<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 13/06/2012 at 22:45:06 using:
COR (0.9.31.1409)
Copyright 2002-2012 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
<model name="severi_fantini_charawi_difrancesco_2012" cmeta:id="severi_fantini_charawi_difrancesco_2012" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units name="per_second">
<unit units="second" exponent="-1"/>
</units>
<units name="millisecond">
<unit units="second" prefix="milli"/>
</units>
<units name="per_millisecond">
<unit units="millisecond" exponent="-1"/>
</units>
<units name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units name="per_millivolt">
<unit units="volt" prefix="milli" exponent="-1"/>
</units>
<units name="per_millivolt_second">
<unit units="millivolt" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units name="millivolt_second">
<unit units="millivolt"/>
<unit units="second"/>
</units>
<units name="microS">
<unit units="siemens" prefix="micro"/>
</units>
<units name="microF">
<unit units="farad" prefix="micro"/>
</units>
<units name="nanoA">
<unit units="ampere" prefix="nano"/>
</units>
<units name="mA_nA">
<unit units="ampere" prefix="milli"/>
<unit units="nanoA" exponent="-1"/>
</units>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="per_millimolar">
<unit units="millimolar" exponent="-1"/>
</units>
<units name="millimolar4">
<unit units="millimolar" exponent="4"/>
</units>
<units name="millimolar_per_second">
<unit units="millimolar"/>
<unit units="second" exponent="-1"/>
</units>
<units name="per_millimolar2_second">
<unit units="millimolar" exponent="-2"/>
<unit units="second" exponent="-1"/>
</units>
<units name="per_millimolar_second">
<unit units="millimolar" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units name="nanoA_per_millimolar">
<unit units="nanoA"/>
<unit units="millimolar" exponent="-1"/>
</units>
<units name="joule_per_kilomole_kelvin">
<unit units="joule"/>
<unit units="mole" prefix="kilo" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units name="coulomb_per_mole">
<unit units="coulomb"/>
<unit units="mole" exponent="-1"/>
</units>
<units name="millimetre">
<unit units="metre" prefix="milli"/>
</units>
<units name="micrometre">
<unit units="metre" prefix="micro"/>
</units>
<units name="millimetre3">
<unit units="metre" prefix="milli" exponent="3"/>
</units>
<units name="litre_millimetre3">
<unit units="litre"/>
<unit units="millimetre3" exponent="-1"/>
</units>
<units name="micrometre_per_femtometre">
<unit units="micrometre"/>
<unit units="metre" prefix="femto" exponent="-1"/>
</units>
<units name="nanoS">
<unit units="siemens" prefix="nano"/>
</units>
<component name="environment">
<variable name="time" units="second" public_interface="out"/>
</component>
<component name="Membrane">
<variable name="R" units="joule_per_kilomole_kelvin" initial_value="8314.472" public_interface="out"/>
<variable name="T" units="kelvin" initial_value="310" public_interface="out"/>
<variable name="F" units="coulomb_per_mole" initial_value="96485.3415" public_interface="out"/>
<variable name="C" units="microF" initial_value="3.2e-5"/>
<variable name="RTONF" units="millivolt" public_interface="out"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="i_f" units="nanoA" public_interface="in"/>
<variable name="i_NaK" units="nanoA" public_interface="in"/>
<variable name="i_NaCa" units="nanoA" public_interface="in"/>
<variable name="i_Na" units="nanoA" public_interface="in"/>
<variable name="i_Kr" units="nanoA" public_interface="in"/>
<variable name="i_Ks" units="nanoA" public_interface="in"/>
<variable name="i_to" units="nanoA" public_interface="in"/>
<variable name="i_CaL" units="nanoA" public_interface="in"/>
<variable name="i_CaT" units="nanoA" public_interface="in"/>
<variable name="i_KACh" units="nanoA" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="out"/>
<variable name="clamp_mode" units="dimensionless" initial_value="0"/>
<variable name="V_clamp" units="millivolt" private_interface="in"/>
<variable name="V_ode" units="millivolt" initial_value="-52"/>
<variable name="i_tot" units="nanoA"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_tot</ci>
<apply>
<plus/>
<ci>i_f</ci>
<ci>i_Kr</ci>
<ci>i_Ks</ci>
<ci>i_to</ci>
<ci>i_NaK</ci>
<ci>i_NaCa</ci>
<ci>i_Na</ci>
<ci>i_CaL</ci>
<ci>i_CaT</ci>
<ci>i_KACh</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V_ode</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>i_tot</ci>
</apply>
<ci>C</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>RTONF</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V</ci>
<piecewise>
<piece>
<ci>V_clamp</ci>
<apply>
<geq/>
<ci>clamp_mode</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<ci>V_ode</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="Voltage_clamp">
<variable name="t_holding" units="second" initial_value="0.5"/>
<variable name="t_test" units="second" initial_value="0.5"/>
<variable name="V_clamp" units="millivolt" public_interface="out"/>
<variable name="V_test" units="millivolt" initial_value="-35"/>
<variable name="V_holding" units="millivolt" initial_value="-45"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_test</ci>
<apply>
<and/>
<apply>
<gt/>
<ci>time</ci>
<ci>t_holding</ci>
</apply>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>t_holding</ci>
<ci>t_test</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>V_holding</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="Rate_modulation_experiments">
<variable name="Iva_3_uM" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="Cs_5_mM" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="ACh" units="millimolar" initial_value="0" public_interface="out"/>
<variable name="Iso_1_uM" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="BAPTA_10_mM" units="dimensionless" initial_value="0" public_interface="out"/>
</component>
<component name="Ionic_values">
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nao" units="millimolar" initial_value="140" public_interface="out"/>
<variable name="Ki" units="millimolar" initial_value="140" public_interface="out"/>
<variable name="Ko" units="millimolar" initial_value="5.4" public_interface="out"/>
<variable name="Ca_sub" units="millimolar" public_interface="in"/>
<variable name="Cao" units="millimolar" initial_value="1.8" public_interface="out"/>
<variable name="RTONF" units="millivolt" public_interface="in"/>
<variable name="E_Na" units="millivolt" public_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="out"/>
<variable name="E_Ca" units="millivolt" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Ca_sub</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Nai_concentration">
<variable name="Nai" units="millimolar" public_interface="out"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="V_sub" units="millimetre3" public_interface="in"/>
<variable name="V_i" units="millimetre3" public_interface="in"/>
<variable name="i_Na" units="nanoA" public_interface="in"/>
<variable name="i_NaCa" units="nanoA" public_interface="in"/>
<variable name="i_NaK" units="nanoA" public_interface="in"/>
<variable name="i_fNa" units="nanoA" public_interface="in"/>
<variable name="i_siNa" units="nanoA" public_interface="in"/>
<variable name="Nai_" units="millimolar" initial_value="7.5"/>
<variable name="BAPTA_10_mM" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai_</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="mA_nA">1</cn>
</apply>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_fNa</ci>
<ci>i_siNa</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaK</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="litre_millimetre3">1</cn>
<apply>
<plus/>
<ci>V_i</ci>
<ci>V_sub</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Nai</ci>
<piecewise>
<piece>
<cn cellml:units="millimolar">7.5</cn>
<apply>
<gt/>
<ci>BAPTA_10_mM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<ci>Nai_</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="i_f">
<variable name="Iva_3_uM" units="dimensionless" public_interface="in"/>
<variable name="Cs_5_mM" units="dimensionless" public_interface="in"/>
<variable name="ACh" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Iso_1_uM" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="ICs_on_Icontrol" units="dimensionless" public_interface="out"/>
<variable name="i_f" units="nanoA" public_interface="out"/>
<variable name="i_fNa" units="nanoA" public_interface="out"/>
<variable name="E_Na" units="millivolt" public_interface="in"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="i_fK" units="nanoA" public_interface="out"/>
<variable name="g_f_Na" units="microS" public_interface="out"/>
<variable name="g_f_K" units="microS" public_interface="out"/>
<variable name="Km_f" units="millimolar" initial_value="45"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="RTONF" units="millivolt" public_interface="in"/>
<variable name="Kc" units="millimolar" public_interface="in"/>
<variable name="y" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_f_Na</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="microS">0.03</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">0.66</cn>
</apply>
</apply>
