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<!--
This CellML file was generated on 8/04/2010 at 1:42:05 at p.m. using:
COR (0.9.31.1371)
Copyright 2002-2010 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
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<title>Dynamics of Muscle Glycogenolysis Modeled with pH Time Course Computation and pH-Dependent Reaction Equilibria and Enzyme Kinetics </title>
<author>
<firstname>Geoffrey</firstname>
<surname>Nunns</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
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<section id="sec_status">
<title>Model Status</title>
<para>
This CellML model runs in PCenv, COR and OpenCell to recreate the published results. The model was adapted from the original matlab, and the units are consistent throughout. This particular model replicates experiment 29, with the fraction of Glycogen Phosphorylase A set to 40%, and it reproduces original matlab output.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: Cellular metabolites are moieties defined by their specific binding constants to H1, Mg21, and K1 or anions without ligands. As a consequence, every biochemical reaction in the cytoplasm has an associated proton stoichiometry that is generally noninteger- and pH-dependent. Therefore, with metabolic flux, pH is altered in a medium with finite buffer capacity. Apparent equilibrium constants and maximum enzyme velocities, which are functions of pH, are also altered. We augmented an earlier mathematical model of skeletal muscle glycogenolysis with pH-dependent enzyme kinetics and reaction equilibria to
compute the time course of pH changes. Analysis shows that kinetics and final equilibrium states of the closed system are highly constrained by the pH-dependent parameters. This kinetic model of glycogenolysis, coupled to creatine kinase and adenylate kinase, simulated published experiments made with a cell-free enzyme mixture to reconstitute the network and to synthesize PCr and lactate in vitro. Using the enzyme kinetic and thermodynamic data in the literature, the simulations required minimal adjustments of parameters to describe the data. These results show that incorporation of appropriate physical chemistry of the reactions with accurate kinetic modeling gives a reasonable simulation of experimental data and is necessary for a physically correct representation of the metabolic network. The approach is general for modeling metabolic networks beyond the specific pathway and conditions presented here.
</para>
<para>
The original paper reference is cited below:
</para>
<para>
Dynamics of Muscle Glycogenolysis Modeled with pH Time Course Computation and pH-Dependent Reaction Equilibria and Enzyme Kinetics, Kalyan Vinnakota, Melissa L. Kemp, and Martin J. Kushmerick, 2006, <emphasis>Biophysical Journal</emphasis>, volume 91, 1264-1287. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/16617075">PubMed ID: 16617075</ulink>
</para>
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<dc:title>Dynamics of Muscle Glycogenolysis Modeled with pH Time Course Computation and pH-Dependent Reaction Equilibria and Enzyme Kinetics (Experiment 29, 40% Glycogen Phosphorylase A)</dc:title>
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<dc:title>The Vinnakota et al. 2006 model of muscle glycogenolysis featuring pH time course computation, pH-dependent reaction equilibria and enzyme kinetics.</dc:title>
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<ci>Par_40</ci>
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<ci>Par_41</ci>
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<ci>Par_42</ci>
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<ci>Par_43</ci>
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<ci>Par_46</ci>
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<ci>Par_49</ci>
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<ci>Par_52</ci>
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<ci>Par_53</ci>
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<ci>Par_54</ci>
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<ci>Par_55</ci>
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<ci>Par_59</ci>
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<ci>Par_60</ci>
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<ci>Par_69</ci>
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<ci>Par_70</ci>
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<ci>Par_71</ci>
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<ci>Par_72</ci>
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<ci>Par_73</ci>
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0</cn>
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<ci>Par_74</ci>
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<ci>Par_75</ci>
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<ci>Par_76</ci>
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<ci>Par_78</ci>
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<ci>Par_79</ci>
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<ci>Par_81</ci>
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<ci>Par_82</ci>
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<ci>Par_88</ci>
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<ci>Par_89</ci>
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<ci>Par_94</ci>
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<ci>Par_97</ci>
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<ci>Par_98</ci>
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<ci>Par_99</ci>
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<apply>
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<ci>Par_100</ci>
<cn cellml:units="dimensionless">29</cn>
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<variable name="c0" units="molar" public_interface="out"/>
<variable name="Par_95" units="molar" public_interface="in"/>
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<variable name="B" units="per_half_molar"/>
<variable name="Icorr" units="kilojoule_per_mole"/>
<variable name="I1" units="molar"/>
<variable name="alphadebye" units="per_half_molar"/>
<variable name="IcorrpKa" units="kilojoule_per_mole"/>
<variable name="TcorrpKa" units="mole_per_kilojoule"/>
<variable name="RTalpha" units="kilojoule_half_liter_per_3_half_mole"/>
<variable name="IcorrdeltaGpof" units="kilojoule_per_mole"/>
<variable name="pKak_Pi" units="dimensionless"/>
<variable name="deltaH1o_Pi" units="kilojoule_per_mole"/>
<variable name="deltaHmgo_Pi" units="kilojoule_per_mole"/>
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<variable name="Navg_Pi" units="dimensionless"/>
<variable name="dNavgPidH" units="per_molar" public_interface="out"/>
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<variable name="dmgPidmg" units="per_molar" public_interface="out"/>
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<variable name="deltaGof_HPi2" units="kilojoule_per_mole"/>
<variable name="deltaGpof_HPi2" units="kilojoule_per_mole"/>
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<variable name="deltaHko_ATP" units="kilojoule_per_mole"/>
<variable name="deltaH1_ATP" units="kilojoule_per_mole"/>
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<variable name="pKak_ATP" units="dimensionless"/>
<variable name="P_ATP" units="dimensionless"/>
<variable name="ATP4" units="dimensionless"/>
<variable name="HATP3" units="dimensionless"/>
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<variable name="Navg_ATP" units="dimensionless"/>
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<variable name="dNavgATPdmg" units="per_molar" public_interface="out"/>
<variable name="dmgATP2dmg" units="per_molar" public_interface="out"/>
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<variable name="NH_ATP4" units="dimensionless"/>
<variable name="deltaGof_ATP4" units="kilojoule_per_mole"/>
<variable name="deltaGpof_ATP4" units="kilojoule_per_mole"/>
<variable name="pKak_ADP" units="dimensionless"/>
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<variable name="deltaHmg_ADP" units="kilojoule_per_mole"/>
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<variable name="ADP3" units="dimensionless"/>
<variable name="HADP2" units="dimensionless"/>
<variable name="mgADP" units="dimensionless" public_interface="out"/>
<variable name="kADP" units="dimensionless"/>
<variable name="Navg_ADP" units="dimensionless"/>
<variable name="dNavgADPdH" units="per_molar" public_interface="out"/>
<variable name="dNavgADPdmg" units="per_molar" public_interface="out"/>
<variable name="dmgADPdmg" units="per_molar" public_interface="out"/>
<variable name="dmgADPdpH" units="dimensionless" public_interface="out"/>
<variable name="NH_ADP3" units="dimensionless"/>
<variable name="deltaGof_ADP3" units="kilojoule_per_mole"/>
<variable name="deltaGpof_ADP3" units="kilojoule_per_mole"/>
<variable name="deltaH1o_AMP" units="kilojoule_per_mole"/>
<variable name="deltaHmgo_AMP" units="kilojoule_per_mole"/>
<variable name="deltaH1_AMP" units="kilojoule_per_mole"/>
<variable name="deltaHmg_AMP" units="kilojoule_per_mole"/>
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<variable name="P_AMP" units="dimensionless"/>
<variable name="AMP2" units="dimensionless"/>
<variable name="HAMP1" units="dimensionless"/>
<variable name="mgAMP" units="dimensionless" public_interface="out"/>
<variable name="Navg_AMP" units="dimensionless"/>
<variable name="dNavgAMPdH" units="per_molar" public_interface="out"/>
<variable name="dNavgAMPdmg" units="per_molar" public_interface="out"/>
<variable name="dmgAMPdmg" units="per_molar" public_interface="out"/>
<variable name="dmgAMPdpH" units="dimensionless" public_interface="out"/>
<variable name="NH_AMP2" units="dimensionless"/>
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<variable name="deltaGpof_AMP2" units="kilojoule_per_mole"/>
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<variable name="HPCR" units="dimensionless"/>
<variable name="H2PCR" units="dimensionless"/>
<variable name="kPCR" units="dimensionless"/>
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<variable name="Navg_PCR" units="dimensionless"/>
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<variable name="dmgPCRdmg" units="per_molar" public_interface="out"/>
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<variable name="Navg_CR" units="dimensionless"/>
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<variable name="dNavgCRdmg" units="per_molar" public_interface="out"/>
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<variable name="UG1P" units="dimensionless"/>
<variable name="HG1P" units="dimensionless"/>
<variable name="mgG1P" units="dimensionless" public_interface="out"/>
<variable name="Navg_G1P" units="dimensionless"/>
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<variable name="Navg_G6P" units="dimensionless"/>
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<variable name="HF6P" units="dimensionless"/>
<variable name="Navg_F6P" units="dimensionless"/>
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<variable name="dNavgF6Pdmg" units="per_molar" public_interface="out"/>
<variable name="NH_UF6P" units="dimensionless"/>
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<variable name="dmgFDPdmg" units="per_molar" public_interface="out"/>
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<variable name="Navg_GAP" units="dimensionless"/>
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<variable name="dNavgGAPdmg" units="per_molar" public_interface="out"/>
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<variable name="NH_UDHAP" units="dimensionless"/>
<variable name="deltaGof_UDHAP" units="kilojoule_per_mole"/>
<variable name="deltaGpof_UDHAP" units="kilojoule_per_mole"/>
<variable name="pKa1_13DPG" units="dimensionless"/>
<variable name="P_13DPG" units="dimensionless"/>
<variable name="U13DPG" units="dimensionless"/>
<variable name="H13DPG" units="dimensionless"/>
<variable name="Navg_13DPG" units="dimensionless"/>
<variable name="dNavg13DPGdH" units="per_molar" public_interface="out"/>
<variable name="dNavg13DPGdmg" units="per_molar" public_interface="out"/>
<variable name="NH_U13DPG" units="dimensionless"/>
<variable name="deltaGof_U13DPG" units="kilojoule_per_mole"/>
<variable name="deltaGpof_U13DPG" units="kilojoule_per_mole"/>
<variable name="pKa1_3PG" units="dimensionless"/>
<variable name="P_3PG" units="dimensionless"/>
<variable name="U3PG" units="dimensionless"/>
<variable name="H3PG" units="dimensionless"/>
<variable name="Navg_3PG" units="dimensionless"/>
<variable name="dNavg3PGdH" units="per_molar" public_interface="out"/>
<variable name="dNavg3PGdmg" units="per_molar" public_interface="out"/>
<variable name="NH_U3PG" units="dimensionless"/>
<variable name="deltaGof_U3PG" units="kilojoule_per_mole"/>
<variable name="deltaGpof_U3PG" units="kilojoule_per_mole"/>
<variable name="pKa1_2PG" units="dimensionless"/>
<variable name="pKamg_2PG" units="dimensionless"/>
<variable name="pKak_2PG" units="dimensionless"/>
<variable name="P_2PG" units="dimensionless"/>
<variable name="U2PG" units="dimensionless"/>
<variable name="H2PG" units="dimensionless"/>
<variable name="mg2PG" units="dimensionless" public_interface="out"/>
<variable name="k2PG" units="dimensionless"/>
<variable name="Navg_2PG" units="dimensionless"/>
<variable name="dNavg2PGdH" units="per_molar" public_interface="out"/>
<variable name="dNavg2PGdmg" units="per_molar" public_interface="out"/>
<variable name="dmg2PGdmg" units="per_molar" public_interface="out"/>
<variable name="dmg2PGdpH" units="dimensionless" public_interface="out"/>
<variable name="NH_U2PG" units="dimensionless"/>
<variable name="deltaGof_U2PG" units="kilojoule_per_mole"/>
<variable name="deltaGpof_U2PG" units="kilojoule_per_mole"/>
<variable name="pKa1_PEP" units="dimensionless"/>
<variable name="pKamg_PEP" units="dimensionless"/>
<variable name="pKak_PEP" units="dimensionless"/>
<variable name="P_PEP" units="dimensionless"/>
<variable name="UPEP" units="dimensionless"/>
<variable name="HPEP" units="dimensionless"/>
<variable name="kPEP" units="dimensionless"/>
<variable name="mgPEP" units="dimensionless" public_interface="out"/>
<variable name="Navg_PEP" units="dimensionless"/>
<variable name="dNavgPEPdH" units="per_molar" public_interface="out"/>
<variable name="dNavgPEPdmg" units="per_molar" public_interface="out"/>
<variable name="dmgPEPdmg" units="per_molar" public_interface="out"/>
<variable name="dmgPEPdpH" units="dimensionless" public_interface="out"/>
<variable name="NH_UPEP" units="dimensionless"/>
<variable name="deltaGof_UPEP" units="kilojoule_per_mole"/>
<variable name="deltaGpof_UPEP" units="kilojoule_per_mole"/>
<variable name="pKa1_PYR" units="dimensionless"/>
<variable name="P_PYR" units="dimensionless"/>
<variable name="UPYR" units="dimensionless"/>
<variable name="HPYR" units="dimensionless"/>
<variable name="Navg_PYR" units="dimensionless"/>
<variable name="dNavgPYRdH" units="per_molar" public_interface="out"/>
<variable name="dNavgPYRdmg" units="per_molar" public_interface="out"/>
<variable name="NH_UPYR" units="dimensionless"/>
<variable name="deltaGof_UPYR" units="kilojoule_per_mole"/>
<variable name="deltaGpof_UPYR" units="kilojoule_per_mole"/>
<variable name="pKamg_LAC" units="dimensionless"/>
<variable name="deltaH1o_LAC" units="kilojoule_per_mole"/>
<variable name="deltaH1_LAC" units="kilojoule_per_mole"/>
<variable name="pKa1_LAC" units="dimensionless"/>
<variable name="P_LAC" units="dimensionless"/>
<variable name="ULAC" units="dimensionless"/>
<variable name="HLAC" units="dimensionless"/>
<variable name="mgLAC" units="dimensionless" public_interface="out"/>
<variable name="Navg_LAC" units="dimensionless"/>
<variable name="dNavgLACdH" units="per_molar" public_interface="out"/>
<variable name="dNavgLACdmg" units="per_molar" public_interface="out"/>
<variable name="dmgLACdmg" units="per_molar" public_interface="out"/>
<variable name="dmgLACdpH" units="dimensionless" public_interface="out"/>
<variable name="NH_ULAC" units="dimensionless"/>
<variable name="deltaGof_ULAC" units="kilojoule_per_mole"/>
<variable name="deltaGpof_ULAC" units="kilojoule_per_mole"/>
<variable name="dNH_GLY" units="dimensionless"/>
<variable name="deltaGpo_GLY" units="kilojoule_per_mole"/>
<variable name="NH_NAD" units="dimensionless"/>
<variable name="deltaGof_NAD" units="kilojoule_per_mole"/>
<variable name="deltaGpof_NAD" units="kilojoule_per_mole"/>
<variable name="NH_NADH" units="dimensionless"/>
<variable name="deltaGof_NADH" units="kilojoule_per_mole"/>
<variable name="deltaGpof_NADH" units="kilojoule_per_mole"/>
<variable name="NH_H2O" units="dimensionless"/>
<variable name="deltaGof_H2O" units="kilojoule_per_mole"/>
<variable name="deltaGpof_H2O" units="kilojoule_per_mole"/>
<variable name="NH_H" units="dimensionless"/>
<variable name="deltaGof_H" units="kilojoule_per_mole"/>
<variable name="deltaGpof_H" units="kilojoule_per_mole"/>
<variable name="deltaH_CK" units="dimensionless" public_interface="out"/>
<variable name="Kref_CK" units="dimensionless"/>
<variable name="deltaHo_CKo" units="kilojoule_per_mole"/>
<variable name="deltaH1_CK" units="kilojoule_per_mole"/>
<variable name="Kref_CKI" units="dimensionless"/>
<variable name="Kref_CKT" units="dimensionless"/>
<variable name="deltaGpo_CK" units="kilojoule_per_mole"/>
<variable name="Kapp_CK" units="dimensionless" public_interface="out"/>
<variable name="deltaH_ADK" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_ADK" units="kilojoule_per_mole"/>
<variable name="Kapp_ADK" units="dimensionless" public_interface="out"/>
<variable name="deltaH_GP" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_GP" units="kilojoule_per_mole"/>
<variable name="Kapp_GP" units="dimensionless" public_interface="out"/>
<variable name="deltaH_PGLM" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_PGLM" units="kilojoule_per_mole"/>
<variable name="Kapp_PGLM" units="dimensionless" public_interface="out"/>
<variable name="deltaH_PGI" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_PGI" units="kilojoule_per_mole"/>
<variable name="Kapp_PGI" units="dimensionless" public_interface="out"/>
<variable name="deltaH_PFK" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_PFK" units="kilojoule_per_mole"/>
<variable name="Kapp_PFK" units="dimensionless" public_interface="out"/>
<variable name="deltaH_ALD" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_ALD" units="kilojoule_per_mole"/>
<variable name="Kapp_ALD" units="molar" public_interface="out"/>
<variable name="deltaH_TPI" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_TPI" units="kilojoule_per_mole"/>
<variable name="Kapp_TPI" units="dimensionless" public_interface="out"/>
<variable name="deltaH_GAPDH" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_GAPDH" units="kilojoule_per_mole"/>
<variable name="Kapp_GAPDH" units="per_molar" public_interface="out"/>
<variable name="deltaH_G3PDH" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_G3PDH" units="kilojoule_per_mole"/>
<variable name="Kapp_G3PDH" units="dimensionless" public_interface="out"/>
<variable name="deltaH_PGK" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_PGK" units="kilojoule_per_mole"/>
<variable name="Kapp_PGK" units="dimensionless" public_interface="out"/>
<variable name="deltaH_PGM" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_PGM" units="kilojoule_per_mole"/>
<variable name="Kapp_PGM" units="dimensionless" public_interface="out"/>
<variable name="deltaH_ENOL" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_ENOL" units="kilojoule_per_mole"/>
<variable name="Kapp_ENOL" units="dimensionless" public_interface="out"/>
<variable name="deltaH_PK" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_PK" units="kilojoule_per_mole"/>
<variable name="Kapp_PK" units="dimensionless" public_interface="out"/>
<variable name="deltaH_LDH" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_LDH" units="kilojoule_per_mole"/>
<variable name="Kapp_LDH" units="dimensionless" public_interface="out"/>
<variable name="deltaH_ATPase" units="dimensionless" public_interface="out"/>
<variable name="deltaGpo_ATPase" units="kilojoule_per_mole"/>
<variable name="Kapp_ATPase" units="dimensionless" public_interface="out"/>
<variable name="R" units="kilojoule_per_kelvin_per_mole" public_interface="in"/>
<variable name="T1" units="kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="I" units="molar" public_interface="in"/>
<variable name="mgT" units="molar" public_interface="in"/>
<variable name="k" units="molar" public_interface="in"/>
<variable name="c0" units="molar" public_interface="in"/>
<variable name="mg" units="molar" public_interface="in"/>
<variable name="pH_cy" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>RT2dadT</ci>
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<eq/>
<ci>B</ci>
<cn cellml:units="per_half_molar">1.6</cn>
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<apply>
<eq/>
<ci>Icorr</ci>
<apply>
<divide/>
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<times/>
<ci>RT2dadT</ci>
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<root/>
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<cn cellml:units="dimensionless">1</cn>
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</apply>
</apply>
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<eq/>
<ci>I1</ci>
<cn cellml:units="molar">0.1</cn>
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<apply>
<eq/>
<ci>alphadebye</ci>
<cn cellml:units="per_half_molar">1.17582</cn>
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<apply>
<eq/>
<ci>IcorrpKa</ci>
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<divide/>
<apply>
<times/>
<cn cellml:units="kilojoule_per_mole">1</cn>
<ci>alphadebye</ci>
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<minus/>
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<divide/>
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<root/>
<ci>I1</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<root/>
<ci>I1</ci>
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</apply>
</apply>
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<apply>
<divide/>
<apply>
<root/>
<ci>I</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<times/>
<ci>B</ci>
<apply>
<root/>
<ci>I</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>TcorrpKa</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>T</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>T1</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>RTalpha</ci>
<cn cellml:units="kilojoule_half_liter_per_3_half_mole">2.91482</cn>
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<apply>
<eq/>
<ci>IcorrdeltaGpof</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>RTalpha</ci>
<apply>
<root/>
<ci>I</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
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<times/>
<ci>B</ci>
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<root/>
