Rendering of the source text

<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 13/06/2012 at 22:45:06 using:

COR (0.9.31.1409)
Copyright 2002-2012 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
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      <unit units="millisecond" exponent="-1"/>
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      <unit units="volt" prefix="milli"/>
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      <variable name="T" units="kelvin" initial_value="310" public_interface="out"/>
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      <variable name="i_NaK" units="nanoA" public_interface="in"/>
      <variable name="i_NaCa" units="nanoA" public_interface="in"/>
      <variable name="i_Na" units="nanoA" public_interface="in"/>
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      <variable name="i_Ks" units="nanoA" public_interface="in"/>
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                  <ci>time</ci>
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                  <ci>V_ode</ci>
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      <variable name="t_test" units="second" initial_value="0.5"/>
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                        <gt/>
                        <ci>time</ci>
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                           <plus/>
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                  <ci>V_holding</ci>
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   </component>
   <component name="Rate_modulation_experiments">
      <variable name="Iva_3_uM" units="dimensionless" initial_value="0" public_interface="out"/>
      <variable name="Cs_5_mM" units="dimensionless" initial_value="0" public_interface="out"/>
      <variable name="ACh" units="millimolar" initial_value="0" public_interface="out"/>
      <variable name="Iso_1_uM" units="dimensionless" initial_value="0" public_interface="out"/>
      <variable name="BAPTA_10_mM" units="dimensionless" initial_value="0" public_interface="out"/>
   </component>
   <component name="Ionic_values">
      <variable name="Nai" units="millimolar" public_interface="in"/>
      <variable name="Nao" units="millimolar" initial_value="140" public_interface="out"/>
      <variable name="Ki" units="millimolar" initial_value="140" public_interface="out"/>
      <variable name="Ko" units="millimolar" initial_value="5.4" public_interface="out"/>
      <variable name="Ca_sub" units="millimolar" public_interface="in"/>
      <variable name="Cao" units="millimolar" initial_value="1.8" public_interface="out"/>
      <variable name="RTONF" units="millivolt" public_interface="in"/>
      <variable name="E_Na" units="millivolt" public_interface="out"/>
      <variable name="E_K" units="millivolt" public_interface="out"/>
      <variable name="E_Ca" units="millivolt" public_interface="out"/>
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            <ci>E_Na</ci>
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               <times/>
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                  <ln/>
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                     <divide/>
                     <ci>Nao</ci>
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            <eq/>
            <ci>E_K</ci>
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               <times/>
               <ci>RTONF</ci>
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                  <ln/>
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                     <divide/>
                     <ci>Ko</ci>
                     <ci>Ki</ci>
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            <eq/>
            <ci>E_Ca</ci>
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                  <ln/>
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                     <ci>Ca_sub</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Nai_concentration">
      <variable name="Nai" units="millimolar" public_interface="out"/>
      <variable name="time" units="second" public_interface="in"/>
      <variable name="F" units="coulomb_per_mole" public_interface="in"/>
      <variable name="V_sub" units="millimetre3" public_interface="in"/>
      <variable name="V_i" units="millimetre3" public_interface="in"/>
      <variable name="i_Na" units="nanoA" public_interface="in"/>
      <variable name="i_NaCa" units="nanoA" public_interface="in"/>
      <variable name="i_NaK" units="nanoA" public_interface="in"/>
      <variable name="i_fNa" units="nanoA" public_interface="in"/>
      <variable name="i_siNa" units="nanoA" public_interface="in"/>
      <variable name="Nai_" units="millimolar" initial_value="7.5"/>
      <variable name="BAPTA_10_mM" units="dimensionless" public_interface="in"/>
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      <variable name="Cs_5_mM" units="dimensionless" public_interface="in"/>
      <variable name="ACh" units="millimolar" public_interface="in" private_interface="out"/>
      <variable name="Iso_1_uM" units="dimensionless" public_interface="in" private_interface="out"/>
      <variable name="ICs_on_Icontrol" units="dimensionless" public_interface="out"/>
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      <variable name="i_fNa" units="nanoA" public_interface="out"/>
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      <variable name="g_f_K" units="microS" public_interface="out"/>
      <variable name="Km_f" units="millimolar" initial_value="45"/>
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      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="RTONF" units="millivolt" public_interface="in"/>
      <variable name="Kc" units="millimolar" public_interface="in"/>
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            <ci>g_f_Na</ci>
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            <ci>g_f_K</ci>
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            <ci>i_fK</ci>
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      <variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
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               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>y_infinity</ci>
                  <ci>y</ci>
               </apply>
               <ci>tau_y</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_NaK">
      <variable name="i_NaK" units="nanoA" public_interface="out"/>
      <variable name="time" units="second" public_interface="in"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="Km_Kp" units="millimolar" initial_value="1.4"/>
      <variable name="Km_Nap" units="millimolar" initial_value="14"/>
      <variable name="i_NaK_max" units="nanoA" initial_value="0.063"/>
      <variable name="Nai" units="millimolar" public_interface="in"/>
      <variable name="Kc" units="millimolar" public_interface="in"/>
      <variable name="E_Na" units="millivolt" public_interface="in"/>
      <variable name="Iso_increase" units="dimensionless"/>
      <variable name="Iso_1_uM" units="dimensionless" public_interface="in" private_interface="out"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Iso_increase</ci>
            <piecewise>
               <piece>
                  <cn cellml:units="dimensionless">1.2</cn>
                  <apply>
                     <gt/>
                     <ci>Iso_1_uM</ci>
                     <cn cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="dimensionless">1</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <times/>
               <ci>Iso_increase</ci>
               <ci>i_NaK_max</ci>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Km_Kp</ci>
                           <ci>Kc</ci>
                        </apply>
                        <cn cellml:units="dimensionless">1.2</cn>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>Km_Nap</ci>
                           <ci>Nai</ci>
                        </apply>
                        <cn cellml:units="dimensionless">1.3</cn>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <ci>E_Na</ci>
                                 </apply>
                                 <cn cellml:units="millivolt">110</cn>
                              </apply>
                           </apply>
                           <cn cellml:units="millivolt">20</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_NaCa">
      <variable name="i_NaCa" units="nanoA" public_interface="out"/>
      <variable name="K_NaCa" units="nanoA" initial_value="4"/>
      <variable name="x1" units="dimensionless"/>
      <variable name="x2" units="dimensionless"/>
      <variable name="x3" units="dimensionless"/>
      <variable name="x4" units="dimensionless"/>
      <variable name="k41" units="dimensionless"/>
      <variable name="k34" units="dimensionless"/>
      <variable name="k23" units="dimensionless"/>
      <variable name="k21" units="dimensionless"/>
      <variable name="k32" units="dimensionless"/>
      <variable name="k43" units="dimensionless"/>
      <variable name="k12" units="dimensionless"/>
      <variable name="k14" units="dimensionless"/>
      <variable name="Qci" units="dimensionless" initial_value="0.1369"/>
      <variable name="Qn" units="dimensionless" initial_value="0.4315"/>
      <variable name="Qco" units="dimensionless" initial_value="0"/>
      <variable name="K3ni" units="millimolar" initial_value="26.44"/>
      <variable name="Kci" units="millimolar" initial_value="0.0207"/>
      <variable name="K1ni" units="millimolar" initial_value="395.3"/>
      <variable name="K2ni" units="millimolar" initial_value="2.289"/>
      <variable name="Kcni" units="millimolar" initial_value="26.44"/>
      <variable name="K3no" units="millimolar" initial_value="4.663"/>
      <variable name="K1no" units="millimolar" initial_value="1628"/>
      <variable name="K2no" units="millimolar" initial_value="561.4"/>
      <variable name="Kco" units="millimolar" initial_value="3.663"/>
      <variable name="do" units="dimensionless"/>
      <variable name="di" units="dimensionless"/>
      <variable name="Cao" units="millimolar" public_interface="in"/>
      <variable name="Nao" units="millimolar" public_interface="in"/>
      <variable name="Ca_sub" units="millimolar" public_interface="in"/>
      <variable name="Nai" units="millimolar" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="RTONF" units="millivolt" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>K_NaCa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>x2</ci>
                        <ci>k21</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>x1</ci>
                        <ci>k12</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <ci>x1</ci>
                  <ci>x2</ci>
                  <ci>x3</ci>
                  <ci>x4</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>x1</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>k41</ci>
                  <ci>k34</ci>
                  <apply>
                     <plus/>
                     <ci>k23</ci>
                     <ci>k21</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>k21</ci>
                  <ci>k32</ci>
                  <apply>
                     <plus/>
                     <ci>k43</ci>
                     <ci>k41</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>x2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>k32</ci>
                  <ci>k43</ci>
                  <apply>
                     <plus/>
                     <ci>k14</ci>
                     <ci>k12</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>k41</ci>
                  <ci>k12</ci>
                  <apply>
                     <plus/>
                     <ci>k34</ci>
                     <ci>k32</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>x3</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>k14</ci>
                  <ci>k43</ci>
                  <apply>
                     <plus/>
                     <ci>k23</ci>
                     <ci>k21</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>k12</ci>
                  <ci>k23</ci>