<apply>
<geq/>
<ci>Iva_3_uM</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="microS">0.03</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>g_f_K</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="microS">0.03</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">0.66</cn>
</apply>
</apply>
<apply>
<geq/>
<ci>Iva_3_uM</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="microS">0.03</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>ICs_on_Icontrol</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<divide/>
<cn cellml:units="millimolar">10.6015</cn>
<cn cellml:units="millimolar">5</cn>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="millimolar">10.6015</cn>
<cn cellml:units="millimolar">5</cn>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.71</cn>
</apply>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<geq/>
<ci>Cs_5_mM</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_fNa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<ci>y</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Kc</ci>
</apply>
<apply>
<plus/>
<ci>Kc</ci>
<ci>Km_f</ci>
</apply>
</apply>
<ci>g_f_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
<ci>ICs_on_Icontrol</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_fK</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<ci>y</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Kc</ci>
</apply>
<apply>
<plus/>
<ci>Kc</ci>
<ci>Km_f</ci>
</apply>
</apply>
<ci>g_f_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<ci>ICs_on_Icontrol</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f</ci>
<apply>
<plus/>
<ci>i_fNa</ci>
<ci>i_fK</ci>
</apply>
</apply>
</math>
</component>
<component name="i_f_y_gate">
<variable name="y" units="dimensionless" initial_value="0.181334538702451" public_interface="out"/>
<variable name="tau_y" units="second"/>
<variable name="y_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="ACh_shift" units="millivolt"/>
<variable name="ACh" units="millimolar" public_interface="in"/>
<variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
<variable name="Iso_shift" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ACh_shift</ci>
<piecewise>
<piece>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">1</cn>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millivolt">9.898</cn>
<apply>
<power/>
<apply>
<times/>
<cn cellml:units="per_millimolar">1</cn>
<ci>ACh</ci>
</apply>
<cn cellml:units="dimensionless">0.618</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<apply>
<times/>
<cn cellml:units="per_millimolar">1</cn>
<ci>ACh</ci>
</apply>
<cn cellml:units="dimensionless">0.618</cn>
</apply>
<cn cellml:units="dimensionless">0.00122423</cn>
</apply>
</apply>
</apply>
<apply>
<gt/>
<ci>ACh</ci>
<cn cellml:units="millimolar">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="millivolt">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>Iso_shift</ci>
<piecewise>
<piece>
<cn cellml:units="millivolt">7.5</cn>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="millivolt">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_y</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.7166529</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_second">0.0708</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
<ci>ACh_shift</ci>
</apply>
<ci>Iso_shift</ci>
</apply>
</apply>
<cn cellml:units="millivolt">20.2791</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_second">10.6</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>ACh_shift</ci>
</apply>
<ci>Iso_shift</ci>
</apply>
<cn cellml:units="millivolt">18</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>y_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">52.5</cn>
</apply>
<ci>ACh_shift</ci>
</apply>
<ci>Iso_shift</ci>
</apply>
<cn cellml:units="millivolt">9</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_infinity</ci>
<ci>y</ci>
</apply>
<ci>tau_y</ci>
</apply>
</apply>
</math>
</component>
<component name="i_NaK">
<variable name="i_NaK" units="nanoA" public_interface="out"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="Km_Kp" units="millimolar" initial_value="1.4"/>
<variable name="Km_Nap" units="millimolar" initial_value="14"/>
<variable name="i_NaK_max" units="nanoA" initial_value="0.063"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Kc" units="millimolar" public_interface="in"/>
<variable name="E_Na" units="millivolt" public_interface="in"/>
<variable name="Iso_increase" units="dimensionless"/>
<variable name="Iso_1_uM" units="dimensionless" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Iso_increase</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">1.2</cn>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
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</piecewise>
</apply>
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<times/>
<ci>Iso_increase</ci>
<ci>i_NaK_max</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Kp</ci>
<ci>Kc</ci>
</apply>
<cn cellml:units="dimensionless">1.2</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nap</ci>
<ci>Nai</ci>
</apply>
<cn cellml:units="dimensionless">1.3</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
<cn cellml:units="millivolt">110</cn>
</apply>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_NaCa">
<variable name="i_NaCa" units="nanoA" public_interface="out"/>
<variable name="K_NaCa" units="nanoA" initial_value="4"/>
<variable name="x1" units="dimensionless"/>
<variable name="x2" units="dimensionless"/>
<variable name="x3" units="dimensionless"/>
<variable name="x4" units="dimensionless"/>
<variable name="k41" units="dimensionless"/>
<variable name="k34" units="dimensionless"/>
<variable name="k23" units="dimensionless"/>
<variable name="k21" units="dimensionless"/>
<variable name="k32" units="dimensionless"/>
<variable name="k43" units="dimensionless"/>
<variable name="k12" units="dimensionless"/>
<variable name="k14" units="dimensionless"/>
<variable name="Qci" units="dimensionless" initial_value="0.1369"/>
<variable name="Qn" units="dimensionless" initial_value="0.4315"/>
<variable name="Qco" units="dimensionless" initial_value="0"/>
<variable name="K3ni" units="millimolar" initial_value="26.44"/>
<variable name="Kci" units="millimolar" initial_value="0.0207"/>
<variable name="K1ni" units="millimolar" initial_value="395.3"/>
<variable name="K2ni" units="millimolar" initial_value="2.289"/>
<variable name="Kcni" units="millimolar" initial_value="26.44"/>
<variable name="K3no" units="millimolar" initial_value="4.663"/>
<variable name="K1no" units="millimolar" initial_value="1628"/>
<variable name="K2no" units="millimolar" initial_value="561.4"/>
<variable name="Kco" units="millimolar" initial_value="3.663"/>
<variable name="do" units="dimensionless"/>
<variable name="di" units="dimensionless"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Ca_sub" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="RTONF" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K_NaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>x2</ci>
<ci>k21</ci>
</apply>
<apply>
<times/>
<ci>x1</ci>
<ci>k12</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>x1</ci>
<ci>x2</ci>
<ci>x3</ci>
<ci>x4</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k41</ci>
<ci>k34</ci>
<apply>
<plus/>
<ci>k23</ci>
<ci>k21</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k21</ci>
<ci>k32</ci>
<apply>
<plus/>
<ci>k43</ci>
<ci>k41</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x2</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k32</ci>
<ci>k43</ci>
<apply>
<plus/>
<ci>k14</ci>
<ci>k12</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k41</ci>
<ci>k12</ci>
<apply>
<plus/>
<ci>k34</ci>
<ci>k32</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x3</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k14</ci>
<ci>k43</ci>
<apply>
<plus/>
<ci>k23</ci>
<ci>k21</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k12</ci>
<ci>k23</ci>
<apply>
<plus/>
<ci>k43</ci>
<ci>k41</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x4</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k23</ci>
<ci>k34</ci>
<apply>
<plus/>
<ci>k14</ci>
<ci>k12</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k14</ci>
<ci>k21</ci>
<apply>
<plus/>
<ci>k34</ci>
<ci>k32</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k43</ci>
<apply>
<divide/>
<ci>Nai</ci>
<apply>
<plus/>
<ci>K3ni</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k12</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Ca_sub</ci>
<ci>Kci</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Qci</ci>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<ci>di</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k14</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K1ni</ci>
</apply>
<ci>Nai</ci>
</apply>
<ci>K2ni</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K3ni</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Qn</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>di</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k41</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Qn</ci>
</apply>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>di</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Ca_sub</ci>
