# MWC_10_test.cellml

### MWC-10 model experiment

In the MWC_10_experiment, the MWC-10 model is configured and parameterised with an applied voltage clamp protocol.

You can change the parameters of stimulation in the component `clamp_para`. You can also bypass the parameters in the components `free_para_10` and `Para`, and define your own parameters.

### Steady states

We have used two approaches to get the steady states of system:

- Apply the double pulse protocol and record the simulation when the system reaches plateau (after 200 ms);

- Use Equation (6) and (7) in the primary paper, denoted by
_{ss}in the following figures.

- Use Equation (6) and (7) in the primary paper, denoted by

The results from these two methods are identical in our simulation.

Figure [1] shows the voltage dependencies and transfer function.

[1] |

Figure [2] shows the voltage dependencies and transfer function under reference conditions.

[2] |

Figure [3] shows the voltage dependencies and transfer function under perchlorate conditions, where the simulation for Fiber 911 case does not match well.

[3] |

### Kinetic transients

Figure [4] shows charge movement transients (simulation data are divided by 5) in reference simulation with different test voltages.

[4] |

Figure [5] shows charge movement transients (simulation data are divided by 5) in perchlorate simulation with different test voltages.

[5] |

For primary Fig. 11, we have tried different settings in Table 1 and two sets of test voltages, but we couldn't find a perfect match.

Figure [6] shows the open probability and charge movement current when 827 parameters are used.

[6] |

Figure [7] shows the open probability and charge movement current when 908 parameters are used.

[7] |

Figure [8] shows the open probability and charge movement current when 906 parameters are used.

[8] |

Figure [9] shows the open probability and charge movement current when 907 parameters are used.

[9] |

The following two figures only have simulation results, which show that the qualitative difference between reference and perchlorate conditions agrees with the original figure, that is, perchlorate conditions slow down the transitions.

Figure [10] shows the open probability and charge movement current under reference and perchlorate conditions when 827 parameters are used.

[10] |

Figure [11] shows the open probability and charge movement current under reference and perchlorate conditions when 908 parameters are used.

[11] |