<?xml version="1.0"?>
<!--
This CellML file was generated on 18/04/2008 at 09:15:12 using:
COR (0.9.31.915)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->
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<title>Modelling the Roles of Individual Current Systems in Ventricular Cells and in the SA Node</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This model has been curated and unit checked by Alan Garny in collaboration with the model authors and it is known to run in COR to reproduce the published results. It also works in JSim as long as the stimulus protocol is altered.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Different types of ion channel, with their distinct gating and conductance properties, play a unique role in generating membrane excitation. Although the behaviours of single ion channels have been extensively studied experimentally, ionic current interactions make it difficult to deduce their individual roles in membrane excitability. In order to better understand the roles of the individual ion currents, Satoshi Matsuoka <emphasis>et al.</emphasis> have developed a mathematical model of membrane excitation for the ventricular cell.
</para>
<para>
The Matsuoka <emphasis>et al.</emphasis> mathematical model is a development of previously published cardiac cellular models. The group's general approach to modelling was based on the methods used in the Difrancesco-Noble, 1985 Model and the Luo-Rudy Ventricular Model II (dynamic), 1994. In addition, the compound <emphasis>Kyoto Model</emphasis> of Matsuoka <emphasis>et al.</emphasis> incorporates the Negroni and Lascano (1996) model of cardiac muscle contraction, allowing simulation of sarcomere shortening, and also, the gating model of Shirokov <emphasis>et al.</emphasis> is used for both the fast Na<superscript>+</superscript> and L-type Ca<superscript>2+</superscript> channels.
</para>
<para>
New experimental data are included, such as new kinetics of the inward rectifier K<superscript>+</superscript> channel, the delayed rectifier K<superscript>+</superscript> channel, and the sustained inward current (for more details on the reaction kinetics, see figure 3 below). Model simulations showed that ion conductance by the L-type Ca<superscript>2+</superscript> channel (I<subscript>CaL</subscript>) dominates the membrane conductance during the action potential. Repolarisation occurs as the following currents are sequentially activated: I<subscript>Ks</subscript>; I<subscript>Kr</subscript>; and I<subscript>K1</subscript>. Agreement between model simulation results and experimental data was taken as supporting evidence for the validity of the model.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
Role of Individual Ionic Current Systems in Ventricular Cells Hypothesized by a Model Study, Matsuoka S, Sarai N, Kuratomi S, Ono K, and Noma A, 2003, <emphasis>The Japanese Journal of Physiology</emphasis>, 53, 105-123. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12877767&dopt=Abstract">PubMed ID: 12877767</ulink>
</para>
<informalfigure float="0" id="fig_ventricular_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>ventricular cell diagram</title>
</objectinfo>
<imagedata fileref="matsuoka_2003.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram describing the ionic components of the Matsuoka <emphasis>et al.</emphasis> 2003 ventricular cell mathematical model. Ions are exchanged between the intracellular and extracellular environments, and between the cytosol and the sarcoplasmic reticulum (SR) via channels and pumps. Unique to the ventricular cells are the transient outward current, I<subscript>to</subscript>, and the slow component of the delayed rectifier K<superscript>+</superscript> current, I<subscript>Ks</subscript>.</caption>
</informalfigure>
<informalfigure float="0" id="fig_reaction_kinetics">
<mediaobject>
<imageobject>
<objectinfo>
<title>reaction kinetics diagram</title>
</objectinfo>
<imagedata fileref="matsuoka_3_2003.png"/>
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</mediaobject>
<caption>A schematic diagram describing the reaction kinetics of the ion channel gates in the Matsuoka <emphasis>et al.</emphasis> 2003 mathematical models. A) The kinetics of the sodium channel voltage-dependent gate. B) The kinetics of the Na-Ca exchange pump. C) The kinetics of the Na-K pump. D) The kinetics of the inward rectifier K<superscript>+</superscript> current. E) The kinetics of the Ca<superscript>2+</superscript>-dependent gate of the L-type Ca<superscript>2+</superscript> channel. F) The kinetics of the ultra-slow gates of several ion channels. G) The kinetics of the SR Ca<superscript>2+</superscript> pump. H) The kinetics of the hyperpolarisation-activated cation current. I) The kinetics of the RyR channel in the SR.</caption>
</informalfigure>
</sect1>
</article>
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<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>F</ci>
</apply>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>CF_Ca</ci>
<piecewise>
<piece>
<apply>
<minus/>
<ci>Cao</ci>
</apply>
<apply>
<eq/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>Cai</ci>
<apply>
<times/>
<ci>Cao</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>F</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>F</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>CF_K</ci>
<piecewise>
<piece>
<ci>Ki</ci>
<apply>
<eq/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>F</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>Ki</ci>
<apply>
<times/>
<ci>Ko</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>F</ci>
</apply>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>F</ci>
</apply>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="ATP_production">
<variable initial_value="4.657102729020499" name="ATPi" public_interface="out" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="dATPdt_NL" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Vi" public_interface="in" units="micrometre3"/>
<variable name="i_NaK" public_interface="in" units="picoA"/>
<variable name="i_SR_U" public_interface="in" units="picoA"/>
<variable initial_value="0.003" name="ProducingRate_Max" units="per_millisecond"/>
<variable initial_value="5" name="Adenosine_Total" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ATPi</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>ProducingRate_Max</ci>
<apply>
<minus/>
<ci>Adenosine_Total</ci>
<ci>ATPi</ci>
</apply>
</apply>
<ci>dATPdt_NL</ci>
</apply>
<apply>
<divide/>
<ci>i_NaK</ci>
<apply>
<times/>
<ci>F</ci>
<ci>Vi</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci>i_SR_U</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>F</ci>
<ci>Vi</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_current">
<variable cmeta:id="sodium_current_i_Na" name="i_Na" public_interface="out" units="picoA"/>
<variable name="i_Na_Na" public_interface="out" units="picoA"/>
<variable name="i_Na_K" public_interface="out" units="picoA"/>
<variable initial_value="2860" name="P_Na" units="picoA_per_millimolar"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="CF_Na" public_interface="in" units="millimolar"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="p_AP_Na" private_interface="in" units="dimensionless"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Na</ci>
<apply>
<plus/>
<ci>i_Na_Na</ci>
<ci>i_Na_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na_Na</ci>
<apply>
<times/>
<ci>P_Na</ci>
<ci>CF_Na</ci>
<ci>p_AP_Na</ci>
<ci>y</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na_K</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
<ci>P_Na</ci>
<ci>CF_K</ci>
<ci>p_AP_Na</ci>
<ci>y</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_current_voltage_dependent_gate">
<variable initial_value="1.779648367445368e-5" name="p_AP_Na" public_interface="out" units="dimensionless"/>
<variable name="p_RI_Na" units="dimensionless"/>
<variable initial_value="0.3556412697995689" name="p_RP_Na" units="dimensionless"/>
<variable initial_value="0.40285968661346977" name="p_AI_Na" units="dimensionless"/>
<variable name="k_RP_AP" units="per_millisecond"/>
<variable name="k_AP_RP" units="per_millisecond"/>
<variable name="k_RI_AI" units="per_millisecond"/>
<variable name="k_AI_RI" units="per_millisecond"/>
<variable name="k_AP_AI" units="per_millisecond"/>
<variable initial_value="0.0000875" name="k_AI_AP" units="per_millisecond"/>
<variable name="k_RP_RI" units="per_millisecond"/>
<variable name="k_RI_RP" units="per_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_RP_Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_AP_Na</ci>
<ci>k_AP_RP</ci>
</apply>
<apply>
<times/>
<ci>p_RI_Na</ci>
<ci>k_RI_RP</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_RP_Na</ci>
