Voigt, Heijman et al. 2013 Human Atrial AP model

Model of the human atrial action potential by Voigt & Heijman et al.

This model was created for a study in atrial fibrillation [1]. It is based on the atrial model by Grandi et al. [2], but with an added IK,ACh current adapted from [3], the INa current from [4], and modifications to IK1 and its dependence on the external potassium concentration.

This model file was adapted (reformatting only) from code provided by Henry Sutanto and Jordi Heijman.

The stimulus was set to 0.5[ms] and -90[A/F].

[1] Impaired Na + -dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic atrial fibrillation. Niels Voigt & Jordi Heijman (shared first), Anne Trausch, Elisa Mintert-Jancke, Lutz Pott, Ursula Ravens, Dobromir Dobrev. 2013, Journal of Molecular and Cellular Cardiology, 61, 142-152. https://doi.org/10.1016/j.yjmcc.2013.03.011

[2] Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation. Eleonora Grandi, Sandeep V Pandit, Niels Voigt, Antony J Workman, Dobromir Dobrev, Jose Jalife, Donald M Bers. 2011, Circulation Research, 109(9):1055-1066. https://doi.org/10.1161/CIRCRESAHA.111.253955

[3] Cholinergic Atrial Fibrillation in a Computer Model of a Two-Dimensional Sheet of Canine Atrial Cells With Realistic Ionic Properties James Kneller, Renqiang Zou, Edward J Vigmond, Zhiguo Wang, L Joshua Leon, Stanley Nattel 2002, Circulation Research, 90:e73-e87 https://doi.org/10.1161/01.RES.0000019783.88094.BA

[4] Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Marc Courtemanche, Rafael J. Ramirez and Stanley Nattel. 1998, American Journal of Physiology, 275, H301-H321. https://doi.org/10.1152/ajpheart.1998.275.1.H301