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Model Mathematics
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Component: environment
d
d
t
q_Na_o
=
v_Na
d
d
t
q_Na_i
=
-
v_Na
d
d
t
q_mem
=
I_mem_Na
Component: Na_parameters
Component: fast_Na
V_mem
=
q_mem
C_m
I_mem_Na
=
F
-
zNa
v_Na
+
z_rm
v_m000
-
z_fm
v_m000
+
z_rm
v_m100
-
z_fm
v_m100
+
z_rm
v_m010
-
z_fm
v_m010
+
z_rm
v_m110
-
z_fm
v_m110
+
z_rm
v_m210
-
z_fm
v_m210
+
z_rh
v_h000
-
z_fh
v_h000
+
z_rh
v_h200
-
z_fh
v_h200
+
z_rj
v_j100
-
z_fj
v_j100
+
z_rj
v_j200
-
z_fj
v_j200
+
z_rj
v_j300
-
z_fj
v_j300
+
z_rm
v_m200
-
z_fm
v_m200
+
z_rh
v_h100
-
z_fh
v_h100
+
z_rh
v_h300
-
z_fh
v_h300
+
z_rj
v_j000
-
z_fj
v_j000
+
z_rm
v_m001
-
z_fm
v_m001
+
z_rm
v_m101
-
z_fm
v_m101
+
z_rm
v_m011
-
z_fm
v_m011
+
z_rm
v_m111
-
z_fm
v_m111
+
z_rm
v_m211
-
z_fm
v_m211
+
z_rh
v_h001
-
z_fh
v_h001
+
z_rh
v_h201
-
z_fh
v_h201
+
z_rj
v_j010
-
z_fj
v_j010
+
z_rj
v_j110
-
z_fj
v_j110
+
z_rj
v_j210
-
z_fj
v_j210
+
z_rj
v_j310
-
z_fj
v_j310
+
z_rm
v_m201
-
z_fm
v_m201
+
z_rh
v_h101
-
z_fh
v_h101
+
z_rh
v_h301
-
z_fh
v_h301
mu_Na_o
=
R
T
ln
K_Na_o
q_Na_o
mu_Na_i
=
R
T
ln
K_Na_i
q_Na_i
mu_S000_Na
=
R
T
ln
K_000_Na
q_S000_Na
mu_S001_Na
=
R
T
ln
K_001_Na
q_S001_Na
mu_S010_Na
=
R
T
ln
K_010_Na
q_S010_Na
mu_S011_Na
=
R
T
ln
K_011_Na
q_S011_Na
mu_S100_Na
=
R
T
ln
K_100_Na
q_S100_Na
mu_S101_Na
=
R
T
ln
K_101_Na
q_S101_Na
mu_S110_Na
=
R
T
ln
K_110_Na
q_S110_Na
mu_S111_Na
=
R
T
ln
K_111_Na
q_S111_Na
mu_S200_Na
=
R
T
ln
K_200_Na
q_S200_Na
mu_S201_Na
=
R
T
ln
K_201_Na
q_S201_Na
mu_S210_Na
=
R
T
ln
K_210_Na
q_S210_Na
mu_S211_Na
=
R
T
ln
K_211_Na
q_S211_Na
mu_S300_Na
=
R
T
ln
K_300_Na
q_S300_Na
mu_S301_Na
=
R
T
ln
K_301_Na
q_S301_Na
mu_S310_Na
=
R
T
ln
K_310_Na
q_S310_Na
mu_S311_Na
=
R
T
ln
K_311_Na
q_S311_Na
v_h000
=
kappa_h000
ⅇ
Af_h000
R
T
-
ⅇ
Ar_h000
R
T
v_h001
=
kappa_h001
ⅇ
Af_h001
R
T
-
ⅇ
Ar_h001
R
T
v_h100
=