<ci>Kci</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Qci</ci>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>Nai</ci>
<ci>Kcni</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K1ni</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K2ni</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K3ni</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k34</ci>
<apply>
<divide/>
<ci>Nao</ci>
<apply>
<plus/>
<ci>K3no</ci>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k21</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Kco</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Qco</ci>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<ci>do</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k23</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K1no</ci>
</apply>
<ci>Nao</ci>
</apply>
<ci>K2no</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K3no</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Qn</ci>
</apply>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>do</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k32</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Qn</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>do</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Kco</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Qco</ci>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K1no</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K2no</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K3no</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Na">
<variable name="i_Na" units="nanoA" public_interface="out"/>
<variable name="g_Na" units="microS" initial_value="0.0125"/>
<variable name="E_mh" units="millivolt"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="RTONF" units="millivolt" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Kc" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="m" units="dimensionless" private_interface="in"/>
<variable name="h" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_mh</ci>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Nao</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>Kc</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Nai</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na</ci>
<apply>
<times/>
<ci>g_Na</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_mh</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Na_m_gate">
<variable name="m" units="dimensionless" initial_value="0.440131579215766" public_interface="out"/>
<variable name="alpha_m" units="per_second"/>
<variable name="beta_m" units="per_second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="delta_m" units="millivolt" initial_value="1e-5"/>
<variable name="E0_m" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E0_m</ci>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">41</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_m</ci>
<piecewise>
<piece>
<cn cellml:units="per_second">2000</cn>
<apply>
<lt/>
<apply>
<abs/>
<ci>E0_m</ci>
</apply>
<ci>delta_m</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">200</cn>
<ci>E0_m</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<ci>E0_m</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<times/>
<cn cellml:units="per_second">8000</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.056</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">66</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_m</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>m</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_m</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Na_h_gate">
<variable name="h" units="dimensionless" initial_value="1.3676940140066e-5" public_interface="out"/>
<variable name="alpha_h" units="per_second"/>
<variable name="beta_h" units="per_second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_h</ci>
<apply>
<times/>
<cn cellml:units="per_second">20</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.125</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<apply>
<divide/>
<cn cellml:units="per_second">2000</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">320</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_h</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>h</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_h</ci>
<ci>h</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_CaL">
<variable name="i_CaL" units="nanoA" public_interface="out"/>
<variable name="i_siCa" units="nanoA" public_interface="out"/>
<variable name="i_siK" units="nanoA" public_interface="out"/>
<variable name="i_siNa" units="nanoA" public_interface="out"/>
<variable name="ACh_block" units="dimensionless"/>
<variable name="ACh" units="millimolar" public_interface="in"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="P_CaL" units="nanoA_per_millimolar" initial_value="0.2"/>
<variable name="RTONF" units="millivolt" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Kc" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="Ca_sub" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="dL" units="dimensionless" private_interface="in"/>
<variable name="fL" units="dimensionless" private_interface="in"/>
<variable name="fCa" units="dimensionless" private_interface="in"/>
<variable name="Iso_increase" units="dimensionless"/>
<variable name="Iso_1_uM" units="dimensionless" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Iso_increase</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">1.23</cn>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_siCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>P_CaL</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ca_sub</ci>
<apply>
<times/>
<ci>Cao</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>dL</ci>
<ci>fL</ci>
<ci>fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_siK</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.000365</cn>
<ci>P_CaL</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ki</ci>
<apply>
<times/>
<ci>Kc</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>dL</ci>
<ci>fL</ci>
<ci>fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_siNa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0000185</cn>
<ci>P_CaL</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Nai</ci>
<apply>
<times/>
<ci>Nao</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>dL</ci>
<ci>fL</ci>
<ci>fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ACh_block</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.31</cn>
<ci>ACh</ci>
</apply>
<apply>
<plus/>
<ci>ACh</ci>
<cn cellml:units="millimolar">0.00009</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>i_siCa</ci>
<ci>i_siK</ci>
<ci>i_siNa</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>ACh_block</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
<ci>Iso_increase</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaL_dL_gate">
<variable name="dL" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="dL_infinity" units="dimensionless"/>
<variable name="tau_dL" units="second"/>
<variable name="alpha_dL" units="per_second"/>
<variable name="beta_dL" units="per_second"/>
<variable name="adVm" units="millivolt"/>
<variable name="bdVm" units="millivolt"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="Iso_shift" units="millivolt"/>
<variable name="Iso_slope" units="dimensionless"/>
<variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Iso_shift</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="millivolt">8</cn>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="millivolt">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>Iso_slope</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">0.69</cn>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>dL_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">20.3</cn>
</apply>
<ci>Iso_shift</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Iso_slope</ci>
<cn cellml:units="millivolt">4.2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_dL</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<plus/>
<ci>alpha_dL</ci>
<ci>beta_dL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_dL</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt_second">0.02839</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>adVm</ci>
<cn cellml:units="millivolt">41.8</cn>
</apply>
<ci>Iso_shift</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>adVm</ci>
<cn cellml:units="millivolt">41.8</cn>
</apply>
<ci>Iso_shift</ci>
</apply>
</apply>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">0.0849</cn>
<apply>
<minus/>
<apply>
<plus/>
<ci>adVm</ci>
<cn cellml:units="millivolt">6.8</cn>
</apply>
<ci>Iso_shift</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>adVm</ci>
<cn cellml:units="millivolt">6.8</cn>
</apply>
<ci>Iso_shift</ci>
</apply>
</apply>
<cn cellml:units="millivolt">4.8</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>adVm</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="millivolt">41.80001</cn>
</apply>
<apply>
<eq/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">41.8</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="millivolt">0</cn>
