Membrane_potential.cellml

Membrane potential model

The Membrane potential component defines the complete equations of the membrane potential and total ionic current. It combines the imported ionic current components and ionic concentrations components:

  • L-type Ca2 +  channels: ICaL

It instantiates the imported Ionic currents component with computed PO using ICaL channel states component, while the Nernst potential ECa computation is defined by the Nernst potential component.

  • T-type Ca2 +  channels: ICaT

It instantiates the imported Ionic currents component with computed PO using ICaT channel states component, while the Nernst potential ECa computation is defined by the Nernst potential component.

  • Voltage dependent K +  channels: IKv

It instantiates the imported Ionic currents component with computed PKv = xKv*yKv. The gating kinetics is defined in the imported gating kinetics component, while the steady states of x and y gate are defined by the imported IKv gating steady state component, the Nernst potential EK computation is defined by the Nernst potential component.

  • Large conductance Ca2 +  and voltage activated K +  channels: IBK

It instantiates the imported Ionic currents component with computed PO using IBK channel states component, while the Nernst potential EK computation is defined by the Nernst potential component.

  • Na +  channels: INa

It instantiates the imported Ionic currents component with computed PO using INa channel states component, while the Nernst potential ENa computation is defined by the Nernst potential component.

  • Na + - K +  pump: INaK
  • Na + - Ca2 +  exchanger: INCX
  • Non-selective sodium leak current: INS_Na
  • Non-selective potassium leak current: INS_K
  • The imported ionic concentrations components include Ca2 + i, Na + i and K + i.