kappa_h100
ⅇ
Af_h100
R
T
-
ⅇ
Ar_h100
R
T
v_h101
=
kappa_h101
ⅇ
Af_h101
R
T
-
ⅇ
Ar_h101
R
T
v_h200
=
kappa_h200
ⅇ
Af_h200
R
T
-
ⅇ
Ar_h200
R
T
v_h201
=
kappa_h201
ⅇ
Af_h201
R
T
-
ⅇ
Ar_h201
R
T
v_h300
=
kappa_h300
ⅇ
Af_h300
R
T
-
ⅇ
Ar_h300
R
T
v_h301
=
kappa_h301
ⅇ
Af_h301
R
T
-
ⅇ
Ar_h301
R
T
v_j000
=
kappa_j000
ⅇ
Af_j000
R
T
-
ⅇ
Ar_j000
R
T
v_j010
=
kappa_j010
ⅇ
Af_j010
R
T
-
ⅇ
Ar_j010
R
T
v_j100
=
kappa_j100
ⅇ
Af_j100
R
T
-
ⅇ
Ar_j100
R
T
v_j110
=
kappa_j110
ⅇ
Af_j110
R
T
-
ⅇ
Ar_j110
R
T
v_j200
=
kappa_j200
ⅇ
Af_j200
R
T
-
ⅇ
Ar_j200
R
T
v_j210
=
kappa_j210
ⅇ
Af_j210
R
T
-
ⅇ
Ar_j210
R
T
v_j300
=
kappa_j300
ⅇ
Af_j300
R
T
-
ⅇ
Ar_j300
R
T
v_j310
=
kappa_j310
ⅇ
Af_j310
R
T
-
ⅇ
Ar_j310
R
T
v_m000
=
kappa_m000
ⅇ
Af_m000
R
T
-
ⅇ
Ar_m000
R
T
v_m001
=
kappa_m001
ⅇ
Af_m001
R
T
-
ⅇ
Ar_m001
R
T
v_m010
=
kappa_m010
ⅇ
Af_m010
R
T
-
ⅇ
Ar_m010
R
T
v_m011
=
kappa_m011
ⅇ
Af_m011
R
T
-
ⅇ
Ar_m011
R
T
v_m100
=
kappa_m100
ⅇ
Af_m100
R
T
-
ⅇ
Ar_m100
R
T
v_m101
=
kappa_m101
ⅇ
Af_m101
R
T
-
ⅇ
Ar_m101
R
T
v_m110
=
kappa_m110
ⅇ
Af_m110
R
T
-
ⅇ
Ar_m110
R
T
v_m111
=
kappa_m111
ⅇ
Af_m111
R
T
-
ⅇ
Ar_m111
R
T
v_m200
=
kappa_m200
ⅇ
Af_m200
R
T
-
ⅇ
Ar_m200
R
T
v_m201
=
kappa_m201
ⅇ
Af_m201
R
T
-
ⅇ
Ar_m201
R
T
v_m210
=
kappa_m210
ⅇ
Af_m210
R
T
-
ⅇ
Ar_m210
R
T
v_m211
=
kappa_m211
ⅇ
Af_m211
R
T
-
ⅇ
Ar_m211
R
T
Af_Na
=
mu_Na_i
+
zNa
F
V_mem
+
mu_S311_Na
Af_h000
=
R
T
ln
K_000_Na
q_S000_Na
+
z_fh
F
V_mem
Af_h001
=
R
T
ln
K_001_Na
q_S001_Na
+
z_fh
F
V_mem
Af_h100
=
R
T
ln
K_100_Na
q_S100_Na
+
z_fh
F
V_mem
Af_h101
=
R
T
ln
K_101_Na
q_S101_Na
+
z_fh
F
V_mem
Af_h200
=
R
T
ln
K_200_Na
q_S200_Na
+
z_fh
F
V_mem
Af_h201
=
R
T
ln
K_201_Na
q_S201_Na
+
z_fh
F
V_mem
Af_h300
=
R
T
ln
K_300_Na
q_S300_Na
+
z_fh
F
V_mem
Af_h301
=
R
T
ln
K_301_Na
q_S301_Na
+
z_fh
F
V_mem
Af_j000
=
R
T
ln
K_000_Na
q_S000_Na
+
z_fj
F
V_mem
Af_j010
=
R
T
ln
K_010_Na
q_S010_Na
+
z_fj
F
V_mem
Af_j100
=
R
T
ln
K_100_Na
q_S100_Na
+
z_fj