                  <apply>
                     <plus/>
                     <ci>k43</ci>
                     <ci>k41</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>x4</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>k23</ci>
                  <ci>k34</ci>
                  <apply>
                     <plus/>
                     <ci>k14</ci>
                     <ci>k12</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>k14</ci>
                  <ci>k21</ci>
                  <apply>
                     <plus/>
                     <ci>k34</ci>
                     <ci>k32</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k43</ci>
            <apply>
               <divide/>
               <ci>Nai</ci>
               <apply>
                  <plus/>
                  <ci>K3ni</ci>
                  <ci>Nai</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k12</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>Ca_sub</ci>
                     <ci>Kci</ci>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>Qci</ci>
                           </apply>
                           <ci>V</ci>
                        </apply>
                        <ci>RTONF</ci>
                     </apply>
                  </apply>
               </apply>
               <ci>di</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k14</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <ci>Nai</ci>
                           <ci>K1ni</ci>
                        </apply>
                        <ci>Nai</ci>
                     </apply>
                     <ci>K2ni</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>Nai</ci>
                        <ci>K3ni</ci>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Qn</ci>
                           <ci>V</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">2</cn>
                           <ci>RTONF</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <ci>di</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k41</ci>
            <apply>
               <exp/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>Qn</ci>
                     </apply>
                     <ci>V</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">2</cn>
                     <ci>RTONF</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>di</ci>
            <apply>
               <plus/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>Ca_sub</ci>
                     <ci>Kci</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>Qci</ci>
                              </apply>
                              <ci>V</ci>
                           </apply>
                           <ci>RTONF</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <ci>Nai</ci>
                        <ci>Kcni</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>Nai</ci>
                     <ci>K1ni</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <ci>Nai</ci>
                           <ci>K2ni</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <cn cellml:units="dimensionless">1</cn>
                           <apply>
                              <divide/>
                              <ci>Nai</ci>
                              <ci>K3ni</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k34</ci>
            <apply>
               <divide/>
               <ci>Nao</ci>
               <apply>
                  <plus/>
                  <ci>K3no</ci>
                  <ci>Nao</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k21</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Kco</ci>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Qco</ci>
                           <ci>V</ci>
                        </apply>
                        <ci>RTONF</ci>
                     </apply>
                  </apply>
               </apply>
               <ci>do</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k23</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <ci>Nao</ci>
                           <ci>K1no</ci>
                        </apply>
                        <ci>Nao</ci>
                     </apply>
                     <ci>K2no</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>Nao</ci>
                        <ci>K3no</ci>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>Qn</ci>
                           </apply>
                           <ci>V</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">2</cn>
                           <ci>RTONF</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <ci>do</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>k32</ci>
            <apply>
               <exp/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>Qn</ci>
                     <ci>V</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">2</cn>
                     <ci>RTONF</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>do</ci>
            <apply>
               <plus/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Kco</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <ci>Qco</ci>
                              <ci>V</ci>
                           </apply>
                           <ci>RTONF</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>Nao</ci>
                     <ci>K1no</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <ci>Nao</ci>
                           <ci>K2no</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <cn cellml:units="dimensionless">1</cn>
                           <apply>
                              <divide/>
                              <ci>Nao</ci>
                              <ci>K3no</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Na">
      <variable name="i_Na" units="nanoA" public_interface="out"/>
      <variable name="g_Na" units="microS" initial_value="0.0125"/>
      <variable name="E_mh" units="millivolt"/>
      <variable name="time" units="second" public_interface="in" private_interface="out"/>
      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="RTONF" units="millivolt" public_interface="in"/>
      <variable name="Nao" units="millimolar" public_interface="in"/>
      <variable name="Nai" units="millimolar" public_interface="in"/>
      <variable name="Kc" units="millimolar" public_interface="in"/>
      <variable name="Ki" units="millimolar" public_interface="in"/>
      <variable name="m" units="dimensionless" private_interface="in"/>
      <variable name="h" units="dimensionless" private_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_mh</ci>
            <apply>
               <times/>
               <ci>RTONF</ci>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>Nao</ci>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">0.12</cn>
                           <ci>Kc</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Nai</ci>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">0.12</cn>
                           <ci>Ki</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Na</ci>
            <apply>
               <times/>
               <ci>g_Na</ci>
               <apply>
                  <power/>
                  <ci>m</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
               <ci>h</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_mh</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Na_m_gate">
      <variable name="m" units="dimensionless" initial_value="0.440131579215766" public_interface="out"/>
      <variable name="alpha_m" units="per_second"/>
      <variable name="beta_m" units="per_second"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <variable name="delta_m" units="millivolt" initial_value="1e-5"/>
      <variable name="E0_m" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E0_m</ci>
            <apply>
               <plus/>
               <ci>V</ci>
               <cn cellml:units="millivolt">41</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_m</ci>
            <piecewise>
               <piece>
                  <cn cellml:units="per_second">2000</cn>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <ci>E0_m</ci>
                     </apply>
                     <ci>delta_m</ci>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt_second">200</cn>
                        <ci>E0_m</ci>
                     </apply>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.1</cn>
                              </apply>
                              <ci>E0_m</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_m</ci>
            <apply>
               <times/>
               <cn cellml:units="per_second">8000</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn cellml:units="per_millivolt">0.056</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="millivolt">66</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_m</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>m</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_m</ci>
                  <ci>m</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Na_h_gate">
      <variable name="h" units="dimensionless" initial_value="1.3676940140066e-5" public_interface="out"/>
      <variable name="alpha_h" units="per_second"/>
      <variable name="beta_h" units="per_second"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_h</ci>
            <apply>
               <times/>
               <cn cellml:units="per_second">20</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn cellml:units="per_millivolt">0.125</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="millivolt">75</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_h</ci>
            <apply>
               <divide/>
               <cn cellml:units="per_second">2000</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">320</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn cellml:units="per_millivolt">0.1</cn>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">75</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_h</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>h</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_h</ci>
                  <ci>h</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_CaL">
      <variable name="i_CaL" units="nanoA" public_interface="out"/>
      <variable name="i_siCa" units="nanoA" public_interface="out"/>
      <variable name="i_siK" units="nanoA" public_interface="out"/>
      <variable name="i_siNa" units="nanoA" public_interface="out"/>
      <variable name="ACh_block" units="dimensionless"/>
      <variable name="ACh" units="millimolar" public_interface="in"/>
      <variable name="time" units="second" public_interface="in" private_interface="out"/>
      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="P_CaL" units="nanoA_per_millimolar" initial_value="0.2"/>
      <variable name="RTONF" units="millivolt" public_interface="in"/>
      <variable name="Nao" units="millimolar" public_interface="in"/>
      <variable name="Nai" units="millimolar" public_interface="in"/>
      <variable name="Kc" units="millimolar" public_interface="in"/>
      <variable name="Ki" units="millimolar" public_interface="in"/>
      <variable name="Cao" units="millimolar" public_interface="in"/>
      <variable name="Ca_sub" units="millimolar" public_interface="in" private_interface="out"/>
      <variable name="dL" units="dimensionless" private_interface="in"/>
      <variable name="fL" units="dimensionless" private_interface="in"/>
      <variable name="fCa" units="dimensionless" private_interface="in"/>
      <variable name="Iso_increase" units="dimensionless"/>
      <variable name="Iso_1_uM" units="dimensionless" public_interface="in" private_interface="out"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Iso_increase</ci>
            <piecewise>
               <piece>
                  <cn cellml:units="dimensionless">1.23</cn>
                  <apply>
                     <gt/>
                     <ci>Iso_1_uM</ci>
                     <cn cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="dimensionless">1</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_siCa</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">2</cn>
