Model Mathematics

Component: cai

ddtimeCai=Cai_bufc-i_up+i_leak+i_rel-Cm2.0VcF+i_CaL_Ca+i_CaT+i_b_Ca+i_PCa-2.0i_NaCa Cai_bufc=1.01.0+Buf_CKbuf_CCai+Kbuf_C2.0

Component: casr

Buf_SR=10.01.2 ddtimeCa_SR=Ca_SR_bufSRVcV_SRi_up-i_rel-i_leak Ca_SR_bufSR=1.01.0+Buf_SRKbuf_SRCa_SR+Kbuf_SR2.0

Component: engine

Component: erev

E_Ca=0.5RTFlnCaoCai E_K=RTFlnKoKi E_Na=RTFlnNaoNai

Component: extra

Component: geom

V_SR=V_totVSR_tenTV_tot_tenT V_tot_tenT=Vc_tenT+VSR_tenT Vc=V_totVc_tenTV_tot_tenT

Component: ibca

g_b_Ca=0.0005920.62 i_b_Ca=g_b_CaV-E_Ca

Component: ibna

g_b_Na=0.000291.5 i_b_Na=g_b_NaV-E_Na

Component: ical

alpha_fCa=1.01.0+scaleCai0.0003258.0 beta_fCa=0.11.0+scaleCai-0.00050.0001 ddtimed=ical_d_inf-dical_d_tau d3=d5d1 d4=1.01.0d2+1.0d6 d6=-6.90988036924199989 ddtimef=ical_f_inf-fical_f_tau f2=-4.95057120338699974e1 f3=f5f1 f4=1.01.0f2+1.0f6 ddtimefCa=k_fcafCa_inf-fCatau_fCa fCa_inf=alpha_fCa+beta_fCa+gamma_fCa+0.231.46 gamma_fCa=0.21.0+scaleCai-0.000750.0008 i_CaL=i_CaL_Ca+i_CaL_Na+i_CaL_K i_CaL_Ca=ibarcadffCa i_CaL_K=ibarkdffCa i_CaL_Na=ibarnadffCa ibarca=p_CaL_Ca4.0VFFRT0.341Cai2.0VFRT-0.341Cao2.0VFRT-1.0 ibark=p_CaL_KVFFRT0.75KiVFRT-0.75KoVFRT-1.0 ibarna=p_CaL_NaVFFRT0.75NaiVFRT-0.75NaoVFRT-1.0 ical_d_a=d1Vd2 ical_d_b=d3Vd4 ical_d_inf=ical_d_aical_d_a+ical_d_b ical_d_tau=1.0ical_d_a+ical_d_b+taud_const ical_f_a=f1Vf2 ical_f_b=f3Vf4 ical_f_inf=ical_f_aical_f_a+ical_f_b ical_f_tau=1.0ical_f_a+ical_f_b+tauf_const k_fca=0.0iffCa_inf>fCaV>-60.01.0otherwise p_CaL_Ca=p_CaL_shannonCapp_CaL p_CaL_K=p_CaL_shannonKpp_CaL p_CaL_Na=p_CaL_shannonNapp_CaL p_CaL_shannonCap=p_CaL_shannonCap_CaL_shannonTot p_CaL_shannonKp=p_CaL_shannonKp_CaL_shannonTot p_CaL_shannonNap=p_CaL_shannonNap_CaL_shannonTot p_CaL_shannonTot=p_CaL_shannonCa+p_CaL_shannonNa+p_CaL_shannonK

Component: icat

ddtimed=icat_d_inf-dicat_d_tau ddtimef=icat_f_inf-ficat_f_tau i_CaT=g_CaTdfV-E_Ca icat_d_inf=1.01.0+V+26.3-6.0 icat_d_tau=1.01.068V+26.330.0+1.068V+26.3-30.0 icat_f_inf=1.01.0+V+61.75.6 icat_f_tau=1.00.0153-V+61.783.3+0.015V+61.715.38

Component: ifunny

Na_frac=NatoK_ratioNatoK_ratio+1.0 ddtimeXf=ifunny_Xf_inf-Xfifunny_Xf_tau i_f=i_fNa+i_fK i_fK=1.0-Na_fracg_fXfV-E_K i_fNa=Na_fracg_fXfV-E_Na ifunny_Xf_a=xF1VxF2 ifunny_Xf_b=xF3VxF4 ifunny_Xf_inf=ifunny_Xf_aifunny_Xf_a+ifunny_Xf_b ifunny_Xf_tau=1.0ifunny_Xf_a+ifunny_Xf_b+xF_const xF2=-1.45897121702000003e1 xF3=xF5xF1 xF4=1.01.0xF2+1.0xF6

Component: ik1

i_K1=g_K1Ko5.4infV-E_K ik1_inf_a=xK11V+xK13xK12 ik1_inf_b=1.0V+xK15xK14 inf=ik1_inf_aik1_inf_a+ik1_inf_b