<apply>
<eq/>
<ci>V</ci>
<cn cellml:units="millivolt">0</cn>
</apply>
</piece>
<piece>
<apply>
<minus/>
<cn cellml:units="millivolt">6.80001</cn>
</apply>
<apply>
<eq/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">6.8</cn>
</apply>
</apply>
</piece>
<otherwise>
<ci>V</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_dL</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">0.01143</cn>
<apply>
<minus/>
<apply>
<plus/>
<ci>bdVm</ci>
<cn cellml:units="millivolt">1.8</cn>
</apply>
<ci>Iso_shift</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>bdVm</ci>
<cn cellml:units="millivolt">1.8</cn>
</apply>
<ci>Iso_shift</ci>
</apply>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>bdVm</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="millivolt">1.80001</cn>
</apply>
<apply>
<eq/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">1.8</cn>
</apply>
</apply>
</piece>
<otherwise>
<ci>V</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>dL</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>dL_infinity</ci>
<ci>dL</ci>
</apply>
<ci>tau_dL</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaL_fL_gate">
<variable name="fL" units="dimensionless" initial_value="0.497133507285601" public_interface="out"/>
<variable name="fL_infinity" units="dimensionless"/>
<variable name="tau_fL" units="second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>fL_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">37.4</cn>
</apply>
<cn cellml:units="millivolt">5.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_fL</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<plus/>
<cn cellml:units="second">44.3</cn>
<apply>
<times/>
<cn cellml:units="second">230</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">36</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fL</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>fL_infinity</ci>
<ci>fL</ci>
</apply>
<ci>tau_fL</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaL_fCa_gate">
<variable name="fCa" units="dimensionless" initial_value="0.697998543259722" public_interface="out"/>
<variable name="alpha_fCa" units="per_second" initial_value="0.01"/>
<variable name="fCa_infinity" units="dimensionless"/>
<variable name="tau_fCa" units="second"/>
<variable name="Km_fCa" units="millimolar" initial_value="0.00035"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="Ca_sub" units="millimolar" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>fCa_infinity</ci>
<apply>
<divide/>
<ci>Km_fCa</ci>
<apply>
<plus/>
<ci>Km_fCa</ci>
<ci>Ca_sub</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_fCa</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<ci>fCa_infinity</ci>
</apply>
<ci>alpha_fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCa</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>fCa_infinity</ci>
<ci>fCa</ci>
</apply>
<ci>tau_fCa</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaT">
<variable name="i_CaT" units="nanoA" public_interface="out"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="P_CaT" units="nanoA_per_millimolar" initial_value="0.02"/>
<variable name="RTONF" units="millivolt" public_interface="in"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="Ca_sub" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="dT" units="dimensionless" private_interface="in"/>
<variable name="fT" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_CaT</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>P_CaT</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ca_sub</ci>
<apply>
<times/>
<ci>Cao</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>dT</ci>
<ci>fT</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaT_dT_gate">
<variable name="dT" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="dT_infinity" units="dimensionless"/>
<variable name="tau_dT" units="second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dT_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">38.3</cn>
</apply>
</apply>
<cn cellml:units="millivolt">5.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_dT</ci>
<apply>
<divide/>
<cn cellml:units="second">0.001</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.068</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">38.3</cn>
</apply>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1.068</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">38.3</cn>
</apply>
</apply>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>dT</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>dT_infinity</ci>
<ci>dT</ci>
</apply>
<ci>tau_dT</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaT_fT_gate">
<variable name="fT" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="fT_infinity" units="dimensionless"/>
<variable name="tau_fT" units="second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>fT_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">58.7</cn>
</apply>
<cn cellml:units="millivolt">3.8</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_fT</ci>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">16.67</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
</apply>
<cn cellml:units="millivolt">83.3</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">16.67</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
<cn cellml:units="millivolt">15.38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fT</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>fT_infinity</ci>
<ci>fT</ci>
</apply>
<ci>tau_fT</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_SR_release">
<variable name="j_SRCarel" units="millimolar_per_second" public_interface="out"/>
<variable name="R" units="dimensionless" initial_value="0.912317231017262"/>
<variable name="O" units="dimensionless" initial_value="1.7340201253e-7"/>
<variable name="I" units="dimensionless" initial_value="7.86181717518e-8"/>
<variable name="RI" units="dimensionless" initial_value="0.211148145512825"/>
<variable name="ks" units="per_second" initial_value="250000000"/>
<variable name="MaxSR" units="dimensionless" initial_value="15"/>
<variable name="MinSR" units="dimensionless" initial_value="1"/>
<variable name="EC50_SR" units="millimolar" initial_value="0.45"/>
<variable name="HSR" units="dimensionless" initial_value="2.5"/>
<variable name="koSRCa" units="per_millimolar2_second"/>
<variable name="kiSRCa" units="per_millimolar_second"/>
<variable name="koCa" units="per_millimolar2_second" initial_value="10000"/>
<variable name="kiCa" units="per_millimolar_second" initial_value="500"/>
<variable name="kCaSR" units="dimensionless"/>
<variable name="kim" units="per_second" initial_value="5"/>
<variable name="kom" units="per_second" initial_value="60"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="Ca_sub" units="millimolar" public_interface="in"/>
<variable name="Ca_jsr" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>j_SRCarel</ci>
<apply>
<times/>
<ci>ks</ci>
<ci>O</ci>
<apply>
<minus/>
<ci>Ca_jsr</ci>
<ci>Ca_sub</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>kCaSR</ci>
<apply>
<minus/>
<ci>MaxSR</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>MaxSR</ci>
<ci>MinSR</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>EC50_SR</ci>
<ci>Ca_jsr</ci>
</apply>
<ci>HSR</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>koSRCa</ci>
<apply>
<divide/>
<ci>koCa</ci>
<ci>kCaSR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>kiSRCa</ci>
<apply>
<times/>
<ci>kiCa</ci>
<ci>kCaSR</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>R</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kim</ci>
<ci>RI</ci>
</apply>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_sub</ci>
<ci>R</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_sub</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>R</ci>
</apply>
<apply>
<times/>
<ci>kom</ci>
<ci>O</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_sub</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>R</ci>
</apply>
<apply>
<times/>
<ci>kom</ci>
<ci>O</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_sub</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<ci>kim</ci>
<ci>I</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_sub</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<ci>kim</ci>
<ci>I</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kom</ci>
<ci>I</ci>
</apply>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_sub</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>RI</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>RI</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kom</ci>
<ci>I</ci>
</apply>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_sub</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>RI</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kim</ci>
<ci>RI</ci>
</apply>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_sub</ci>
<ci>R</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_intracellular_fluxes">
<variable name="j_Ca_dif" units="millimolar_per_second" public_interface="out"/>
<variable name="j_up" units="millimolar_per_second" public_interface="out"/>
<variable name="j_tr" units="millimolar_per_second" public_interface="out"/>