                     <ci>P_CaL</ci>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <cn cellml:units="millivolt">0</cn>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>RTONF</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">0</cn>
                                 </apply>
                                 <cn cellml:units="dimensionless">2</cn>
                              </apply>
                              <ci>RTONF</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>Ca_sub</ci>
                  <apply>
                     <times/>
                     <ci>Cao</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="dimensionless">2</cn>
                              </apply>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">0</cn>
                              </apply>
                           </apply>
                           <ci>RTONF</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <ci>dL</ci>
               <ci>fL</ci>
               <ci>fCa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_siK</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.000365</cn>
                     <ci>P_CaL</ci>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <cn cellml:units="millivolt">0</cn>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>RTONF</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">0</cn>
                                 </apply>
                              </apply>
                              <ci>RTONF</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>Ki</ci>
                  <apply>
                     <times/>
                     <ci>Kc</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="dimensionless">1</cn>
                              </apply>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">0</cn>
                              </apply>
                           </apply>
                           <ci>RTONF</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <ci>dL</ci>
               <ci>fL</ci>
               <ci>fCa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_siNa</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.0000185</cn>
                     <ci>P_CaL</ci>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <cn cellml:units="millivolt">0</cn>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>RTONF</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">0</cn>
                                 </apply>
                              </apply>
                              <ci>RTONF</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>Nai</ci>
                  <apply>
                     <times/>
                     <ci>Nao</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="dimensionless">1</cn>
                              </apply>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">0</cn>
                              </apply>
                           </apply>
                           <ci>RTONF</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <ci>dL</ci>
               <ci>fL</ci>
               <ci>fCa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ACh_block</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">0.31</cn>
                  <ci>ACh</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>ACh</ci>
                  <cn cellml:units="millimolar">0.00009</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaL</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>i_siCa</ci>
                  <ci>i_siK</ci>
                  <ci>i_siNa</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>ACh_block</ci>
               </apply>
               <cn cellml:units="dimensionless">1</cn>
               <ci>Iso_increase</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_CaL_dL_gate">
      <variable name="dL" units="dimensionless" initial_value="0" public_interface="out"/>
      <variable name="dL_infinity" units="dimensionless"/>
      <variable name="tau_dL" units="second"/>
      <variable name="alpha_dL" units="per_second"/>
      <variable name="beta_dL" units="per_second"/>
      <variable name="adVm" units="millivolt"/>
      <variable name="bdVm" units="millivolt"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <variable name="Iso_shift" units="millivolt"/>
      <variable name="Iso_slope" units="dimensionless"/>
      <variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Iso_shift</ci>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <cn cellml:units="millivolt">8</cn>
                  </apply>
                  <apply>
                     <gt/>
                     <ci>Iso_1_uM</ci>
                     <cn cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="millivolt">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>Iso_slope</ci>
            <piecewise>
               <piece>
                  <cn cellml:units="dimensionless">0.69</cn>
                  <apply>
                     <gt/>
                     <ci>Iso_1_uM</ci>
                     <cn cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="dimensionless">1</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>dL_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">20.3</cn>
                              </apply>
                              <ci>Iso_shift</ci>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Iso_slope</ci>
                           <cn cellml:units="millivolt">4.2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_dL</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">0.001</cn>
               <apply>
                  <plus/>
                  <ci>alpha_dL</ci>
                  <ci>beta_dL</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_dL</ci>
            <apply>
               <minus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn cellml:units="per_millivolt_second">0.02839</cn>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>adVm</ci>
                           <cn cellml:units="millivolt">41.8</cn>
                        </apply>
                        <ci>Iso_shift</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>adVm</ci>
                                    <cn cellml:units="millivolt">41.8</cn>
                                 </apply>
                                 <ci>Iso_shift</ci>
                              </apply>
                           </apply>
                           <cn cellml:units="millivolt">2.5</cn>
                        </apply>
                     </apply>
                     <cn cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn cellml:units="per_millivolt_second">0.0849</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>adVm</ci>
                           <cn cellml:units="millivolt">6.8</cn>
                        </apply>
                        <ci>Iso_shift</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>adVm</ci>
                                    <cn cellml:units="millivolt">6.8</cn>
                                 </apply>
                                 <ci>Iso_shift</ci>
                              </apply>
                           </apply>
                           <cn cellml:units="millivolt">4.8</cn>
                        </apply>
                     </apply>
                     <cn cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>adVm</ci>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <cn cellml:units="millivolt">41.80001</cn>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="millivolt">41.8</cn>
                     </apply>
                  </apply>
               </piece>
               <piece>
                  <cn cellml:units="millivolt">0</cn>
                  <apply>
                     <eq/>
                     <ci>V</ci>
                     <cn cellml:units="millivolt">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <minus/>
                     <cn cellml:units="millivolt">6.80001</cn>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="millivolt">6.8</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <ci>V</ci>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_dL</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="per_millivolt_second">0.01143</cn>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>bdVm</ci>
                        <cn cellml:units="millivolt">1.8</cn>
                     </apply>
                     <ci>Iso_shift</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>bdVm</ci>
                              <cn cellml:units="millivolt">1.8</cn>
                           </apply>
                           <ci>Iso_shift</ci>
                        </apply>
                        <cn cellml:units="millivolt">2.5</cn>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>bdVm</ci>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <cn cellml:units="millivolt">1.80001</cn>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="millivolt">1.8</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <ci>V</ci>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>dL</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>dL_infinity</ci>
                  <ci>dL</ci>
               </apply>
               <ci>tau_dL</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_CaL_fL_gate">
      <variable name="fL" units="dimensionless" initial_value="0.497133507285601" public_interface="out"/>
      <variable name="fL_infinity" units="dimensionless"/>
      <variable name="tau_fL" units="second"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>fL_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">37.4</cn>
                        </apply>
                        <cn cellml:units="millivolt">5.3</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_fL</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.001</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="second">44.3</cn>
                  <apply>
                     <times/>
                     <cn cellml:units="second">230</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">36</cn>
                                 </apply>
                                 <cn cellml:units="millivolt">10</cn>
                              </apply>
                              <cn cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fL</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>fL_infinity</ci>
                  <ci>fL</ci>
               </apply>
               <ci>tau_fL</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_CaL_fCa_gate">
      <variable name="fCa" units="dimensionless" initial_value="0.697998543259722" public_interface="out"/>
      <variable name="alpha_fCa" units="per_second" initial_value="0.01"/>
      <variable name="fCa_infinity" units="dimensionless"/>
      <variable name="tau_fCa" units="second"/>
      <variable name="Km_fCa" units="millimolar" initial_value="0.00035"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="Ca_sub" units="millimolar" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>fCa_infinity</ci>
            <apply>
               <divide/>
               <ci>Km_fCa</ci>
               <apply>
                  <plus/>
                  <ci>Km_fCa</ci>
                  <ci>Ca_sub</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_fCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">0.001</cn>
                  <ci>fCa_infinity</ci>
               </apply>
               <ci>alpha_fCa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fCa</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>fCa_infinity</ci>
                  <ci>fCa</ci>
               </apply>
               <ci>tau_fCa</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_CaT">
      <variable name="i_CaT" units="nanoA" public_interface="out"/>
      <variable name="time" units="second" public_interface="in" private_interface="out"/>
      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="P_CaT" units="nanoA_per_millimolar" initial_value="0.02"/>
      <variable name="RTONF" units="millivolt" public_interface="in"/>
      <variable name="Cao" units="millimolar" public_interface="in"/>
      <variable name="Ca_sub" units="millimolar" public_interface="in" private_interface="out"/>
      <variable name="dT" units="dimensionless" private_interface="in"/>
