A Model of the Ventricular Cardiac Action Potential. Depolarization, repolarization and their interaction

Model Status

This model has been curated and unit checked and is known to replicate the published results in OpenCell and COR.

Model Structure

In 1991, Ching-hsing Luo and Yoram Rudy published a mathematical model of the ventricular cardiac action potential. This original model is the first of the two Luo-Rudy models, and it has subsequently come to be known as the Luo-Rudy I model. It is a significant update of the Beeler-Reuter mammalian ventricular model (1977) (see the figure below), and like the the Beeler-Reuter model, the Luo-Rudy I model uses Hodgkin-Huxley type equations to calculate ionic currents.

The complete original paper reference is cited below:

A Model of the Ventricular Cardiac Action Potential - Depolarisation, Repolarisation and Their Interaction, Ching-hsing Luo and Yoram Rudy, 1991 Circulation Research, 68, 1501-1526. PubMed ID: 1709839

A schematic diagram describing the current flows across the cell membrane that are captured in the LR-I model.