<variable name="tau_dif_Ca" units="second" initial_value="4e-5"/>
<variable name="tau_tr" units="second" initial_value="0.04"/>
<variable name="P_up" units="millimolar_per_second"/>
<variable name="P_up_basal" units="millimolar_per_second" initial_value="12"/>
<variable name="b_up" units="dimensionless"/>
<variable name="ACh" units="millimolar" public_interface="in"/>
<variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
<variable name="K_up" units="millimolar" initial_value="0.0006"/>
<variable name="Ca_nsr" units="millimolar" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Ca_sub" units="millimolar" public_interface="in"/>
<variable name="Ca_jsr" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>b_up</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.25</cn>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.7</cn>
<ci>ACh</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="millimolar">0.00009</cn>
<ci>ACh</ci>
</apply>
</apply>
<apply>
<gt/>
<ci>ACh</ci>
<cn cellml:units="millimolar">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>P_up</ci>
<apply>
<times/>
<ci>P_up_basal</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>b_up</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>j_Ca_dif</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_sub</ci>
<ci>Cai</ci>
</apply>
<ci>tau_dif_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>j_up</ci>
<apply>
<divide/>
<ci>P_up</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_up</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>j_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_nsr</ci>
<ci>Ca_jsr</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_buffering">
<variable name="TC_tot" units="millimolar" initial_value="0.031" public_interface="out"/>
<variable name="TMC_tot" units="millimolar" initial_value="0.062" public_interface="out"/>
<variable name="CM_tot" units="millimolar" initial_value="0.045" public_interface="out"/>
<variable name="CQ_tot" units="millimolar" initial_value="10" public_interface="out"/>
<variable name="delta_fTC" units="per_second" public_interface="out"/>
<variable name="delta_fTMC" units="per_second" public_interface="out"/>
<variable name="delta_fCMs" units="per_second" public_interface="out"/>
<variable name="delta_fCMi" units="per_second" public_interface="out"/>
<variable name="delta_fCQ" units="per_second" public_interface="out"/>
<variable name="delta_fTMM" units="per_second"/>
<variable name="fTMM" units="dimensionless" initial_value="0.501049376634"/>
<variable name="fCMi" units="dimensionless" initial_value="0.0373817991524254"/>
<variable name="fCMs" units="dimensionless" initial_value="0.054381370046"/>
<variable name="fTC" units="dimensionless" initial_value="0.0180519400676086"/>
<variable name="fTMC" units="dimensionless" initial_value="0.281244308217086"/>
<variable name="fCQ" units="dimensionless" initial_value="0.299624275428735"/>
<variable name="kf_TC" units="per_millimolar_second" initial_value="88800"/>
<variable name="kf_TMM" units="per_millimolar_second" initial_value="2277"/>
<variable name="kf_TMC" units="per_millimolar_second" initial_value="227700"/>
<variable name="kf_CM" units="per_millimolar_second" initial_value="227700"/>
<variable name="kf_CQ" units="per_millimolar_second" initial_value="534"/>
<variable name="kb_TC" units="per_second" initial_value="446"/>
<variable name="kb_TMC" units="per_second" initial_value="7.51"/>
<variable name="kb_TMM" units="per_second" initial_value="751"/>
<variable name="kb_CM" units="per_second" initial_value="542"/>
<variable name="kb_CQ" units="per_second" initial_value="445"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="Mgi" units="millimolar" initial_value="2.5"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Ca_sub" units="millimolar" public_interface="in"/>
<variable name="Ca_jsr" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fTC</ci>
</apply>
<ci>delta_fTC</ci>
</apply>
<apply>
<eq/>
<ci>delta_fTC</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_TC</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fTC</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kb_TC</ci>
<ci>fTC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fTMC</ci>
</apply>
<ci>delta_fTMC</ci>
</apply>
<apply>
<eq/>
<ci>delta_fTMC</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_TMC</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>fTMC</ci>
<ci>fTMM</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>kb_TMC</ci>
<ci>fTMC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fTMM</ci>
</apply>
<ci>delta_fTMM</ci>
</apply>
<apply>
<eq/>
<ci>delta_fTMM</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_TMM</ci>
<ci>Mgi</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>fTMC</ci>
<ci>fTMM</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>kb_TMM</ci>
<ci>fTMM</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCMi</ci>
</apply>
<ci>delta_fCMi</ci>
</apply>
<apply>
<eq/>
<ci>delta_fCMi</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_CM</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCMi</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kb_CM</ci>
<ci>fCMi</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCMs</ci>
</apply>
<ci>delta_fCMs</ci>
</apply>
<apply>
<eq/>
<ci>delta_fCMs</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_CM</ci>
<ci>Ca_sub</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCMs</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kb_CM</ci>
<ci>fCMs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCQ</ci>
</apply>
<ci>delta_fCQ</ci>
</apply>
<apply>
<eq/>
<ci>delta_fCQ</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_CQ</ci>
<ci>Ca_jsr</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCQ</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kb_CQ</ci>
<ci>fCQ</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_dynamics">
<variable name="Cai" units="millimolar" initial_value="1e-5" public_interface="out"/>
<variable name="Ca_nsr" units="millimolar" initial_value="1.05386465080816" public_interface="out"/>
<variable name="Ca_jsr" units="millimolar" initial_value="0.316762674605" public_interface="out"/>
<variable name="Ca_sub" units="millimolar" initial_value="1e-5" public_interface="out"/>
<variable name="V_i" units="millimetre3" public_interface="in"/>
<variable name="V_jsr" units="millimetre3" public_interface="in"/>
<variable name="V_nsr" units="millimetre3" public_interface="in"/>
<variable name="V_sub" units="millimetre3" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="i_siCa" units="nanoA" public_interface="in"/>
<variable name="i_CaT" units="nanoA" public_interface="in"/>
<variable name="i_NaCa" units="nanoA" public_interface="in"/>
<variable name="j_SRCarel" units="millimolar_per_second" public_interface="in"/>
<variable name="j_Ca_dif" units="millimolar_per_second" public_interface="in"/>
<variable name="j_tr" units="millimolar_per_second" public_interface="in"/>
<variable name="j_up" units="millimolar_per_second" public_interface="in"/>
<variable name="TMC_tot" units="millimolar" public_interface="in"/>
<variable name="CM_tot" units="millimolar" public_interface="in"/>
<variable name="TC_tot" units="millimolar" public_interface="in"/>
<variable name="CQ_tot" units="millimolar" public_interface="in"/>
<variable name="delta_fTMC" units="per_second" public_interface="in"/>
<variable name="delta_fCMi" units="per_second" public_interface="in"/>
<variable name="delta_fCMs" units="per_second" public_interface="in"/>
<variable name="delta_fTC" units="per_second" public_interface="in"/>
<variable name="delta_fCQ" units="per_second" public_interface="in"/>
<variable name="BAPTA_10_mM" units="dimensionless" public_interface="in"/>
<variable name="BAPTA" units="millimolar"/>
<variable name="kfBAPTA" units="per_millimolar_second" initial_value="940000"/>
<variable name="kbBAPTA" units="per_second" initial_value="119.38"/>
<variable name="fBAPTA" units="millimolar" initial_value="0" public_interface="out"/>
<variable name="fBAPTA_sub" units="millimolar" initial_value="0" public_interface="out"/>
<variable name="T" units="second" initial_value="6.928" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>BAPTA</ci>
<piecewise>
<piece>
<cn cellml:units="millimolar">10</cn>
<apply>
<and/>
<apply>
<gt/>
<ci>BAPTA_10_mM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
<apply>
<gt/>
<ci>time</ci>
<ci>T</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="millimolar">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>j_Ca_dif</ci>
<ci>V_sub</ci>
</apply>
<apply>
<times/>
<ci>j_up</ci>
<ci>V_nsr</ci>
</apply>
</apply>
</apply>
<ci>V_i</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>CM_tot</ci>
<ci>delta_fCMi</ci>
</apply>
<apply>
<times/>
<ci>TC_tot</ci>
<ci>delta_fTC</ci>
</apply>
<apply>
<times/>
<ci>TMC_tot</ci>
<ci>delta_fTMC</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kfBAPTA</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>BAPTA</ci>
<ci>fBAPTA</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kbBAPTA</ci>