      <variable name="fT" units="dimensionless" private_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_CaT</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">2</cn>
                     <ci>P_CaT</ci>
                     <ci>V</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>RTONF</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <cn cellml:units="dimensionless">2</cn>
                              </apply>
                              <ci>RTONF</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>Ca_sub</ci>
                  <apply>
                     <times/>
                     <ci>Cao</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="dimensionless">2</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                           <ci>RTONF</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <ci>dT</ci>
               <ci>fT</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_CaT_dT_gate">
      <variable name="dT" units="dimensionless" initial_value="0" public_interface="out"/>
      <variable name="dT_infinity" units="dimensionless"/>
      <variable name="tau_dT" units="second"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>dT_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">38.3</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">5.5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_dT</ci>
            <apply>
               <divide/>
               <cn cellml:units="second">0.001</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">1.068</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">38.3</cn>
                           </apply>
                           <cn cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">1.068</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">38.3</cn>
                              </apply>
                           </apply>
                           <cn cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>dT</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>dT_infinity</ci>
                  <ci>dT</ci>
               </apply>
               <ci>tau_dT</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_CaT_fT_gate">
      <variable name="fT" units="dimensionless" initial_value="0" public_interface="out"/>
      <variable name="fT_infinity" units="dimensionless"/>
      <variable name="tau_fT" units="second"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>fT_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">58.7</cn>
                        </apply>
                        <cn cellml:units="millivolt">3.8</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_fT</ci>
            <apply>
               <divide/>
               <cn cellml:units="second">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">16.67</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">75</cn>
                              </apply>
                           </apply>
                           <cn cellml:units="millivolt">83.3</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">16.67</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">75</cn>
                           </apply>
                           <cn cellml:units="millivolt">15.38</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fT</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>fT_infinity</ci>
                  <ci>fT</ci>
               </apply>
               <ci>tau_fT</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_SR_release">
      <variable name="j_SRCarel" units="millimolar_per_second" public_interface="out"/>
      <variable name="R" units="dimensionless" initial_value="0.912317231017262"/>
      <variable name="O" units="dimensionless" initial_value="1.7340201253e-7"/>
      <variable name="I" units="dimensionless" initial_value="7.86181717518e-8"/>
      <variable name="RI" units="dimensionless" initial_value="0.211148145512825"/>
      <variable name="ks" units="per_second" initial_value="250000000"/>
      <variable name="MaxSR" units="dimensionless" initial_value="15"/>
      <variable name="MinSR" units="dimensionless" initial_value="1"/>
      <variable name="EC50_SR" units="millimolar" initial_value="0.45"/>
      <variable name="HSR" units="dimensionless" initial_value="2.5"/>
      <variable name="koSRCa" units="per_millimolar2_second"/>
      <variable name="kiSRCa" units="per_millimolar_second"/>
      <variable name="koCa" units="per_millimolar2_second" initial_value="10000"/>
      <variable name="kiCa" units="per_millimolar_second" initial_value="500"/>
      <variable name="kCaSR" units="dimensionless"/>
      <variable name="kim" units="per_second" initial_value="5"/>
      <variable name="kom" units="per_second" initial_value="60"/>
      <variable name="time" units="second" public_interface="in"/>
      <variable name="Ca_sub" units="millimolar" public_interface="in"/>
      <variable name="Ca_jsr" units="millimolar" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>j_SRCarel</ci>
            <apply>
               <times/>
               <ci>ks</ci>
               <ci>O</ci>
               <apply>
                  <minus/>
                  <ci>Ca_jsr</ci>
                  <ci>Ca_sub</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kCaSR</ci>
            <apply>
               <minus/>
               <ci>MaxSR</ci>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>MaxSR</ci>
                     <ci>MinSR</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>EC50_SR</ci>
                           <ci>Ca_jsr</ci>
                        </apply>
                        <ci>HSR</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>koSRCa</ci>
            <apply>
               <divide/>
               <ci>koCa</ci>
               <ci>kCaSR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kiSRCa</ci>
            <apply>
               <times/>
               <ci>kiCa</ci>
               <ci>kCaSR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>R</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kim</ci>
                     <ci>RI</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kiSRCa</ci>
                     <ci>Ca_sub</ci>
                     <ci>R</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>koSRCa</ci>
                     <apply>
                        <power/>
                        <ci>Ca_sub</ci>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                     <ci>R</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kom</ci>
                     <ci>O</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>koSRCa</ci>
                     <apply>
                        <power/>
                        <ci>Ca_sub</ci>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                     <ci>R</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kom</ci>
                     <ci>O</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kiSRCa</ci>
                     <ci>Ca_sub</ci>
                     <ci>O</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kim</ci>
                     <ci>I</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>I</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kiSRCa</ci>
                     <ci>Ca_sub</ci>
                     <ci>O</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kim</ci>
                     <ci>I</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kom</ci>
                     <ci>I</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>koSRCa</ci>
                     <apply>
                        <power/>
                        <ci>Ca_sub</ci>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                     <ci>RI</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>RI</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kom</ci>
                     <ci>I</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>koSRCa</ci>
                     <apply>
                        <power/>
                        <ci>Ca_sub</ci>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                     <ci>RI</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kim</ci>
                     <ci>RI</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kiSRCa</ci>
                     <ci>Ca_sub</ci>
                     <ci>R</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_intracellular_fluxes">
      <variable name="j_Ca_dif" units="millimolar_per_second" public_interface="out"/>
      <variable name="j_up" units="millimolar_per_second" public_interface="out"/>
      <variable name="j_tr" units="millimolar_per_second" public_interface="out"/>
      <variable name="tau_dif_Ca" units="second" initial_value="4e-5"/>
      <variable name="tau_tr" units="second" initial_value="0.04"/>
      <variable name="P_up" units="millimolar_per_second"/>
      <variable name="P_up_basal" units="millimolar_per_second" initial_value="12"/>
      <variable name="b_up" units="dimensionless"/>
      <variable name="ACh" units="millimolar" public_interface="in"/>
      <variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
      <variable name="K_up" units="millimolar" initial_value="0.0006"/>
      <variable name="Ca_nsr" units="millimolar" public_interface="in"/>
      <variable name="Cai" units="millimolar" public_interface="in"/>
      <variable name="Ca_sub" units="millimolar" public_interface="in"/>
      <variable name="Ca_jsr" units="millimolar" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>b_up</ci>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">0.25</cn>
                  </apply>
                  <apply>
                     <gt/>
                     <ci>Iso_1_uM</ci>
                     <cn cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.7</cn>
                        <ci>ACh</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="millimolar">0.00009</cn>
                        <ci>ACh</ci>
                     </apply>
                  </apply>
                  <apply>
                     <gt/>
                     <ci>ACh</ci>
                     <cn cellml:units="millimolar">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="dimensionless">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>P_up</ci>
            <apply>
               <times/>
               <ci>P_up_basal</ci>
               <apply>
                  <minus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>b_up</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>j_Ca_dif</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Ca_sub</ci>
                  <ci>Cai</ci>
               </apply>
               <ci>tau_dif_Ca</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>j_up</ci>
            <apply>
               <divide/>
               <ci>P_up</ci>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>K_up</ci>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>j_tr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Ca_nsr</ci>
                  <ci>Ca_jsr</ci>
               </apply>
               <ci>tau_tr</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_buffering">
      <variable name="TC_tot" units="millimolar" initial_value="0.031" public_interface="out"/>
      <variable name="TMC_tot" units="millimolar" initial_value="0.062" public_interface="out"/>
      <variable name="CM_tot" units="millimolar" initial_value="0.045" public_interface="out"/>
      <variable name="CQ_tot" units="millimolar" initial_value="10" public_interface="out"/>
      <variable name="delta_fTC" units="per_second" public_interface="out"/>
      <variable name="delta_fTMC" units="per_second" public_interface="out"/>
      <variable name="delta_fCMs" units="per_second" public_interface="out"/>
      <variable name="delta_fCMi" units="per_second" public_interface="out"/>
      <variable name="delta_fCQ" units="per_second" public_interface="out"/>
      <variable name="delta_fTMM" units="per_second"/>
      <variable name="fTMM" units="dimensionless" initial_value="0.501049376634"/>
      <variable name="fCMi" units="dimensionless" initial_value="0.0373817991524254"/>
      <variable name="fCMs" units="dimensionless" initial_value="0.054381370046"/>
      <variable name="fTC" units="dimensionless" initial_value="0.0180519400676086"/>