<apply>
<plus/>
<ci>k_RP_RI</ci>
<ci>k_RP_AP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_AP_Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_RP_Na</ci>
<ci>k_RP_AP</ci>
</apply>
<apply>
<times/>
<ci>p_AI_Na</ci>
<ci>k_AI_AP</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_AP_Na</ci>
<apply>
<plus/>
<ci>k_AP_RP</ci>
<ci>k_AP_AI</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_AI_Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_RI_Na</ci>
<ci>k_RI_AI</ci>
</apply>
<apply>
<times/>
<ci>p_AP_Na</ci>
<ci>k_AP_AI</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_AI_Na</ci>
<apply>
<plus/>
<ci>k_AI_RI</ci>
<ci>k_AI_AP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_RI_Na</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>p_RP_Na</ci>
</apply>
<ci>p_AP_Na</ci>
</apply>
<ci>p_AI_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RP_AP</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1027</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.25</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_AP_RP</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">26</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">800</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_AP_AI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">400</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_AI_RI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1300</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.04</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">800</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RI_AI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0001027</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">400</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RP_RI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.01</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>k_AI_AP</ci>
<ci>k_AP_RP</ci>
<ci>k_RI_AI</ci>
</apply>
<apply>
<times/>
<ci>k_AP_AI</ci>
<ci>k_RP_AP</ci>
<ci>k_AI_RI</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RI_RP</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.01</cn>
<ci>k_RP_RI</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_current_ultra_slow_gate">
<variable initial_value="0.5861887862983165" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">9000000000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.014</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4000</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel">
<variable cmeta:id="L_type_Ca_channel_i_Ca_L" name="i_Ca_L" public_interface="out" units="picoA"/>
<variable name="i_CaL_Na" public_interface="out" units="picoA"/>
<variable name="i_CaL_Ca" public_interface="out" units="picoA"/>
<variable name="i_CaL_K" public_interface="out" units="picoA"/>
<variable name="p_open_CaL" private_interface="out" public_interface="out" units="dimensionless"/>
<variable name="CaDiadic" private_interface="in" public_interface="out" units="picoA"/>
<variable initial_value="8712" name="P_CaL" units="picoA_per_millimolar"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="CF_Na" public_interface="in" units="millimolar"/>
<variable name="CF_Ca" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="Cai" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="ATPi" public_interface="in" units="millimolar"/>
<variable name="p_AP_CaL" private_interface="in" units="dimensionless"/>
<variable name="p_U" private_interface="in" units="dimensionless"/>
<variable name="p_UCa" private_interface="in" units="dimensionless"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ca_L</ci>
<apply>
<plus/>
<ci>i_CaL_Na</ci>
<ci>i_CaL_Ca</ci>
<ci>i_CaL_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Ca</ci>
<apply>
<times/>
<ci>P_CaL</ci>
<ci>CF_Ca</ci>
<ci>p_open_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Na</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0000185</cn>
<ci>P_CaL</ci>
<ci>CF_Na</ci>
<ci>p_open_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_K</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.000365</cn>
<ci>P_CaL</ci>
<ci>CF_K</ci>
<ci>p_open_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_open_CaL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>p_AP_CaL</ci>
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<ci>p_UCa</ci>
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<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
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<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1.4</cn>
<ci>ATPi</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_voltage_dependent_gate">
<variable initial_value="1.5445004166497696e-6" name="p_AP_CaL" public_interface="out" units="dimensionless"/>
<variable name="p_RI_CaL" units="dimensionless"/>
<variable initial_value="0.9968480629364956" name="p_RP_CaL" units="dimensionless"/>
<variable initial_value="8.77325391245903e-4" name="p_AI_CaL" units="dimensionless"/>
<variable name="k_RP_AP" units="per_millisecond"/>
<variable name="k_AP_RP" units="per_millisecond"/>
<variable name="k_RI_AI" units="per_millisecond"/>
<variable name="k_AI_RI" units="per_millisecond"/>
<variable initial_value="0.004" name="k_AP_AI" units="per_millisecond"/>
<variable initial_value="0.001" name="k_AI_AP" units="per_millisecond"/>
<variable name="k_RP_RI" units="per_millisecond"/>
<variable name="k_RI_RP" units="per_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_RP_CaL</ci>
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<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_AP_CaL</ci>
<ci>k_AP_RP</ci>
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<apply>
<times/>
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<ci>k_RI_RP</ci>
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<apply>
<times/>
<ci>p_RP_CaL</ci>
<apply>
<plus/>
<ci>k_RP_RI</ci>
<ci>k_RP_AP</ci>
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</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_AP_CaL</ci>
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<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_RP_CaL</ci>
<ci>k_RP_AP</ci>
</apply>
<apply>
<times/>
<ci>p_AI_CaL</ci>
<ci>k_AI_AP</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_AP_CaL</ci>
<apply>
<plus/>
<ci>k_AP_RP</ci>
<ci>k_AP_AI</ci>
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</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_AI_CaL</ci>
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<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_RI_CaL</ci>
<ci>k_RI_AI</ci>
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<apply>
<times/>
<ci>p_AP_CaL</ci>
<ci>k_AP_AI</ci>
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<apply>
<times/>
<ci>p_AI_CaL</ci>
<apply>
<plus/>
<ci>k_AI_RI</ci>
<ci>k_AI_AP</ci>
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</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_RI_CaL</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>p_AP_CaL</ci>
</apply>
<ci>p_RP_CaL</ci>
</apply>
<ci>p_AI_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RP_AP</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.27</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.9</cn>
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</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
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</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_AP_RP</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">480</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
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<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RI_AI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0018</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.4</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
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</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_AI_RI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2200000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.4</cn>
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</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">11</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
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<apply>
<eq/>
<ci>k_RP_RI</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.04</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>k_AI_AP</ci>
<ci>k_AP_RP</ci>
<ci>k_RI_AI</ci>
</apply>
<apply>
<times/>
<ci>k_AP_AI</ci>
<ci>k_RP_AP</ci>
<ci>k_AI_RI</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_RI_RP</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.04</cn>
<ci>k_RP_RI</ci>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_Ca_dependent_gate">