<ci>fBAPTA</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fBAPTA</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kfBAPTA</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>BAPTA</ci>
<ci>fBAPTA</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kbBAPTA</ci>
<ci>fBAPTA</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_sub</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>j_SRCarel</ci>
<ci>V_jsr</ci>
</apply>
<ci>V_sub</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_siCa</ci>
<ci>i_CaT</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>V_sub</ci>
</apply>
</apply>
<ci>j_Ca_dif</ci>
<apply>
<times/>
<ci>CM_tot</ci>
<ci>delta_fCMs</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kfBAPTA</ci>
<ci>Ca_sub</ci>
<apply>
<minus/>
<ci>BAPTA</ci>
<ci>fBAPTA_sub</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kbBAPTA</ci>
<ci>fBAPTA_sub</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fBAPTA_sub</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kfBAPTA</ci>
<ci>Ca_sub</ci>
<apply>
<minus/>
<ci>BAPTA</ci>
<ci>fBAPTA_sub</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kbBAPTA</ci>
<ci>fBAPTA_sub</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_nsr</ci>
</apply>
<apply>
<minus/>
<ci>j_up</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>j_tr</ci>
<ci>V_jsr</ci>
</apply>
<ci>V_nsr</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_jsr</ci>
</apply>
<apply>
<minus/>
<ci>j_tr</ci>
<apply>
<plus/>
<ci>j_SRCarel</ci>
<apply>
<times/>
<ci>CQ_tot</ci>
<ci>delta_fCQ</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cell_parameters">
<variable name="V_sub" units="millimetre3" public_interface="out"/>
<variable name="V_jsr" units="millimetre3" public_interface="out"/>
<variable name="V_nsr" units="millimetre3" public_interface="out"/>
<variable name="V_i" units="millimetre3" public_interface="out"/>
<variable name="V_cell" units="millimetre3"/>
<variable name="V_jsr_part" units="dimensionless" initial_value="0.0012"/>
<variable name="V_i_part" units="dimensionless" initial_value="0.46"/>
<variable name="V_nsr_part" units="dimensionless" initial_value="0.0116"/>
<variable name="R_cell" units="micrometre" initial_value="4"/>
<variable name="L_cell" units="micrometre" initial_value="70"/>
<variable name="L_sub" units="micrometre" initial_value="0.02"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_cell</ci>
<apply>
<times/>
<cn cellml:units="micrometre_per_femtometre">0.000000001</cn>
<pi/>
<apply>
<power/>
<ci>R_cell</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>L_cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_sub</ci>
<apply>
<times/>
<cn cellml:units="micrometre_per_femtometre">0.000000001</cn>
<cn cellml:units="dimensionless">2</cn>
<pi/>
<ci>L_sub</ci>
<apply>
<minus/>
<ci>R_cell</ci>
<apply>
<divide/>
<ci>L_sub</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>L_cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_jsr</ci>
<apply>
<times/>
<ci>V_jsr_part</ci>
<ci>V_cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_i</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>V_i_part</ci>
<ci>V_cell</ci>
</apply>
<ci>V_sub</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_nsr</ci>
<apply>
<times/>
<ci>V_nsr_part</ci>
<ci>V_cell</ci>
</apply>
</apply>
</math>
</component>
<component name="i_to">
<variable name="i_to" units="nanoA" public_interface="out"/>
<variable name="g_to" units="microS" initial_value="0.002"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="q" units="dimensionless" private_interface="in"/>
<variable name="r" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_to</ci>
<apply>
<times/>
<ci>g_to</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<ci>q</ci>
<ci>r</ci>
</apply>
</apply>
</math>
</component>
<component name="i_to_q_gate">
<variable name="q" units="dimensionless" initial_value="0.506139850982478" public_interface="out"/>
<variable name="q_infinity" units="dimensionless"/>
<variable name="tau_q" units="second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>q_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">49</cn>
</apply>
<cn cellml:units="millivolt">13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_q</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<cn cellml:units="dimensionless">0.6</cn>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">65.17</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_second">0.57</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.08</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">44</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_second">0.065</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.1</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45.93</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">10.1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>q_infinity</ci>
<ci>q</ci>
</apply>
<ci>tau_q</ci>
</apply>
</apply>
</math>
</component>
<component name="i_to_r_gate">
<variable name="r" units="dimensionless" initial_value="0.0144605370597924" public_interface="out"/>
<variable name="r_infinity" units="dimensionless"/>
<variable name="tau_r" units="second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">19.3</cn>
</apply>
</apply>
<cn cellml:units="millivolt">15</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<cn cellml:units="dimensionless">0.66</cn>
<cn cellml:units="dimensionless">1.4</cn>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="second">15.59</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.037</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.09</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30.61</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.369</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.12</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">23.84</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">2.98</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_infinity</ci>
<ci>r</ci>
</apply>
<ci>tau_r</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Kr">
<variable name="i_Kr" units="nanoA" public_interface="out"/>
<variable name="g_Kr" units="microS" initial_value="0.0021637"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="paS" units="dimensionless" private_interface="in"/>
<variable name="paF" units="dimensionless" private_interface="in"/>
<variable name="piy" units="dimensionless" private_interface="in"/>
<variable name="RTONF" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<ci>g_Kr</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.9</cn>
<ci>paF</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1</cn>
<ci>paS</ci>
</apply>
</apply>
<ci>piy</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Kr_pa_gate">
<variable name="paS" units="dimensionless" initial_value="0.322999177802891" public_interface="out"/>
<variable name="paF" units="dimensionless" initial_value="0.0990510403258968" public_interface="out"/>
<variable name="pa_infinity" units="dimensionless"/>
<variable name="alfapaF" units="per_second"/>
<variable name="betapaF" units="per_second"/>
<variable name="tau_paS" units="second"/>
<variable name="tau_paF" units="second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alfapaF</ci>
<apply>
<divide/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">23.2</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6.6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="second">0.84655354</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">37.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">11.9</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.96</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">18.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>betapaF</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">37.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">15.9</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.96</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">22.5</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.84655354</cn>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">23.2</cn>
</apply>
</apply>
<cn cellml:units="millivolt">10.6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="second">0.84655354</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">37.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">15.9</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.96</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">22.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pa_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.8</cn>
</apply>
</apply>
<cn cellml:units="millivolt">8.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_paS</ci>
<apply>
<divide/>
<cn cellml:units="second">0.84655354</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.15</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">21.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_paF</ci>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">30</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">12</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>paS</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>pa_infinity</ci>
<ci>paS</ci>
</apply>