<ci>I</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKak_Pi</ci>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
<apply>
<eq/>
<ci>deltaH1o_Pi</ci>
<cn cellml:units="kilojoule_per_mole">3</cn>
</apply>
<apply>
<eq/>
<ci>deltaHmgo_Pi</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">2.9</cn>
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<apply>
<eq/>
<ci>deltaH1_Pi</ci>
<apply>
<plus/>
<ci>deltaH1o_Pi</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
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<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaHmg_Pi</ci>
<apply>
<plus/>
<ci>deltaHmgo_Pi</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
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<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">0</cn>
<cn cellml:units="dimensionless">2</cn>
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</apply>
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<apply>
<eq/>
<ci>pKa1_Pi</ci>
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<plus/>
<cn cellml:units="dimensionless">6.75</cn>
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<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
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<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
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<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
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<apply>
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<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
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<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaH1_Pi</ci>
</apply>
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<apply>
<eq/>
<ci>pKamg_Pi</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.65</cn>
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<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
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<minus/>
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<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
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<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
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<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaHmg_Pi</ci>
</apply>
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<apply>
<eq/>
<ci>P_Pi</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_Pi</ci>
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<times/>
<apply>
<divide/>
<ci>mg</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_Pi</ci>
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<times/>
<apply>
<divide/>
<ci>k</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKak_Pi</ci>
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<ci>HPi2</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_Pi</ci>
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<apply>
<eq/>
<ci>H2Pi1</ci>
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<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_Pi</ci>
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<ci>HPi2</ci>
</apply>
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<apply>
<eq/>
<ci>kPi</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>k</ci>
<ci>c0</ci>
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<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKak_Pi</ci>
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<ci>HPi2</ci>
</apply>
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<apply>
<eq/>
<ci>mgPi</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
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<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_Pi</ci>
</apply>
<ci>HPi2</ci>
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<apply>
<eq/>
<ci>Navg_Pi</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>H2Pi1</ci>
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<eq/>
<ci>dNavgPidH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_Pi</ci>
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<apply>
<minus/>
<ci>P_Pi</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_Pi</ci>
</apply>
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</apply>
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<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_Pi</ci>
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<apply>
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<ci>dNavgPidmg</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>c0</ci>
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<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<ci>pKa1_Pi</ci>
<ci>pKamg_Pi</ci>
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<apply>
<power/>
<ci>P_Pi</ci>
<cn cellml:units="dimensionless">2</cn>
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</apply>
</apply>
<apply>
<eq/>
<ci>dmgPidmg</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_Pi</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_Pi</ci>
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<ci>c0</ci>
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<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
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<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>pKamg_Pi</ci>
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<ci>c0</ci>
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<apply>
<power/>
<ci>P_Pi</ci>
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<apply>
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<ci>dmgPidpH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_Pi</ci>
<ci>pKamg_Pi</ci>
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<apply>
<ln/>
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<apply>
<power/>
<ci>P_Pi</ci>
<cn cellml:units="dimensionless">2</cn>
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</apply>
<apply>
<eq/>
<ci>NH_HPi2</ci>
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<apply>
<eq/>
<ci>deltaGof_HPi2</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">1096.1</cn>
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<apply>
<eq/>
<ci>deltaGpof_HPi2</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_HPi2</ci>
<apply>
<times/>
<ci>NH_HPi2</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">4</cn>
<ci>NH_HPi2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH1o_ATP</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">5</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaHmgo_ATP</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">18</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaHko_ATP</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH1_ATP</ci>
<apply>
<plus/>
<ci>deltaH1o_ATP</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">4</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">3</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaHmg_ATP</ci>
<apply>
<plus/>
<ci>deltaHmgo_ATP</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">4</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaHk_ATP</ci>
<apply>
<plus/>
<ci>deltaHko_ATP</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">4</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">3</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKa1_ATP</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">6.48</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">4</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">3</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaH1_ATP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKamg_ATP</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">4.19</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">4</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaHmg_ATP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKak_ATP</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.17</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">4</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">3</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaHk_ATP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_ATP</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_ATP</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_ATP</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>k</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKak_ATP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ATP4</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_ATP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>HATP3</ci>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_ATP</ci>
</apply>
</apply>
<ci>ATP4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>mgATP2</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_ATP</ci>
</apply>
<ci>ATP4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>kATP</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>k</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKak_ATP</ci>
</apply>
<ci>ATP4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Navg_ATP</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>ATP4</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>HATP3</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>mgATP2</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>kATP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgATPdH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_ATP</ci>
</apply>
<apply>
<minus/>
<ci>P_ATP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_ATP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_ATP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgATPdmg</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<ci>pKa1_ATP</ci>
<ci>pKamg_ATP</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>P_ATP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgATP2dmg</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_ATP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_ATP</ci>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>pKamg_ATP</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
</apply>
<apply>
<power/>
<ci>P_ATP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgATP2dpH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_ATP</ci>
<ci>pKamg_ATP</ci>
</apply>
</apply>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
<apply>
<power/>
<ci>P_ATP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NH_ATP4</ci>
<cn cellml:units="dimensionless">12</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_ATP4</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">2768.1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpof_ATP4</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_ATP4</ci>
<apply>
<times/>
<ci>NH_ATP4</ci>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">16</cn>
<ci>NH_ATP4</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKak_ADP</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>deltaH1o_ADP</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">3</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaHmgo_ADP</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">15</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH1_ADP</ci>
<apply>
<plus/>
<ci>deltaH1o_ADP</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">3</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaHmg_ADP</ci>
<apply>
<plus/>
<ci>deltaHmgo_ADP</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">3</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKa1_ADP</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">6.38</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">3</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaH1_ADP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKamg_ADP</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">3.25</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">3</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaHmg_ADP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_ADP</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_ADP</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_ADP</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>k</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKak_ADP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ADP3</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_ADP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>HADP2</ci>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_ADP</ci>
</apply>
</apply>
<ci>ADP3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>mgADP</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>ADP3</ci>
<ci>mg</ci>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_ADP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>kADP</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>ADP3</ci>
<ci>k</ci>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKak_ADP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Navg_ADP</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>ADP3</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>HADP2</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>mgADP</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>kADP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgADPdH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_ADP</ci>
</apply>
<apply>
<minus/>
<ci>P_ADP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_ADP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_ADP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgADPdmg</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<ci>pKa1_ADP</ci>
<ci>pKamg_ADP</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>P_ADP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgADPdmg</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_ADP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_ADP</ci>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>pKamg_ADP</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
</apply>
<apply>
<power/>
<ci>P_ADP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgADPdpH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_ADP</ci>
<ci>pKamg_ADP</ci>
</apply>
</apply>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
<apply>
<power/>
<ci>P_ADP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NH_ADP3</ci>
<cn cellml:units="dimensionless">12</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_ADP3</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">1906.13</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpof_ADP3</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_ADP3</ci>
<apply>
<times/>
<ci>NH_ADP3</ci>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">9</cn>
<ci>NH_ADP3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH1o_AMP</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">3</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaHmgo_AMP</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">7.5</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH1_AMP</ci>
<apply>
<plus/>
<ci>deltaH1o_AMP</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaHmg_AMP</ci>
<apply>
<plus/>
<ci>deltaHmgo_AMP</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKa1_AMP</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">6.29</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaH1_AMP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKamg_AMP</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.92</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaHmg_AMP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_AMP</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pKa1_AMP</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_AMP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>AMP2</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_AMP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>HAMP1</ci>
<apply>
<times/>
<ci>AMP2</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pKa1_AMP</ci>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mgAMP</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_AMP</ci>
</apply>
<ci>AMP2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Navg_AMP</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>AMP2</ci>
</apply>
<ci>HAMP1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>mgAMP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgAMPdH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_AMP</ci>
</apply>
<apply>
<minus/>
<ci>P_AMP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_AMP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_AMP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgAMPdmg</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<ci>pKa1_AMP</ci>
<ci>pKamg_AMP</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>P_AMP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgAMPdmg</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_AMP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_AMP</ci>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>pKamg_AMP</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
</apply>
<apply>
<power/>
<ci>P_AMP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgAMPdpH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_AMP</ci>
<ci>pKamg_AMP</ci>
</apply>
</apply>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
<apply>
<power/>
<ci>P_AMP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NH_AMP2</ci>
<cn cellml:units="dimensionless">12</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_AMP2</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">1040.45</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpof_AMP2</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_AMP2</ci>
<apply>
<times/>
<ci>NH_AMP2</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">4</cn>
<ci>NH_AMP2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKak_PCR</ci>
<cn cellml:units="dimensionless">0.31</cn>
</apply>
<apply>
<eq/>
<ci>deltaH1o_PCR</ci>
<cn cellml:units="kilojoule_per_mole">2.66</cn>
</apply>
<apply>
<eq/>
<ci>deltaHmgo_PCR</ci>
<cn cellml:units="kilojoule_per_mole">8.19</cn>
</apply>
<apply>
<eq/>
<ci>deltaH1_PCR</ci>
<apply>
<plus/>
<ci>deltaH1o_PCR</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaHmg_PCR</ci>
<apply>
<plus/>
<ci>deltaHmgo_PCR</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKa1_PCR</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">4.5</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaH1_PCR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKamg_PCR</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.6</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaHmg_PCR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_PCR</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_PCR</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_PCR</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>k</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKak_PCR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>HPCR</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_PCR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>H2PCR</ci>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_PCR</ci>
</apply>
</apply>
<ci>HPCR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>kPCR</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>k</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKak_PCR</ci>
</apply>
<ci>HPCR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>mgPCR</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_PCR</ci>
</apply>
<ci>HPCR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Navg_PCR</ci>
<ci>H2PCR</ci>
</apply>
<apply>
<eq/>
<ci>dNavgPCRdH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_PCR</ci>
</apply>
<apply>
<minus/>
<ci>P_PCR</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_PCR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_PCR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgPCRdmg</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<ci>pKa1_PCR</ci>
<ci>pKamg_PCR</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>P_PCR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgPCRdmg</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_PCR</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_PCR</ci>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>pKamg_PCR</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
</apply>
<apply>
<power/>
<ci>P_PCR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgPCRdpH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_PCR</ci>
<ci>pKamg_PCR</ci>
</apply>
</apply>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
<apply>
<power/>
<ci>P_PCR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NH_HPCR</ci>
<cn cellml:units="dimensionless">8</cn>
</apply>
<apply>
<eq/>
<ci>pKa1_CR</ci>
<cn cellml:units="dimensionless">2.3</cn>
</apply>
<apply>
<eq/>
<ci>P_CR</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_CR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>HCR</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_CR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>H2CR</ci>
<apply>
<times/>
<ci>HCR</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_CR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Navg_CR</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>HCR</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>H2CR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgCRdH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_CR</ci>
</apply>
<apply>
<minus/>
<ci>P_CR</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_CR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_CR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgCRdmg</ci>
<cn cellml:units="per_molar">0</cn>
</apply>
<apply>
<eq/>
<ci>NH_HCR</ci>
<cn cellml:units="dimensionless">9</cn>
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<eq/>
<ci>deltaH1o_G1P</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">1.7</cn>
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<eq/>
<ci>deltaHmgo_G1P</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">12</cn>
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<eq/>
<ci>deltaH1_G1P</ci>
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<plus/>
<ci>deltaH1o_G1P</ci>
<apply>
<times/>
<ci>Icorr</ci>
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<minus/>
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<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
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<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
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<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
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<eq/>
<ci>deltaHmg_G1P</ci>
<apply>
<plus/>
<ci>deltaHmgo_G1P</ci>
<apply>
<times/>
<ci>Icorr</ci>
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<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
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<apply>
<power/>