      <variable name="fTMC" units="dimensionless" initial_value="0.281244308217086"/>
      <variable name="fCQ" units="dimensionless" initial_value="0.299624275428735"/>
      <variable name="kf_TC" units="per_millimolar_second" initial_value="88800"/>
      <variable name="kf_TMM" units="per_millimolar_second" initial_value="2277"/>
      <variable name="kf_TMC" units="per_millimolar_second" initial_value="227700"/>
      <variable name="kf_CM" units="per_millimolar_second" initial_value="227700"/>
      <variable name="kf_CQ" units="per_millimolar_second" initial_value="534"/>
      <variable name="kb_TC" units="per_second" initial_value="446"/>
      <variable name="kb_TMC" units="per_second" initial_value="7.51"/>
      <variable name="kb_TMM" units="per_second" initial_value="751"/>
      <variable name="kb_CM" units="per_second" initial_value="542"/>
      <variable name="kb_CQ" units="per_second" initial_value="445"/>
      <variable name="time" units="second" public_interface="in"/>
      <variable name="Mgi" units="millimolar" initial_value="2.5"/>
      <variable name="Cai" units="millimolar" public_interface="in"/>
      <variable name="Ca_sub" units="millimolar" public_interface="in"/>
      <variable name="Ca_jsr" units="millimolar" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fTC</ci>
            </apply>
            <ci>delta_fTC</ci>
         </apply>
         <apply>
            <eq/>
            <ci>delta_fTC</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kf_TC</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>fTC</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kb_TC</ci>
                  <ci>fTC</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fTMC</ci>
            </apply>
            <ci>delta_fTMC</ci>
         </apply>
         <apply>
            <eq/>
            <ci>delta_fTMC</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kf_TMC</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <plus/>
                        <ci>fTMC</ci>
                        <ci>fTMM</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kb_TMC</ci>
                  <ci>fTMC</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fTMM</ci>
            </apply>
            <ci>delta_fTMM</ci>
         </apply>
         <apply>
            <eq/>
            <ci>delta_fTMM</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kf_TMM</ci>
                  <ci>Mgi</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <plus/>
                        <ci>fTMC</ci>
                        <ci>fTMM</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kb_TMM</ci>
                  <ci>fTMM</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fCMi</ci>
            </apply>
            <ci>delta_fCMi</ci>
         </apply>
         <apply>
            <eq/>
            <ci>delta_fCMi</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kf_CM</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>fCMi</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kb_CM</ci>
                  <ci>fCMi</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fCMs</ci>
            </apply>
            <ci>delta_fCMs</ci>
         </apply>
         <apply>
            <eq/>
            <ci>delta_fCMs</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kf_CM</ci>
                  <ci>Ca_sub</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>fCMs</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kb_CM</ci>
                  <ci>fCMs</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fCQ</ci>
            </apply>
            <ci>delta_fCQ</ci>
         </apply>
         <apply>
            <eq/>
            <ci>delta_fCQ</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kf_CQ</ci>
                  <ci>Ca_jsr</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>fCQ</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kb_CQ</ci>
                  <ci>fCQ</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_dynamics">
      <variable name="Cai" units="millimolar" initial_value="1e-5" public_interface="out"/>
      <variable name="Ca_nsr" units="millimolar" initial_value="1.05386465080816" public_interface="out"/>
      <variable name="Ca_jsr" units="millimolar" initial_value="0.316762674605" public_interface="out"/>
      <variable name="Ca_sub" units="millimolar" initial_value="1e-5" public_interface="out"/>
      <variable name="V_i" units="millimetre3" public_interface="in"/>
      <variable name="V_jsr" units="millimetre3" public_interface="in"/>
      <variable name="V_nsr" units="millimetre3" public_interface="in"/>
      <variable name="V_sub" units="millimetre3" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <variable name="F" units="coulomb_per_mole" public_interface="in"/>
      <variable name="i_siCa" units="nanoA" public_interface="in"/>
      <variable name="i_CaT" units="nanoA" public_interface="in"/>
      <variable name="i_NaCa" units="nanoA" public_interface="in"/>
      <variable name="j_SRCarel" units="millimolar_per_second" public_interface="in"/>
      <variable name="j_Ca_dif" units="millimolar_per_second" public_interface="in"/>
      <variable name="j_tr" units="millimolar_per_second" public_interface="in"/>
      <variable name="j_up" units="millimolar_per_second" public_interface="in"/>
      <variable name="TMC_tot" units="millimolar" public_interface="in"/>
      <variable name="CM_tot" units="millimolar" public_interface="in"/>
      <variable name="TC_tot" units="millimolar" public_interface="in"/>
      <variable name="CQ_tot" units="millimolar" public_interface="in"/>
      <variable name="delta_fTMC" units="per_second" public_interface="in"/>
      <variable name="delta_fCMi" units="per_second" public_interface="in"/>
      <variable name="delta_fCMs" units="per_second" public_interface="in"/>
      <variable name="delta_fTC" units="per_second" public_interface="in"/>
      <variable name="delta_fCQ" units="per_second" public_interface="in"/>
      <variable name="BAPTA_10_mM" units="dimensionless" public_interface="in"/>
      <variable name="BAPTA" units="millimolar"/>
      <variable name="kfBAPTA" units="per_millimolar_second" initial_value="940000"/>
      <variable name="kbBAPTA" units="per_second" initial_value="119.38"/>
      <variable name="fBAPTA" units="millimolar" initial_value="0" public_interface="out"/>
      <variable name="fBAPTA_sub" units="millimolar" initial_value="0" public_interface="out"/>
      <variable name="T" units="second" initial_value="6.928" public_interface="out"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>BAPTA</ci>
            <piecewise>
               <piece>
                  <cn cellml:units="millimolar">10</cn>
                  <apply>
                     <and/>
                     <apply>
                        <gt/>
                        <ci>BAPTA_10_mM</ci>
                        <cn cellml:units="dimensionless">0</cn>
                     </apply>
                     <apply>
                        <gt/>
                        <ci>time</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="millimolar">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Cai</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <times/>
                              <ci>j_Ca_dif</ci>
                              <ci>V_sub</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>j_up</ci>
                              <ci>V_nsr</ci>
                           </apply>
                        </apply>
                     </apply>
                     <ci>V_i</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>CM_tot</ci>
                        <ci>delta_fCMi</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>TC_tot</ci>
                        <ci>delta_fTC</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>TMC_tot</ci>
                        <ci>delta_fTMC</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kfBAPTA</ci>
                     <ci>Cai</ci>
                     <apply>
                        <minus/>
                        <ci>BAPTA</ci>
                        <ci>fBAPTA</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kbBAPTA</ci>
                     <ci>fBAPTA</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fBAPTA</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kfBAPTA</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <ci>BAPTA</ci>
                     <ci>fBAPTA</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kbBAPTA</ci>
                  <ci>fBAPTA</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_sub</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>j_SRCarel</ci>
                        <ci>V_jsr</ci>
                     </apply>
                     <ci>V_sub</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>i_siCa</ci>
                              <ci>i_CaT</ci>
                           </apply>
                           <apply>
                              <times/>
                              <cn cellml:units="dimensionless">2</cn>
                              <ci>i_NaCa</ci>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">2</cn>
                           <ci>F</ci>
                           <ci>V_sub</ci>
                        </apply>
                     </apply>
                     <ci>j_Ca_dif</ci>
                     <apply>
                        <times/>
                        <ci>CM_tot</ci>
                        <ci>delta_fCMs</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>kfBAPTA</ci>
                     <ci>Ca_sub</ci>
                     <apply>
                        <minus/>
                        <ci>BAPTA</ci>
                        <ci>fBAPTA_sub</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kbBAPTA</ci>
                     <ci>fBAPTA_sub</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fBAPTA_sub</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kfBAPTA</ci>
                  <ci>Ca_sub</ci>
                  <apply>
                     <minus/>
                     <ci>BAPTA</ci>
                     <ci>fBAPTA_sub</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kbBAPTA</ci>
                  <ci>fBAPTA_sub</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_nsr</ci>
            </apply>
            <apply>
               <minus/>
               <ci>j_up</ci>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>j_tr</ci>
                     <ci>V_jsr</ci>
                  </apply>
                  <ci>V_nsr</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_jsr</ci>
            </apply>
            <apply>
               <minus/>
               <ci>j_tr</ci>
               <apply>
                  <plus/>
                  <ci>j_SRCarel</ci>
                  <apply>
                     <times/>
                     <ci>CQ_tot</ci>
                     <ci>delta_fCQ</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Cell_parameters">
      <variable name="V_sub" units="millimetre3" public_interface="out"/>
      <variable name="V_jsr" units="millimetre3" public_interface="out"/>
      <variable name="V_nsr" units="millimetre3" public_interface="out"/>
      <variable name="V_i" units="millimetre3" public_interface="out"/>
      <variable name="V_cell" units="millimetre3"/>
      <variable name="V_jsr_part" units="dimensionless" initial_value="0.0012"/>
      <variable name="V_i_part" units="dimensionless" initial_value="0.46"/>
      <variable name="V_nsr_part" units="dimensionless" initial_value="0.0116"/>
      <variable name="R_cell" units="micrometre" initial_value="4"/>
      <variable name="L_cell" units="micrometre" initial_value="70"/>
      <variable name="L_sub" units="micrometre" initial_value="0.02"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>V_cell</ci>
            <apply>
               <times/>
               <cn cellml:units="micrometre_per_femtometre">0.000000001</cn>
               <pi/>
               <apply>
                  <power/>
                  <ci>R_cell</ci>
                  <cn cellml:units="dimensionless">2</cn>
               </apply>
               <ci>L_cell</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_sub</ci>