<variable initial_value="0.17246483915629204" name="p_U" public_interface="out" units="dimensionless"/>
<variable initial_value="6.098246017787626e-5" name="p_UCa" public_interface="out" units="dimensionless"/>
<variable name="iCaL" units="picoA"/>
<variable name="Cacm" units="millimolar"/>
<variable name="p_CCa" units="dimensionless"/>
<variable initial_value="0.4250747299372254" name="p_C" units="dimensionless"/>
<variable initial_value="0.0003" name="k_CCa_UCa" units="per_millisecond"/>
<variable initial_value="0.35" name="k_UCa_CCa" units="per_millisecond"/>
<variable initial_value="0.143" name="k_C_U" units="per_millisecond"/>
<variable initial_value="0.35" name="k_U_C" units="per_millisecond"/>
<variable name="k_UCa_U" units="per_millisecond"/>
<variable initial_value="6.954" name="k_U_UCa" units="per_millimolar_millisecond"/>
<variable initial_value="0.0042" name="k_CCa_C" units="per_millisecond"/>
<variable initial_value="6.954" name="k_C_CCa" units="per_millimolar_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="CF_Ca" public_interface="in" units="millimolar"/>
<variable name="p_AP_CaL" public_interface="in" units="dimensionless"/>
<variable name="CaEffC" units="millimolar"/>
<variable name="CaEffU" units="millimolar"/>
<variable name="k_UUCa_Ca" units="per_millisecond"/>
<variable name="k_CCCa_Ca" units="per_millisecond"/>
<variable name="CaDiadic" public_interface="out" units="picoA"/>
<variable name="p_open_CaL" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>iCaL</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="picoA_per_millimolar">0.0676</cn>
<ci>CF_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CaDiadic</ci>
<apply>
<times/>
<ci>iCaL</ci>
<ci>p_open_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Cacm</ci>
<apply>
<minus/>
<ci>Cai</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar_per_picoA">0.3</cn>
<ci>iCaL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CaEffC</ci>
<apply>
<times/>
<ci>Cacm</ci>
<ci>p_AP_CaL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CaEffU</ci>
<apply>
<plus/>
<ci>CaEffC</ci>
<apply>
<times/>
<ci>Cai</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>p_AP_CaL</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_UUCa_Ca</ci>
<apply>
<times/>
<ci>k_U_UCa</ci>
<ci>CaEffU</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_CCCa_Ca</ci>
<apply>
<times/>
<ci>k_C_CCa</ci>
<ci>CaEffC</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_U</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_C</ci>
<ci>k_C_U</ci>
</apply>
<apply>
<times/>
<ci>p_UCa</ci>
<ci>k_UCa_U</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_U</ci>
<apply>
<plus/>
<ci>k_UUCa_Ca</ci>
<ci>k_U_C</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_UCa</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_U</ci>
<ci>k_UUCa_Ca</ci>
</apply>
<apply>
<times/>
<ci>p_CCa</ci>
<ci>k_CCa_UCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_UCa</ci>
<apply>
<plus/>
<ci>k_UCa_CCa</ci>
<ci>k_UCa_U</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_C</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>p_CCa</ci>
<ci>k_CCa_C</ci>
</apply>
<apply>
<times/>
<ci>p_U</ci>
<ci>k_U_C</ci>
</apply>
</apply>
<apply>
<times/>
<ci>p_C</ci>
<apply>
<plus/>
<ci>k_C_U</ci>
<apply>
<times/>
<ci>k_C_CCa</ci>
<ci>Cacm</ci>
<ci>p_AP_CaL</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_CCa</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>p_C</ci>
</apply>
<ci>p_U</ci>
</apply>
<ci>p_UCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_UCa_U</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k_CCa_C</ci>
<ci>k_C_U</ci>
<ci>k_U_UCa</ci>
<ci>k_UCa_CCa</ci>
</apply>
<apply>
<times/>
<ci>k_U_C</ci>
<ci>k_C_CCa</ci>
<ci>k_CCa_UCa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_ultra_slow_gate">
<variable initial_value="0.9985266538252986" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">250000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">58</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1800</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14</cn>
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</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">66</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel">
<variable cmeta:id="T_type_Ca_channel_i_Ca_T" name="i_Ca_T" public_interface="out" units="picoA"/>
<variable initial_value="612" name="P_CaT" units="picoA_per_millimolar"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="CF_Ca" public_interface="in" units="millimolar"/>
<variable name="y1" private_interface="in" units="dimensionless"/>
<variable name="y2" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ca_T</ci>
<apply>
<times/>
<ci>P_CaT</ci>
<ci>CF_Ca</ci>
<ci>y1</ci>
<ci>y2</ci>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel_y1_gate">
<variable initial_value="1.6882718240109127e-5" name="y1" public_interface="out" units="dimensionless"/>
<variable name="alpha_y1" units="per_millisecond"/>
<variable name="beta_y1" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.019</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.6</cn>
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</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.82</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">250</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">40</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.3</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10000</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y1</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y1</ci>
<ci>y1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel_y2_gate">
<variable initial_value="0.8585352091865849" name="y2" public_interface="out" units="dimensionless"/>
<variable name="alpha_y2" units="per_millisecond"/>
<variable name="beta_y2" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y2</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">62000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.1</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">30</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3000</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y2</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0006</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.7</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y2</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y2</ci>
<ci>y2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="time_independent_potassium_current">
<variable cmeta:id="time_independent_potassium_current_i_K1" name="i_K1" public_interface="out" units="picoA"/>
<variable name="E_K" private_interface="out" public_interface="out" units="millivolt"/>
<variable name="g_K1" units="nanoS"/>
<variable initial_value="1.146" name="P_K1_0" units="nanoS_per_picoF"/>
<variable name="fO" private_interface="out" units="dimensionless"/>
<variable name="fO2" units="dimensionless"/>
<variable name="fO3" units="dimensionless"/>
<variable name="fO4" units="dimensionless"/>
<variable name="fB" units="dimensionless"/>
<variable name="mu" units="per_millisecond"/>
<variable name="lambda" units="per_millisecond"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="Ki" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="coulomb_millivolt_per_kelvin_millimole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<times/>
<ci>g_K1</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<apply>
<plus/>
<ci>fO4</ci>
<ci>fO3</ci>
<ci>fO2</ci>
</apply>
<ci>y</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>g_K1</ci>
<apply>
<times/>
<ci>P_K1_0</ci>
<ci>Cm</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fB</ci>
<apply>
<divide/>
<ci>mu</ci>
<apply>
<plus/>
<ci>mu</ci>
<ci>lambda</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fO</ci>
<apply>
<divide/>
<ci>lambda</ci>
<apply>
<plus/>
<ci>mu</ci>
<ci>lambda</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fO2</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<power/>
<ci>fO</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>fB</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fO3</ci>
<apply>
<times/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>fO</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>fB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fO4</ci>
<apply>
<power/>
<ci>fO</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>mu</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.75</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.035</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.015</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">140</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>lambda</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.048</cn>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.064</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">70</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="time_independent_potassium_current_y_gate">