<cn cellml:units="dimensionless">0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
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</apply>
</apply>
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<eq/>
<ci>pKa1_G1P</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">6.09</cn>
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<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
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<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
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<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
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<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
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<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaH1_G1P</ci>
</apply>
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<eq/>
<ci>pKamg_G1P</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">2.48</cn>
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<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
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<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
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<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
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<power/>
<cn cellml:units="dimensionless">0</cn>
<cn cellml:units="dimensionless">2</cn>
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<times/>
<ci>TcorrpKa</ci>
<ci>deltaHmg_G1P</ci>
</apply>
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<eq/>
<ci>P_G1P</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_G1P</ci>
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<times/>
<apply>
<divide/>
<ci>mg</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_G1P</ci>
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<eq/>
<ci>UG1P</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_G1P</ci>
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<eq/>
<ci>HG1P</ci>
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<times/>
<ci>UG1P</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_G1P</ci>
</apply>
</apply>
</apply>
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<eq/>
<ci>mgG1P</ci>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>UG1P</ci>
<ci>mg</ci>
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<ci>c0</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_G1P</ci>
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<eq/>
<ci>Navg_G1P</ci>
<ci>HG1P</ci>
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<eq/>
<ci>dNavgG1PdH</ci>
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<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_G1P</ci>
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<minus/>
<ci>P_G1P</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_G1P</ci>
</apply>
</apply>
</apply>
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<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_G1P</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
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<eq/>
<ci>dNavgG1Pdmg</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
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<ci>c0</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<ci>pKa1_G1P</ci>
<ci>pKamg_G1P</ci>
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<power/>
<ci>P_G1P</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
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<eq/>
<ci>dmgG1Pdmg</ci>
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<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_G1P</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_G1P</ci>
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<ci>c0</ci>
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<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>pKamg_G1P</ci>
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<ci>c0</ci>
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<power/>
<ci>P_G1P</ci>
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<eq/>
<ci>dmgG1PdpH</ci>
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<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_G1P</ci>
<ci>pKamg_G1P</ci>
</apply>
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<ln/>
<cn cellml:units="dimensionless">10</cn>
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<power/>
<ci>P_G1P</ci>
<cn cellml:units="dimensionless">2</cn>
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<eq/>
<ci>NH_UG1P</ci>
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<eq/>
<ci>deltaGof_UG1P</ci>
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<minus/>
<cn cellml:units="kilojoule_per_mole">1756.87</cn>
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<eq/>
<ci>deltaGpof_UG1P</ci>
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<minus/>
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<plus/>
<ci>deltaGof_UG1P</ci>
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<times/>
<ci>NH_UG1P</ci>
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<ln/>
<cn cellml:units="dimensionless">10</cn>
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<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
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<times/>
<ci>IcorrdeltaGpof</ci>
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<minus/>
<cn cellml:units="dimensionless">4</cn>
<ci>NH_UG1P</ci>
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<eq/>
<ci>pKa1_G6P</ci>
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<eq/>
<ci>P_G6P</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_G6P</ci>
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<eq/>
<ci>UG6P</ci>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_G6P</ci>
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<ci>HG6P</ci>
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<times/>
<ci>UG6P</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
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<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_G6P</ci>
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<ci>Navg_G6P</ci>
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<eq/>
<ci>dNavgG6PdH</ci>
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<divide/>
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<times/>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<ci>P_G6P</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<minus/>
<ci>pH_cy</ci>
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<ci>c0</ci>
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<power/>
<ci>P_G6P</ci>
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<ci>dNavgG6Pdmg</ci>
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<ci>NH_UG6P</ci>
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<ci>deltaGof_UG6P</ci>
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<minus/>
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<minus/>
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<ci>deltaGof_UG6P</ci>
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<ci>NH_UG6P</ci>
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<ln/>
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<ci>IcorrdeltaGpof</ci>
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<minus/>
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<ci>pKa1_F6P</ci>
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<ci>P_F6P</ci>
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<minus/>
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<divide/>
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<ci>HF6P</ci>
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<ci>UF6P</ci>
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<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_F6P</ci>
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<ci>dNavgF6PdH</ci>
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<divide/>
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<ci>pH_cy</ci>
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<ci>c0</ci>
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<ci>deltaGof_UF6P</ci>
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<plus/>
<ci>deltaGof_UF6P</ci>
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<ln/>
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<ci>IcorrdeltaGpof</ci>
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<minus/>
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<eq/>
<ci>pKa2_FDP</ci>
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<minus/>
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<minus/>
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<ci>pH_cy</ci>
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<ci>HFDP</ci>
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<ci>UFDP</ci>
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<ci>pKa1_FDP</ci>
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<ci>H2FDP</ci>
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<ci>UFDP</ci>
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<ci>pH_cy</ci>
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<divide/>
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<times/>
<ci>UFDP</ci>
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<ci>Navg_FDP</ci>
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<plus/>
<ci>HFDP</ci>
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<ci>dNavgFDPdH</ci>
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<times/>
<ci>P_FDP</ci>
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<cn cellml:units="dimensionless">2</cn>
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<cn cellml:units="dimensionless">10</cn>
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<minus/>
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<ci>pKa2_FDP</ci>
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<apply>
<plus/>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_FDP</ci>
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<cn cellml:units="dimensionless">2</cn>
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<cn cellml:units="dimensionless">10</cn>
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<apply>
<times/>
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<minus/>
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<ci>pH_cy</ci>
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<ci>pKa1_FDP</ci>
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<cn cellml:units="dimensionless">2</cn>
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<cn cellml:units="dimensionless">10</cn>
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<minus/>
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<ci>pKa2_FDP</ci>
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<ci>c0</ci>
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<ci>P_FDP</ci>
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<ci>dNavgFDPdmg</ci>
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<divide/>
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<times/>
<apply>
<minus/>
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<plus/>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_FDP</ci>
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<cn cellml:units="dimensionless">2</cn>
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<minus/>
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<ci>pH_cy</ci>
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<ci>pKa1_FDP</ci>
<ci>pKa2_FDP</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_FDP</ci>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_FDP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgFDPdmg</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_FDP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_FDP</ci>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>pKamg_FDP</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
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<apply>
<power/>
<ci>P_FDP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgFDPdpH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_FDP</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>P_FDP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_FDP</ci>
</apply>
</apply>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_FDP</ci>
<ci>pKa2_FDP</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>P_FDP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NH_UFDP</ci>
<cn cellml:units="dimensionless">10</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_UFDP</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">2601.4</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpof_UFDP</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_UFDP</ci>
<apply>
<times/>
<ci>NH_UFDP</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">16</cn>
<ci>NH_UFDP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKa1_GAP</ci>
<cn cellml:units="dimensionless">6.45</cn>
</apply>
<apply>
<eq/>
<ci>P_GAP</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_GAP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>UGAP</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_GAP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>HGAP</ci>
<apply>
<times/>
<ci>UGAP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_GAP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Navg_GAP</ci>
<ci>HGAP</ci>
</apply>
<apply>
<eq/>
<ci>dNavgGAPdH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_GAP</ci>
</apply>
<apply>
<minus/>
<ci>P_GAP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_GAP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_GAP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgGAPdmg</ci>
<cn cellml:units="per_molar">0</cn>
</apply>
<apply>
<eq/>
<ci>NH_UGAP</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_UGAP</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">1288.6</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpof_UGAP</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_UGAP</ci>
<apply>
<times/>
<ci>NH_UGAP</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">4</cn>
<ci>NH_UGAP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKamg_G3P</ci>
<cn cellml:units="dimensionless">1.63</cn>
</apply>
<apply>
<eq/>
<ci>deltaH1o_G3P</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">3.1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH1_G3P</ci>
<apply>
<plus/>
<ci>deltaH1o_G3P</ci>
<apply>
<times/>
<ci>Icorr</ci>
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<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKa1_G3P</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">6.22</cn>
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<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
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<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
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<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaH1_G3P</ci>
</apply>
</apply>
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<eq/>
<ci>P_G3P</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_G3P</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_G3P</ci>
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</apply>
</apply>
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<eq/>
<ci>UG3P</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_G3P</ci>
</apply>
</apply>
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<eq/>
<ci>HG3P</ci>
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<times/>
<ci>UG3P</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_G3P</ci>
</apply>
</apply>
</apply>
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<eq/>
<ci>mgG3P</ci>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>UG3P</ci>
<ci>mg</ci>
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<ci>c0</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_G3P</ci>
</apply>
</apply>
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<eq/>
<ci>Navg_G3P</ci>
<ci>HG3P</ci>
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<eq/>
<ci>dNavgG3PdH</ci>
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<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_G3P</ci>
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<minus/>
<ci>P_G3P</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_G3P</ci>
</apply>
</apply>
</apply>
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<apply>
<times/>
<ci>c0</ci>
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<power/>
<ci>P_G3P</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
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<eq/>
<ci>dNavgG3Pdmg</ci>
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<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
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<ci>c0</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<ci>pKa1_G3P</ci>
<ci>pKamg_G3P</ci>
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<power/>
<ci>P_G3P</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
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<eq/>
<ci>dmgG3Pdmg</ci>
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<divide/>
<apply>
<minus/>
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<divide/>
<apply>
<times/>
<ci>P_G3P</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_G3P</ci>
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<ci>c0</ci>
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<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>pKamg_G3P</ci>
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<ci>c0</ci>
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<power/>
<ci>P_G3P</ci>
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<eq/>
<ci>dmgG3PdpH</ci>
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<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_G3P</ci>
<ci>pKamg_G3P</ci>
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<ln/>
<cn cellml:units="dimensionless">10</cn>
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<power/>
<ci>P_G3P</ci>
<cn cellml:units="dimensionless">2</cn>
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</apply>
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<eq/>
<ci>NH_UG3P</ci>
<cn cellml:units="dimensionless">7</cn>
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<eq/>
<ci>deltaGof_UG3P</ci>
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<minus/>
<cn cellml:units="kilojoule_per_mole">1339.25</cn>
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<eq/>
<ci>deltaGpof_UG3P</ci>
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<minus/>
<apply>
<plus/>
<ci>deltaGof_UG3P</ci>
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<times/>
<ci>NH_UG3P</ci>
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<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
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<times/>
<ci>IcorrdeltaGpof</ci>
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<minus/>
<cn cellml:units="dimensionless">4</cn>
<ci>NH_UG3P</ci>
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<eq/>
<ci>pKa1_DHAP</ci>
<cn cellml:units="dimensionless">5.9</cn>
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<eq/>
<ci>pKamg_DHAP</ci>
<cn cellml:units="dimensionless">1.57</cn>
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<eq/>
<ci>P_DHAP</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_DHAP</ci>
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<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_DHAP</ci>
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<eq/>
<ci>UDHAP</ci>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_DHAP</ci>
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<eq/>
<ci>HDHAP</ci>
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<times/>
<ci>UDHAP</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_DHAP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mgDHAP</ci>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>UDHAP</ci>
<ci>mg</ci>
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<ci>c0</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_DHAP</ci>
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</apply>
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<eq/>
<ci>Navg_DHAP</ci>
<ci>HDHAP</ci>
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<eq/>
<ci>dNavgDHAPdH</ci>
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<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_DHAP</ci>
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<minus/>
<ci>P_DHAP</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_DHAP</ci>
</apply>
</apply>
</apply>
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<times/>
<ci>c0</ci>
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<power/>
<ci>P_DHAP</ci>
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</apply>
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<eq/>
<ci>dNavgDHAPdmg</ci>
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<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
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</apply>
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<ci>c0</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
<ci>pKa1_DHAP</ci>
<ci>pKamg_DHAP</ci>
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<power/>
<ci>P_DHAP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
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<eq/>
<ci>dmgDHAPdmg</ci>
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<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_DHAP</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_DHAP</ci>
</apply>
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<ci>c0</ci>
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<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>pKamg_DHAP</ci>
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<ci>c0</ci>
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<power/>
<ci>P_DHAP</ci>
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<eq/>
<ci>dmgDHAPdpH</ci>
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<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_DHAP</ci>
<ci>pKamg_DHAP</ci>
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<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
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<power/>
<ci>P_DHAP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
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<eq/>
<ci>NH_UDHAP</ci>
<cn cellml:units="dimensionless">5</cn>
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<eq/>
<ci>deltaGof_UDHAP</ci>
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<minus/>
<cn cellml:units="kilojoule_per_mole">1296.26</cn>
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<eq/>
<ci>deltaGpof_UDHAP</ci>