            <apply>
               <times/>
               <cn cellml:units="micrometre_per_femtometre">0.000000001</cn>
               <cn cellml:units="dimensionless">2</cn>
               <pi/>
               <ci>L_sub</ci>
               <apply>
                  <minus/>
                  <ci>R_cell</ci>
                  <apply>
                     <divide/>
                     <ci>L_sub</ci>
                     <cn cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <ci>L_cell</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_jsr</ci>
            <apply>
               <times/>
               <ci>V_jsr_part</ci>
               <ci>V_cell</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_i</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>V_i_part</ci>
                  <ci>V_cell</ci>
               </apply>
               <ci>V_sub</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_nsr</ci>
            <apply>
               <times/>
               <ci>V_nsr_part</ci>
               <ci>V_cell</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_to">
      <variable name="i_to" units="nanoA" public_interface="out"/>
      <variable name="g_to" units="microS" initial_value="0.002"/>
      <variable name="E_K" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in" private_interface="out"/>
      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="q" units="dimensionless" private_interface="in"/>
      <variable name="r" units="dimensionless" private_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_to</ci>
            <apply>
               <times/>
               <ci>g_to</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
               <ci>q</ci>
               <ci>r</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_to_q_gate">
      <variable name="q" units="dimensionless" initial_value="0.506139850982478" public_interface="out"/>
      <variable name="q_infinity" units="dimensionless"/>
      <variable name="tau_q" units="second"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>q_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">49</cn>
                        </apply>
                        <cn cellml:units="millivolt">13</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_q</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.001</cn>
               <cn cellml:units="dimensionless">0.6</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <cn cellml:units="dimensionless">65.17</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <cn cellml:units="per_second">0.57</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn cellml:units="per_millivolt">0.08</cn>
                                 </apply>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">44</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <cn cellml:units="per_second">0.065</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="per_millivolt">0.1</cn>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">45.93</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="second">10.1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>q_infinity</ci>
                  <ci>q</ci>
               </apply>
               <ci>tau_q</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_to_r_gate">
      <variable name="r" units="dimensionless" initial_value="0.0144605370597924" public_interface="out"/>
      <variable name="r_infinity" units="dimensionless"/>
      <variable name="tau_r" units="second"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>r_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">19.3</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">15</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_r</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.001</cn>
               <cn cellml:units="dimensionless">0.66</cn>
               <cn cellml:units="dimensionless">1.4</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <cn cellml:units="second">15.59</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">1.037</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="per_millivolt">0.09</cn>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">30.61</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">0.369</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn cellml:units="per_millivolt">0.12</cn>
                                 </apply>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">23.84</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="second">2.98</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>r</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>r_infinity</ci>
                  <ci>r</ci>
               </apply>
               <ci>tau_r</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kr">
      <variable name="i_Kr" units="nanoA" public_interface="out"/>
      <variable name="g_Kr" units="microS" initial_value="0.0021637"/>
      <variable name="time" units="second" public_interface="in" private_interface="out"/>
      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="E_K" units="millivolt" public_interface="in"/>
      <variable name="Ko" units="millimolar" public_interface="in"/>
      <variable name="paS" units="dimensionless" private_interface="in"/>
      <variable name="paF" units="dimensionless" private_interface="in"/>
      <variable name="piy" units="dimensionless" private_interface="in"/>
      <variable name="RTONF" units="millivolt" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kr</ci>
            <apply>
               <times/>
               <ci>g_Kr</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.9</cn>
                     <ci>paF</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.1</cn>
                     <ci>paS</ci>
                  </apply>
               </apply>
               <ci>piy</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kr_pa_gate">
      <variable name="paS" units="dimensionless" initial_value="0.322999177802891" public_interface="out"/>
      <variable name="paF" units="dimensionless" initial_value="0.0990510403258968" public_interface="out"/>
      <variable name="pa_infinity" units="dimensionless"/>
      <variable name="alfapaF" units="per_second"/>
      <variable name="betapaF" units="per_second"/>
      <variable name="tau_paS" units="second"/>
      <variable name="tau_paF" units="second"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alfapaF</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">23.2</cn>
                              </apply>
                           </apply>
                           <cn cellml:units="millivolt">6.6</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn cellml:units="second">0.84655354</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">37.2</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">11.9</cn>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.96</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                              </apply>
                              <cn cellml:units="millivolt">18.5</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>betapaF</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">4</cn>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">37.2</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">15.9</cn>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">0.96</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                 </apply>
                                 <cn cellml:units="millivolt">22.5</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <cn cellml:units="second">0.84655354</cn>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <plus/>
                           <cn cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn cellml:units="millivolt">23.2</cn>
                                    </apply>
                                 </apply>
                                 <cn cellml:units="millivolt">10.6</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <cn cellml:units="second">0.84655354</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <cn cellml:units="dimensionless">37.2</cn>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <divide/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">15.9</cn>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <cn cellml:units="dimensionless">0.96</cn>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <divide/>
                                    <apply>
                                       <minus/>
                                       <ci>V</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">22.5</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pa_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">14.8</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">8.5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_paS</ci>
            <apply>
               <divide/>
               <cn cellml:units="second">0.84655354</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">4.2</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">17</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.15</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                           </apply>
                           <cn cellml:units="millivolt">21.6</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_paF</ci>
            <apply>
               <divide/>
               <cn cellml:units="second">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">30</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                        </apply>
                        <cn cellml:units="millivolt">12</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>paS</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>pa_infinity</ci>
                  <ci>paS</ci>
               </apply>
               <ci>tau_paS</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>paF</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>pa_infinity</ci>
                  <ci>paF</ci>
               </apply>
               <ci>tau_paF</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kr_pi_gate">
      <variable name="piy" units="dimensionless" initial_value="0.705410877258545" public_interface="out"/>
      <variable name="pi_infinity" units="dimensionless"/>
      <variable name="tau_pi" units="second"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>tau_pi</ci>
            <apply>
               <divide/>
               <cn cellml:units="second">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">100</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                           </apply>
                           <cn cellml:units="millivolt">54.645</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">656</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">106.157</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pi_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">28.6</cn>
                        </apply>
                        <cn cellml:units="millivolt">17.1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>piy</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>pi_infinity</ci>
                  <ci>piy</ci>
               </apply>
               <ci>tau_pi</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ks">
      <variable name="i_Ks" units="nanoA" public_interface="out"/>
      <variable name="g_Ks" units="microS" public_interface="out"/>
      <variable name="E_Ks" units="millivolt"/>
      <variable name="time" units="second" public_interface="in" private_interface="out"/>
      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="Ki" units="millimolar" public_interface="in"/>
      <variable name="Ko" units="millimolar" public_interface="in"/>
      <variable name="Nai" units="millimolar" public_interface="in"/>
      <variable name="Nao" units="millimolar" public_interface="in"/>
      <variable name="RTONF" units="millivolt" public_interface="in"/>
      <variable name="n" units="dimensionless" private_interface="in"/>
      <variable name="Iso_1_uM" units="dimensionless" public_interface="in" private_interface="out"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_Ks</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">1.2</cn>