<variable initial_value="0.6080573900752752" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="fO" public_interface="in" units="dimensionless"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8000</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">97</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8.5</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">97</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">300</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<ci>fO</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00014</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">97</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9.1</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">97</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">500</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_time_dependent_potassium_current">
<variable cmeta:id="rapid_time_dependent_potassium_current_i_Kr" name="i_Kr" public_interface="out" units="picoA"/>
<variable name="g_Kr" units="nanoS"/>
<variable initial_value="0.00864" name="P_Kr" units="nanoS_per_picoF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="E_K" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="y1" private_interface="in" units="dimensionless"/>
<variable name="y2" private_interface="in" units="dimensionless"/>
<variable name="y3" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<ci>g_Kr</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
<ci>y1</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4</cn>
<ci>y2</ci>
</apply>
</apply>
<ci>y3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>g_Kr</ci>
<apply>
<times/>
<ci>P_Kr</ci>
<ci>Cm</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_time_dependent_potassium_current_y1_gate">
<variable initial_value="0.0018339931180983765" name="y1" public_interface="out" units="dimensionless"/>
<variable name="alpha_y1" units="per_millisecond"/>
<variable name="beta_y1" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">20</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.5</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">300</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y1</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">160</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">200</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1000</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2500</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y1</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y1</ci>
<ci>y1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_time_dependent_potassium_current_y2_gate">
<variable initial_value="0.20443083454225305" name="y2" public_interface="out" units="dimensionless"/>
<variable name="alpha_y2" units="per_millisecond"/>
<variable name="beta_y2" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y2</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">200</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">20</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">300</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y2</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1600</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1000</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10000</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y2</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y2</ci>
<ci>y2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_time_dependent_potassium_current_y3_gate">
<variable initial_value="0.967887666264921" name="y3" public_interface="out" units="dimensionless"/>
<variable name="alpha_y3" units="per_millisecond"/>
<variable name="beta_y3" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y3</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">300</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y3</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.35</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">150</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y3</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y3</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y3</ci>
<ci>y3</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slow_time_dependent_potassium_current">
<variable cmeta:id="slow_time_dependent_potassium_current_i_Ks" name="i_Ks" public_interface="out" units="picoA"/>
<variable name="i_Ks_Na" public_interface="out" units="picoA"/>
<variable name="i_Ks_K" public_interface="out" units="picoA"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="Cai" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="CF_Na" public_interface="in" units="millimolar"/>
<variable name="y1" private_interface="in" units="dimensionless"/>
<variable name="y2" private_interface="in" units="dimensionless"/>
<variable initial_value="5.04" name="P_Ks_K" units="picoA_per_millimolar"/>
<variable initial_value="0.2016" name="P_Ks_Na" units="picoA_per_millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<plus/>
<ci>i_Ks_Na</ci>
<ci>i_Ks_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ks_K</ci>
<apply>
<times/>
<ci>P_Ks_K</ci>
<ci>CF_K</ci>
<apply>
<power/>
<ci>y1</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.9</cn>
<ci>y2</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ks_Na</ci>
<apply>
<times/>
<ci>P_Ks_Na</ci>
<ci>CF_Na</ci>
<apply>
<power/>
<ci>y1</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.9</cn>
<ci>y2</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slow_time_dependent_potassium_current_y1_gate">
<variable initial_value="0.09738789658609195" name="y1" public_interface="out" units="dimensionless"/>
<variable name="alpha_y1" units="per_millisecond"/>
<variable name="beta_y1" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">85</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.5</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">370</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">62</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1450</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">260</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y1</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y1</ci>
<ci>y1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slow_time_dependent_potassium_current_y2_gate">
<variable initial_value="0.09745345578743213" name="y2" public_interface="out" units="dimensionless"/>
<variable name="alpha_y2" units="per_millisecond"/>
<variable initial_value="0.004444" name="beta_y2" units="per_millisecond"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y2</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millimolar_millisecond">3.7</cn>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y2</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y2</ci>
<ci>y2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_current">
<variable cmeta:id="transient_outward_current_i_to" name="i_to" public_interface="out" units="picoA"/>
<variable name="i_to_Na" public_interface="out" units="picoA"/>
<variable name="i_to_K" public_interface="out" units="picoA"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="Vm" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="CF_Na" public_interface="in" units="millimolar"/>
<variable name="y1" private_interface="in" units="dimensionless"/>
<variable name="y2" private_interface="in" units="dimensionless"/>
<variable initial_value="0.033" name="P_to_K" units="picoA_per_millimolar"/>
<variable initial_value="0.00297" name="P_to_Na" units="picoA_per_millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_to</ci>
<apply>
<plus/>
<ci>i_to_Na</ci>
<ci>i_to_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_to_K</ci>
<apply>
<times/>
<ci>P_to_K</ci>
<ci>CF_K</ci>
<apply>
<power/>
<ci>y1</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>y2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_to_Na</ci>
<apply>
<times/>
<ci>P_to_Na</ci>
<ci>CF_Na</ci>
<apply>
<power/>
<ci>y1</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>y2</ci>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_current_y1_gate">
<variable initial_value="7.956883250874798e-4" name="y1" public_interface="out" units="dimensionless"/>
<variable name="alpha_y1" units="per_millisecond"/>
<variable name="beta_y1" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">11</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">400</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.4</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">500</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y1</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y1</ci>
