_current_from_JSR" component_2="Ca_release_current_from_JSR_u_gate"/>
<map_variables variable_1="u" variable_2="u"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Fn" variable_2="Fn"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Ca_release_current_from_JSR" component_2="Ca_release_current_from_JSR_v_gate"/>
<map_variables variable_1="v" variable_2="v"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Fn" variable_2="Fn"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Ca_release_current_from_JSR" component_2="Ca_release_current_from_JSR_w_gate"/>
<map_variables variable_1="w" variable_2="w"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
</model>