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<minus/>
<apply>
<plus/>
<ci>deltaGof_UDHAP</ci>
<apply>
<times/>
<ci>NH_UDHAP</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
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</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">4</cn>
<ci>NH_UDHAP</ci>
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</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKa1_13DPG</ci>
<cn cellml:units="dimensionless">7.5</cn>
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<eq/>
<ci>P_13DPG</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_13DPG</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>U13DPG</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_13DPG</ci>
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</apply>
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<eq/>
<ci>H13DPG</ci>
<apply>
<times/>
<ci>U13DPG</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>pKa1_13DPG</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Navg_13DPG</ci>
<ci>H13DPG</ci>
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<apply>
<eq/>
<ci>dNavg13DPGdH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_13DPG</ci>
</apply>
<apply>
<minus/>
<ci>P_13DPG</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_13DPG</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_13DPG</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavg13DPGdmg</ci>
<cn cellml:units="per_molar">0</cn>
</apply>
<apply>
<eq/>
<ci>NH_U13DPG</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_U13DPG</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">2356.14</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpof_U13DPG</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_U13DPG</ci>
<apply>
<times/>
<ci>NH_U13DPG</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">16</cn>
<ci>NH_U13DPG</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKa1_3PG</ci>
<cn cellml:units="dimensionless">6.21</cn>
</apply>
<apply>
<eq/>
<ci>P_3PG</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<cn cellml:units="dimensionless">6.21</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>U3PG</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_3PG</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>H3PG</ci>
<apply>
<times/>
<ci>U3PG</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<cn cellml:units="dimensionless">6.21</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Navg_3PG</ci>
<ci>H3PG</ci>
</apply>
<apply>
<eq/>
<ci>dNavg3PGdH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_3PG</ci>
</apply>
<apply>
<minus/>
<ci>P_3PG</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_3PG</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_3PG</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavg3PGdmg</ci>
<cn cellml:units="per_molar">0</cn>
</apply>
<apply>
<eq/>
<ci>NH_U3PG</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_U3PG</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">1502.54</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpof_U3PG</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_U3PG</ci>
<apply>
<times/>
<ci>NH_U3PG</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">9</cn>
<ci>NH_U3PG</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKa1_2PG</ci>
<cn cellml:units="dimensionless">7</cn>
</apply>
<apply>
<eq/>
<ci>pKamg_2PG</ci>
<cn cellml:units="dimensionless">2.45</cn>
</apply>
<apply>
<eq/>
<ci>pKak_2PG</ci>
<cn cellml:units="dimensionless">1.18</cn>
</apply>
<apply>
<eq/>
<ci>P_2PG</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_2PG</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_2PG</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>k</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKak_2PG</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>U2PG</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_2PG</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>H2PG</ci>
<apply>
<times/>
<ci>U2PG</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_2PG</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mg2PG</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>U2PG</ci>
<ci>mg</ci>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_2PG</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k2PG</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>U2PG</ci>
<ci>k</ci>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKak_2PG</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Navg_2PG</ci>
<ci>H2PG</ci>
</apply>
<apply>
<eq/>
<ci>dNavg2PGdH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_2PG</ci>
</apply>
<apply>
<minus/>
<ci>P_2PG</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_2PG</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_2PG</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavg2PGdmg</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<ci>pKa1_2PG</ci>
<ci>pKamg_2PG</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>P_2PG</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmg2PGdmg</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_2PG</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_2PG</ci>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>pKamg_2PG</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
</apply>
<apply>
<power/>
<ci>P_2PG</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmg2PGdpH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_2PG</ci>
<ci>pKamg_2PG</ci>
</apply>
</apply>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
<apply>
<power/>
<ci>P_2PG</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NH_U2PG</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_U2PG</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">1496.38</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpof_U2PG</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_U2PG</ci>
<apply>
<times/>
<ci>NH_U2PG</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">9</cn>
<ci>NH_U2PG</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKa1_PEP</ci>
<cn cellml:units="dimensionless">6.35</cn>
</apply>
<apply>
<eq/>
<ci>pKamg_PEP</ci>
<cn cellml:units="dimensionless">2.26</cn>
</apply>
<apply>
<eq/>
<ci>pKak_PEP</ci>
<cn cellml:units="dimensionless">1.08</cn>
</apply>
<apply>
<eq/>
<ci>P_PEP</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pKa1_PEP</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_PEP</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>k</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKak_PEP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>UPEP</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_PEP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>HPEP</ci>
<apply>
<times/>
<ci>UPEP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pKa1_PEP</ci>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>kPEP</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>UPEP</ci>
<ci>k</ci>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKak_PEP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mgPEP</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>UPEP</ci>
<ci>mg</ci>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_PEP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Navg_PEP</ci>
<ci>HPEP</ci>
</apply>
<apply>
<eq/>
<ci>dNavgPEPdH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_PEP</ci>
</apply>
<apply>
<minus/>
<ci>P_PEP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_PEP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_PEP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgPEPdmg</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<ci>pKa1_PEP</ci>
<ci>pKamg_PEP</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>P_PEP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgPEPdmg</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_PEP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_PEP</ci>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>pKamg_PEP</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
</apply>
<apply>
<power/>
<ci>P_PEP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgPEPdpH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_PEP</ci>
<ci>pKamg_PEP</ci>
</apply>
</apply>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
<apply>
<power/>
<ci>P_PEP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NH_UPEP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_UPEP</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">1263.65</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpof_UPEP</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_UPEP</ci>
<apply>
<times/>
<ci>NH_UPEP</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">9</cn>
<ci>NH_UPEP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKa1_PYR</ci>
<cn cellml:units="dimensionless">2.49</cn>
</apply>
<apply>
<eq/>
<ci>P_PYR</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_PYR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>UPYR</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_PYR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>HPYR</ci>
<apply>
<times/>
<ci>UPYR</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_PYR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Navg_PYR</ci>
<ci>HPYR</ci>
</apply>
<apply>
<eq/>
<ci>dNavgPYRdH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_PYR</ci>
</apply>
<apply>
<minus/>
<ci>P_PYR</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_PYR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_PYR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgPYRdmg</ci>
<cn cellml:units="per_molar">0</cn>
</apply>
<apply>
<eq/>
<ci>NH_UPYR</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_UPYR</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">472.27</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpof_UPYR</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_UPYR</ci>
<apply>
<times/>
<ci>NH_UPYR</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>NH_UPYR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKamg_LAC</ci>
<cn cellml:units="dimensionless">0.98</cn>
</apply>
<apply>
<eq/>
<ci>deltaH1o_LAC</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">0.33</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH1_LAC</ci>
<apply>
<plus/>
<ci>deltaH1o_LAC</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pKa1_LAC</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">3.67</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>IcorrpKa</ci>
<cn cellml:units="kilojoule_per_mole">1</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaH1_LAC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_LAC</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_LAC</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_LAC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ULAC</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_LAC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>HLAC</ci>
<apply>
<times/>
<ci>ULAC</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_LAC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mgLAC</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_LAC</ci>
</apply>
<ci>ULAC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Navg_LAC</ci>
<ci>HLAC</ci>
</apply>
<apply>
<eq/>
<ci>dNavgLACdH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKa1_LAC</ci>
</apply>
<apply>
<minus/>
<ci>P_LAC</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_LAC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>c0</ci>
<apply>
<power/>
<ci>P_LAC</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNavgLACdmg</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<ci>pKa1_LAC</ci>
<ci>pKamg_LAC</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>P_LAC</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgLACdmg</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_LAC</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<ci>pKamg_LAC</ci>
</apply>
</apply>
<ci>c0</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>pKamg_LAC</ci>
</apply>
</apply>
</apply>
<ci>c0</ci>
</apply>
</apply>
<apply>
<power/>
<ci>P_LAC</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dmgLACdpH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>mg</ci>
<ci>c0</ci>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<ci>pKa1_LAC</ci>
<ci>pKamg_LAC</ci>
</apply>
</apply>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
<apply>
<power/>
<ci>P_LAC</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NH_ULAC</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_ULAC</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">516.72</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpof_ULAC</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_ULAC</ci>
<apply>
<times/>
<ci>NH_ULAC</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>NH_ULAC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNH_GLY</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_GLY</ci>
<apply>
<plus/>
<cn cellml:units="kilojoule_per_mole">655.7</cn>
<apply>
<times/>
<ci>dNH_GLY</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NH_NAD</ci>
<cn cellml:units="dimensionless">26</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_NAD</ci>
<cn cellml:units="kilojoule_per_mole">0</cn>
</apply>
<apply>
<eq/>
<ci>deltaGpof_NAD</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_NAD</ci>
<apply>
<times/>
<ci>NH_NAD</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>NH_NAD</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NH_NADH</ci>
<cn cellml:units="dimensionless">27</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_NADH</ci>
<cn cellml:units="kilojoule_per_mole">22.65</cn>
</apply>
<apply>
<eq/>
<ci>deltaGpof_NADH</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_NADH</ci>
<apply>
<times/>
<ci>NH_NADH</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">4</cn>
<ci>NH_NADH</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NH_H2O</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_H2O</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">237.19</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpof_H2O</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGof_H2O</ci>
<apply>
<times/>
<ci>NH_H2O</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IcorrdeltaGpof</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">0</cn>
<ci>NH_H2O</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NH_H</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>deltaGof_H</ci>
<cn cellml:units="kilojoule_per_mole">0</cn>
</apply>
<apply>
<eq/>
<ci>deltaGpof_H</ci>
<apply>
<plus/>
<ci>deltaGof_H</ci>
<apply>
<times/>
<ci>NH_H</ci>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>R</ci>
<ci>T</ci>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_CK</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Navg_ATP</ci>
<ci>Navg_CR</ci>
</apply>
<ci>Navg_PCR</ci>
</apply>
<ci>Navg_ADP</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>NH_ATP4</ci>
<ci>NH_HCR</ci>
</apply>
<ci>NH_HPCR</ci>
</apply>
<ci>NH_ADP3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Kref_CK</ci>
<cn type="e-notation" cellml:units="dimensionless">2.58 <sep/>
8</cn>
</apply>
<apply>
<eq/>
<ci>deltaHo_CKo</ci>
<apply>
<minus/>
<cn cellml:units="kilojoule_per_mole">17.55</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH1_CK</ci>
<apply>
<plus/>
<ci>deltaHo_CKo</ci>
<apply>
<times/>
<ci>Icorr</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">3</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">4</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Kref_CKI</ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<ln/>
<ci>Kref_CK</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>alphadebye</ci>
<apply>
<root/>
<ci>I</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">3</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">4</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">0</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>B</ci>
<apply>
<root/>
<ci>I</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Kref_CKT</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<apply>
<log/>
<ci>Kref_CKI</ci>
</apply>
<apply>
<times/>
<ci>TcorrpKa</ci>
<ci>deltaH1_CK</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_CK</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>R</ci>
</apply>
<ci>T</ci>
<apply>
<ln/>
<ci>Kref_CKT</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_CK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_CK</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
<ci>P_ATP</ci>
<ci>P_CR</ci>
</apply>
<apply>
<times/>
<ci>P_PCR</ci>
<ci>P_ADP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_ADK</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Navg_ADP</ci>
</apply>
<ci>Navg_ATP</ci>
</apply>
<ci>Navg_AMP</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>NH_ADP3</ci>
</apply>
<ci>NH_ATP4</ci>
</apply>
<ci>NH_AMP2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_ADK</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>deltaGpof_ADP3</ci>
</apply>
<ci>deltaGpof_ATP4</ci>
</apply>
<ci>deltaGpof_AMP2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_ADK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_ADK</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>P_ADP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>P_ATP</ci>
<ci>P_AMP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_GP</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Navg_G1P</ci>
<ci>Navg_Pi</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>NH_HPi2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_GP</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGpo_GLY</ci>
<ci>deltaGpof_UG1P</ci>
</apply>
<ci>deltaGpof_HPi2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_GP</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_GP</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_G1P</ci>
</apply>
<ci>P_Pi</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_PGLM</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Navg_G6P</ci>
<ci>Navg_G1P</ci>
</apply>
<apply>
<minus/>
<ci>NH_UG6P</ci>
<ci>NH_UG1P</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_PGLM</ci>
<apply>
<minus/>
<ci>deltaGpof_UG6P</ci>
<ci>deltaGpof_UG1P</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_PGLM</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_PGLM</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_G6P</ci>
</apply>
<ci>P_G1P</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_PGI</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Navg_F6P</ci>
<ci>Navg_G6P</ci>
</apply>
<apply>
<minus/>
<ci>NH_UF6P</ci>
<ci>NH_UG6P</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_PGI</ci>
<apply>
<minus/>
<ci>deltaGpof_UF6P</ci>
<ci>deltaGpof_UG6P</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_PGI</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_PGI</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_F6P</ci>
</apply>
<ci>P_G6P</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_PFK</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Navg_ADP</ci>
<ci>Navg_FDP</ci>
</apply>
<ci>Navg_F6P</ci>
</apply>
<ci>Navg_ATP</ci>
</apply>
<ci>NH_ADP3</ci>
<ci>NH_UFDP</ci>
</apply>
<ci>NH_UF6P</ci>
</apply>
<ci>NH_ATP4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_PFK</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGpof_UFDP</ci>
<ci>deltaGpof_ADP3</ci>
<ci>deltaGpof_H</ci>
</apply>
<ci>deltaGpof_UF6P</ci>
</apply>
<ci>deltaGpof_ATP4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_PFK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_PFK</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_FDP</ci>
<ci>P_ADP</ci>
</apply>
<apply>
<times/>
<ci>P_F6P</ci>
<ci>P_ATP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_ALD</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Navg_DHAP</ci>
<ci>Navg_GAP</ci>
</apply>
<ci>Navg_FDP</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>NH_UDHAP</ci>
<ci>NH_UGAP</ci>
</apply>
<ci>NH_UFDP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_ALD</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGpof_UDHAP</ci>
<ci>deltaGpof_UGAP</ci>
</apply>
<ci>deltaGpof_UFDP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_ALD</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="molar">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_ALD</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_GAP</ci>
<ci>P_FDP</ci>
</apply>
<ci>P_DHAP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_TPI</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Navg_DHAP</ci>
<ci>Navg_GAP</ci>
</apply>
<apply>
<minus/>
<ci>NH_UDHAP</ci>
<ci>NH_UGAP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_TPI</ci>
<apply>
<minus/>
<ci>deltaGpof_UDHAP</ci>
<ci>deltaGpof_UGAP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_TPI</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_TPI</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_DHAP</ci>
</apply>
<ci>P_GAP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_GAPDH</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Navg_13DPG</ci>
<ci>Navg_GAP</ci>
</apply>
<ci>Navg_Pi</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>NH_U13DPG</ci>
<ci>NH_NADH</ci>
</apply>
<ci>NH_UGAP</ci>
</apply>
<ci>NH_HPi2</ci>
</apply>
<ci>NH_NAD</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_GAPDH</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGpof_U13DPG</ci>
<ci>deltaGpof_NADH</ci>
<ci>deltaGpof_H</ci>
</apply>
<ci>deltaGpof_HPi2</ci>
</apply>
<ci>deltaGpof_UGAP</ci>
</apply>
<ci>deltaGpof_NAD</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_GAPDH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_GAPDH</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_13DPG</ci>
</apply>
<apply>
<times/>
<ci>P_Pi</ci>
<ci>P_GAP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
<cn cellml:units="molar">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_G3PDH</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Navg_DHAP</ci>
<ci>Navg_G3P</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>NH_UDHAP</ci>
<ci>NH_NADH</ci>
</apply>
<ci>NH_NAD</ci>
</apply>
<ci>NH_UG3P</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_G3PDH</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGpof_H</ci>
<ci>deltaGpof_NADH</ci>
<ci>deltaGpof_UDHAP</ci>
</apply>
<ci>deltaGpof_NAD</ci>
</apply>
<ci>deltaGpof_UG3P</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_G3PDH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_G3PDH</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_DHAP</ci>
</apply>
<apply>
<times/>
<ci>P_G3P</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_PGK</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Navg_3PG</ci>
<ci>Navg_ATP</ci>
</apply>
<ci>Navg_13DPG</ci>
</apply>
<ci>Navg_ADP</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>NH_U3PG</ci>
<ci>NH_ATP4</ci>
</apply>
<ci>NH_U13DPG</ci>
</apply>
<ci>NH_ADP3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_PGK</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGpof_ATP4</ci>