<ci>y1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_current_y2_gate">
<variable initial_value="0.9999125083105881" name="y2" public_interface="out" units="dimensionless"/>
<variable name="alpha_y2" units="per_millisecond"/>
<variable name="beta_y2" units="per_millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y2</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0038</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.5</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.3</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.051335</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.5</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y2</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0038</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.5</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.3</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.067083</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.5</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y2</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y2</ci>
<ci>y2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="background_NSC_current">
<variable cmeta:id="background_NSC_current_i_bNSC" name="i_bNSC" public_interface="out" units="picoA"/>
<variable name="i_bNSC_Na" public_interface="out" units="picoA"/>
<variable name="i_bNSC_K" public_interface="out" units="picoA"/>
<variable initial_value="0.385" name="P_bNSC" units="picoA_per_millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="CF_Na" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_bNSC</ci>
<apply>
<plus/>
<ci>i_bNSC_K</ci>
<ci>i_bNSC_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_bNSC_K</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4</cn>
<ci>P_bNSC</ci>
<ci>CF_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_bNSC_Na</ci>
<apply>
<times/>
<ci>P_bNSC</ci>
<ci>CF_Na</ci>
</apply>
</apply>
</math>
</component>
<component name="background_Kpl_current">
<variable cmeta:id="background_Kpl_current_i_Kpl" name="i_Kpl" public_interface="out" units="picoA"/>
<variable name="P_Kpl" units="nanoS_per_millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kpl</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>P_Kpl</ci>
<ci>CF_K</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.0077</cn>
</apply>
<apply>
<eq/>
<ci>Vm</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<ci>P_Kpl</ci>
<ci>CF_K</ci>
<apply>
<plus/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3</cn>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Vm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>P_Kpl</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoS_per_millimolar">0.00011</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.16</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="background_lCa_current">
<variable name="i_lCa" public_interface="out" units="picoA"/>
<variable name="i_lCa_Na" public_interface="out" units="picoA"/>
<variable name="i_lCa_K" public_interface="out" units="picoA"/>
<variable initial_value="0.11" name="P_lCa" units="picoA_per_millimolar"/>
<variable name="p_open" units="dimensionless"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="CF_K" public_interface="in" units="millimolar"/>
<variable name="CF_Na" public_interface="in" units="millimolar"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_lCa</ci>
<apply>
<plus/>
<ci>i_lCa_K</ci>
<ci>i_lCa_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_lCa_K</ci>
<apply>
<times/>
<ci>P_lCa</ci>
<ci>CF_K</ci>
<ci>p_open</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_lCa_Na</ci>
<apply>
<times/>
<ci>P_lCa</ci>
<ci>CF_Na</ci>
<ci>p_open</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_open</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0012</cn>
<ci>Cai</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="background_KATP_current">
<variable cmeta:id="background_KATP_current_i_KATP" name="i_KATP" public_interface="out" units="picoA"/>
<variable name="p_open" units="dimensionless"/>
<variable name="gamma" units="nanoS"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="ATPi" public_interface="in" units="millimolar"/>
<variable initial_value="0.0236" name="P_KATP" units="nanoS_per_picoF"/>
<variable initial_value="2333" name="N" units="picoF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_KATP</ci>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<ci>p_open</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<times/>
<ci>P_KATP</ci>
<ci>N</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.24</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_open</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>ATPi</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="background_Cab_current">
<variable cmeta:id="background_Cab_current_i_Cab" name="i_Cab" public_interface="out" units="picoA"/>
<variable initial_value="0.04" name="P_Cab" units="picoA_per_millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="CF_Ca" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Cab</ci>
<apply>
<times/>
<ci>P_Cab</ci>
<ci>CF_Ca</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_calcium_exchanger">
<variable cmeta:id="sodium_calcium_exchanger_i_NaCa" name="i_NaCa" public_interface="out" units="picoA"/>
<variable name="p_E2Na" private_interface="out" units="dimensionless"/>
<variable name="p_E1Na" private_interface="out" units="dimensionless"/>
<variable name="p_E1Ca" private_interface="out" units="dimensionless"/>
<variable name="p_E2Ca" private_interface="out" units="dimensionless"/>
<variable name="k1" private_interface="out" units="per_millisecond"/>
<variable name="k2" private_interface="out" units="per_millisecond"/>
<variable initial_value="1" name="k3" private_interface="out" units="per_millisecond"/>
<variable initial_value="1" name="k4" private_interface="out" units="per_millisecond"/>
<variable initial_value="8.75" name="Km_Nai" units="millimolar"/>
<variable initial_value="87.5" name="Km_Nao" units="millimolar"/>
<variable initial_value="0.00138" name="Km_Cai" units="millimolar"/>
<variable initial_value="1.38" name="Km_Cao" units="millimolar"/>
<variable name="Nai" public_interface="in" units="millimolar"/>
<variable name="Nao" public_interface="in" units="millimolar"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="Cao" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="coulomb_millivolt_per_kelvin_millimole"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<variable initial_value="6.81" name="P_NaCa" units="picoA_per_picoF"/>
<variable initial_value="0.32" name="Partition" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<times/>
<ci>P_NaCa</ci>
<ci>Cm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>k1</ci>
<ci>p_E1Na</ci>
<ci>y</ci>
</apply>
<apply>
<times/>
<ci>k2</ci>
<ci>p_E2Na</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E1Na</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nai</ci>
<ci>Nai</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Km_Cai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E2Na</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nao</ci>
<ci>Nao</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Km_Cao</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E1Ca</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Km_Cai</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>Km_Nai</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E2Ca</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Km_Cao</ci>
<ci>Cao</ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Km_Nao</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k1</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Partition</ci>
<ci>F</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k2</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Partition</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<ci>F</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_calcium_exchanger_y_gate">
<variable initial_value="0.9891789193465331" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="p_E1Na" public_interface="in" units="dimensionless"/>
<variable name="p_E2Na" public_interface="in" units="dimensionless"/>
<variable name="p_E1Ca" public_interface="in" units="dimensionless"/>
<variable name="p_E2Ca" public_interface="in" units="dimensionless"/>
<variable name="k1" public_interface="in" units="per_millisecond"/>
<variable name="k2" public_interface="in" units="per_millisecond"/>
<variable name="k3" public_interface="in" units="per_millisecond"/>
<variable name="k4" public_interface="in" units="per_millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k2</ci>
<ci>p_E2Na</ci>
</apply>
<apply>
<times/>
<ci>k4</ci>