                     <cn cellml:units="microS">0.0016576</cn>
                  </apply>
                  <apply>
                     <gt/>
                     <ci>Iso_1_uM</ci>
                     <cn cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="microS">0.0016576</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>E_Ks</ci>
            <apply>
               <times/>
               <ci>RTONF</ci>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">0</cn>
                           <ci>Nao</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Ki</ci>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">0</cn>
                           <ci>Nai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <times/>
               <ci>g_Ks</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ks</ci>
               </apply>
               <apply>
                  <power/>
                  <ci>n</ci>
                  <cn cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ks_n_gate">
      <variable name="n" units="dimensionless" initial_value="0" public_interface="out"/>
      <variable name="n_infinity" units="dimensionless"/>
      <variable name="tau_n" units="second"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
      <variable name="Iso_shift" units="millivolt"/>
      <variable name="shift" units="millivolt" initial_value="0"/>
      <variable name="alpha_n" units="per_second"/>
      <variable name="beta_n" units="per_second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Iso_shift</ci>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <cn cellml:units="millivolt">14</cn>
                  </apply>
                  <apply>
                     <gt/>
                     <ci>Iso_1_uM</ci>
                     <cn cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="millivolt">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>n_infinity</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <cn cellml:units="per_second">14</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">40</cn>
                                 </apply>
                                 <ci>Iso_shift</ci>
                              </apply>
                           </apply>
                           <cn cellml:units="millivolt">12</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <cn cellml:units="per_second">14</cn>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <minus/>
                                       <ci>V</ci>
                                       <cn cellml:units="millivolt">40</cn>
                                    </apply>
                                    <ci>Iso_shift</ci>
                                 </apply>
                              </apply>
                              <cn cellml:units="millivolt">12</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="per_second">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <ci>Iso_shift</ci>
                              </apply>
                           </apply>
                           <cn cellml:units="millivolt">45</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_n</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_n</ci>
                  <ci>beta_n</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_n</ci>
            <apply>
               <divide/>
               <cn cellml:units="per_second">28</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">40</cn>
                              </apply>
                              <ci>Iso_shift</ci>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">3</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_n</ci>
            <apply>
               <times/>
               <cn cellml:units="per_second">1</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <ci>Iso_shift</ci>
                              </apply>
                              <ci>shift</ci>
                           </apply>
                           <cn cellml:units="millivolt">5</cn>
                        </apply>
                     </apply>
                     <cn cellml:units="millivolt">25</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>n</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>n_infinity</ci>
                  <ci>n</ci>
               </apply>
               <ci>tau_n</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_KACh">
      <variable name="ACh" units="millimolar" public_interface="in" private_interface="out"/>
      <variable name="i_KACh" units="nanoA" public_interface="out"/>
      <variable name="g_KACh" units="microS" initial_value="0.00864"/>
      <variable name="E_K" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in" private_interface="out"/>
      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="a" units="dimensionless" private_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_KACh</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <ci>g_KACh</ci>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">20</cn>
                              </apply>
                              <cn cellml:units="millivolt">20</cn>
                           </apply>
                        </apply>
                     </apply>
                     <ci>a</ci>
                  </apply>
                  <apply>
                     <gt/>
                     <ci>ACh</ci>
                     <cn cellml:units="millimolar">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="nanoA">0</cn>
               </otherwise>
            </piecewise>
         </apply>
      </math>
   </component>
   <component name="i_KACh_a_gate">
      <variable name="a" units="dimensionless" initial_value="0" public_interface="out"/>
      <variable name="alpha_a" units="per_second"/>
      <variable name="beta_a" units="per_second"/>
      <variable name="a_infinity" units="dimensionless"/>
      <variable name="tau_a" units="second"/>
      <variable name="ACh" units="millimolar" public_interface="in"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="second" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_a</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <cn cellml:units="per_second">3.5988</cn>
                     <cn cellml:units="per_second">0.025641</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">0.0000012155</cn>
                        <apply>
                           <power/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millimolar">1</cn>
                              <ci>ACh</ci>
                           </apply>
                           <cn cellml:units="dimensionless">1.6951</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn cellml:units="per_second">0.025641</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_a</ci>
            <apply>
               <times/>
               <cn cellml:units="per_second">10</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn cellml:units="per_millivolt">0.0133</cn>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_a</ci>
               <apply>
                  <plus/>
                  <ci>alpha_a</ci>
                  <ci>beta_a</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_a</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_a</ci>
                  <ci>beta_a</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>a</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>a_infinity</ci>
                  <ci>a</ci>
               </apply>
               <ci>tau_a</ci>
            </apply>
         </apply>
      </math>
   </component>
   <group>
      <relationship_ref relationship="containment"/>
      <component_ref component="Membrane">
         <component_ref component="Ionic_values"/>
         <component_ref component="Voltage_clamp"/>
         <component_ref component="i_NaK"/>
         <component_ref component="i_NaCa"/>
         <component_ref component="Ca_SR_release"/>
         <component_ref component="Ca_intracellular_fluxes"/>
         <component_ref component="Ca_buffering"/>
         <component_ref component="Ca_dynamics"/>
         <component_ref component="Cell_parameters"/>
         <component_ref component="Nai_concentration"/>
         <component_ref component="Rate_modulation_experiments"/>
         <component_ref component="i_f">
            <component_ref component="i_f_y_gate"/>
         </component_ref>
         <component_ref component="i_Na">
            <component_ref component="i_Na_m_gate"/>
            <component_ref component="i_Na_h_gate"/>
         </component_ref>
         <component_ref component="i_CaL">
            <component_ref component="i_CaL_dL_gate"/>
            <component_ref component="i_CaL_fL_gate"/>
            <component_ref component="i_CaL_fCa_gate"/>
         </component_ref>
         <component_ref component="i_CaT">
            <component_ref component="i_CaT_dT_gate"/>
            <component_ref component="i_CaT_fT_gate"/>
         </component_ref>
         <component_ref component="i_to">
            <component_ref component="i_to_q_gate"/>
            <component_ref component="i_to_r_gate"/>
         </component_ref>
         <component_ref component="i_Kr">
            <component_ref component="i_Kr_pa_gate"/>
            <component_ref component="i_Kr_pi_gate"/>
         </component_ref>
         <component_ref component="i_Ks">
            <component_ref component="i_Ks_n_gate"/>
         </component_ref>
         <component_ref component="i_KACh">
            <component_ref component="i_KACh_a_gate"/>
         </component_ref>
      </component_ref>
   </group>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="Membrane">
         <component_ref component="Voltage_clamp"/>
      </component_ref>
      <component_ref component="i_f">
         <component_ref component="i_f_y_gate"/>
      </component_ref>
      <component_ref component="i_Na">
         <component_ref component="i_Na_m_gate"/>
         <component_ref component="i_Na_h_gate"/>
      </component_ref>
      <component_ref component="i_CaL">
         <component_ref component="i_CaL_dL_gate"/>
         <component_ref component="i_CaL_fL_gate"/>
         <component_ref component="i_CaL_fCa_gate"/>
      </component_ref>
      <component_ref component="i_CaT">
         <component_ref component="i_CaT_dT_gate"/>
         <component_ref component="i_CaT_fT_gate"/>
      </component_ref>
      <component_ref component="i_to">
         <component_ref component="i_to_q_gate"/>
         <component_ref component="i_to_r_gate"/>
      </component_ref>
      <component_ref component="i_Kr">
         <component_ref component="i_Kr_pa_gate"/>
         <component_ref component="i_Kr_pi_gate"/>
      </component_ref>
      <component_ref component="i_Ks">
         <component_ref component="i_Ks_n_gate"/>
      </component_ref>
      <component_ref component="i_KACh">
         <component_ref component="i_KACh_a_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="Membrane" component_2="Voltage_clamp"/>
      <map_variables variable_1="V_clamp" variable_2="V_clamp"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Membrane" component_2="Ionic_values"/>
      <map_variables variable_1="RTONF" variable_2="RTONF"/>
   </connection>
   <connection>
      <map_components component_1="Membrane" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Nai_concentration" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_f" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_NaK" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_NaCa" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Na" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_CaL" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_CaT" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_SR_release" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_buffering" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_dynamics" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_to" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Kr" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Ks" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_KACh" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Nai_concentration" component_2="Membrane"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="i_f" component_2="Membrane"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="RTONF" variable_2="RTONF"/>