<ci>deltaGpof_U3PG</ci>
</apply>
<ci>deltaGpof_U13DPG</ci>
</apply>
<ci>deltaGpof_ADP3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_PGK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_PGK</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_ATP</ci>
<ci>P_3PG</ci>
</apply>
<apply>
<times/>
<ci>P_13DPG</ci>
<ci>P_ADP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_PGM</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Navg_2PG</ci>
<ci>Navg_3PG</ci>
</apply>
<apply>
<minus/>
<ci>NH_U2PG</ci>
<ci>NH_U3PG</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_PGM</ci>
<apply>
<minus/>
<ci>deltaGpof_U2PG</ci>
<ci>deltaGpof_U3PG</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_PGM</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_PGM</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_2PG</ci>
</apply>
<ci>P_3PG</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_ENOL</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Navg_PEP</ci>
<ci>Navg_2PG</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>NH_H2O</ci>
<ci>NH_UPEP</ci>
</apply>
<ci>NH_U2PG</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_ENOL</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGpof_H2O</ci>
<ci>deltaGpof_UPEP</ci>
</apply>
<ci>deltaGpof_U2PG</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_ENOL</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_ENOL</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_PEP</ci>
</apply>
<ci>P_2PG</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_PK</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Navg_PYR</ci>
<ci>Navg_ATP</ci>
</apply>
<ci>Navg_PEP</ci>
</apply>
<ci>Navg_ADP</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>NH_UPYR</ci>
<ci>NH_ATP4</ci>
</apply>
<ci>NH_UPEP</ci>
</apply>
<ci>NH_ADP3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_PK</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGpof_UPYR</ci>
<ci>deltaGpof_ATP4</ci>
</apply>
<ci>deltaGpof_H</ci>
</apply>
<ci>deltaGpof_UPEP</ci>
</apply>
<ci>deltaGpof_ADP3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_PK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_PK</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_PYR</ci>
<ci>P_ATP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>P_PEP</ci>
<ci>P_ADP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_LDH</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Navg_LAC</ci>
<ci>Navg_PYR</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>NH_ULAC</ci>
<ci>NH_NAD</ci>
</apply>
<ci>NH_UPYR</ci>
</apply>
<ci>NH_NADH</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_LDH</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGpof_ULAC</ci>
<ci>deltaGpof_NAD</ci>
</apply>
<ci>deltaGpof_UPYR</ci>
</apply>
<ci>deltaGpof_NADH</ci>
</apply>
<ci>deltaGpof_H</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_LDH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_LDH</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_LAC</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
<ci>P_PYR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaH_ATPase</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Navg_ADP</ci>
<ci>Navg_Pi</ci>
</apply>
<ci>Navg_ATP</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>NH_ADP3</ci>
<ci>NH_HPi2</ci>
</apply>
<ci>NH_ATP4</ci>
</apply>
<ci>NH_H2O</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>deltaGpo_ATPase</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>deltaGpof_ADP3</ci>
<ci>deltaGpof_HPi2</ci>
<ci>deltaGpof_H</ci>
</apply>
<ci>deltaGpof_H2O</ci>
</apply>
<ci>deltaGpof_ATP4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kapp_ATPase</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>deltaGpo_ATPase</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<ci>P_ADP</ci>
<ci>P_Pi</ci>
</apply>
<apply>
<times/>
<ci>P_ATP</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="glycogen_phosphorylase">
<variable name="Vfgly" units="molar_per_minute" public_interface="out"/>
<variable name="expno" units="dimensionless" public_interface="out"/>
<variable name="fracA" units="dimensionless" public_interface="out"/>
<variable name="KgpA_glyf" units="molar"/>
<variable name="KgpA_pi" units="molar"/>
<variable name="KgpA_igly" units="molar"/>
<variable name="KgpA_ipi" units="molar"/>
<variable name="KgpA_glyb" units="molar"/>
<variable name="KgpA_g1p" units="molar"/>
<variable name="KgpA_ig1p" units="molar"/>
<variable name="Dglya" units="dimensionless"/>
<variable name="pa" units="dimensionless"/>
<variable name="VbglyA" units="molar_per_minute"/>
<variable name="glyAF" units="per_minute"/>
<variable name="glyAR" units="per_minute"/>
<variable name="flux_GPa" units="molar_per_minute" public_interface="out"/>
<variable name="time" units="minute" public_interface="in"/>
<variable name="G1P" units="molar" public_interface="in"/>
<variable name="Pi" units="molar" public_interface="in"/>
<variable name="Gly" units="molar" public_interface="in"/>
<variable name="pH_cy" units="dimensionless" public_interface="in"/>
<variable name="Kapp_GP" units="dimensionless" public_interface="in"/>
<variable name="Par_1" units="molar_per_minute" public_interface="in"/>
<variable name="Par_2" units="dimensionless" public_interface="in"/>
<variable name="Par_3" units="molar" public_interface="in"/>
<variable name="Par_4" units="molar" public_interface="in"/>
<variable name="Par_5" units="molar" public_interface="in"/>
<variable name="Par_6" units="molar" public_interface="in"/>
<variable name="Par_7" units="molar" public_interface="in"/>
<variable name="Par_8" units="molar" public_interface="in"/>
<variable name="Par_9" units="molar" public_interface="in"/>
<variable name="Par_100" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vfgly</ci>
<ci>Par_1</ci>
</apply>
<apply>
<eq/>
<ci>expno</ci>
<ci>Par_100</ci>
</apply>
<apply>
<eq/>
<ci>fracA</ci>
<piecewise>
<piece>
<ci>Par_2</ci>
<apply>
<neq/>
<ci>expno</ci>
<cn cellml:units="dimensionless">45</cn>
</apply>
</piece>
<piece>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<lt/>
<ci>time</ci>
<cn cellml:units="minute">40</cn>
</apply>
</piece>
<piece>
<cn cellml:units="dimensionless">0.004</cn>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<cn cellml:units="minute">40</cn>
</apply>
<apply>
<lt/>
<ci>time</ci>
<cn cellml:units="minute">80</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="dimensionless">0.01</cn>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<cn cellml:units="minute">80</cn>
</apply>
<apply>
<lt/>
<ci>time</ci>
<cn cellml:units="minute">100</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="dimensionless">0.04</cn>
<apply>
<geq/>
<ci>time</ci>
<cn cellml:units="minute">100</cn>
</apply>
</piece>
</piecewise>
</apply>
<apply>
<eq/>
<ci>KgpA_glyf</ci>
<ci>Par_3</ci>
</apply>
<apply>
<eq/>
<ci>KgpA_pi</ci>
<ci>Par_4</ci>
</apply>
<apply>
<eq/>
<ci>KgpA_igly</ci>
<ci>Par_5</ci>
</apply>
<apply>
<eq/>
<ci>KgpA_ipi</ci>
<ci>Par_6</ci>
</apply>
<apply>
<eq/>
<ci>KgpA_glyb</ci>
<ci>Par_7</ci>
</apply>
<apply>
<eq/>
<ci>KgpA_g1p</ci>
<ci>Par_8</ci>
</apply>
<apply>
<eq/>
<ci>KgpA_ig1p</ci>
<ci>Par_9</ci>
</apply>
<apply>
<eq/>
<ci>Dglya</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Gly</ci>
<ci>KgpA_glyf</ci>
</apply>
<apply>
<divide/>
<ci>Pi</ci>
<ci>KgpA_pi</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Gly</ci>
<ci>Pi</ci>
</apply>
<apply>
<times/>
<ci>KgpA_glyf</ci>
<ci>KgpA_ipi</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>Gly</ci>
<ci>KgpA_glyb</ci>
</apply>
<apply>
<divide/>
<ci>G1P</ci>
<ci>KgpA_g1p</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Gly</ci>
<ci>G1P</ci>
</apply>
<apply>
<times/>
<ci>KgpA_ig1p</ci>
<ci>KgpA_glyb</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pa</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.404</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">5.94</cn>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
<cn cellml:units="dimensionless">7.29</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>VbglyA</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>pa</ci>
<ci>Vfgly</ci>
<ci>KgpA_glyb</ci>
<ci>KgpA_ig1p</ci>
</apply>
<apply>
<times/>
<ci>KgpA_igly</ci>
<ci>KgpA_pi</ci>
<ci>Kapp_GP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>glyAF</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>pa</ci>
<ci>Vfgly</ci>
<ci>Pi</ci>
</apply>
<apply>
<times/>
<ci>KgpA_igly</ci>
<ci>KgpA_pi</ci>
</apply>
</apply>
<ci>Dglya</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>glyAR</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>VbglyA</ci>
<ci>Gly</ci>
</apply>
<apply>
<times/>
<ci>KgpA_glyb</ci>
<ci>KgpA_ig1p</ci>
</apply>
</apply>
<ci>Dglya</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>flux_GPa</ci>
<apply>
<times/>
<ci>fracA</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Gly</ci>
<ci>glyAF</ci>
</apply>
<apply>
<times/>
<ci>G1P</ci>
<ci>glyAR</ci>
</apply>
</apply>
</apply>
</apply>
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<component xmlns="http://www.cellml.org/cellml/1.0#" name="glycogen_phosphorylase_B">
<variable name="fracB" units="dimensionless"/>
<variable name="KgpB_pi" units="molar"/>
<variable name="KgpB_ipi" units="molar"/>
<variable name="KgpB_iglyf" units="molar"/>
<variable name="KgpB_g1p" units="molar"/>
<variable name="KgpB_ig1p" units="molar"/>
<variable name="KgpB_iglyb" units="molar"/>
<variable name="Kgp_amp" units="molar"/>
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<variable name="nH" units="dimensionless"/>
<variable name="M" units="dimensionless"/>
<variable name="Dglyb" units="dimensionless"/>
<variable name="pb" units="dimensionless"/>
<variable name="VbglyB" units="molar_per_minute"/>
<variable name="glyBF" units="per_minute"/>
<variable name="glyBR" units="per_minute"/>
<variable name="flux_GPb" units="molar_per_minute" public_interface="out"/>
<variable name="fracA" units="dimensionless" public_interface="in"/>
<variable name="Vfgly" units="molar_per_minute" public_interface="in"/>
<variable name="AMP" units="molar" public_interface="in"/>
<variable name="G1P" units="molar" public_interface="in"/>
<variable name="Gly" units="molar" public_interface="in"/>
<variable name="Pi" units="molar" public_interface="in"/>
<variable name="Kapp_GP" units="dimensionless" public_interface="in"/>
<variable name="pH_cy" units="dimensionless" public_interface="in"/>
<variable name="Par_10" units="molar" public_interface="in"/>
<variable name="Par_11" units="molar" public_interface="in"/>
<variable name="Par_12" units="molar" public_interface="in"/>
<variable name="Par_13" units="molar" public_interface="in"/>
<variable name="Par_14" units="molar" public_interface="in"/>
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<variable name="Par_16" units="molar" public_interface="in"/>
<variable name="Par_17" units="dimensionless" public_interface="in"/>
<variable name="Par_18" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>fracB</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fracA</ci>
</apply>
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<eq/>
<ci>KgpB_pi</ci>
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<eq/>
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<eq/>
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<ci>Par_12</ci>
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<eq/>
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<ci>Par_13</ci>
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<eq/>
<ci>KgpB_ig1p</ci>
<ci>Par_14</ci>
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<eq/>
<ci>KgpB_iglyb</ci>
<ci>Par_15</ci>
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<eq/>
<ci>Kgp_amp</ci>
<ci>Par_16</ci>
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<apply>
<eq/>
<ci>interactioncoeff</ci>
<ci>Par_17</ci>
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<eq/>
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<ci>Par_18</ci>
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<eq/>
<ci>M</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<power/>
<apply>
<divide/>
<ci>AMP</ci>
<ci>Kgp_amp</ci>
</apply>
<ci>nH</ci>
</apply>
<ci>interactioncoeff</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<power/>
<apply>
<divide/>
<ci>AMP</ci>
<ci>Kgp_amp</ci>
</apply>
<ci>nH</ci>
</apply>
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</apply>
</apply>
</apply>
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<apply>
<eq/>
<ci>Dglyb</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Gly</ci>
<ci>KgpB_iglyf</ci>
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<divide/>
<ci>Pi</ci>
<ci>KgpB_ipi</ci>
</apply>
<apply>
<divide/>
<ci>Gly</ci>
<ci>KgpB_iglyb</ci>
</apply>
<apply>
<divide/>
<ci>G1P</ci>
<ci>KgpB_ig1p</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Gly</ci>
<ci>Pi</ci>
</apply>
<apply>
<times/>
<ci>KgpB_iglyf</ci>
<ci>KgpB_pi</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Gly</ci>
<ci>G1P</ci>
</apply>
<apply>
<times/>
<ci>KgpB_g1p</ci>
<ci>KgpB_iglyb</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pb</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.75</cn>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">6.12</cn>
<ci>pH_cy</ci>
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</apply>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
<cn cellml:units="dimensionless">7.03</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>VbglyB</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>pb</ci>
<ci>Vfgly</ci>
<ci>KgpB_g1p</ci>
<ci>KgpB_iglyb</ci>
</apply>
<apply>
<times/>
<ci>KgpB_iglyf</ci>
<ci>KgpB_pi</ci>
<ci>Kapp_GP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>glyBF</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>pb</ci>
<ci>M</ci>
<ci>Vfgly</ci>
<ci>Pi</ci>
</apply>
<apply>
<times/>
<ci>KgpB_iglyf</ci>
<ci>KgpB_pi</ci>
</apply>
</apply>
<ci>Dglyb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>glyBR</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>M</ci>
<ci>VbglyB</ci>
<ci>Gly</ci>
</apply>
<apply>
<times/>
<ci>KgpB_g1p</ci>
<ci>KgpB_iglyb</ci>
</apply>
</apply>
<ci>Dglyb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>flux_GPb</ci>
<apply>
<times/>
<ci>fracB</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Gly</ci>
<ci>glyBF</ci>
</apply>
<apply>
<times/>
<ci>G1P</ci>
<ci>glyBR</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="PGLM">
<variable name="Vffpglm" units="molar_per_minute"/>
<variable name="Kpglm_g1p" units="molar"/>
<variable name="Kpglm_g6p" units="molar"/>
<variable name="Vfpglm" units="molar_per_minute"/>
<variable name="Vbpglm" units="molar_per_minute"/>
<variable name="v_PGLM" units="molar_per_minute" public_interface="out"/>
<variable name="pH_cy" units="dimensionless" public_interface="in"/>
<variable name="Kapp_PGLM" units="dimensionless" public_interface="in"/>
<variable name="G1P" units="molar" public_interface="in"/>
<variable name="G6P" units="molar" public_interface="in"/>
<variable name="Par_19" units="molar_per_minute" public_interface="in"/>
<variable name="Par_20" units="molar" public_interface="in"/>
<variable name="Par_21" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vffpglm</ci>
<ci>Par_19</ci>
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<apply>
<eq/>
<ci>Kpglm_g1p</ci>
<ci>Par_20</ci>
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<eq/>
<ci>Kpglm_g6p</ci>
<ci>Par_21</ci>
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<apply>
<eq/>
<ci>Vfpglm</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vffpglm</ci>
<cn cellml:units="dimensionless">1.329</cn>
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<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<cn cellml:units="dimensionless">6.64</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
<cn cellml:units="dimensionless">8.36</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Vbpglm</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfpglm</ci>
<ci>Kpglm_g6p</ci>
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<apply>
<times/>
<ci>Kpglm_g1p</ci>
<ci>Kapp_PGLM</ci>
</apply>
</apply>
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<apply>
<eq/>
<ci>v_PGLM</ci>
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<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfpglm</ci>
<ci>G1P</ci>
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<ci>Kpglm_g1p</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbpglm</ci>
<ci>G6P</ci>
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<ci>Kpglm_g6p</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>G1P</ci>
<ci>Kpglm_g1p</ci>
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<divide/>
<ci>G6P</ci>
<ci>Kpglm_g6p</ci>
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</apply>
</apply>
</math>
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<variable name="Vbbpgi" units="molar_per_minute"/>
<variable name="Kpgi_g6p" units="molar"/>
<variable name="Kpgi_f6p" units="molar"/>
<variable name="Vbpgi" units="molar_per_minute"/>
<variable name="Vfpgi" units="molar_per_minute"/>
<variable name="v_PGI" units="molar_per_minute" public_interface="out"/>
<variable name="pH_cy" units="dimensionless" public_interface="in"/>
<variable name="Kapp_PGI" units="dimensionless" public_interface="in"/>
<variable name="F6P" units="molar" public_interface="in"/>
<variable name="G6P" units="molar" public_interface="in"/>
<variable name="Par_22" units="molar_per_minute" public_interface="in"/>
<variable name="Par_23" units="molar" public_interface="in"/>
<variable name="Par_24" units="molar" public_interface="in"/>
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<eq/>
<ci>Vbbpgi</ci>
<ci>Par_22</ci>
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<eq/>
<ci>Kpgi_g6p</ci>
<ci>Par_23</ci>
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<eq/>
<ci>Kpgi_f6p</ci>
<ci>Par_24</ci>
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<eq/>
<ci>Vbpgi</ci>
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<divide/>
<ci>Vbbpgi</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<power/>
<cn cellml:units="dimensionless">10</cn>
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<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
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<cn cellml:units="dimensionless">6.94</cn>
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<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
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<ci>Vfpgi</ci>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbpgi</ci>
<ci>Kpgi_g6p</ci>
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<ci>Kpgi_f6p</ci>
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<ci>Kapp_PGI</ci>
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<ci>v_PGI</ci>
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<divide/>
<apply>
<minus/>
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<divide/>
<apply>
<times/>
<ci>Vfpgi</ci>
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<ci>Kpgi_g6p</ci>
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<divide/>
<apply>
<times/>
<ci>Vbpgi</ci>
<ci>F6P</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<divide/>
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<divide/>
<ci>G6P</ci>
<ci>Kpgi_g6p</ci>
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</math>
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<variable name="Kpfk_atpT" units="molar"/>
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<variable name="Kpfk_adpT" units="molar"/>
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<variable name="Vbpfk" units="molar_per_minute"/>
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<variable name="ATP" units="molar" public_interface="in"/>
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<variable name="Par_27" units="molar" public_interface="in"/>
<variable name="Par_28" units="molar" public_interface="in"/>
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<variable name="Par_30" units="molar" public_interface="in"/>
<variable name="Par_31" units="molar" public_interface="in"/>
<variable name="Par_32" units="molar" public_interface="in"/>
<variable name="Par_33" units="molar" public_interface="in"/>
<variable name="Par_34" units="molar" public_interface="in"/>
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<variable name="Par_36" units="dimensionless" public_interface="in"/>
<variable name="Par_37" units="dimensionless" public_interface="in"/>
<variable name="Par_38" units="dimensionless" public_interface="in"/>
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<eq/>
<ci>Vffpfk</ci>
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<eq/>
<ci>Kpfk_f6p</ci>
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<eq/>
<ci>Kpfk_f6pT</ci>
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<eq/>
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<eq/>
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<eq/>
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<eq/>
<ci>Kpfk_fbpT</ci>
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<eq/>
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<eq/>
<ci>Kpfk_adpT</ci>
<ci>Par_33</ci>
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<eq/>
<ci>Kpfki</ci>
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<eq/>
<ci>Kmpfk</ci>
<ci>Par_35</ci>
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<eq/>
<ci>d</ci>
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<eq/>
<ci>e_</ci>
<ci>Par_37</ci>
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<eq/>
<ci>Lo</ci>
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<eq/>
<ci>Vfpfk</ci>
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<divide/>
<ci>Vffpfk</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<power/>
<apply>
<divide/>
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<minus/>
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<apply>
<eq/>
<ci>Vbpfk</ci>
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<divide/>
<apply>
<times/>
<ci>Vfpfk</ci>
<ci>Kpfk_fbp</ci>
<ci>Kpfk_adp</ci>
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<times/>
<ci>Kpfk_f6p</ci>
<ci>Kpfk_atp</ci>
<ci>Kapp_PFK</ci>
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<ci>L</ci>
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<times/>
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<power/>
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<divide/>
<apply>
<times/>
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<divide/>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<divide/>
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<plus/>
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<divide/>
<apply>
<times/>
<ci>d</ci>
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<ci>Kpfki</ci>
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<plus/>
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<divide/>
