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CREATED :  14th November 2007

LAST MODIFIED : 14th November 2007

AUTHOR :  Catherine Lloyd
          Bioengineering Institute
          The University of Auckland
          
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DESCRIPTION :  This file contains a CellML description of Bingzheng, Zhenye, and Liansong's 1990 mathematical model of the regulation system of the secretion of glucocorticoids.

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  <title>A mathematical model of the regulation system of the secretion of glucocorticoids</title>
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          <surname>Lloyd</surname>
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      <shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
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<title>Model Structure</title>

<para>
ABSTRACT: We propose a mathematical model for the regulation system of the secretion of glucocorticoids and determined the coefficients in the system of ordinary differential equations. Some results are calculated which agree with the experimental results.
</para>

<para>
The original paper reference is cited below:
</para>

<para>
A mathematical model of the regulation system of the secretion of glucocorticoids, Liu Bingzheng, Zhao Zhenye and Chen Liansong, 1990, 
            <emphasis>Journal of Biological Physics</emphasis>, volume 17, issue 4, 221-233.  
</para>

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<caption>The HPA axis model has three compartments, namely the hypothalamus, pituitary and adrenals.  Neural signals trigger CRF secretion by the hypothalamus.  In turn, this signals to the pituitary to release ACTH which stimulates the adrenal gland to release cortisol.  Cortisol acts on the hypothalamus and the pituitary to have a negative feedback effect on the release of CRH and ACTH respectively.</caption>
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    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Bingzheng</vCard:Family>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#af4b0ec3-8580-4d6e-b5cb-6b0579e26a39">
    <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">James</vCard:Given>
    <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lawson</vCard:Family>
    <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Richard</vCard:Other>
  </rdf:Description>
</rdf:RDF>
</model>