<?xml version="1.0" encoding="utf-8"?><model cmeta:id="BestPractice_Cdecoupled" name="BestPractice_Cdecoupled" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#"> <units name="uM"> <unit units="mole" prefix="micro"/> <unit units="litre" exponent="-1"/> </units> <units name="per_um"> <unit units="meter" prefix="micro" exponent="-1"/> </units> <units name="per_um2"> <unit units="per_um" exponent="2"/> </units> <units name="per_s"> <unit units="second" exponent="-1"/> </units> <units name="uM_per_s"> <unit units="uM"/> <unit units="per_s"/> </units> <units name="per_uM_per_s"> <unit units="uM" exponent="-1"/> <unit units="second" exponent="-1"/> </units> <units name="per_um2_per_s"> <unit units="per_um2"/> <unit units="per_s"/> </units> <units name="um2"> <unit units="metre" prefix="micro" exponent="2"/> </units> <units name="uM_um2"> <unit units="uM"/> <unit units="um2"/> </units> <units name="per_uM_per_um3"> <unit units="uM" exponent="-1"/> <unit units="metre" prefix="micro" exponent="-3"/> </units> <component name="time"> <variable name="t" units="second" public_interface="out"/> </component> <component name="geometry"> <variable name="R" units="per_um" initial_value="5" public_interface="out"/> </component> <component name="C_interface"> <variable name="JPlusRx1" units="uM_per_s" public_interface="in"/> <variable name="JMinusRx2" units="per_um2_per_s" public_interface="in"/> <variable name="Cpc" units="uM_um2"/> <variable name="JTotal" units="uM_per_s" public_interface="out"/> <variable name="R" units="per_um" public_interface="in"/> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq/> <ci>Cpc</ci> <apply> <divide/> <ci>R</ci> <cn cellml:units="per_uM_per_um3">602.2</cn> </apply> </apply> <apply> <eq/> <ci>JTotal</ci> <apply> <minus/> <ci>JPlusRx1</ci> <apply> <times/> <ci>Cpc</ci> <ci>JMinusRx2</ci> </apply> </apply> </apply> </math> </component> <component name="C"> <variable name="C" units="uM" initial_value="0" public_interface="out"/> <variable name="JGain" units="uM_per_s" public_interface="in"/> <variable name="t" units="second" public_interface="in"/> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq/> <apply> <diff/> <bvar> <ci>t</ci> </bvar> <ci>C</ci> </apply> <ci>JGain</ci> </apply> </math> </component> <component name="Cformation"> <variable name="A" units="uM" initial_value="10"/> <variable name="B" units="uM" initial_value="5"/> <variable name="J1" units="uM_per_s" public_interface="out"/> <variable name="kf1" units="per_uM_per_s" initial_value="0.2"/> <variable name="kr1" units="per_s" initial_value="0.05"/> <variable name="C" units="uM" public_interface="in"/> <variable name="t" units="second" public_interface="in"/> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq/> <ci>J1</ci> <apply> <minus/> <apply> <times/> <ci>kf1</ci> <ci>A</ci> <ci>B</ci> </apply> <apply> <times/> <ci>kr1</ci> <ci>C</ci> </apply> </apply> </apply> <apply> <eq/> <apply> <diff/> <bvar> <ci>t</ci> </bvar> <ci>A</ci> </apply> <apply> <minus/> <ci>J1</ci> </apply> </apply> <apply> <eq/> <apply> <diff/> <bvar> <ci>t</ci> </bvar> <ci>B</ci> </apply> <apply> <minus/> <ci>J1</ci> </apply> </apply> </math> </component> <component name="Eformation"> <variable name="D" units="per_um2" initial_value="4"/> <variable name="E" units="per_um2" initial_value="0"/> <variable name="J2" units="per_um2_per_s" public_interface="out"/> <variable name="kf2" units="per_uM_per_s" initial_value="0.006"/> <variable name="kr2" units="per_s" initial_value="0.001"/> <variable name="C" units="uM" public_interface="in"/> <variable name="t" units="second" public_interface="in"/> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <eq/> <ci>J2</ci> <apply> <minus/> <apply> <times/> <ci>kf2</ci> <ci>C</ci> <ci>D</ci> </apply> <apply> <times/> <ci>kr2</ci> <ci>E</ci> </apply> </apply> </apply> <apply> <eq/> <apply> <diff/> <bvar> <ci>t</ci> </bvar> <ci>D</ci> </apply> <apply> <minus/> <ci>J2</ci> </apply> </apply> <apply> <eq/> <apply> <diff/> <bvar> <ci>t</ci> </bvar> <ci>E</ci> </apply> <ci>J2</ci> </apply> </math> </component> <connection> <map_components component_1="time" component_2="C"/> <map_variables variable_1="t" variable_2="t"/> </connection> <connection> <map_components component_1="geometry" component_2="C_interface"/> <map_variables variable_1="R" variable_2="R"/> </connection> <connection> <map_components component_1="Cformation" component_2="C_interface"/> <map_variables variable_1="J1" variable_2="JPlusRx1"/> </connection> <connection> <map_components component_1="Eformation" component_2="C_interface"/> <map_variables variable_1="J2" variable_2="JMinusRx2"/> </connection> <connection> <map_components component_1="C_interface" component_2="C"/> <map_variables variable_1="JTotal" variable_2="JGain"/> </connection> <connection> <map_components component_1="C" component_2="Cformation"/> <map_variables variable_1="C" variable_2="C"/> </connection> <connection> <map_components component_1="C" component_2="Eformation"/> <map_variables variable_1="C" variable_2="C"/> </connection> <connection> <map_components component_1="time" component_2="Cformation"/> <map_variables variable_1="t" variable_2="t"/> </connection> <connection> <map_components component_1="time" component_2="Eformation"/> <map_variables variable_1="t" variable_2="t"/> </connection></model>