      <map_variables variable_1="i_f" variable_2="i_f"/>
   </connection>
   <connection>
      <map_components component_1="i_NaK" component_2="Membrane"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
   </connection>
   <connection>
      <map_components component_1="i_NaCa" component_2="Membrane"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="RTONF" variable_2="RTONF"/>
   </connection>
   <connection>
      <map_components component_1="i_Na" component_2="Membrane"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
      <map_variables variable_1="RTONF" variable_2="RTONF"/>
   </connection>
   <connection>
      <map_components component_1="i_CaL" component_2="Membrane"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="RTONF" variable_2="RTONF"/>
      <map_variables variable_1="i_CaL" variable_2="i_CaL"/>
   </connection>
   <connection>
      <map_components component_1="i_CaT" component_2="Membrane"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="RTONF" variable_2="RTONF"/>
      <map_variables variable_1="i_CaT" variable_2="i_CaT"/>
   </connection>
   <connection>
      <map_components component_1="Ca_dynamics" component_2="Membrane"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="i_to" component_2="Membrane"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_to" variable_2="i_to"/>
   </connection>
   <connection>
      <map_components component_1="i_Kr" component_2="Membrane"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
      <map_variables variable_1="RTONF" variable_2="RTONF"/>
   </connection>
   <connection>
      <map_components component_1="i_Ks" component_2="Membrane"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="RTONF" variable_2="RTONF"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
   </connection>
   <connection>
      <map_components component_1="i_KACh" component_2="Membrane"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_KACh" variable_2="i_KACh"/>
   </connection>
   <connection>
      <map_components component_1="Nai_concentration" component_2="Ionic_values"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
   </connection>
   <connection>
      <map_components component_1="i_f" component_2="Ionic_values"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
      <map_variables variable_1="Kc" variable_2="Ko"/>
   </connection>
   <connection>
      <map_components component_1="i_Na" component_2="Ionic_values"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Kc" variable_2="Ko"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
   </connection>
   <connection>
      <map_components component_1="i_NaK" component_2="Ionic_values"/>
      <map_variables variable_1="Kc" variable_2="Ko"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="i_NaCa" component_2="Ionic_values"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
   </connection>
   <connection>
      <map_components component_1="Ca_dynamics" component_2="Ionic_values"/>
      <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
   </connection>
   <connection>
      <map_components component_1="i_CaL" component_2="Ionic_values"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Kc" variable_2="Ko"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
   </connection>
   <connection>
      <map_components component_1="i_CaT" component_2="Ionic_values"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
   </connection>
   <connection>
      <map_components component_1="i_to" component_2="Ionic_values"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="i_Kr" component_2="Ionic_values"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="i_Ks" component_2="Ionic_values"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
   </connection>
   <connection>
      <map_components component_1="i_KACh" component_2="Ionic_values"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="i_f" component_2="i_f_y_gate"/>
      <map_variables variable_1="y" variable_2="y"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="ACh" variable_2="ACh"/>
      <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
   </connection>
   <connection>
      <map_components component_1="i_Na" component_2="i_Na_m_gate"/>
      <map_variables variable_1="m" variable_2="m"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="i_Na" component_2="i_Na_h_gate"/>
      <map_variables variable_1="h" variable_2="h"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="i_CaL" component_2="i_CaL_dL_gate"/>
      <map_variables variable_1="dL" variable_2="dL"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
   </connection>
   <connection>
      <map_components component_1="i_CaL" component_2="i_CaL_fL_gate"/>
      <map_variables variable_1="fL" variable_2="fL"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="i_CaL" component_2="i_CaL_fCa_gate"/>
      <map_variables variable_1="fCa" variable_2="fCa"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
   </connection>
   <connection>
      <map_components component_1="i_CaT" component_2="i_CaT_dT_gate"/>
      <map_variables variable_1="dT" variable_2="dT"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_CaT" component_2="i_CaT_fT_gate"/>
      <map_variables variable_1="fT" variable_2="fT"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_to" component_2="i_to_q_gate"/>
      <map_variables variable_1="q" variable_2="q"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="i_to" component_2="i_to_r_gate"/>
      <map_variables variable_1="r" variable_2="r"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="i_Kr" component_2="i_Kr_pa_gate"/>
      <map_variables variable_1="paF" variable_2="paF"/>
      <map_variables variable_1="paS" variable_2="paS"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="i_Kr" component_2="i_Kr_pi_gate"/>
      <map_variables variable_1="piy" variable_2="piy"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="i_Ks" component_2="i_Ks_n_gate"/>
      <map_variables variable_1="n" variable_2="n"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
   </connection>
   <connection>
      <map_components component_1="i_KACh" component_2="i_KACh_a_gate"/>
      <map_variables variable_1="a" variable_2="a"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="ACh" variable_2="ACh"/>
   </connection>
   <connection>
      <map_components component_1="Nai_concentration" component_2="i_Ks"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
   </connection>
   <connection>
      <map_components component_1="Ca_dynamics" component_2="Cell_parameters"/>
      <map_variables variable_1="V_i" variable_2="V_i"/>
      <map_variables variable_1="V_jsr" variable_2="V_jsr"/>
      <map_variables variable_1="V_nsr" variable_2="V_nsr"/>
      <map_variables variable_1="V_sub" variable_2="V_sub"/>
   </connection>
   <connection>
      <map_components component_1="Ca_dynamics" component_2="Ca_buffering"/>
      <map_variables variable_1="TMC_tot" variable_2="TMC_tot"/>
      <map_variables variable_1="CM_tot" variable_2="CM_tot"/>
      <map_variables variable_1="TC_tot" variable_2="TC_tot"/>
      <map_variables variable_1="CQ_tot" variable_2="CQ_tot"/>
      <map_variables variable_1="delta_fTMC" variable_2="delta_fTMC"/>
      <map_variables variable_1="delta_fCMi" variable_2="delta_fCMi"/>
      <map_variables variable_1="delta_fCMs" variable_2="delta_fCMs"/>
      <map_variables variable_1="delta_fTC" variable_2="delta_fTC"/>
      <map_variables variable_1="delta_fCQ" variable_2="delta_fCQ"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
      <map_variables variable_1="Ca_jsr" variable_2="Ca_jsr"/>
   </connection>
   <connection>
      <map_components component_1="i_NaCa" component_2="Ca_dynamics"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
   </connection>
   <connection>
      <map_components component_1="Ca_SR_release" component_2="Ca_dynamics"/>
      <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
      <map_variables variable_1="Ca_jsr" variable_2="Ca_jsr"/>
      <map_variables variable_1="j_SRCarel" variable_2="j_SRCarel"/>
   </connection>
   <connection>
      <map_components component_1="Ca_intracellular_fluxes" component_2="Ca_dynamics"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="Ca_nsr" variable_2="Ca_nsr"/>
      <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
      <map_variables variable_1="Ca_jsr" variable_2="Ca_jsr"/>
      <map_variables variable_1="j_Ca_dif" variable_2="j_Ca_dif"/>
      <map_variables variable_1="j_tr" variable_2="j_tr"/>
      <map_variables variable_1="j_up" variable_2="j_up"/>
   </connection>
   <connection>
      <map_components component_1="i_CaL" component_2="Ca_dynamics"/>
      <map_variables variable_1="i_siCa" variable_2="i_siCa"/>
      <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
   </connection>
   <connection>
      <map_components component_1="i_CaT" component_2="Ca_dynamics"/>
      <map_variables variable_1="i_CaT" variable_2="i_CaT"/>
      <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
   </connection>
   <connection>
      <map_components component_1="Nai_concentration" component_2="Cell_parameters"/>
      <map_variables variable_1="V_i" variable_2="V_i"/>
      <map_variables variable_1="V_sub" variable_2="V_sub"/>
   </connection>
   <connection>
      <map_components component_1="Nai_concentration" component_2="i_f"/>
      <map_variables variable_1="i_fNa" variable_2="i_fNa"/>
   </connection>
   <connection>
      <map_components component_1="Nai_concentration" component_2="i_NaK"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
   </connection>
   <connection>
      <map_components component_1="Nai_concentration" component_2="i_NaCa"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_1="Nai_concentration" component_2="i_Na"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
   </connection>
   <connection>
      <map_components component_1="Nai_concentration" component_2="i_CaL"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="i_siNa" variable_2="i_siNa"/>
   </connection>
   <connection>
      <map_components component_1="i_f" component_2="Rate_modulation_experiments"/>
      <map_variables variable_1="Iva_3_uM" variable_2="Iva_3_uM"/>
      <map_variables variable_1="Cs_5_mM" variable_2="Cs_5_mM"/>
      <map_variables variable_1="ACh" variable_2="ACh"/>
      <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
   </connection>
   <connection>
      <map_components component_1="i_CaL" component_2="Rate_modulation_experiments"/>
      <map_variables variable_1="ACh" variable_2="ACh"/>
      <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
   </connection>
   <connection>
      <map_components component_1="i_NaK" component_2="Rate_modulation_experiments"/>
      <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
   </connection>
   <connection>
      <map_components component_1="i_Ks" component_2="Rate_modulation_experiments"/>
      <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
   </connection>
   <connection>
      <map_components component_1="i_KACh" component_2="Rate_modulation_experiments"/>
      <map_variables variable_1="ACh" variable_2="ACh"/>
   </connection>
   <connection>
      <map_components component_1="Ca_dynamics" component_2="Rate_modulation_experiments"/>
      <map_variables variable_1="BAPTA_10_mM" variable_2="BAPTA_10_mM"/>
   </connection>
   <connection>
      <map_components component_1="Ca_intracellular_fluxes" component_2="Rate_modulation_experiments"/>
      <map_variables variable_1="ACh" variable_2="ACh"/>
      <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
   </connection>
   <connection>
      <map_components component_1="Nai_concentration" component_2="Rate_modulation_experiments"/>
      <map_variables variable_1="BAPTA_10_mM" variable_2="BAPTA_10_mM"/>
   </connection>
</model>
Source
Derived from workspace severi_fantini_charawi_difrancesco_2012 at changeset 1acf719d8f4b.
This exposure was expired.
Collaboration
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License
The terms of use/license for this work is unspecified.