<ci>p_E2Ca</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k1</ci>
<ci>p_E1Na</ci>
</apply>
<apply>
<times/>
<ci>k3</ci>
<ci>p_E1Ca</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump">
<variable cmeta:id="sodium_potassium_pump_i_NaK" name="i_NaK" public_interface="out" units="picoA"/>
<variable name="p_E2Na" private_interface="out" units="dimensionless"/>
<variable name="p_E1Na" private_interface="out" units="dimensionless"/>
<variable name="p_E1K" private_interface="out" units="dimensionless"/>
<variable name="p_E2K" private_interface="out" units="dimensionless"/>
<variable name="k1" private_interface="out" units="per_millisecond"/>
<variable initial_value="0.04" name="k2" private_interface="out" units="per_millisecond"/>
<variable initial_value="0.01" name="k3" private_interface="out" units="per_millisecond"/>
<variable initial_value="0.165" name="k4" private_interface="out" units="per_millisecond"/>
<variable initial_value="4.05" name="Km_Nai" units="millimolar"/>
<variable initial_value="69.8" name="Km_Nao" units="millimolar"/>
<variable initial_value="32.88" name="Km_Ki" units="millimolar"/>
<variable initial_value="0.258" name="Km_Ko" units="millimolar"/>
<variable initial_value="0.094" name="Km_ATP" units="millimolar"/>
<variable name="Nao_Eff" units="millimolar"/>
<variable name="ATPi" public_interface="in" units="millimolar"/>
<variable name="Nai" public_interface="in" units="millimolar"/>
<variable name="Nao" public_interface="in" units="millimolar"/>
<variable name="Ki" public_interface="in" units="millimolar"/>
<variable name="Ko" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="coulomb_millivolt_per_kelvin_millimole"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="Vm" public_interface="in" units="millivolt"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<variable initial_value="21" name="P_NaK" units="picoA_per_picoF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<times/>
<ci>P_NaK</ci>
<ci>Cm</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>k1</ci>
<ci>p_E1Na</ci>
<ci>y</ci>
</apply>
<apply>
<times/>
<ci>k2</ci>
<ci>p_E2Na</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E1Na</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nai</ci>
<ci>Nai</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Ki</ci>
<ci>Km_Ki</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E2Na</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nao</ci>
<ci>Nao_Eff</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Km_Ko</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E1K</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Ki</ci>
<ci>Ki</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>Km_Nai</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E2K</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Ko</ci>
<ci>Ko</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.12</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Nao_Eff</ci>
<ci>Km_Nao</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.06</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k1</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.37</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Km_ATP</ci>
<ci>ATPi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Nao_Eff</ci>
<apply>
<times/>
<ci>Nao</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.82</cn>
</apply>
<ci>F</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump_y_gate">
<variable initial_value="0.5910747147428818" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="p_E1Na" public_interface="in" units="dimensionless"/>
<variable name="p_E2Na" public_interface="in" units="dimensionless"/>
<variable name="p_E1K" public_interface="in" units="dimensionless"/>
<variable name="p_E2K" public_interface="in" units="dimensionless"/>
<variable name="k1" public_interface="in" units="per_millisecond"/>
<variable name="k2" public_interface="in" units="per_millisecond"/>
<variable name="k3" public_interface="in" units="per_millisecond"/>
<variable name="k4" public_interface="in" units="per_millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k2</ci>
<ci>p_E2Na</ci>
</apply>
<apply>
<times/>
<ci>k4</ci>
<ci>p_E2K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k1</ci>
<ci>p_E1Na</ci>
</apply>
<apply>
<times/>
<ci>k3</ci>
<ci>p_E1K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SR_calcium_pump">
<variable name="i_SR_U" public_interface="out" units="picoA"/>
<variable name="p_E2Ca" private_interface="out" units="dimensionless"/>
<variable name="p_E1Ca" private_interface="out" units="dimensionless"/>
<variable name="p_E1" private_interface="out" units="dimensionless"/>
<variable name="p_E2" private_interface="out" units="dimensionless"/>
<variable initial_value="0.01" name="k1" private_interface="out" units="per_millisecond"/>
<variable name="k2" private_interface="out" units="per_millisecond"/>
<variable initial_value="1" name="k3" private_interface="out" units="per_millisecond"/>
<variable initial_value="0.01" name="k4" private_interface="out" units="per_millisecond"/>
<variable initial_value="0.08" name="Km_CaSR" units="millimolar"/>
<variable initial_value="0.0008" name="Km_CaCyto" units="millimolar"/>
<variable initial_value="0.1" name="Km_ATP" units="millimolar"/>
<variable initial_value="162500" name="i_max" units="picoA"/>
<variable name="ATPi" public_interface="in" units="millimolar"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="Caup" public_interface="in" units="millimolar"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_SR_U</ci>
<apply>
<times/>
<ci>i_max</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>k1</ci>
<ci>p_E1Ca</ci>
<ci>y</ci>
</apply>
<apply>
<times/>
<ci>k2</ci>
<ci>p_E2Ca</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E1Ca</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Km_CaSR</ci>
<ci>Caup</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E2Ca</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Km_CaCyto</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E1</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>p_E1Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>p_E2</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>p_E2Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k2</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Km_ATP</ci>
<ci>ATPi</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SR_calcium_pump_y_gate">
<variable initial_value="0.46108441538480216" name="y" public_interface="out" units="dimensionless"/>
<variable name="alpha_y" units="per_millisecond"/>
<variable name="beta_y" units="per_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="p_E1Ca" public_interface="in" units="dimensionless"/>
<variable name="p_E2Ca" public_interface="in" units="dimensionless"/>
<variable name="p_E1" public_interface="in" units="dimensionless"/>
<variable name="p_E2" public_interface="in" units="dimensionless"/>
<variable name="k1" public_interface="in" units="per_millisecond"/>
<variable name="k2" public_interface="in" units="per_millisecond"/>
<variable name="k3" public_interface="in" units="per_millisecond"/>
<variable name="k4" public_interface="in" units="per_millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_y</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k2</ci>
<ci>p_E2Ca</ci>
</apply>
<apply>
<times/>
<ci>k4</ci>
<ci>p_E2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k1</ci>
<ci>p_E1Ca</ci>
</apply>
<apply>
<times/>
<ci>k3</ci>
<ci>p_E1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="RyR_channel">
<variable name="i_RyR" public_interface="out" units="picoA"/>
<variable initial_value="62000" name="P_RyR" units="picoA_per_millimolar"/>
<variable name="k1" units="per_millisecond"/>
<variable name="k2" units="per_millisecond"/>
<variable name="k3" units="per_millisecond"/>
<variable initial_value="0.000849" name="k4" units="per_millisecond"/>
<variable initial_value="3.4314360001543243e-4" name="p_open_RyR" units="dimensionless"/>
<variable initial_value="0.19135178123107768" name="p_close_RyR" units="dimensionless"/>
<variable name="p_open_CaL" public_interface="in" units="dimensionless"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="Carel" public_interface="in" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable initial_value="-150" name="Diadid_Factor" units="per_picoA_millisecond"/>
<variable name="CaDiadic" public_interface="in" units="picoA"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_RyR</ci>
<apply>
<times/>
<ci>P_RyR</ci>
<apply>
<minus/>
<ci>Carel</ci>
<ci>Cai</ci>
</apply>
<ci>p_open_RyR</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_open_RyR</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>p_close_RyR</ci>
<ci>k1</ci>
</apply>
<apply>
<times/>
<ci>p_open_RyR</ci>