Component: ikr

ddtimeXr1=ikr_Xr1_inf-Xr1ikr_Xr1_tau Xr1_3=Xr1_5Xr1_1 Xr1_4=1.01.0Xr1_2+1.0Xr1_6 Xr1_6=-7.06808742965549008 ddtimeXr2=ikr_Xr2_inf-Xr2ikr_Xr2_tau Xr2_2=-2.59944581644376989e1 Xr2_3=Xr2_5Xr2_1 Xr2_4=1.01.0Xr2_2+1.0Xr2_6 i_Kr=g_KrKo5.4Xr1Xr2V-E_K ikr_Xr1_a=Xr1_1VXr1_2 ikr_Xr1_b=Xr1_3VXr1_4 ikr_Xr1_inf=ikr_Xr1_aikr_Xr1_a+ikr_Xr1_b ikr_Xr1_tau=1.0ikr_Xr1_a+ikr_Xr1_b+tau_1_offset ikr_Xr2_a=Xr2_1VXr2_2 ikr_Xr2_b=Xr2_3VXr2_4 ikr_Xr2_inf=ikr_Xr2_aikr_Xr2_a+ikr_Xr2_b ikr_Xr2_tau=1.0ikr_Xr2_a+ikr_Xr2_b+tau_2_offset

Component: iks

ddtimeXs=iks_Xs_inf-Xsiks_Xs_tau i_Ks=g_KsXs2.0V-E_K iks_Xs_a=ks1Vks2 iks_Xs_b=ks3Vks4 iks_Xs_inf=iks_Xs_aiks_Xs_a+iks_Xs_b iks_Xs_tau=1.0iks_Xs_a+iks_Xs_b+tauks_const ks3=ks5ks1 ks4=1.01.0ks2+1.0ks6 ks6=-1.88669715729099998e1

Component: ileak

V_leak=8e-050.02 i_leak=Ca_SR-CaiV_leak

Component: ina

ddtimeh=ina_h_inf-hina_h_tau h2=-1.98393588600259996e1 h3=h5h1 h4=1.01.0h2+1.0h6 i_Na=g_Nam3.0hjV-E_Na ina_h_a=h1Vh2 ina_h_b=h3Vh4 ina_h_inf=ina_h_aina_h_a+ina_h_b ina_h_tau=1.0ina_h_a+ina_h_b+tau_h_const ina_j_a=j1Vj2 ina_j_b=j3Vj4 ina_j_inf=ina_j_aina_j_a+ina_j_b ina_j_tau=1.0ina_j_a+ina_j_b+tau_j_const ina_m_a=m1Vm2 ina_m_b=m3Vm4 ina_m_inf=ina_m_aina_m_a+ina_m_b ina_m_tau=1.0ina_m_a+ina_m_b+tau_m_const ddtimej=ina_j_inf-jina_j_tau j2=-6.65837555026519965e01 j3=j5j1 j4=1.01.0j2+1.0j6 j5=h5 j6=h6 ddtimem=ina_m_inf-mina_m_tau m3=m5m1 m4=1.01.0m2+1.0m6 m6=-7.91772628951300028

Component: inaca

alpha=2.51.1 gamma=0.352.0 i_NaCa=kNaCagammaVFRTNai3.0Cao-gamma-1.0VFRTNao3.0CaialphaKmNai3.0+Nao3.0KmCa+Cao1.0+Ksatgamma-1.0VFRT kNaCa=1000.01.1

Component: inak

PNaK=1.3621.818 i_NaK=PNaKKoNaiKo+Km_KNai+Km_Na1.0+0.1245-0.1VFRT+0.0353-VFRT

Component: ipca

g_PCa=0.02510.5 i_PCa=g_PCaCaiCai+KPCa

Component: irel

ddtimeI=kiSRCaCaiO-kimI-komI+koSRCaCai2.0RI ddtimeO=koSRCaCai2.0R-komO-kiSRCaCaiO+kimI ddtimeR=kimRI-kiSRCaCaiR-koSRCaCai2.0R+komO RI=1.0-R-O-I i_rel=ksOCa_SR-CaiV_SRVc kCaSR=MaxSR-MaxSR-MinSR1.0+ec50SRCa_SR2.5 kiCa=54.00.3425 kiSRCa=kiCakCaSR kim=0.0010.5571 koCa=56320.011.43025 koSRCa=koCakCaSR kom=1.50.1429

Component: ito

i_to=g_torsV-E_K ito_r_a=r1Vr2 ito_r_b=r3Vr4 ito_r_inf=ito_r_aito_r_a+ito_r_b ito_r_tau=1.0ito_r_a+ito_r_b+tau_r_const ito_s_a=s1Vs2 ito_s_b=s3Vs4 ito_s_inf=ito_s_aito_s_a+ito_s_b ito_s_tau=1.0ito_s_a+ito_s_b+tau_s_const ddtimer=ito_r_inf-rito_r_tau r3=r5r1 r4=1.01.0r2+1.0r6 r6=-1.10471393012032006e1 ddtimes=ito_s_inf-sito_s_tau s2=-1.76344722898096009e1 s3=s5s1 s4=1.01.0s2+1.0s6

Component: iup

Kup=0.000250.702 VmaxUp=0.0004250.26 i_up=VmaxUp1.0+Kup2.0Cai2.0

Component: ki

ddtimeKi=-CmFVc+i_K1+i_to+i_Kr+i_Ks+i_fK-2.0i_NaK+i_CaL_K

Component: membrane

ddtimeV=-+i_K1+i_to+i_Kr+i_Ks+i_CaL+i_CaT+i_NaK+i_Na+i_NaCa+i_PCa+i_f+i_b_Na+i_b_Ca+i_stim

Component: nai

ddtimeNai=-CmFVc+i_Na+i_b_Na+i_fNa+3.0i_NaK+3.0i_NaCa+i_CaL_Na

Component: phys

FFRT=FFRT FRT=FRT RTF=RTF

Component: stimulus

amplitude=-3.0 i_stim=paceamplitude
Source
Derived from workspace Kernik et al. 2019 at changeset 2c123f3eba5b.
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