<ci>tau_paS</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>paF</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>pa_infinity</ci>
<ci>paF</ci>
</apply>
<ci>tau_paF</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Kr_pi_gate">
<variable name="piy" units="dimensionless" initial_value="0.705410877258545" public_interface="out"/>
<variable name="pi_infinity" units="dimensionless"/>
<variable name="tau_pi" units="second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>tau_pi</ci>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">100</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">54.645</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">656</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">106.157</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pi_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28.6</cn>
</apply>
<cn cellml:units="millivolt">17.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>piy</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>pi_infinity</ci>
<ci>piy</ci>
</apply>
<ci>tau_pi</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Ks">
<variable name="i_Ks" units="nanoA" public_interface="out"/>
<variable name="g_Ks" units="microS" public_interface="out"/>
<variable name="E_Ks" units="millivolt"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="RTONF" units="millivolt" public_interface="in"/>
<variable name="n" units="dimensionless" private_interface="in"/>
<variable name="Iso_1_uM" units="dimensionless" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Ks</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="dimensionless">1.2</cn>
<cn cellml:units="microS">0.0016576</cn>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="microS">0.0016576</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>E_Ks</ci>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ko</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>Nao</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Ki</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<times/>
<ci>g_Ks</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ks</ci>
</apply>
<apply>
<power/>
<ci>n</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Ks_n_gate">
<variable name="n" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="n_infinity" units="dimensionless"/>
<variable name="tau_n" units="second"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
<variable name="Iso_shift" units="millivolt"/>
<variable name="shift" units="millivolt" initial_value="0"/>
<variable name="alpha_n" units="per_second"/>
<variable name="beta_n" units="per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Iso_shift</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="millivolt">14</cn>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="millivolt">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>n_infinity</ci>
<apply>
<divide/>
<apply>
<divide/>
<cn cellml:units="per_second">14</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
<ci>Iso_shift</ci>
</apply>
</apply>
<cn cellml:units="millivolt">12</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="per_second">14</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
<ci>Iso_shift</ci>
</apply>
</apply>
<cn cellml:units="millivolt">12</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_second">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>Iso_shift</ci>
</apply>
</apply>
<cn cellml:units="millivolt">45</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_n</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_n</ci>
<ci>beta_n</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_n</ci>
<apply>
<divide/>
<cn cellml:units="per_second">28</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
<ci>Iso_shift</ci>
</apply>
</apply>
<cn cellml:units="millivolt">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_n</ci>
<apply>
<times/>
<cn cellml:units="per_second">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>Iso_shift</ci>
</apply>
<ci>shift</ci>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>n</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>n_infinity</ci>
<ci>n</ci>
</apply>
<ci>tau_n</ci>
</apply>
</apply>
</math>
</component>
<component name="i_KACh">
<variable name="ACh" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="i_KACh" units="nanoA" public_interface="out"/>
<variable name="g_KACh" units="microS" initial_value="0.00864"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="a" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_KACh</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>g_KACh</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">20</cn>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
<ci>a</ci>
</apply>
<apply>
<gt/>
<ci>ACh</ci>
<cn cellml:units="millimolar">0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="nanoA">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="i_KACh_a_gate">
<variable name="a" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="alpha_a" units="per_second"/>
<variable name="beta_a" units="per_second"/>
<variable name="a_infinity" units="dimensionless"/>
<variable name="tau_a" units="second"/>
<variable name="ACh" units="millimolar" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_a</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="per_second">3.5988</cn>
<cn cellml:units="per_second">0.025641</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.0000012155</cn>
<apply>
<power/>
<apply>
<times/>
<cn cellml:units="per_millimolar">1</cn>
<ci>ACh</ci>
</apply>
<cn cellml:units="dimensionless">1.6951</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="per_second">0.025641</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_a</ci>
<apply>
<times/>
<cn cellml:units="per_second">10</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0133</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a_infinity</ci>
<apply>
<divide/>
<ci>alpha_a</ci>
<apply>
<plus/>
<ci>alpha_a</ci>
<ci>beta_a</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_a</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_a</ci>
<ci>beta_a</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>a</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>a_infinity</ci>
<ci>a</ci>
</apply>
<ci>tau_a</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="Membrane">
<component_ref component="Ionic_values"/>
<component_ref component="Voltage_clamp"/>
<component_ref component="i_NaK"/>
<component_ref component="i_NaCa"/>
<component_ref component="Ca_SR_release"/>
<component_ref component="Ca_intracellular_fluxes"/>
<component_ref component="Ca_buffering"/>
<component_ref component="Ca_dynamics"/>
<component_ref component="Cell_parameters"/>
<component_ref component="Nai_concentration"/>
<component_ref component="Rate_modulation_experiments"/>
<component_ref component="i_f">
<component_ref component="i_f_y_gate"/>
</component_ref>
<component_ref component="i_Na">
<component_ref component="i_Na_m_gate"/>
<component_ref component="i_Na_h_gate"/>
</component_ref>
<component_ref component="i_CaL">
<component_ref component="i_CaL_dL_gate"/>
<component_ref component="i_CaL_fL_gate"/>
<component_ref component="i_CaL_fCa_gate"/>
</component_ref>
<component_ref component="i_CaT">
<component_ref component="i_CaT_dT_gate"/>
<component_ref component="i_CaT_fT_gate"/>
</component_ref>
<component_ref component="i_to">
<component_ref component="i_to_q_gate"/>
<component_ref component="i_to_r_gate"/>
</component_ref>
<component_ref component="i_Kr">
<component_ref component="i_Kr_pa_gate"/>
<component_ref component="i_Kr_pi_gate"/>
</component_ref>
<component_ref component="i_Ks">
<component_ref component="i_Ks_n_gate"/>
</component_ref>
<component_ref component="i_KACh">
<component_ref component="i_KACh_a_gate"/>
</component_ref>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="Membrane">
<component_ref component="Voltage_clamp"/>
</component_ref>
<component_ref component="i_f">
<component_ref component="i_f_y_gate"/>
</component_ref>
<component_ref component="i_Na">
<component_ref component="i_Na_m_gate"/>
<component_ref component="i_Na_h_gate"/>
</component_ref>
<component_ref component="i_CaL">
<component_ref component="i_CaL_dL_gate"/>
<component_ref component="i_CaL_fL_gate"/>
<component_ref component="i_CaL_fCa_gate"/>
</component_ref>
<component_ref component="i_CaT">
<component_ref component="i_CaT_dT_gate"/>
<component_ref component="i_CaT_fT_gate"/>
</component_ref>
<component_ref component="i_to">
<component_ref component="i_to_q_gate"/>
<component_ref component="i_to_r_gate"/>
</component_ref>
<component_ref component="i_Kr">
<component_ref component="i_Kr_pa_gate"/>
<component_ref component="i_Kr_pi_gate"/>
</component_ref>
<component_ref component="i_Ks">
<component_ref component="i_Ks_n_gate"/>
</component_ref>
<component_ref component="i_KACh">
<component_ref component="i_KACh_a_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="Membrane" component_2="Voltage_clamp"/>