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<times/>
<ci>e_</ci>
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<ci>Kmpfk</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<divide/>
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<ci>Kmpfk</ci>
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<cn cellml:units="dimensionless">4</cn>
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<eq/>
<ci>alpha</ci>
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<divide/>
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<times/>
<ci>Kpfk_f6p</ci>
<ci>Kpfk_atp</ci>
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<times/>
<ci>Kpfk_f6pT</ci>
<ci>Kpfk_atpT</ci>
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<eq/>
<ci>Delta</ci>
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<plus/>
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<times/>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<divide/>
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<ci>Kpfk_f6p</ci>
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<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>ATP</ci>
<ci>Kpfk_atp</ci>
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<apply>
<divide/>
<ci>FBP</ci>
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<times/>
<apply>
<divide/>
<ci>ADP</ci>
<ci>Kpfk_adp</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<divide/>
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<ci>Kpfk_fbp</ci>
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<apply>
<eq/>
<ci>Deltap</ci>
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<plus/>
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<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
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<divide/>
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<ci>Kpfk_f6pT</ci>
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<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>ATP</ci>
<ci>Kpfk_atpT</ci>
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<apply>
<divide/>
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<ci>Kpfk_fbpT</ci>
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<apply>
<times/>
<apply>
<divide/>
<ci>ADP</ci>
<ci>Kpfk_adpT</ci>
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<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
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<divide/>
<ci>FBP</ci>
<ci>Kpfk_fbpT</ci>
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<eq/>
<ci>v_PFK</ci>
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<divide/>
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<times/>
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<minus/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfpfk</ci>
<ci>F6P</ci>
<ci>ATP</ci>
</apply>
<apply>
<times/>
<ci>Kpfk_f6p</ci>
<ci>Kpfk_atp</ci>
</apply>
</apply>
<ci>Delta</ci>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbpfk</ci>
<ci>ADP</ci>
<ci>FBP</ci>
</apply>
<apply>
<times/>
<ci>Kpfk_adp</ci>
<ci>Kpfk_fbp</ci>
</apply>
</apply>
<ci>Delta</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>alpha</ci>
<ci>L</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Deltap</ci>
<ci>Delta</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>L</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Deltap</ci>
<ci>Delta</ci>
</apply>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="ALD">
<variable name="Vffald" units="molar_per_minute"/>
<variable name="Kald_fbp" units="molar"/>
<variable name="Kald_dhap" units="molar"/>
<variable name="Kald_gap" units="molar"/>
<variable name="Vfald" units="molar_per_minute"/>
<variable name="Vbald" units="molar_per_minute"/>
<variable name="v_ALD" units="molar_per_minute" public_interface="out"/>
<variable name="pH_cy" units="dimensionless" public_interface="in"/>
<variable name="Kapp_ALD" units="molar" public_interface="in"/>
<variable name="DHAP" units="molar" public_interface="in"/>
<variable name="FBP" units="molar" public_interface="in"/>
<variable name="GAP" units="molar" public_interface="in"/>
<variable name="Par_39" units="molar_per_minute" public_interface="in"/>
<variable name="Par_40" units="molar" public_interface="in"/>
<variable name="Par_41" units="molar" public_interface="in"/>
<variable name="Par_42" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vffald</ci>
<ci>Par_39</ci>
</apply>
<apply>
<eq/>
<ci>Kald_fbp</ci>
<ci>Par_40</ci>
</apply>
<apply>
<eq/>
<ci>Kald_dhap</ci>
<ci>Par_41</ci>
</apply>
<apply>
<eq/>
<ci>Kald_gap</ci>
<ci>Par_42</ci>
</apply>
<apply>
<eq/>
<ci>Vfald</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vffald</ci>
<cn cellml:units="dimensionless">1.013</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<cn cellml:units="dimensionless">5.32</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
<cn cellml:units="dimensionless">9.15</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Vbald</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfald</ci>
<ci>Kald_gap</ci>
<ci>Kald_dhap</ci>
</apply>
<apply>
<times/>
<ci>Kald_fbp</ci>
<ci>Kapp_ALD</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_ALD</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfald</ci>
<ci>FBP</ci>
</apply>
<ci>Kald_fbp</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbald</ci>
<ci>GAP</ci>
<ci>DHAP</ci>
</apply>
<apply>
<times/>
<ci>Kald_gap</ci>
<ci>Kald_dhap</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>FBP</ci>
<ci>Kald_fbp</ci>
</apply>
<apply>
<divide/>
<ci>GAP</ci>
<ci>Kald_gap</ci>
</apply>
<apply>
<divide/>
<ci>DHAP</ci>
<ci>Kald_dhap</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="TPI">
<variable name="Vfftpi" units="molar_per_minute"/>
<variable name="Ktpi_gap" units="molar"/>
<variable name="Ktpi_dhap" units="molar"/>
<variable name="Vftpi" units="molar_per_minute"/>
<variable name="Vbtpi" units="molar_per_minute"/>
<variable name="v_TPI" units="molar_per_minute" public_interface="out"/>
<variable name="Kapp_TPI" units="dimensionless" public_interface="in"/>
<variable name="DHAP" units="molar" public_interface="in"/>
<variable name="GAP" units="molar" public_interface="in"/>
<variable name="Par_43" units="molar_per_minute" public_interface="in"/>
<variable name="Par_44" units="molar" public_interface="in"/>
<variable name="Par_45" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vfftpi</ci>
<ci>Par_43</ci>
</apply>
<apply>
<eq/>
<ci>Ktpi_gap</ci>
<ci>Par_44</ci>
</apply>
<apply>
<eq/>
<ci>Ktpi_dhap</ci>
<ci>Par_45</ci>
</apply>
<apply>
<eq/>
<ci>Vftpi</ci>
<ci>Vfftpi</ci>
</apply>
<apply>
<eq/>
<ci>Vbtpi</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vftpi</ci>
<ci>Ktpi_dhap</ci>
</apply>
<apply>
<times/>
<ci>Ktpi_gap</ci>
<ci>Kapp_TPI</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_TPI</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vftpi</ci>
<ci>GAP</ci>
</apply>
<ci>Ktpi_gap</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbtpi</ci>
<ci>DHAP</ci>
</apply>
<ci>Ktpi_dhap</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>GAP</ci>
<ci>Ktpi_gap</ci>
</apply>
<apply>
<divide/>
<ci>DHAP</ci>
<ci>Ktpi_dhap</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="G3PDH">
<variable name="Vbbg3pdh" units="molar_per_minute"/>
<variable name="Kg3pdh_g3p" units="molar"/>
<variable name="Kg3pdh_nad" units="molar"/>
<variable name="Kg3pdh_dhap" units="molar"/>
<variable name="Kg3pdh_nadh" units="molar"/>
<variable name="Dg3pdh" units="dimensionless"/>
<variable name="Vbg3pdh" units="molar_per_minute"/>
<variable name="Vfg3pdh" units="molar_per_minute"/>
<variable name="v_G3PDH" units="molar_per_minute" public_interface="out"/>
<variable name="Kapp_G3PDH" units="dimensionless" public_interface="in"/>
<variable name="DHAP" units="molar" public_interface="in"/>
<variable name="G3P" units="molar" public_interface="in"/>
<variable name="NAD" units="molar" public_interface="in"/>
<variable name="NADH" units="molar" public_interface="in"/>
<variable name="Par_46" units="molar_per_minute" public_interface="in"/>
<variable name="Par_47" units="molar" public_interface="in"/>
<variable name="Par_48" units="molar" public_interface="in"/>
<variable name="Par_49" units="molar" public_interface="in"/>
<variable name="Par_50" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vbbg3pdh</ci>
<ci>Par_46</ci>
</apply>
<apply>
<eq/>
<ci>Kg3pdh_g3p</ci>
<ci>Par_47</ci>
</apply>
<apply>
<eq/>
<ci>Kg3pdh_nad</ci>
<ci>Par_48</ci>
</apply>
<apply>
<eq/>
<ci>Kg3pdh_dhap</ci>
<ci>Par_49</ci>
</apply>
<apply>
<eq/>
<ci>Kg3pdh_nadh</ci>
<ci>Par_50</ci>
</apply>
<apply>
<eq/>
<ci>Dg3pdh</ci>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>G3P</ci>
<ci>Kg3pdh_g3p</ci>
</apply>
<apply>
<divide/>
<ci>NADH</ci>
<ci>Kg3pdh_nadh</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>DHAP</ci>
<ci>Kg3pdh_dhap</ci>
</apply>
<apply>
<divide/>
<ci>NAD</ci>
<ci>Kg3pdh_nadh</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Vbg3pdh</ci>
<ci>Vbbg3pdh</ci>
</apply>
<apply>
<eq/>
<ci>Vfg3pdh</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbg3pdh</ci>
<ci>Kg3pdh_g3p</ci>
<ci>Kg3pdh_nad</ci>
<ci>Kapp_G3PDH</ci>
</apply>
<apply>
<times/>
<ci>Kg3pdh_dhap</ci>
<ci>Kg3pdh_nadh</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_G3PDH</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfg3pdh</ci>
<ci>G3P</ci>
<ci>NAD</ci>
</apply>
<apply>
<times/>
<ci>Kg3pdh_g3p</ci>
<ci>Kg3pdh_nad</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbg3pdh</ci>
<ci>DHAP</ci>
<ci>NADH</ci>
</apply>
<apply>
<times/>
<ci>Kg3pdh_dhap</ci>
<ci>Kg3pdh_nadh</ci>
</apply>
</apply>
</apply>
<ci>Dg3pdh</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="GAPDH">
<variable name="Vffgad" units="molar_per_minute"/>
<variable name="Kgapdh_gap" units="molar"/>
<variable name="Kgapdh_nad" units="molar"/>
<variable name="Kgapdh_pi" units="molar"/>
<variable name="Kgapdh_bpg" units="molar"/>
<variable name="Kgapdh_nadh" units="molar"/>
<variable name="Dgap" units="dimensionless"/>
<variable name="Vfgad" units="molar_per_minute"/>
<variable name="Vbgad" units="molar_per_minute"/>
<variable name="v_GAPDH" units="molar_per_minute" public_interface="out"/>
<variable name="pH_cy" units="dimensionless" public_interface="in"/>
<variable name="Kapp_GAPDH" units="per_molar" public_interface="in"/>
<variable name="BPG" units="molar" public_interface="in"/>
<variable name="GAP" units="molar" public_interface="in"/>
<variable name="NAD" units="molar" public_interface="in"/>
<variable name="NADH" units="molar" public_interface="in"/>
<variable name="Pi" units="molar" public_interface="in"/>
<variable name="Par_51" units="molar_per_minute" public_interface="in"/>
<variable name="Par_52" units="molar" public_interface="in"/>
<variable name="Par_53" units="molar" public_interface="in"/>
<variable name="Par_54" units="molar" public_interface="in"/>
<variable name="Par_55" units="molar" public_interface="in"/>
<variable name="Par_56" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vffgad</ci>
<ci>Par_51</ci>
</apply>
<apply>
<eq/>
<ci>Kgapdh_gap</ci>
<ci>Par_52</ci>
</apply>
<apply>
<eq/>
<ci>Kgapdh_nad</ci>
<ci>Par_53</ci>
</apply>
<apply>
<eq/>
<ci>Kgapdh_pi</ci>
<ci>Par_54</ci>
</apply>
<apply>
<eq/>
<ci>Kgapdh_bpg</ci>
<ci>Par_55</ci>
</apply>
<apply>
<eq/>
<ci>Kgapdh_nadh</ci>
<ci>Par_56</ci>
</apply>
<apply>
<eq/>
<ci>Dgap</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Pi</ci>
<ci>Kgapdh_pi</ci>
</apply>
<apply>
<divide/>
<ci>GAP</ci>
<ci>Kgapdh_gap</ci>
</apply>
<apply>
<divide/>
<ci>NAD</ci>
<ci>Kgapdh_nad</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>GAP</ci>
<ci>NAD</ci>
</apply>
<apply>
<times/>
<ci>Kgapdh_gap</ci>
<ci>Kgapdh_nad</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>GAP</ci>
<ci>NAD</ci>
<ci>Pi</ci>
</apply>
<apply>
<times/>
<ci>Kgapdh_gap</ci>
<ci>Kgapdh_nad</ci>
<ci>Kgapdh_pi</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>BPG</ci>
<ci>Kgapdh_bpg</ci>
</apply>
<apply>
<divide/>
<ci>NADH</ci>
<ci>Kgapdh_nadh</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>BPG</ci>
<ci>NADH</ci>
</apply>
<apply>
<times/>
<ci>Kgapdh_nadh</ci>
<ci>Kgapdh_bpg</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Vfgad</ci>
<apply>
<times/>
<ci>Vffgad</ci>
<cn cellml:units="dimensionless">0.0007</cn>
<apply>
<exp/>
<apply>
<times/>
<ci>pH_cy</ci>
<cn cellml:units="dimensionless">0.8979</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Vbgad</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfgad</ci>
<ci>Kgapdh_bpg</ci>
<ci>Kgapdh_nadh</ci>
</apply>
<apply>
<times/>
<ci>Kgapdh_gap</ci>
<ci>Kgapdh_pi</ci>
<ci>Kgapdh_nad</ci>
<ci>Kapp_GAPDH</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_GAPDH</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfgad</ci>
<ci>GAP</ci>
<ci>NAD</ci>
<ci>Pi</ci>
</apply>
<apply>
<times/>
<ci>Kgapdh_nad</ci>
<ci>Kgapdh_gap</ci>
<ci>Kgapdh_pi</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbgad</ci>
<ci>BPG</ci>
<ci>NADH</ci>
</apply>
<apply>
<times/>
<ci>Kgapdh_bpg</ci>
<ci>Kgapdh_nadh</ci>
</apply>
</apply>
</apply>
<ci>Dgap</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="PGK">
<variable name="Vbbpgk" units="molar_per_minute"/>
<variable name="Kpgk_bpg" units="molar"/>
<variable name="Kpgk_adp" units="molar"/>
<variable name="Kpgk_3pg" units="molar"/>
<variable name="Kpgk_atp" units="molar"/>
<variable name="Vbpgk" units="molar_per_minute"/>
<variable name="Vfpgk" units="molar_per_minute"/>
<variable name="D_PGK" units="dimensionless"/>
<variable name="v_PGK" units="molar_per_minute" public_interface="out"/>
<variable name="Kapp_PGK" units="dimensionless" public_interface="in"/>
<variable name="BPG" units="molar" public_interface="in"/>
<variable name="P3G" units="molar" public_interface="in"/>
<variable name="ADP" units="molar" public_interface="in"/>
<variable name="ATP" units="molar" public_interface="in"/>
<variable name="Par_57" units="molar_per_minute" public_interface="in"/>
<variable name="Par_58" units="molar" public_interface="in"/>
<variable name="Par_59" units="molar" public_interface="in"/>
<variable name="Par_60" units="molar" public_interface="in"/>
<variable name="Par_61" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vbbpgk</ci>
<ci>Par_57</ci>
</apply>
<apply>
<eq/>
<ci>Kpgk_bpg</ci>
<ci>Par_58</ci>
</apply>
<apply>
<eq/>
<ci>Kpgk_adp</ci>
<ci>Par_59</ci>
</apply>
<apply>
<eq/>
<ci>Kpgk_3pg</ci>
<ci>Par_60</ci>
</apply>
<apply>
<eq/>
<ci>Kpgk_atp</ci>
<ci>Par_61</ci>
</apply>
<apply>
<eq/>
<ci>Vbpgk</ci>
<ci>Vbbpgk</ci>
</apply>
<apply>
<eq/>
<ci>Vfpgk</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbpgk</ci>
<ci>Kpgk_bpg</ci>
<ci>Kpgk_adp</ci>
</apply>
<apply>
<times/>
<ci>Kpgk_3pg</ci>
<ci>Kpgk_atp</ci>
</apply>
</apply>
<ci>Kapp_PGK</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>D_PGK</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>ADP</ci>
<ci>Kpgk_adp</ci>
</apply>
<apply>
<divide/>
<ci>BPG</ci>
<ci>Kpgk_bpg</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>BPG</ci>
<ci>ADP</ci>
</apply>
<apply>
<times/>
<ci>Kpgk_bpg</ci>
<ci>Kpgk_adp</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>P3G</ci>
<ci>Kpgk_3pg</ci>
</apply>
<apply>
<divide/>
<ci>ATP</ci>
<ci>Kpgk_atp</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>P3G</ci>
<ci>ATP</ci>
</apply>
<apply>
<times/>
<ci>Kpgk_3pg</ci>
<ci>Kpgk_atp</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_PGK</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfpgk</ci>
<ci>BPG</ci>
<ci>ADP</ci>
</apply>
<apply>
<times/>
<ci>Kpgk_adp</ci>
<ci>Kpgk_bpg</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbpgk</ci>
<ci>ATP</ci>
<ci>P3G</ci>
</apply>
<apply>
<times/>
<ci>Kpgk_atp</ci>
<ci>Kpgk_3pg</ci>
</apply>
</apply>
</apply>
<ci>D_PGK</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="PGM">
<variable name="Vffpgm" units="molar_per_minute"/>
<variable name="Kpgm_3pg" units="molar"/>
<variable name="Kpgm_2pg" units="molar"/>
<variable name="Vfpgm" units="molar_per_minute"/>
<variable name="Vbpgm" units="molar_per_minute"/>
<variable name="v_PGM" units="molar_per_minute" public_interface="out"/>
<variable name="pH_cy" units="dimensionless" public_interface="in"/>
<variable name="Kapp_PGM" units="dimensionless" public_interface="in"/>
<variable name="P2G" units="molar" public_interface="in"/>
<variable name="P3G" units="molar" public_interface="in"/>
<variable name="Par_62" units="molar_per_minute" public_interface="in"/>
<variable name="Par_63" units="molar" public_interface="in"/>
<variable name="Par_64" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vffpgm</ci>
<ci>Par_62</ci>
</apply>
<apply>
<eq/>
<ci>Kpgm_3pg</ci>
<ci>Par_63</ci>
</apply>
<apply>
<eq/>
<ci>Kpgm_2pg</ci>
<ci>Par_64</ci>
</apply>
<apply>
<eq/>
<ci>Vfpgm</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vffpgm</ci>
<cn cellml:units="dimensionless">0.989</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<cn cellml:units="dimensionless">5.62</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
<cn cellml:units="dimensionless">8.74</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Vbpgm</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfpgm</ci>
<ci>Kpgm_2pg</ci>
</apply>
<apply>
<times/>
<ci>Kpgm_3pg</ci>
<ci>Kapp_PGM</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_PGM</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfpgm</ci>
<ci>P3G</ci>
</apply>
<ci>Kpgm_3pg</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbpgm</ci>
<ci>P2G</ci>
</apply>
<ci>Kpgm_2pg</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>P3G</ci>
<ci>Kpgm_3pg</ci>
</apply>
<apply>
<divide/>
<ci>P2G</ci>
<ci>Kpgm_2pg</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="ENOL">
<variable name="Vffen" units="molar_per_minute"/>
<variable name="Ken_2pg" units="molar"/>
<variable name="Ken_pep" units="molar"/>
<variable name="Vfen" units="molar_per_minute"/>
<variable name="Vben" units="molar_per_minute"/>
<variable name="v_ENOL" units="molar_per_minute" public_interface="out"/>
<variable name="Kapp_ENOL" units="dimensionless" public_interface="in"/>
<variable name="P2G" units="molar" public_interface="in"/>
<variable name="PEP" units="molar" public_interface="in"/>
<variable name="Par_65" units="molar_per_minute" public_interface="in"/>
<variable name="Par_66" units="molar" public_interface="in"/>
<variable name="Par_67" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vffen</ci>
<ci>Par_65</ci>
</apply>
<apply>
<eq/>
<ci>Ken_2pg</ci>
<ci>Par_66</ci>
</apply>
<apply>
<eq/>
<ci>Ken_pep</ci>
<ci>Par_67</ci>
</apply>
<apply>
<eq/>
<ci>Vfen</ci>
<ci>Vffen</ci>
</apply>
<apply>
<eq/>
<ci>Vben</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfen</ci>
<ci>Ken_pep</ci>
</apply>
<apply>
<times/>
<ci>Ken_2pg</ci>
<ci>Kapp_ENOL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_ENOL</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfen</ci>
<ci>P2G</ci>
</apply>
<ci>Ken_2pg</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vben</ci>
<ci>PEP</ci>
</apply>
<ci>Ken_pep</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>PEP</ci>
<ci>Ken_pep</ci>
</apply>
<apply>
<divide/>
<ci>P2G</ci>
<ci>Ken_2pg</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="PK">
<variable name="Vffpk" units="molar_per_minute"/>
<variable name="Kpk_pep" units="molar"/>
<variable name="Kpk_adp" units="molar"/>
<variable name="Kpk_pyr" units="molar"/>
<variable name="Kpk_atp" units="molar"/>
<variable name="Vfpk" units="molar_per_minute"/>
<variable name="Vbpk" units="molar_per_minute"/>
<variable name="v_PK" units="molar_per_minute" public_interface="out"/>
<variable name="pH_cy" units="dimensionless" public_interface="in"/>
<variable name="Kapp_PK" units="dimensionless" public_interface="in"/>
<variable name="PEP" units="molar" public_interface="in"/>
<variable name="PYR" units="molar" public_interface="in"/>
<variable name="ADP" units="molar" public_interface="in"/>
<variable name="ATP" units="molar" public_interface="in"/>
<variable name="Par_68" units="molar_per_minute" public_interface="in"/>
<variable name="Par_69" units="molar" public_interface="in"/>
<variable name="Par_70" units="molar" public_interface="in"/>
<variable name="Par_71" units="molar" public_interface="in"/>
<variable name="Par_72" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vffpk</ci>
<ci>Par_68</ci>
</apply>
<apply>
<eq/>
<ci>Kpk_pep</ci>
<ci>Par_69</ci>
</apply>
<apply>
<eq/>
<ci>Kpk_adp</ci>
<ci>Par_70</ci>
</apply>
<apply>
<eq/>
<ci>Kpk_pyr</ci>
<ci>Par_71</ci>
</apply>
<apply>
<eq/>
<ci>Kpk_atp</ci>
<ci>Par_72</ci>
</apply>
<apply>
<eq/>
<ci>Vfpk</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vffpk</ci>
<cn cellml:units="dimensionless">1.05</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<cn cellml:units="dimensionless">5.58</cn>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
<cn cellml:units="dimensionless">8.79</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Vbpk</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfpk</ci>
<ci>Kpk_pyr</ci>
<ci>Kpk_atp</ci>
</apply>
<apply>
<times/>
<ci>Kpk_pep</ci>
<ci>Kpk_adp</ci>
<ci>Kapp_PK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_PK</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfpk</ci>
<ci>PEP</ci>
<ci>ADP</ci>
</apply>
<apply>
<times/>
<ci>Kpk_pep</ci>
<ci>Kpk_adp</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbpk</ci>
<ci>PYR</ci>
<ci>ATP</ci>
</apply>
<apply>
<times/>
<ci>Kpk_pyr</ci>
<ci>Kpk_atp</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>PEP</ci>
<ci>Kpk_pep</ci>
</apply>
<apply>
<divide/>
<ci>ADP</ci>
<ci>Kpk_adp</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>PEP</ci>
<ci>ADP</ci>
</apply>
<apply>
<times/>
<ci>Kpk_pep</ci>
<ci>Kpk_adp</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>ATP</ci>
<ci>Kpk_atp</ci>
</apply>
<apply>
<divide/>
<ci>PYR</ci>
<ci>Kpk_pyr</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>PYR</ci>
<ci>ATP</ci>
</apply>
<apply>
<times/>
<ci>Kpk_pyr</ci>
<ci>Kpk_atp</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="LDH">
<variable name="Vffldh" units="molar_per_minute"/>
<variable name="Kldh_pyr" units="molar"/>
<variable name="Kldh_nadh" units="molar"/>
<variable name="Kldh_lac" units="molar"/>
<variable name="Kldh_nad" units="molar"/>
<variable name="Vfldh" units="molar_per_minute"/>
<variable name="Vbldh" units="molar_per_minute"/>
<variable name="v_LDH" units="molar_per_minute" public_interface="out"/>
<variable name="pH_cy" units="dimensionless" public_interface="in"/>
<variable name="Kapp_LDH" units="dimensionless" public_interface="in"/>
<variable name="LAC" units="molar" public_interface="in"/>
<variable name="NAD" units="molar" public_interface="in"/>
<variable name="NADH" units="molar" public_interface="in"/>
<variable name="PYR" units="molar" public_interface="in"/>
<variable name="Par_73" units="molar_per_minute" public_interface="in"/>
<variable name="Par_74" units="molar" public_interface="in"/>
<variable name="Par_75" units="molar" public_interface="in"/>
<variable name="Par_76" units="molar" public_interface="in"/>