<ci>k2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>p_close_RyR</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k3</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>p_open_RyR</ci>
<ci>p_close_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>k1</ci>
<ci>k4</ci>
</apply>
<ci>p_close_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k1</ci>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">280000</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>Diadid_Factor</ci>
<ci>CaDiadic</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k2</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.08</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.36</cn>
<ci>Carel</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k3</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.000377</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Carel</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SR_T_current">
<variable name="i_SR_T" public_interface="out" units="picoA"/>
<variable initial_value="386" name="P_SR_T" units="picoA_per_millimolar"/>
<variable name="Carel" public_interface="in" units="millimolar"/>
<variable name="Caup" public_interface="in" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_SR_T</ci>
<apply>
<times/>
<ci>P_SR_T</ci>
<apply>
<minus/>
<ci>Caup</ci>
<ci>Carel</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SR_L_current">
<variable name="i_SR_L" public_interface="out" units="picoA"/>
<variable initial_value="459" name="P_SR_L" units="picoA_per_millimolar"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="Caup" public_interface="in" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_SR_L</ci>
<apply>
<times/>
<ci>P_SR_L</ci>
<apply>
<minus/>
<ci>Caup</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_concentrations_in_SR">
<variable initial_value="9.455741736977666" name="Ca_Total" units="millimolar"/>
<variable cmeta:id="Ca_concentrations_in_SR_Carel" name="Carel" public_interface="out" units="millimolar"/>
<variable cmeta:id="Ca_concentrations_in_SR_Caup" initial_value="2.611712901567567" name="Caup" public_interface="out" units="millimolar"/>
<variable cmeta:id="Ca_concentrations_in_SR_V_rel" initial_value="160" name="V_rel" units="micrometre3"/>
<variable cmeta:id="Ca_concentrations_in_SR_V_up" initial_value="400" name="V_up" units="micrometre3"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="i_SR_L" public_interface="in" units="picoA"/>
<variable name="i_SR_T" public_interface="in" units="picoA"/>
<variable name="i_RyR" public_interface="in" units="picoA"/>
<variable name="i_SR_U" public_interface="in" units="picoA"/>
<variable initial_value="10" name="CSQN_max" units="millimolar"/>
<variable initial_value="0.8" name="K_mCSQN" units="millimolar"/>
<variable name="b1" units="millimolar"/>
<variable name="c1" units="millimolar2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>b1</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>CSQN_max</ci>
<ci>Ca_Total</ci>
</apply>
<ci>K_mCSQN</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>c1</ci>
<apply>
<times/>
<ci>K_mCSQN</ci>
<ci>Ca_Total</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Carel</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<root/>
<apply>
<plus/>
<apply>
<power/>
<ci>b1</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>c1</ci>
</apply>
</apply>
</apply>
<ci>b1</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Total</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>i_SR_T</ci>
<ci>i_RyR</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>V_rel</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Caup</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>i_SR_U</ci>
</apply>
<ci>i_SR_T</ci>
</apply>
<ci>i_SR_L</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>V_up</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="NL_model">
<variable name="dCaidt" public_interface="out" units="millimolar_per_millisecond"/>
<variable name="dATPdt" public_interface="out" units="millimolar_per_millisecond"/>
<variable name="EffFraction" units="dimensionless"/>
<variable initial_value="0.02490898775497523" name="pCa" units="dimensionless"/>
<variable initial_value="0.001990153835322864" name="pCaCB" units="dimensionless"/>
<variable initial_value="4.2941813853474524e-4" name="pCB" units="dimensionless"/>
<variable name="p" units="dimensionless"/>
<variable initial_value="0.07" name="T_t" units="millimolar"/>
<variable name="Q_a" units="per_millisecond"/>
<variable name="Q_b" units="per_millisecond"/>
<variable name="Q_r" units="per_millisecond"/>
<variable name="Q_d" units="per_millisecond"/>
<variable name="Q_d1" units="per_millisecond"/>
<variable name="Q_d2" units="per_millisecond"/>
<variable initial_value="39" name="Y_1" units="per_millimolar_millisecond"/>
<variable initial_value="0.0039" name="Y_2" units="per_millisecond"/>
<variable initial_value="0.03" name="Y_3" units="per_millisecond"/>
<variable initial_value="0.12" name="Y_4" units="per_millisecond"/>
<variable initial_value="0.027" name="Y_d" units="millisecond_per_micrometre2"/>
<variable initial_value="0.03" name="Z_1" units="per_millisecond"/>
<variable initial_value="0.0039" name="Z_2" units="per_millisecond"/>
<variable initial_value="1560" name="Z_3" units="per_millimolar_millisecond"/>
<variable name="h" units="micrometre"/>
<variable initial_value="1.17" name="L_a" units="micrometre"/>
<variable initial_value="0.9623799975411884" name="L" units="micrometre"/>
<variable name="ForceCB" units="mN_per_mm2"/>
<variable initial_value="0.9573749975411884" name="X" units="micrometre"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Cai" public_interface="in" units="millimolar"/>
<variable name="NewCBF" units="mN_per_mm2_micrometre"/>
<variable name="CBBound" units="millimolar"/>
<variable initial_value="140000" name="KForceEC" units="mN_per_mm2_micrometre5"/>
<variable initial_value="0.97" name="ZeroForceEL" units="micrometre"/>
<variable initial_value="200" name="KForceLinearEc" units="mN_per_mm2_micrometre"/>
<variable initial_value="1800000" name="ForceFactor" units="mN_per_mm2_micrometre_millimolar"/>
<variable name="ForceEcomp" units="mN_per_mm2"/>
<variable initial_value="1.2" name="B" units="per_millisecond"/>
<variable initial_value="0.005" name="h_c" units="micrometre"/>
<variable name="ForceExt" units="mN_per_mm2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>h</ci>
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<minus/>
<ci>L</ci>
<ci>X</ci>
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</apply>
<apply>
<eq/>
<ci>p</ci>
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<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>pCa</ci>
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<ci>pCaCB</ci>
</apply>
<ci>pCB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_b</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Y_1</ci>
<ci>Cai</ci>
<ci>p</ci>
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<apply>
<times/>
<ci>Z_1</ci>
<ci>pCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>EffFraction</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_micrometre2">20</cn>
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<apply>
<power/>
<apply>
<minus/>
<ci>L</ci>
<ci>L_a</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_a</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Y_2</ci>
<ci>pCa</ci>
<ci>EffFraction</ci>
</apply>
<apply>
<times/>
<ci>Z_2</ci>
<ci>pCaCB</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_r</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Y_3</ci>
<ci>pCaCB</ci>
</apply>
<apply>
<times/>
<ci>Z_3</ci>
<ci>pCB</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_d</ci>
<apply>
<times/>
<ci>Y_4</ci>
<ci>pCB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_d1</ci>
<apply>
<times/>
<ci>Y_d</ci>
<apply>
<power/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>pCB</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_d2</ci>
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<times/>
<ci>Y_d</ci>
<apply>
<power/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>pCaCB</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>pCa</ci>
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<apply>
<minus/>
<ci>Q_b</ci>
<ci>Q_a</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>pCaCB</ci>
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<apply>
<minus/>
<apply>
<minus/>
<ci>Q_a</ci>
<ci>Q_r</ci>
</apply>
<ci>Q_d2</ci>
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</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>pCB</ci>
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<apply>
<minus/>
<apply>
<minus/>
<ci>Q_r</ci>
<ci>Q_d</ci>
</apply>
<ci>Q_d1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dCaidt</ci>