<map_variables variable_1="V_clamp" variable_2="V_clamp"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="Ionic_values"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_f" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_NaK" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_NaCa" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_Na" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_CaT" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_SR_release" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_buffering" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_to" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_Kr" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_Ks" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_KACh" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="Membrane"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="i_f" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
<map_variables variable_1="i_f" variable_2="i_f"/>
</connection>
<connection>
<map_components component_1="i_NaK" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="i_NaCa" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
</connection>
<connection>
<map_components component_1="i_Na" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
<map_variables variable_1="i_CaL" variable_2="i_CaL"/>
</connection>
<connection>
<map_components component_1="i_CaT" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
<map_variables variable_1="i_CaT" variable_2="i_CaT"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="Membrane"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="i_to" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_to" variable_2="i_to"/>
</connection>
<connection>
<map_components component_1="i_Kr" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
</connection>
<connection>
<map_components component_1="i_Ks" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection>
<map_components component_1="i_KACh" component_2="Membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_KACh" variable_2="i_KACh"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="Ionic_values"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="i_f" component_2="Ionic_values"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
<map_variables variable_1="Kc" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="i_Na" component_2="Ionic_values"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Kc" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="i_NaK" component_2="Ionic_values"/>
<map_variables variable_1="Kc" variable_2="Ko"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="i_NaCa" component_2="Ionic_values"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="Ionic_values"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="Ionic_values"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Kc" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="i_CaT" component_2="Ionic_values"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="i_to" component_2="Ionic_values"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="i_Kr" component_2="Ionic_values"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="i_Ks" component_2="Ionic_values"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="i_KACh" component_2="Ionic_values"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="i_f" component_2="i_f_y_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="ACh" variable_2="ACh"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="i_Na" component_2="i_Na_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="i_Na" component_2="i_Na_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="i_CaL_dL_gate"/>
<map_variables variable_1="dL" variable_2="dL"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="i_CaL_fL_gate"/>
<map_variables variable_1="fL" variable_2="fL"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="i_CaL_fCa_gate"/>
<map_variables variable_1="fCa" variable_2="fCa"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
</connection>
<connection>
<map_components component_1="i_CaT" component_2="i_CaT_dT_gate"/>
<map_variables variable_1="dT" variable_2="dT"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_CaT" component_2="i_CaT_fT_gate"/>
<map_variables variable_1="fT" variable_2="fT"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_to" component_2="i_to_q_gate"/>
<map_variables variable_1="q" variable_2="q"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="i_to" component_2="i_to_r_gate"/>
<map_variables variable_1="r" variable_2="r"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="i_Kr" component_2="i_Kr_pa_gate"/>
<map_variables variable_1="paF" variable_2="paF"/>
<map_variables variable_1="paS" variable_2="paS"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="i_Kr" component_2="i_Kr_pi_gate"/>
<map_variables variable_1="piy" variable_2="piy"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="i_Ks" component_2="i_Ks_n_gate"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="i_KACh" component_2="i_KACh_a_gate"/>
<map_variables variable_1="a" variable_2="a"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="ACh" variable_2="ACh"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="i_Ks"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="Cell_parameters"/>
<map_variables variable_1="V_i" variable_2="V_i"/>
<map_variables variable_1="V_jsr" variable_2="V_jsr"/>
<map_variables variable_1="V_nsr" variable_2="V_nsr"/>
<map_variables variable_1="V_sub" variable_2="V_sub"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="Ca_buffering"/>
<map_variables variable_1="TMC_tot" variable_2="TMC_tot"/>
<map_variables variable_1="CM_tot" variable_2="CM_tot"/>
<map_variables variable_1="TC_tot" variable_2="TC_tot"/>
<map_variables variable_1="CQ_tot" variable_2="CQ_tot"/>
<map_variables variable_1="delta_fTMC" variable_2="delta_fTMC"/>
<map_variables variable_1="delta_fCMi" variable_2="delta_fCMi"/>
<map_variables variable_1="delta_fCMs" variable_2="delta_fCMs"/>
<map_variables variable_1="delta_fTC" variable_2="delta_fTC"/>
<map_variables variable_1="delta_fCQ" variable_2="delta_fCQ"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
<map_variables variable_1="Ca_jsr" variable_2="Ca_jsr"/>
</connection>
<connection>
<map_components component_1="i_NaCa" component_2="Ca_dynamics"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
</connection>
<connection>
<map_components component_1="Ca_SR_release" component_2="Ca_dynamics"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
<map_variables variable_1="Ca_jsr" variable_2="Ca_jsr"/>
<map_variables variable_1="j_SRCarel" variable_2="j_SRCarel"/>
</connection>
<connection>
<map_components component_1="Ca_intracellular_fluxes" component_2="Ca_dynamics"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Ca_nsr" variable_2="Ca_nsr"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
<map_variables variable_1="Ca_jsr" variable_2="Ca_jsr"/>
<map_variables variable_1="j_Ca_dif" variable_2="j_Ca_dif"/>
<map_variables variable_1="j_tr" variable_2="j_tr"/>
<map_variables variable_1="j_up" variable_2="j_up"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="Ca_dynamics"/>
<map_variables variable_1="i_siCa" variable_2="i_siCa"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
</connection>
<connection>
<map_components component_1="i_CaT" component_2="Ca_dynamics"/>
<map_variables variable_1="i_CaT" variable_2="i_CaT"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="Cell_parameters"/>
<map_variables variable_1="V_i" variable_2="V_i"/>
<map_variables variable_1="V_sub" variable_2="V_sub"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="i_f"/>
<map_variables variable_1="i_fNa" variable_2="i_fNa"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="i_NaK"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="i_NaCa"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="i_Na"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="i_CaL"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_siNa" variable_2="i_siNa"/>
</connection>
<connection>
<map_components component_1="i_f" component_2="Rate_modulation_experiments"/>
<map_variables variable_1="Iva_3_uM" variable_2="Iva_3_uM"/>
<map_variables variable_1="Cs_5_mM" variable_2="Cs_5_mM"/>
<map_variables variable_1="ACh" variable_2="ACh"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="Rate_modulation_experiments"/>
<map_variables variable_1="ACh" variable_2="ACh"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="i_NaK" component_2="Rate_modulation_experiments"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="i_Ks" component_2="Rate_modulation_experiments"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="i_KACh" component_2="Rate_modulation_experiments"/>
<map_variables variable_1="ACh" variable_2="ACh"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="Rate_modulation_experiments"/>
<map_variables variable_1="BAPTA_10_mM" variable_2="BAPTA_10_mM"/>
</connection>
<connection>
<map_components component_1="Ca_intracellular_fluxes" component_2="Rate_modulation_experiments"/>
<map_variables variable_1="ACh" variable_2="ACh"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="Rate_modulation_experiments"/>
<map_variables variable_1="BAPTA_10_mM" variable_2="BAPTA_10_mM"/>
</connection>
</model>