<variable name="Par_77" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vffldh</ci>
<ci>Par_73</ci>
</apply>
<apply>
<eq/>
<ci>Kldh_pyr</ci>
<ci>Par_74</ci>
</apply>
<apply>
<eq/>
<ci>Kldh_nadh</ci>
<ci>Par_75</ci>
</apply>
<apply>
<eq/>
<ci>Kldh_lac</ci>
<ci>Par_76</ci>
</apply>
<apply>
<eq/>
<ci>Kldh_nad</ci>
<ci>Par_77</ci>
</apply>
<apply>
<eq/>
<ci>Vfldh</ci>
<apply>
<times/>
<ci>Vffldh</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1134</cn>
</apply>
<ci>pH_cy</ci>
</apply>
<cn cellml:units="dimensionless">1.6069</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Vbldh</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfldh</ci>
<ci>Kldh_lac</ci>
<ci>Kldh_nad</ci>
</apply>
<apply>
<times/>
<ci>Kldh_pyr</ci>
<ci>Kldh_nadh</ci>
<ci>Kapp_LDH</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_LDH</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfldh</ci>
<ci>PYR</ci>
<ci>NADH</ci>
</apply>
<apply>
<times/>
<ci>Kldh_pyr</ci>
<ci>Kldh_nadh</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vbldh</ci>
<ci>LAC</ci>
<ci>NAD</ci>
</apply>
<apply>
<times/>
<ci>Kldh_lac</ci>
<ci>Kldh_nad</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>PYR</ci>
<ci>Kldh_pyr</ci>
</apply>
<apply>
<divide/>
<ci>NADH</ci>
<ci>Kldh_nadh</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>PYR</ci>
<ci>NADH</ci>
</apply>
<apply>
<times/>
<ci>Kldh_pyr</ci>
<ci>Kldh_nadh</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>LAC</ci>
<ci>Kldh_lac</ci>
</apply>
<apply>
<divide/>
<ci>NAD</ci>
<ci>Kldh_nad</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>LAC</ci>
<ci>NAD</ci>
</apply>
<apply>
<times/>
<ci>Kldh_lac</ci>
<ci>Kldh_nad</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="ATPase">
<variable name="VmaxATPase" units="molar_per_minute"/>
<variable name="Katp_ATPase" units="molar"/>
<variable name="ATPase" units="molar_per_minute" public_interface="out"/>
<variable name="time" units="minute" public_interface="in"/>
<variable name="ATP" units="molar" public_interface="in"/>
<variable name="expno" units="dimensionless" public_interface="in"/>
<variable name="Par_88" units="molar_per_minute" public_interface="in"/>
<variable name="Par_89" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>VmaxATPase</ci>
<piecewise>
<piece>
<ci>Par_88</ci>
<apply>
<and/>
<apply>
<neq/>
<ci>expno</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<neq/>
<ci>expno</ci>
<cn cellml:units="dimensionless">45</cn>
</apply>
</apply>
</piece>
<piece>
<ci>Par_88</ci>
<apply>
<and/>
<apply>
<neq/>
<ci>expno</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>expno</ci>
<cn cellml:units="dimensionless">45</cn>
</apply>
<apply>
<geq/>
<ci>time</ci>
<cn cellml:units="minute">110</cn>
</apply>
</apply>
</piece>
<piece>
<ci>Par_88</ci>
<apply>
<and/>
<apply>
<eq/>
<ci>expno</ci>
<cn cellml:units="dimensionless">5</cn>
</apply>
<apply>
<gt/>
<ci>time</ci>
<cn cellml:units="minute">30</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="molar_per_minute">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>Katp_ATPase</ci>
<ci>Par_89</ci>
</apply>
<apply>
<eq/>
<ci>ATPase</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>VmaxATPase</ci>
<ci>ATP</ci>
</apply>
<apply>
<plus/>
<ci>Katp_ATPase</ci>
<ci>ATP</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="creatine_kinase">
<variable name="VforCK" units="molar_per_minute"/>
<variable name="Kck_pcr" units="molar"/>
<variable name="Kck_iatp" units="molar"/>
<variable name="Kck_iadp" units="molar"/>
<variable name="Kck_ipcr" units="molar"/>
<variable name="Kck_cr" units="molar"/>
<variable name="VrevCK" units="molar_per_minute"/>
<variable name="CK" units="molar_per_minute" public_interface="out"/>
<variable name="Kapp_CK" units="dimensionless" public_interface="in"/>
<variable name="ADP" units="molar" public_interface="in"/>
<variable name="ATP" units="molar" public_interface="in"/>
<variable name="Cr" units="molar" public_interface="in"/>
<variable name="PCr" units="molar" public_interface="in"/>
<variable name="Par_78" units="molar_per_minute" public_interface="in"/>
<variable name="Par_79" units="molar" public_interface="in"/>
<variable name="Par_80" units="molar" public_interface="in"/>
<variable name="Par_81" units="molar" public_interface="in"/>
<variable name="Par_82" units="molar" public_interface="in"/>
<variable name="Par_83" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>VforCK</ci>
<ci>Par_78</ci>
</apply>
<apply>
<eq/>
<ci>Kck_pcr</ci>
<ci>Par_79</ci>
</apply>
<apply>
<eq/>
<ci>Kck_iatp</ci>
<ci>Par_80</ci>
</apply>
<apply>
<eq/>
<ci>Kck_iadp</ci>
<ci>Par_81</ci>
</apply>
<apply>
<eq/>
<ci>Kck_ipcr</ci>
<ci>Par_82</ci>
</apply>
<apply>
<eq/>
<ci>Kck_cr</ci>
<ci>Par_83</ci>
</apply>
<apply>
<eq/>
<ci>VrevCK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>VforCK</ci>
<ci>Kapp_CK</ci>
</apply>
<ci>Kck_iatp</ci>
<ci>Kck_cr</ci>
</apply>
<apply>
<times/>
<ci>Kck_iadp</ci>
<ci>Kck_pcr</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CK</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>VrevCK</ci>
<ci>ATP</ci>
<ci>Cr</ci>
</apply>
<apply>
<times/>
<ci>Kck_iatp</ci>
<ci>Kck_cr</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>VforCK</ci>
<ci>ADP</ci>
<ci>PCr</ci>
</apply>
<apply>
<times/>
<ci>Kck_iadp</ci>
<ci>Kck_pcr</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>ADP</ci>
<ci>Kck_iadp</ci>
</apply>
<apply>
<divide/>
<ci>PCr</ci>
<ci>Kck_ipcr</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>PCr</ci>
<ci>ADP</ci>
</apply>
<apply>
<times/>
<ci>Kck_iadp</ci>
<ci>Kck_pcr</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>ATP</ci>
<ci>Kck_iatp</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Cr</ci>
<ci>ATP</ci>
</apply>
<apply>
<times/>
<ci>Kck_cr</ci>
<ci>Kck_iatp</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="adenylate_kinase">
<variable name="Vfadk" units="molar_per_minute"/>
<variable name="Kadk_amp" units="molar"/>
<variable name="Kadk_atp" units="molar"/>
<variable name="Kadk_adp" units="molar"/>
<variable name="Vbadk" units="molar_per_minute"/>
<variable name="ADK" units="molar_per_minute" public_interface="out"/>
<variable name="Kapp_ADK" units="dimensionless" public_interface="in"/>
<variable name="AMP" units="molar" public_interface="in"/>
<variable name="ADP" units="molar" public_interface="in"/>
<variable name="ATP" units="molar" public_interface="in"/>
<variable name="Par_84" units="molar_per_minute" public_interface="in"/>
<variable name="Par_85" units="molar" public_interface="in"/>
<variable name="Par_86" units="molar" public_interface="in"/>
<variable name="Par_87" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vfadk</ci>
<ci>Par_84</ci>
</apply>
<apply>
<eq/>
<ci>Kadk_amp</ci>
<ci>Par_85</ci>
</apply>
<apply>
<eq/>
<ci>Kadk_atp</ci>
<ci>Par_86</ci>
</apply>
<apply>
<eq/>
<ci>Kadk_adp</ci>
<ci>Par_87</ci>
</apply>
<apply>
<eq/>
<ci>Vbadk</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfadk</ci>
<apply>
<power/>
<ci>Kadk_adp</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>Kadk_amp</ci>
<ci>Kadk_atp</ci>
<ci>Kapp_ADK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ADK</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vfadk</ci>
<ci>ATP</ci>
<ci>AMP</ci>
</apply>
<apply>
<times/>
<ci>Kadk_atp</ci>
<ci>Kadk_amp</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Vbadk</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>ADP</ci>
<ci>Kadk_adp</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>ATP</ci>
<ci>Kadk_atp</ci>
</apply>
<apply>
<divide/>
<ci>AMP</ci>
<ci>Kadk_amp</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>ATP</ci>
<ci>AMP</ci>
</apply>
<apply>
<times/>
<ci>Kadk_atp</ci>
<ci>Kadk_amp</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>ADP</ci>
</apply>
<ci>Kadk_adp</ci>
</apply>
<apply>
<divide/>
<apply>
<power/>
<ci>ADP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Kadk_adp</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="buffer_capacity">
<variable name="carnosine" units="molar"/>
<variable name="tris" units="molar"/>
<variable name="acetate" units="molar"/>
<variable name="bufcapfixed" units="molar"/>
<variable name="bufcapmetab" units="molar"/>
<variable name="protons_consumed" units="molar_per_minute" public_interface="out"/>
<variable name="CKprtflux" units="molar_per_minute"/>
<variable name="glycprtflux" units="molar_per_minute"/>
<variable name="pHODEterm1" units="per_minute" public_interface="out"/>
<variable name="pHODEterm2" units="per_molar" public_interface="out"/>
<variable name="denom_mgODE" units="dimensionless" public_interface="out"/>
<variable name="RHSterm1_mgODE" units="molar" public_interface="out"/>
<variable name="denomMgpHODE" units="dimensionless" public_interface="out"/>
<variable name="pH_cy" units="dimensionless" public_interface="in"/>
<variable name="PCr" units="molar" public_interface="in"/>
<variable name="Cr" units="molar" public_interface="in"/>
<variable name="NAD" units="molar" public_interface="in"/>
<variable name="NADH" units="molar" public_interface="in"/>
<variable name="ATP" units="molar" public_interface="in"/>
<variable name="ADP" units="molar" public_interface="in"/>
<variable name="AMP" units="molar" public_interface="in"/>
<variable name="Pi" units="molar" public_interface="in"/>
<variable name="Gly" units="molar" public_interface="in"/>
<variable name="G1P" units="molar" public_interface="in"/>
<variable name="G6P" units="molar" public_interface="in"/>
<variable name="F6P" units="molar" public_interface="in"/>
<variable name="FBP" units="molar" public_interface="in"/>
<variable name="DHAP" units="molar" public_interface="in"/>
<variable name="G3P" units="molar" public_interface="in"/>
<variable name="GAP" units="molar" public_interface="in"/>
<variable name="BPG" units="molar" public_interface="in"/>
<variable name="P3G" units="molar" public_interface="in"/>
<variable name="P2G" units="molar" public_interface="in"/>
<variable name="PEP" units="molar" public_interface="in"/>
<variable name="PYR" units="molar" public_interface="in"/>
<variable name="LAC" units="molar" public_interface="in"/>
<variable name="ADK" units="molar_per_minute" public_interface="in"/>
<variable name="CK" units="molar_per_minute" public_interface="in"/>
<variable name="dNavg13DPGdH" units="per_molar" public_interface="in"/>
<variable name="dNavg3PGdH" units="per_molar" public_interface="in"/>
<variable name="dNavg2PGdH" units="per_molar" public_interface="in"/>
<variable name="dNavgADPdH" units="per_molar" public_interface="in"/>
<variable name="dNavgAMPdH" units="per_molar" public_interface="in"/>
<variable name="dNavgATPdH" units="per_molar" public_interface="in"/>
<variable name="dNavgCRdH" units="per_molar" public_interface="in"/>
<variable name="dNavgDHAPdH" units="per_molar" public_interface="in"/>
<variable name="dNavgF6PdH" units="per_molar" public_interface="in"/>
<variable name="dNavgFDPdH" units="per_molar" public_interface="in"/>
<variable name="dNavgG1PdH" units="per_molar" public_interface="in"/>
<variable name="dNavgG3PdH" units="per_molar" public_interface="in"/>
<variable name="dNavgG6PdH" units="per_molar" public_interface="in"/>
<variable name="dNavgGAPdH" units="per_molar" public_interface="in"/>
<variable name="dNavgLACdH" units="per_molar" public_interface="in"/>
<variable name="dNavgPCRdH" units="per_molar" public_interface="in"/>
<variable name="dNavgPEPdH" units="per_molar" public_interface="in"/>
<variable name="dNavgPYRdH" units="per_molar" public_interface="in"/>
<variable name="dNavgPidH" units="per_molar" public_interface="in"/>
<variable name="deltaH_ADK" units="dimensionless" public_interface="in"/>
<variable name="deltaH_ALD" units="dimensionless" public_interface="in"/>
<variable name="deltaH_CK" units="dimensionless" public_interface="in"/>
<variable name="deltaH_ENOL" units="dimensionless" public_interface="in"/>
<variable name="deltaH_G3PDH" units="dimensionless" public_interface="in"/>
<variable name="deltaH_GAPDH" units="dimensionless" public_interface="in"/>
<variable name="deltaH_GP" units="dimensionless" public_interface="in"/>
<variable name="deltaH_LDH" units="dimensionless" public_interface="in"/>
<variable name="deltaH_PFK" units="dimensionless" public_interface="in"/>
<variable name="deltaH_PGI" units="dimensionless" public_interface="in"/>
<variable name="deltaH_PGK" units="dimensionless" public_interface="in"/>
<variable name="deltaH_PGLM" units="dimensionless" public_interface="in"/>
<variable name="deltaH_PGM" units="dimensionless" public_interface="in"/>
<variable name="deltaH_PK" units="dimensionless" public_interface="in"/>
<variable name="deltaH_TPI" units="dimensionless" public_interface="in"/>
<variable name="dNavg13DPGdmg" units="per_molar" public_interface="in"/>
<variable name="dNavg2PGdmg" units="per_molar" public_interface="in"/>
<variable name="dNavg3PGdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgADPdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgAMPdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgATPdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgCRdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgDHAPdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgF6Pdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgFDPdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgG1Pdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgG3Pdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgG6Pdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgGAPdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgLACdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgPCRdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgPEPdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgPYRdmg" units="per_molar" public_interface="in"/>
<variable name="dNavgPidmg" units="per_molar" public_interface="in"/>
<variable name="dmg2PGdmg" units="per_molar" public_interface="in"/>
<variable name="dmgATP2dmg" units="per_molar" public_interface="in"/>
<variable name="dmgADPdmg" units="per_molar" public_interface="in"/>
<variable name="dmgAMPdmg" units="per_molar" public_interface="in"/>
<variable name="dmgDHAPdmg" units="per_molar" public_interface="in"/>
<variable name="dmgFDPdmg" units="per_molar" public_interface="in"/>
<variable name="dmgG1Pdmg" units="per_molar" public_interface="in"/>
<variable name="dmgG3Pdmg" units="per_molar" public_interface="in"/>
<variable name="dmgLACdmg" units="per_molar" public_interface="in"/>
<variable name="dmgPCRdmg" units="per_molar" public_interface="in"/>
<variable name="dmgPEPdmg" units="per_molar" public_interface="in"/>
<variable name="dmgPidmg" units="per_molar" public_interface="in"/>
<variable name="dmg2PGdpH" units="dimensionless" public_interface="in"/>
<variable name="dmgADPdpH" units="dimensionless" public_interface="in"/>
<variable name="dmgAMPdpH" units="dimensionless" public_interface="in"/>
<variable name="dmgATP2dpH" units="dimensionless" public_interface="in"/>
<variable name="dmgDHAPdpH" units="dimensionless" public_interface="in"/>
<variable name="dmgFDPdpH" units="dimensionless" public_interface="in"/>
<variable name="dmgG1PdpH" units="dimensionless" public_interface="in"/>
<variable name="dmgG3PdpH" units="dimensionless" public_interface="in"/>
<variable name="dmgLACdpH" units="dimensionless" public_interface="in"/>
<variable name="dmgPCRdpH" units="dimensionless" public_interface="in"/>
<variable name="dmgPEPdpH" units="dimensionless" public_interface="in"/>
<variable name="dmgPidpH" units="dimensionless" public_interface="in"/>
<variable name="flux_GPa" units="molar_per_minute" public_interface="in"/>
<variable name="flux_GPb" units="molar_per_minute" public_interface="in"/>
<variable name="v_ALD" units="molar_per_minute" public_interface="in"/>
<variable name="v_ENOL" units="molar_per_minute" public_interface="in"/>
<variable name="v_G3PDH" units="molar_per_minute" public_interface="in"/>
<variable name="v_GAPDH" units="molar_per_minute" public_interface="in"/>
<variable name="v_LDH" units="molar_per_minute" public_interface="in"/>
<variable name="v_PFK" units="molar_per_minute" public_interface="in"/>
<variable name="v_PGI" units="molar_per_minute" public_interface="in"/>
<variable name="v_PGK" units="molar_per_minute" public_interface="in"/>
<variable name="v_PGLM" units="molar_per_minute" public_interface="in"/>
<variable name="v_PGM" units="molar_per_minute" public_interface="in"/>
<variable name="v_PK" units="molar_per_minute" public_interface="in"/>
<variable name="v_TPI" units="molar_per_minute" public_interface="in"/>
<variable name="c0" units="molar" public_interface="in"/>
<variable name="Par_91" units="molar" public_interface="in"/>
<variable name="Par_92" units="molar" public_interface="in"/>
<variable name="Par_93" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>carnosine</ci>
<ci>Par_92</ci>
</apply>
<apply>
<eq/>
<ci>tris</ci>
<ci>Par_91</ci>
</apply>
<apply>
<eq/>
<ci>acetate</ci>
<ci>Par_93</ci>
</apply>
<apply>
<eq/>
<ci>bufcapfixed</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>carnosine</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<cn cellml:units="dimensionless">6.87</cn>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">6.87</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>tris</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<cn cellml:units="dimensionless">8.3</cn>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">8.3</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<ci>acetate</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
<cn cellml:units="dimensionless">4.8</cn>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">4.8</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>bufcapmetab</ci>
<apply>
<times/>
<apply>
<ln/>
<cn cellml:units="dimensionless">10</cn>
</apply>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_cy</ci>
</apply>
</apply>
<ci>c0</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>dNavgPidH</ci>
<ci>Pi</ci>
</apply>
<apply>
<times/>
<ci>dNavgATPdH</ci>
<ci>ATP</ci>
</apply>
<apply>
<times/>
<ci>dNavgADPdH</ci>
<ci>ADP</ci>
</apply>
<apply>
<times/>
<ci>dNavgAMPdH</ci>
<ci>AMP</ci>
</apply>
<apply>
<times/>
<ci>dNavgPCRdH</ci>
<ci>PCr</ci>
</apply>
<apply>
<times/>
<ci>dNavgCRdH</ci>
<ci>Cr</ci>
</apply>
<apply>
<times/>
<ci>dNavgG1PdH</ci>
<ci>G1P</ci>
</apply>
<apply>
<times/>
<ci>dNavgG6PdH</ci>
<ci>G6P</ci>
</apply>
<apply>
<times/>
<ci>dNavgF6PdH</ci>
<ci>F6P</ci>
</apply>
<apply>
<times/>
<ci>dNavgFDPdH</ci>
<ci>FBP</ci>
</apply>
<apply>
<times/>
<ci>dNavgGAPdH</ci>
<ci>GAP</ci>
</apply>
<apply>
<times/>
<ci>dNavgDHAPdH</ci>
<ci>DHAP</ci>
</apply>
<apply>
<times/>
<ci>dNavgG3PdH</ci>
<ci>G3P</ci>
</apply>
<apply>
<times/>
<ci>dNavg13DPGdH</ci>
<ci>BPG</ci>
</apply>
<apply>
<times/>
<ci>dNavg3PGdH</ci>
<ci>P3G</ci>
</apply>
<apply>
<times/>
<ci>dNavg2PGdH</ci>
<ci>P2G</ci>
</apply>
<apply>
<times/>
<ci>dNavgPEPdH</ci>
<ci>PEP</ci>
</apply>
<apply>
<times/>
<ci>dNavgPYRdH</ci>
<ci>PYR</ci>
</apply>
<apply>
<times/>
<ci>dNavgLACdH</ci>
<ci>LAC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>protons_consumed</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>deltaH_CK</ci>
<apply>
<minus/>
<ci>CK</ci>
</apply>
</apply>
<apply>
<times/>
<ci>deltaH_ADK</ci>
<ci>ADK</ci>
</apply>
<apply>
<times/>
<ci>deltaH_PGLM</ci>
<ci>v_PGLM</ci>
</apply>
<apply>
<times/>
<ci>deltaH_GP</ci>
<apply>
<plus/>
<ci>flux_GPa</ci>
<ci>flux_GPb</ci>
</apply>
</apply>
<apply>
<times/>
<ci>deltaH_PGI</ci>
<ci>v_PGI</ci>
</apply>
<apply>
<times/>
<ci>deltaH_PFK</ci>
<ci>v_PFK</ci>
</apply>
<apply>
<times/>
<ci>deltaH_ALD</ci>
<ci>v_ALD</ci>
</apply>
<apply>
<times/>
<ci>deltaH_TPI</ci>
<ci>v_TPI</ci>
</apply>
<apply>
<times/>
<ci>deltaH_GAPDH</ci>
<ci>v_GAPDH</ci>
</apply>
<apply>
<times/>
<ci>deltaH_PGK</ci>
<ci>v_PGK</ci>
</apply>
<apply>
<times/>
<ci>deltaH_PGM</ci>
<ci>v_PGM</ci>
</apply>
<apply>
<times/>
<ci>deltaH_ENOL</ci>
<ci>v_ENOL</ci>
</apply>
<apply>
<times/>
<ci>deltaH_PK</ci>
<ci>v_PK</ci>
</apply>
<apply>
<times/>
<ci>deltaH_LDH</ci>
<ci>v_LDH</ci>
</apply>
<apply>
<times/>
<ci>deltaH_G3PDH</ci>
<ci>v_G3PDH</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CKprtflux</ci>
<apply>
<times/>
<ci>deltaH_CK</ci>
<apply>
<minus/>
<ci>CK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>glycprtflux</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>deltaH_PGLM</ci>
<ci>v_PGLM</ci>
</apply>
<apply>
<times/>
<ci>deltaH_GP</ci>
<apply>
<plus/>
<ci>flux_GPa</ci>
<ci>flux_GPb</ci>
</apply>
</apply>
<apply>
<times/>
<ci>deltaH_PGI</ci>
<ci>v_PGI</ci>
</apply>
<apply>
<times/>
<ci>deltaH_PFK</ci>
<ci>v_PFK</ci>
</apply>
<apply>
<times/>
<ci>deltaH_ALD</ci>
<ci>v_ALD</ci>
</apply>
<apply>
<times/>
<ci>deltaH_TPI</ci>
<ci>v_TPI</ci>
</apply>
<apply>
<times/>
<ci>deltaH_GAPDH</ci>
<ci>v_GAPDH</ci>
</apply>
<apply>
<times/>
<ci>deltaH_PGK</ci>
<ci>v_PGK</ci>
</apply>
<apply>
<times/>
<ci>deltaH_PGM</ci>
<ci>v_PGM</ci>
</apply>
<apply>
<times/>
<ci>deltaH_ENOL</ci>
<ci>v_ENOL</ci>
</apply>
<apply>
<times/>
<ci>deltaH_PK</ci>
<ci>v_PK</ci>
</apply>
<apply>
<times/>
<ci>deltaH_LDH</ci>
<ci>v_LDH</ci>
</apply>
<apply>
<times/>
<ci>deltaH_G3PDH</ci>
<ci>v_G3PDH</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pHODEterm1</ci>
<apply>
<divide/>
<ci>protons_consumed</ci>
<apply>
<plus/>
<ci>bufcapfixed</ci>
<ci>bufcapmetab</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>pHODEterm2</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>dNavgPidmg</ci>
<ci>Pi</ci>
</apply>
<apply>
<times/>
<ci>dNavgATPdmg</ci>
<ci>ATP</ci>
</apply>
<apply>
<times/>
<ci>dNavgADPdmg</ci>
<ci>ADP</ci>
</apply>
<apply>
<times/>
<ci>dNavgAMPdmg</ci>
<ci>AMP</ci>
</apply>
<apply>
<times/>
<ci>dNavgPCRdmg</ci>
<ci>PCr</ci>
</apply>
<apply>
<times/>
<ci>dNavgCRdmg</ci>
<ci>Cr</ci>
</apply>
<apply>
<times/>
<ci>dNavgG1Pdmg</ci>
<ci>G1P</ci>
</apply>
<apply>
<times/>
<ci>dNavgG6Pdmg</ci>
<ci>G6P</ci>
</apply>
<apply>
<times/>
<ci>dNavgF6Pdmg</ci>
<ci>F6P</ci>
</apply>
<apply>
<times/>
<ci>dNavgFDPdmg</ci>
<ci>FBP</ci>
</apply>
<apply>
<times/>
<ci>dNavgGAPdmg</ci>
<ci>GAP</ci>
</apply>
<apply>
<times/>
<ci>dNavgDHAPdmg</ci>
<ci>DHAP</ci>
</apply>
<apply>
<times/>
<ci>dNavgG3Pdmg</ci>
<ci>G3P</ci>
</apply>
<apply>
<times/>
<ci>dNavg13DPGdmg</ci>
<ci>BPG</ci>
</apply>
<apply>
<times/>
<ci>dNavg3PGdmg</ci>
<ci>P3G</ci>
</apply>
<apply>
<times/>
<ci>dNavg2PGdmg</ci>
<ci>P2G</ci>
</apply>
<apply>
<times/>
<ci>dNavgPEPdmg</ci>
<ci>PEP</ci>
</apply>
<apply>
<times/>
<ci>dNavgPYRdmg</ci>
<ci>PYR</ci>
</apply>
<apply>
<times/>
<ci>dNavgLACdmg</ci>
<ci>LAC</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>bufcapfixed</ci>
<ci>bufcapmetab</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>denom_mgODE</ci>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>dmgATP2dmg</ci>
<ci>ATP</ci>
</apply>
<apply>
<times/>
<ci>dmgADPdmg</ci>
<ci>ADP</ci>
</apply>
<apply>
<times/>
<ci>dmgAMPdmg</ci>
<ci>AMP</ci>
</apply>
<apply>
<times/>
<ci>dmgPidmg</ci>
<ci>Pi</ci>
</apply>
<apply>
<times/>
<ci>dmgPCRdmg</ci>
<ci>PCr</ci>
</apply>
<apply>
<times/>
<ci>dmgG1Pdmg</ci>
