Clamped_current_Xi.cellml

Clamped current model

The Clamped current component defines the complete equations of the total ionic current. It combines the imported ionic current components:

• L-type Ca^2 + channels: ICaL

It instantiates the imported Ionic currents component with computed PO using ICaL channel states component, while the Nernst potential E_Ca computation is defined by the Nernst potential component.

• T-type Ca^2 + channels: ICaT

It instantiates the imported Ionic currents component with computed PO using ICaT channel states component, while the Nernst potential E_Ca computation is defined by the Nernst potential component.

• Voltage dependent K⁺ channels: IKv

It instantiates the imported Ionic currents component with computed P_Kv = x_Kv*y_Kv. The gating kinetics is defined in the imported gating kinetics component, while the steady states of x and y gate are defined by the imported IKv gating steady state component, the Nernst potential E_K computation is defined by the Nernst potential component.

• Large conductance Ca^2 + and voltage activated K⁺ channels: IBK

It instantiates the imported Ionic currents component with computed PO using IBK channel states component, while the Nernst potential E_K computation is defined by the Nernst potential component.

• Na⁺ channels: INa

It instantiates the imported Ionic currents component with computed PO using INa channel states component, while the Nernst potential E_Na computation is defined by the Nernst potential component.

• Na⁺- K⁺ pump: INaK
• Na⁺- Ca^2 + exchanger: INCX
• Non-selective sodium leak current: INS_Na
• Non-selective potassium leak current: INS_K

The intracellular ionic concentrations Ca^2 +_i, Na⁺_i and K⁺_i should be given by the clamping parameters.