F
V_mem
Af_j110
=
R
T
ln
K_110_Na
q_S110_Na
+
z_fj
F
V_mem
Af_j200
=
R
T
ln
K_200_Na
q_S200_Na
+
z_fj
F
V_mem
Af_j210
=
R
T
ln
K_210_Na
q_S210_Na
+
z_fj
F
V_mem
Af_j300
=
R
T
ln
K_300_Na
q_S300_Na
+
z_fj
F
V_mem
Af_j310
=
R
T
ln
K_310_Na
q_S310_Na
+
z_fj
F
V_mem
Af_m000
=
R
T
ln
K_000_Na
q_S000_Na
+
z_fm
F
V_mem
Af_m001
=
R
T
ln
K_001_Na
q_S001_Na
+
z_fm
F
V_mem
Af_m010
=
R
T
ln
K_010_Na
q_S010_Na
+
z_fm
F
V_mem
Af_m011
=
R
T
ln
K_011_Na
q_S011_Na
+
z_fm
F
V_mem
Af_m100
=
R
T
ln
K_100_Na
q_S100_Na
+
z_fm
F
V_mem
Af_m101
=
R
T
ln
K_101_Na
q_S101_Na
+
z_fm
F
V_mem
Af_m110
=
R
T
ln
K_110_Na
q_S110_Na
+
z_fm
F
V_mem
Af_m111
=
R
T
ln
K_111_Na
q_S111_Na
+
z_fm
F
V_mem
Af_m200
=
R
T
ln
K_200_Na
q_S200_Na
+
z_fm
F
V_mem
Af_m201
=
R
T
ln
K_201_Na
q_S201_Na
+
z_fm
F
V_mem
Af_m210
=
R
T
ln
K_210_Na
q_S210_Na
+
z_fm
F
V_mem
Af_m211
=
R
T
ln
K_211_Na
q_S211_Na
+
z_fm
F
V_mem
Am_Na
=
zNa
F
V_mem
Ar_Na
=
mu_Na_o
+
mu_S311_Na
Ar_h000
=
R
T
ln
K_010_Na
q_S010_Na
+
z_rh
F
V_mem
Ar_h001
=
R
T
ln
K_011_Na
q_S011_Na
+
z_rh
F
V_mem
Ar_h100
=
R
T
ln
K_110_Na
q_S110_Na
+
z_rh
F
V_mem
Ar_h101
=
R
T
ln
K_111_Na
q_S111_Na
+
z_rh
F
V_mem
Ar_h200
=
R
T
ln
K_210_Na
q_S210_Na
+
z_rh
F
V_mem
Ar_h201
=
R
T
ln
K_211_Na
q_S211_Na
+
z_rh
F
V_mem
Ar_h300
=
R
T
ln
K_310_Na
q_S310_Na
+
z_rh
F
V_mem
Ar_h301
=
R
T
ln
K_311_Na
q_S311_Na
+
z_rh
F
V_mem
Ar_j000
=
R
T
ln
K_001_Na
q_S001_Na
+
z_rj
F
V_mem
Ar_j010
=
R
T
ln
K_011_Na
q_S011_Na
+
z_rj
F
V_mem
Ar_j100
=
R
T
ln
K_101_Na
q_S101_Na
+
z_rj
F
V_mem
Ar_j110
=
R
T
ln
K_111_Na
q_S111_Na
+
z_rj
F
V_mem
Ar_j200
=
R
T
ln
K_201_Na
q_S201_Na
+
z_rj
F
V_mem
Ar_j210
=
R
T
ln
K_211_Na
q_S211_Na
+
z_rj
F
V_mem
Ar_j300
=
R
T
ln
K_301_Na
q_S301_Na
+
z_rj
F
V_mem
Ar_j310
=
R
T
ln
K_311_Na
q_S311_Na
+
z_rj
F
V_mem
Ar_m000
=
R
T
ln
K_100_Na
q_S100_Na
+
z_rm
F
V_mem
Ar_m001
=
R
T
ln
K_101_Na
q_S101_Na
+
z_rm
F
V_mem
Ar_m010
=
R
T
ln
K_110_Na
q_S110_Na
+
z_rm
