Patch_clampXi_experiment.cellml

Voltage clamp experiment

In the Voltage clamp experiment, the Clamped current component is configured and parameterised with an applied Patch clamp protocol.

You can change the clamping parameters in the component Clamp_parameters.

You can also bypass the parameters in the component model_parameters and initial_conditions and define your own parameters.

The simulation experiment can be obtained by loading the corresponding SED-ML document into OpenCOR and executing the simulation.

Clamped ICaL

Figure [1] shows normalized L-type calcium channels peak I–V plot for simulated data derived from the publication (dots) and the current CellML model (solid line) with different intracelluar concentrations.

[1]
simFig2

Clamped ICaT

Figure [2] shows normalized T-type calcium channels peak I–V plot for simulated data derived from the publication (dots) and the current CellML model (solid line) with different intracelluar concentrations.

[2]
simFig3

Clamped IKv

Figure [3] shows normalized I–V plot of whole cell voltage-activated potassium currents for simulated data derived from the publication (dots) and the current CellML model (solid line).

[3]
simFig4

Clamped PBK

Figure [4] shows Open probability of BK channel versus clamping voltage (@ various Ca2 + i) for simulated data derived from the publication (dots) and the current CellML model (solid line).

[4]
simFig5

Clamped INa

Figure [5] shows normalized Na +  channel peak I–V plot for simulated data derived from the publication (dots) and the current CellML model (solid line) with different intracelluar concentrations.

[5]
simFig6

Figure [6] shows whole cell current versus time traces subjected to voltage clamp at different holding voltages for simulated data derived from the publication (dots) and the current CellML model (solid line).

[6]
simFig10

Figure [7] shows whole cell normalized I–V data from hJSMC model under near calcium-free conditions for simulated data derived from the publication (dots) and the current CellML model (solid line).

[7]
simFig11