<ci>G1P</ci>
</apply>
<apply>
<times/>
<ci>dmgFDPdmg</ci>
<ci>FBP</ci>
</apply>
<apply>
<times/>
<ci>dmgG3Pdmg</ci>
<ci>G3P</ci>
</apply>
<apply>
<times/>
<ci>dmgDHAPdmg</ci>
<ci>DHAP</ci>
</apply>
<apply>
<times/>
<ci>dmgPEPdmg</ci>
<ci>PEP</ci>
</apply>
<apply>
<times/>
<ci>dmg2PGdmg</ci>
<ci>P2G</ci>
</apply>
<apply>
<times/>
<ci>dmgLACdmg</ci>
<ci>LAC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>RHSterm1_mgODE</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>dmgATP2dpH</ci>
<ci>ATP</ci>
</apply>
<apply>
<times/>
<ci>dmgADPdpH</ci>
<ci>ADP</ci>
</apply>
<apply>
<times/>
<ci>dmgAMPdpH</ci>
<ci>AMP</ci>
</apply>
<apply>
<times/>
<ci>dmgPidpH</ci>
<ci>Pi</ci>
</apply>
<apply>
<times/>
<ci>dmgPCRdpH</ci>
<ci>PCr</ci>
</apply>
<apply>
<times/>
<ci>dmgG1PdpH</ci>
<ci>G1P</ci>
</apply>
<apply>
<times/>
<ci>dmgFDPdpH</ci>
<ci>FBP</ci>
</apply>
<apply>
<times/>
<ci>dmgG3PdpH</ci>
<ci>G3P</ci>
</apply>
<apply>
<times/>
<ci>dmgDHAPdpH</ci>
<ci>DHAP</ci>
</apply>
<apply>
<times/>
<ci>dmgPEPdpH</ci>
<ci>PEP</ci>
</apply>
<apply>
<times/>
<ci>dmg2PGdpH</ci>
<ci>P2G</ci>
</apply>
<apply>
<times/>
<ci>dmgLACdpH</ci>
<ci>LAC</ci>
</apply>
</apply>
<ci>denom_mgODE</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>denomMgpHODE</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>RHSterm1_mgODE</ci>
<ci>pHODEterm2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="differential_equations">
<variable name="PCr" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="Cr" units="molar" initial_value="0.029999999" public_interface="out"/>
<variable name="NAD" units="molar" initial_value="0.0005" public_interface="out"/>
<variable name="NADH" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="ATP" units="molar" initial_value="0.005" public_interface="out"/>
<variable name="ADP" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="AMP" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="Pi" units="molar" initial_value="0.03" public_interface="out"/>
<variable name="Gly" units="molar" initial_value="0.04" public_interface="out"/>
<variable name="G1P" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="G6P" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="F6P" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="FBP" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="DHAP" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="G3P" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="GAP" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="BPG" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="P3G" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="P2G" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="PEP" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="PYR" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="LAC" units="molar" initial_value="1e-9" public_interface="out"/>
<variable name="RHSterm2_mgODE" units="molar_per_minute"/>
<variable name="fixmg" units="dimensionless"/>
<variable name="Mg" units="molar" initial_value="5.132658807e-4" public_interface="out"/>
<variable name="fixpH" units="dimensionless"/>
<variable name="pH_calc" units="dimensionless" initial_value="7.8" public_interface="out"/>
<variable name="protonload" units="molar" initial_value="0" public_interface="out"/>
<variable name="time" units="minute" public_interface="in"/>
<variable name="ADK" units="molar_per_minute" public_interface="in"/>
<variable name="CK" units="molar_per_minute" public_interface="in"/>
<variable name="flux_GPa" units="molar_per_minute" public_interface="in"/>
<variable name="flux_GPb" units="molar_per_minute" public_interface="in"/>
<variable name="v_ALD" units="molar_per_minute" public_interface="in"/>
<variable name="v_ENOL" units="molar_per_minute" public_interface="in"/>
<variable name="v_G3PDH" units="molar_per_minute" public_interface="in"/>
<variable name="v_GAPDH" units="molar_per_minute" public_interface="in"/>
<variable name="v_LDH" units="molar_per_minute" public_interface="in"/>
<variable name="v_PFK" units="molar_per_minute" public_interface="in"/>
<variable name="v_PGI" units="molar_per_minute" public_interface="in"/>
<variable name="v_PGK" units="molar_per_minute" public_interface="in"/>
<variable name="v_PGLM" units="molar_per_minute" public_interface="in"/>
<variable name="v_PGM" units="molar_per_minute" public_interface="in"/>
<variable name="v_PK" units="molar_per_minute" public_interface="in"/>
<variable name="v_TPI" units="molar_per_minute" public_interface="in"/>
<variable name="ATPase" units="molar_per_minute" public_interface="in"/>
<variable name="dATPdt" units="molar_per_minute"/>
<variable name="dADPdt" units="molar_per_minute"/>
<variable name="dAMPdt" units="molar_per_minute"/>
<variable name="dDHAPdt" units="molar_per_minute"/>
<variable name="dFBPdt" units="molar_per_minute"/>
<variable name="dG1Pdt" units="molar_per_minute"/>
<variable name="dG3Pdt" units="molar_per_minute"/>
<variable name="dLACdt" units="molar_per_minute"/>
<variable name="dP2Gdt" units="molar_per_minute"/>
<variable name="dPCrdt" units="molar_per_minute"/>
<variable name="dPEPdt" units="molar_per_minute"/>
<variable name="dPidt" units="molar_per_minute"/>
<variable name="dCrdt" units="molar_per_minute"/>
<variable name="dNADdt" units="molar_per_minute"/>
<variable name="dNADHdt" units="molar_per_minute"/>
<variable name="dGlydt" units="molar_per_minute"/>
<variable name="dG6Pdt" units="molar_per_minute"/>
<variable name="dF6Pdt" units="molar_per_minute"/>
<variable name="dGAPdt" units="molar_per_minute"/>
<variable name="dBGPdt" units="molar_per_minute"/>
<variable name="dP3Gdt" units="molar_per_minute"/>
<variable name="dPYRdt" units="molar_per_minute"/>
<variable name="protons_consumed" units="molar_per_minute" public_interface="in"/>
<variable name="pHODEterm1" units="per_minute" public_interface="in"/>
<variable name="pHODEterm2" units="per_molar" public_interface="in"/>
<variable name="denom_mgODE" units="dimensionless" public_interface="in"/>
<variable name="RHSterm1_mgODE" units="molar" public_interface="in"/>
<variable name="mg2PG" units="dimensionless" public_interface="in"/>
<variable name="mgATP2" units="dimensionless" public_interface="in"/>
<variable name="mgADP" units="dimensionless" public_interface="in"/>
<variable name="mgAMP" units="dimensionless" public_interface="in"/>
<variable name="mgDHAP" units="dimensionless" public_interface="in"/>
<variable name="mgFDP" units="dimensionless" public_interface="in"/>
<variable name="mgG1P" units="dimensionless" public_interface="in"/>
<variable name="mgG3P" units="dimensionless" public_interface="in"/>
<variable name="mgLAC" units="dimensionless" public_interface="in"/>
<variable name="mgPCR" units="dimensionless" public_interface="in"/>
<variable name="mgPEP" units="dimensionless" public_interface="in"/>
<variable name="mgPi" units="dimensionless" public_interface="in"/>
<variable name="Par_99" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PCr</ci>
</apply>
<ci>dPCrdt</ci>
</apply>
<apply>
<eq/>
<ci>dPCrdt</ci>
<ci>CK</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cr</ci>
</apply>
<ci>dCrdt</ci>
</apply>
<apply>
<eq/>
<ci>dCrdt</ci>
<apply>
<minus/>
<ci>CK</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>NAD</ci>
</apply>
<ci>dNADdt</ci>
</apply>
<apply>
<eq/>
<ci>dNADdt</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_GAPDH</ci>
</apply>
<ci>v_G3PDH</ci>
</apply>
<ci>v_LDH</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>NADH</ci>
</apply>
<ci>dNADHdt</ci>
</apply>
<apply>
<eq/>
<ci>dNADHdt</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>v_GAPDH</ci>
<ci>v_G3PDH</ci>
</apply>
<ci>v_LDH</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ATP</ci>
</apply>
<ci>dATPdt</ci>
</apply>
<apply>
<eq/>
<ci>dATPdt</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>CK</ci>
</apply>
<ci>ADK</ci>
</apply>
<ci>v_PFK</ci>
</apply>
<ci>v_PGK</ci>
<ci>v_PK</ci>
</apply>
<ci>ATPase</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ADP</ci>
</apply>
<ci>dADPdt</ci>
</apply>
<apply>
<eq/>
<ci>dADPdt</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>CK</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>ADK</ci>
</apply>
<ci>v_PFK</ci>
</apply>
<ci>v_PGK</ci>
</apply>
<ci>v_PK</ci>
</apply>
<ci>ATPase</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>AMP</ci>
</apply>
<ci>dAMPdt</ci>
</apply>
<apply>
<eq/>
<ci>dAMPdt</ci>
<apply>
<minus/>
<ci>ADK</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Pi</ci>
</apply>
<ci>dPidt</ci>
</apply>
<apply>
<eq/>
<ci>dPidt</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>flux_GPa</ci>
<ci>flux_GPb</ci>
</apply>
</apply>
<ci>v_GAPDH</ci>
</apply>
<ci>ATPase</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Gly</ci>
</apply>
<ci>dGlydt</ci>
</apply>
<apply>
<eq/>
<ci>dGlydt</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>flux_GPa</ci>
<ci>flux_GPb</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>G1P</ci>
</apply>
<ci>dG1Pdt</ci>
</apply>
<apply>
<eq/>
<ci>dG1Pdt</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>flux_GPa</ci>
<ci>flux_GPb</ci>
</apply>
<ci>v_PGLM</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>G6P</ci>
</apply>
<ci>dG6Pdt</ci>
</apply>
<apply>
<eq/>
<ci>dG6Pdt</ci>
<apply>
<minus/>
<ci>v_PGLM</ci>
<ci>v_PGI</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F6P</ci>
</apply>
<ci>dF6Pdt</ci>
</apply>
<apply>
<eq/>
<ci>dF6Pdt</ci>
<apply>
<minus/>
<ci>v_PGI</ci>
<ci>v_PFK</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>FBP</ci>
</apply>
<ci>dFBPdt</ci>
</apply>
<apply>
<eq/>
<ci>dFBPdt</ci>
<apply>
<minus/>
<ci>v_PFK</ci>
<ci>v_ALD</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>DHAP</ci>
</apply>
<ci>dDHAPdt</ci>
</apply>
<apply>
<eq/>
<ci>dDHAPdt</ci>
<apply>
<plus/>
<ci>v_ALD</ci>
<ci>v_TPI</ci>
<ci>v_G3PDH</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>G3P</ci>
</apply>
<ci>dG3Pdt</ci>
</apply>
<apply>
<eq/>
<ci>dG3Pdt</ci>
<apply>
<minus/>
<ci>v_G3PDH</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>GAP</ci>
</apply>
<ci>dGAPdt</ci>
</apply>
<apply>
<eq/>
<ci>dGAPdt</ci>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_ALD</ci>
<ci>v_TPI</ci>
</apply>
<ci>v_GAPDH</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>BPG</ci>
</apply>
<ci>dBGPdt</ci>
</apply>
<apply>
<eq/>
<ci>dBGPdt</ci>
<apply>
<minus/>
<ci>v_GAPDH</ci>
<ci>v_PGK</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P3G</ci>
</apply>
<ci>dP3Gdt</ci>
</apply>
<apply>
<eq/>
<ci>dP3Gdt</ci>
<apply>
<minus/>
<ci>v_PGK</ci>
<ci>v_PGM</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P2G</ci>
</apply>
<ci>dP2Gdt</ci>
</apply>
<apply>
<eq/>
<ci>dP2Gdt</ci>
<apply>
<minus/>
<ci>v_PGM</ci>
<ci>v_ENOL</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PEP</ci>
</apply>
<ci>dPEPdt</ci>
</apply>
<apply>
<eq/>
<ci>dPEPdt</ci>
<apply>
<minus/>
<ci>v_ENOL</ci>
<ci>v_PK</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PYR</ci>
</apply>
<ci>dPYRdt</ci>
</apply>
<apply>
<eq/>
<ci>dPYRdt</ci>
<apply>
<minus/>
<ci>v_PK</ci>
<ci>v_LDH</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LAC</ci>
</apply>
<ci>dLACdt</ci>
</apply>
<apply>
<eq/>
<ci>dLACdt</ci>
<ci>v_LDH</ci>
</apply>
<apply>
<eq/>
<ci>RHSterm2_mgODE</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>mgATP2</ci>
<ci>dATPdt</ci>
</apply>
<apply>
<times/>
<ci>mgADP</ci>
<ci>dADPdt</ci>
</apply>
<apply>
<times/>
<ci>mgAMP</ci>
<ci>dAMPdt</ci>
</apply>
<apply>
<times/>
<ci>mgPi</ci>
<ci>dPidt</ci>
</apply>
<apply>
<times/>
<ci>mgPCR</ci>
<ci>dPCrdt</ci>
</apply>
<apply>
<times/>
<ci>mgG1P</ci>
<ci>dG1Pdt</ci>
</apply>
<apply>
<times/>
<ci>mgFDP</ci>
<ci>dFBPdt</ci>
</apply>
<apply>
<times/>
<ci>mgG3P</ci>
<ci>dG3Pdt</ci>
</apply>
<apply>
<times/>
<ci>mgDHAP</ci>
<ci>dDHAPdt</ci>
</apply>
<apply>
<times/>
<ci>mgPEP</ci>
<ci>dPEPdt</ci>
</apply>
<apply>
<times/>
<ci>mg2PG</ci>
<ci>dP2Gdt</ci>
</apply>
<apply>
<times/>
<ci>mgLAC</ci>
<ci>dLACdt</ci>
</apply>
</apply>
<ci>denom_mgODE</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fixmg</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Mg</ci>
</apply>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>fixmg</ci>
<apply>
<plus/>
<ci>RHSterm2_mgODE</ci>
<apply>
<times/>
<ci>RHSterm1_mgODE</ci>
<ci>pHODEterm1</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>RHSterm1_mgODE</ci>
<ci>pHODEterm2</ci>
</apply>
</apply>
</apply>
<apply>
<leq/>
<ci>time</ci>
<cn cellml:units="minute">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>fixmg</ci>
<ci>RHSterm2_mgODE</ci>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>fixpH</ci>
<ci>Par_99</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>pH_calc</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>fixpH</ci>
<apply>
<plus/>
<ci>pHODEterm1</ci>
<apply>
<times/>
<ci>RHSterm2_mgODE</ci>
<ci>pHODEterm2</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>RHSterm1_mgODE</ci>
<ci>pHODEterm2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>protonload</ci>
</apply>
<apply>
<minus/>
<ci>protons_consumed</ci>
</apply>
</apply>
</math>
</component>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="environment" component_2="correction_factors"/>
<map_variables variable_1="pH_cy" variable_2="pH_cy"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="environment" component_2="glycogen_phosphorylase"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="pH_cy" variable_2="pH_cy"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="environment" component_2="glycogen_phosphorylase_B"/>
<map_variables variable_1="pH_cy" variable_2="pH_cy"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="environment" component_2="PGLM"/>
<map_variables variable_1="pH_cy" variable_2="pH_cy"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="environment" component_2="PGI"/>
<map_variables variable_1="pH_cy" variable_2="pH_cy"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="environment" component_2="PFK"/>
<map_variables variable_1="pH_cy" variable_2="pH_cy"/>
</connection>
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<map_variables variable_1="dNavgADPdH" variable_2="dNavgADPdH"/>
<map_variables variable_1="dNavgAMPdH" variable_2="dNavgAMPdH"/>
<map_variables variable_1="dNavgATPdH" variable_2="dNavgATPdH"/>
<map_variables variable_1="dNavgCRdH" variable_2="dNavgCRdH"/>
<map_variables variable_1="dNavgDHAPdH" variable_2="dNavgDHAPdH"/>
<map_variables variable_1="dNavgF6PdH" variable_2="dNavgF6PdH"/>
<map_variables variable_1="dNavgFDPdH" variable_2="dNavgFDPdH"/>
<map_variables variable_1="dNavgG1PdH" variable_2="dNavgG1PdH"/>
<map_variables variable_1="dNavgG3PdH" variable_2="dNavgG3PdH"/>
<map_variables variable_1="dNavgG6PdH" variable_2="dNavgG6PdH"/>
<map_variables variable_1="dNavgGAPdH" variable_2="dNavgGAPdH"/>
<map_variables variable_1="dNavgLACdH" variable_2="dNavgLACdH"/>
<map_variables variable_1="dNavgPCRdH" variable_2="dNavgPCRdH"/>
<map_variables variable_1="dNavgPEPdH" variable_2="dNavgPEPdH"/>
<map_variables variable_1="dNavgPYRdH" variable_2="dNavgPYRdH"/>
<map_variables variable_1="dNavgPidH" variable_2="dNavgPidH"/>
<map_variables variable_1="deltaH_ADK" variable_2="deltaH_ADK"/>
<map_variables variable_1="deltaH_ALD" variable_2="deltaH_ALD"/>
<map_variables variable_1="deltaH_CK" variable_2="deltaH_CK"/>
<map_variables variable_1="deltaH_ENOL" variable_2="deltaH_ENOL"/>
<map_variables variable_1="deltaH_G3PDH" variable_2="deltaH_G3PDH"/>
<map_variables variable_1="deltaH_GAPDH" variable_2="deltaH_GAPDH"/>
<map_variables variable_1="deltaH_GP" variable_2="deltaH_GP"/>
<map_variables variable_1="deltaH_LDH" variable_2="deltaH_LDH"/>
<map_variables variable_1="deltaH_PFK" variable_2="deltaH_PFK"/>
<map_variables variable_1="deltaH_PGI" variable_2="deltaH_PGI"/>
<map_variables variable_1="deltaH_PGK" variable_2="deltaH_PGK"/>
<map_variables variable_1="deltaH_PGLM" variable_2="deltaH_PGLM"/>
<map_variables variable_1="deltaH_PGM" variable_2="deltaH_PGM"/>
<map_variables variable_1="deltaH_PK" variable_2="deltaH_PK"/>
<map_variables variable_1="deltaH_TPI" variable_2="deltaH_TPI"/>
<map_variables variable_1="dNavg13DPGdmg" variable_2="dNavg13DPGdmg"/>
<map_variables variable_1="dNavg2PGdmg" variable_2="dNavg2PGdmg"/>
<map_variables variable_1="dNavg3PGdmg" variable_2="dNavg3PGdmg"/>
<map_variables variable_1="dNavgADPdmg" variable_2="dNavgADPdmg"/>
<map_variables variable_1="dNavgAMPdmg" variable_2="dNavgAMPdmg"/>
<map_variables variable_1="dNavgATPdmg" variable_2="dNavgATPdmg"/>
<map_variables variable_1="dNavgCRdmg" variable_2="dNavgCRdmg"/>
<map_variables variable_1="dNavgDHAPdmg" variable_2="dNavgDHAPdmg"/>
<map_variables variable_1="dNavgF6Pdmg" variable_2="dNavgF6Pdmg"/>
<map_variables variable_1="dNavgFDPdmg" variable_2="dNavgFDPdmg"/>
<map_variables variable_1="dNavgG1Pdmg" variable_2="dNavgG1Pdmg"/>
<map_variables variable_1="dNavgG3Pdmg" variable_2="dNavgG3Pdmg"/>
<map_variables variable_1="dNavgG6Pdmg" variable_2="dNavgG6Pdmg"/>
<map_variables variable_1="dNavgGAPdmg" variable_2="dNavgGAPdmg"/>
<map_variables variable_1="dNavgLACdmg" variable_2="dNavgLACdmg"/>
<map_variables variable_1="dNavgPCRdmg" variable_2="dNavgPCRdmg"/>
<map_variables variable_1="dNavgPEPdmg" variable_2="dNavgPEPdmg"/>
<map_variables variable_1="dNavgPYRdmg" variable_2="dNavgPYRdmg"/>
<map_variables variable_1="dNavgPidmg" variable_2="dNavgPidmg"/>
<map_variables variable_1="dmg2PGdmg" variable_2="dmg2PGdmg"/>
<map_variables variable_1="dmgATP2dmg" variable_2="dmgATP2dmg"/>
<map_variables variable_1="dmgADPdmg" variable_2="dmgADPdmg"/>
<map_variables variable_1="dmgAMPdmg" variable_2="dmgAMPdmg"/>
<map_variables variable_1="dmgDHAPdmg" variable_2="dmgDHAPdmg"/>
<map_variables variable_1="dmgFDPdmg" variable_2="dmgFDPdmg"/>
<map_variables variable_1="dmgG1Pdmg" variable_2="dmgG1Pdmg"/>
<map_variables variable_1="dmgG3Pdmg" variable_2="dmgG3Pdmg"/>
<map_variables variable_1="dmgLACdmg" variable_2="dmgLACdmg"/>
<map_variables variable_1="dmgPCRdmg" variable_2="dmgPCRdmg"/>
<map_variables variable_1="dmgPEPdmg" variable_2="dmgPEPdmg"/>
<map_variables variable_1="dmgPidmg" variable_2="dmgPidmg"/>
<map_variables variable_1="dmg2PGdpH" variable_2="dmg2PGdpH"/>
<map_variables variable_1="dmgADPdpH" variable_2="dmgADPdpH"/>
<map_variables variable_1="dmgAMPdpH" variable_2="dmgAMPdpH"/>
<map_variables variable_1="dmgATP2dpH" variable_2="dmgATP2dpH"/>
<map_variables variable_1="dmgDHAPdpH" variable_2="dmgDHAPdpH"/>
<map_variables variable_1="dmgFDPdpH" variable_2="dmgFDPdpH"/>
<map_variables variable_1="dmgG1PdpH" variable_2="dmgG1PdpH"/>
<map_variables variable_1="dmgG3PdpH" variable_2="dmgG3PdpH"/>
<map_variables variable_1="dmgLACdpH" variable_2="dmgLACdpH"/>
<map_variables variable_1="dmgPCRdpH" variable_2="dmgPCRdpH"/>
<map_variables variable_1="dmgPEPdpH" variable_2="dmgPEPdpH"/>
<map_variables variable_1="dmgPidpH" variable_2="dmgPidpH"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="glycogen_phosphorylase"/>
<map_variables variable_1="flux_GPa" variable_2="flux_GPa"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="glycogen_phosphorylase_B"/>
<map_variables variable_1="flux_GPb" variable_2="flux_GPb"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="ALD"/>
<map_variables variable_1="v_ALD" variable_2="v_ALD"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="ENOL"/>
<map_variables variable_1="v_ENOL" variable_2="v_ENOL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="G3PDH"/>
<map_variables variable_1="v_G3PDH" variable_2="v_G3PDH"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="GAPDH"/>
<map_variables variable_1="v_GAPDH" variable_2="v_GAPDH"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="LDH"/>
<map_variables variable_1="v_LDH" variable_2="v_LDH"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="PFK"/>
<map_variables variable_1="v_PFK" variable_2="v_PFK"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="PGI"/>
<map_variables variable_1="v_PGI" variable_2="v_PGI"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="PGK"/>
<map_variables variable_1="v_PGK" variable_2="v_PGK"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="PGLM"/>
<map_variables variable_1="v_PGLM" variable_2="v_PGLM"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="PGM"/>
<map_variables variable_1="v_PGM" variable_2="v_PGM"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="PK"/>
<map_variables variable_1="v_PK" variable_2="v_PK"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="TPI"/>
<map_variables variable_1="v_TPI" variable_2="v_TPI"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="equilibrium_constants"/>
<map_variables variable_1="c0" variable_2="c0"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="buffer_capacity" component_2="differential_equations"/>
<map_variables variable_1="PCr" variable_2="PCr"/>
<map_variables variable_1="Cr" variable_2="Cr"/>
<map_variables variable_1="NAD" variable_2="NAD"/>
<map_variables variable_1="NADH" variable_2="NADH"/>
<map_variables variable_1="ATP" variable_2="ATP"/>
<map_variables variable_1="ADP" variable_2="ADP"/>
<map_variables variable_1="AMP" variable_2="AMP"/>
<map_variables variable_1="Pi" variable_2="Pi"/>
<map_variables variable_1="Gly" variable_2="Gly"/>
<map_variables variable_1="G1P" variable_2="G1P"/>
<map_variables variable_1="G6P" variable_2="G6P"/>
<map_variables variable_1="F6P" variable_2="F6P"/>
<map_variables variable_1="FBP" variable_2="FBP"/>
<map_variables variable_1="DHAP" variable_2="DHAP"/>
<map_variables variable_1="G3P" variable_2="G3P"/>
<map_variables variable_1="GAP" variable_2="GAP"/>
<map_variables variable_1="BPG" variable_2="BPG"/>
<map_variables variable_1="P3G" variable_2="P3G"/>
<map_variables variable_1="P2G" variable_2="P2G"/>
<map_variables variable_1="PEP" variable_2="PEP"/>
<map_variables variable_1="PYR" variable_2="PYR"/>
<map_variables variable_1="LAC" variable_2="LAC"/>
<map_variables variable_1="protons_consumed" variable_2="protons_consumed"/>
<map_variables variable_1="pHODEterm1" variable_2="pHODEterm1"/>
<map_variables variable_1="pHODEterm2" variable_2="pHODEterm2"/>
<map_variables variable_1="denom_mgODE" variable_2="denom_mgODE"/>
<map_variables variable_1="RHSterm1_mgODE" variable_2="RHSterm1_mgODE"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="differential_equations" component_2="correction_factors"/>
<map_variables variable_1="mg2PG" variable_2="mg2PG"/>
<map_variables variable_1="mgATP2" variable_2="mgATP2"/>
<map_variables variable_1="mgADP" variable_2="mgADP"/>
<map_variables variable_1="mgAMP" variable_2="mgAMP"/>
<map_variables variable_1="mgDHAP" variable_2="mgDHAP"/>
<map_variables variable_1="mgFDP" variable_2="mgFDP"/>
<map_variables variable_1="mgG1P" variable_2="mgG1P"/>
<map_variables variable_1="mgG3P" variable_2="mgG3P"/>
<map_variables variable_1="mgLAC" variable_2="mgLAC"/>
<map_variables variable_1="mgPCR" variable_2="mgPCR"/>
<map_variables variable_1="mgPEP" variable_2="mgPEP"/>
<map_variables variable_1="mgPi" variable_2="mgPi"/>
<map_variables variable_1="Mg" variable_2="mg"/>
</connection>
</model>