F
V_mem
Ar_m011
=
R
T
ln
K_111_Na
q_S111_Na
+
z_rm
F
V_mem
Ar_m100
=
R
T
ln
K_200_Na
q_S200_Na
+
z_rm
F
V_mem
Ar_m101
=
R
T
ln
K_201_Na
q_S201_Na
+
z_rm
F
V_mem
Ar_m110
=
R
T
ln
K_210_Na
q_S210_Na
+
z_rm
F
V_mem
Ar_m111
=
R
T
ln
K_211_Na
q_S211_Na
+
z_rm
F
V_mem
Ar_m200
=
R
T
ln
K_300_Na
q_S300_Na
+
z_rm
F
V_mem
Ar_m201
=
R
T
ln
K_301_Na
q_S301_Na
+
z_rm
F
V_mem
Ar_m210
=
R
T
ln
K_310_Na
q_S310_Na
+
z_rm
F
V_mem
Ar_m211
=
R
T
ln
K_311_Na
q_S311_Na
+
z_rm
F
V_mem
v_S000_Na
=
-
v_m000
-
v_h000
-
v_j000
v_S001_Na
=
-
v_m001
-
v_h001
-
-
v_j000
v_S010_Na
=
-
v_m010
+
v_h000
-
v_j010
v_S011_Na
=
-
v_m011
+
v_h001
-
-
v_j010
v_S100_Na
=
v_m000
-
v_m100
-
v_h100
-
v_j100
v_S101_Na
=
v_m001
-
v_m101
-
v_h101
-
-
v_j100
v_S110_Na
=
v_m010
-
v_m110
+
v_h100
-
v_j110
v_S111_Na
=
v_m011
-
v_m111
+
v_h101
-
-
v_j110
v_S200_Na
=
v_m100
-
v_m200
-
v_h200
-
v_j200
v_S201_Na
=
v_m101
-
v_m201
-
v_h201
-
-
v_j200
v_S210_Na
=
v_m110
-
v_m210
+
v_h200
-
v_j210
v_S211_Na
=
v_m111
-
v_m211
+
v_h201
-
-
v_j210
v_S300_Na
=
v_m200
-
v_h300
-
v_j300
v_S301_Na
=
v_m201
-
v_h301
-
-
v_j300
v_S310_Na
=
v_m210
+
v_h300
-
v_j310
v_S311_Na
=
v_m211
+
v_h301
-
-
v_j310
+
v_Na
-
v_Na
d
d
t
q_S000_Na
=
v_S000_Na
d
d
t
q_S010_Na
=
v_S010_Na
d
d
t
q_S100_Na
=
v_S100_Na
d
d
t
q_S110_Na
=
v_S110_Na
d
d
t
q_S200_Na
=
v_S200_Na
d
d
t
q_S210_Na
=
v_S210_Na
d
d
t
q_S300_Na
=
v_S300_Na
d
d
t
q_S310_Na
=
v_S310_Na
d
d
t
q_S001_Na
=
v_S001_Na
d
d
t
q_S011_Na
=
v_S011_Na
d
d
t
q_S101_Na
=
v_S101_Na
d
d
t
q_S111_Na
=
v_S111_Na
d
d
t
q_S201_Na
=
v_S201_Na
d
d
t
q_S211_Na
=
v_S211_Na
d
d
t
q_S301_Na
=
v_S301_Na
d
d
t
q_S311_Na
=
v_S311_Na
v_Na
=
kappa_Na
ⅇ
Af_Na
R
T
-
ⅇ
Ar_Na
R
T
if
Am_Na
=
0
kappa_Na
Am_Na
R
T
ⅇ
Am_Na
R
T
-
1
ⅇ
Af_Na
R
T
-
ⅇ
Ar_Na
R
T
otherwise
Source
Derived from workspace
Na channel knowledge page
at changeset
5d289b0b1991
.
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