<apply>
<times/>
<ci>T_t</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>Q_d2</ci>
<ci>Q_r</ci>
</apply>
<ci>Q_b</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dATPdt</ci>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.4</cn>
</apply>
<ci>pCaCB</ci>
<ci>T_t</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CBBound</ci>
<apply>
<times/>
<ci>T_t</ci>
<apply>
<plus/>
<ci>pCaCB</ci>
<ci>pCB</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NewCBF</ci>
<apply>
<times/>
<ci>ForceFactor</ci>
<ci>CBBound</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ForceEcomp</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>KForceEC</ci>
<apply>
<power/>
<apply>
<minus/>
<ci>ZeroForceEL</ci>
<ci>L</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
</apply>
</apply>
<apply>
<times/>
<ci>KForceLinearEc</ci>
<apply>
<minus/>
<ci>ZeroForceEL</ci>
<ci>L</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ForceCB</ci>
<apply>
<times/>
<ci>NewCBF</ci>
<ci>h</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ForceExt</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>ForceEcomp</ci>
</apply>
<ci>ForceCB</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X</ci>
</apply>
<apply>
<times/>
<ci>B</ci>
<apply>
<minus/>
<ci>h</ci>
<ci>h_c</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="internal_concentrations"/>
<component name="intracellular_currents"/>
<component name="transmembrane_currents"/>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="internal_concentrations">
<component_ref component="internal_ion_concentrations"/>
<component_ref component="Ca_concentrations_in_SR"/>
<component_ref component="constant_field_equations"/>
<component_ref component="ATP_production"/>
<component_ref component="NL_model"/>
</component_ref>
<component_ref component="transmembrane_currents">
<component_ref component="sodium_current">
<component_ref component="sodium_current_voltage_dependent_gate"/>
<component_ref component="sodium_current_ultra_slow_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_voltage_dependent_gate"/>
<component_ref component="L_type_Ca_channel_Ca_dependent_gate"/>
<component_ref component="L_type_Ca_channel_ultra_slow_gate"/>
</component_ref>
<component_ref component="T_type_Ca_channel">
<component_ref component="T_type_Ca_channel_y1_gate"/>
<component_ref component="T_type_Ca_channel_y2_gate"/>
</component_ref>
<component_ref component="time_independent_potassium_current">
<component_ref component="time_independent_potassium_current_y_gate"/>
</component_ref>
<component_ref component="rapid_time_dependent_potassium_current">
<component_ref component="rapid_time_dependent_potassium_current_y1_gate"/>
<component_ref component="rapid_time_dependent_potassium_current_y2_gate"/>
<component_ref component="rapid_time_dependent_potassium_current_y3_gate"/>
</component_ref>
<component_ref component="slow_time_dependent_potassium_current">
<component_ref component="slow_time_dependent_potassium_current_y1_gate"/>
<component_ref component="slow_time_dependent_potassium_current_y2_gate"/>
</component_ref>
<component_ref component="transient_outward_current">
<component_ref component="transient_outward_current_y1_gate"/>
<component_ref component="transient_outward_current_y2_gate"/>
</component_ref>
<component_ref component="background_NSC_current"/>
<component_ref component="background_Kpl_current"/>
<component_ref component="background_lCa_current"/>
<component_ref component="background_Cab_current"/>
<component_ref component="background_KATP_current"/>
<component_ref component="sodium_calcium_exchanger">
<component_ref component="sodium_calcium_exchanger_y_gate"/>
</component_ref>
<component_ref component="sodium_potassium_pump">
<component_ref component="sodium_potassium_pump_y_gate"/>
</component_ref>
</component_ref>
<component_ref component="intracellular_currents">
<component_ref component="SR_calcium_pump">
<component_ref component="SR_calcium_pump_y_gate"/>
</component_ref>
<component_ref component="RyR_channel"/>
<component_ref component="SR_T_current"/>
<component_ref component="SR_L_current"/>
</component_ref>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="sodium_current">
<component_ref component="sodium_current_voltage_dependent_gate"/>
<component_ref component="sodium_current_ultra_slow_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_voltage_dependent_gate"/>
<component_ref component="L_type_Ca_channel_Ca_dependent_gate"/>
<component_ref component="L_type_Ca_channel_ultra_slow_gate"/>
</component_ref>
<component_ref component="T_type_Ca_channel">
<component_ref component="T_type_Ca_channel_y1_gate"/>
<component_ref component="T_type_Ca_channel_y2_gate"/>
</component_ref>
<component_ref component="time_independent_potassium_current">
<component_ref component="time_independent_potassium_current_y_gate"/>
</component_ref>
<component_ref component="rapid_time_dependent_potassium_current">
<component_ref component="rapid_time_dependent_potassium_current_y1_gate"/>
<component_ref component="rapid_time_dependent_potassium_current_y2_gate"/>
<component_ref component="rapid_time_dependent_potassium_current_y3_gate"/>
</component_ref>
<component_ref component="slow_time_dependent_potassium_current">
<component_ref component="slow_time_dependent_potassium_current_y1_gate"/>
<component_ref component="slow_time_dependent_potassium_current_y2_gate"/>
</component_ref>
<component_ref component="transient_outward_current">
<component_ref component="transient_outward_current_y1_gate"/>
<component_ref component="transient_outward_current_y2_gate"/>
</component_ref>
<component_ref component="sodium_calcium_exchanger">
<component_ref component="sodium_calcium_exchanger_y_gate"/>
</component_ref>
<component_ref component="sodium_potassium_pump">
<component_ref component="sodium_potassium_pump_y_gate"/>
</component_ref>
<component_ref component="SR_calcium_pump">
<component_ref component="SR_calcium_pump_y_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ATP_production" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="T_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="SR_T_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="SR_L_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="rapid_time_dependent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="slow_time_dependent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="transient_outward_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="background_NSC_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="background_Kpl_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="background_lCa_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="background_KATP_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="background_Cab_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_calcium_exchanger" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="SR_calcium_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="RyR_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_concentrations_in_SR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="NL_model" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="internal_ion_concentrations"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_ext" variable_2="i_ext"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="constant_field_equations"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ATP_production"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_current"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_Ca_channel"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="T_type_Ca_channel"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_potassium_current"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="rapid_time_dependent_potassium_current"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="slow_time_dependent_potassium_current"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="transient_outward_current"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_to" variable_2="i_to"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_NSC_current"/>
<map_variables variable_1="i_bNSC" variable_2="i_bNSC"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_Kpl_current"/>
<map_variables variable_1="i_Kpl" variable_2="i_Kpl"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_lCa_current"/>
<map_variables variable_1="i_lCa" variable_2="i_lCa"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_KATP_current"/>
<map_variables variable_1="i_KATP" variable_2="i_KATP"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_Cab_current"/>
<map_variables variable_1="i_Cab" variable_2="i_Cab"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_calcium_exchanger"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Ca_concentrations_in_SR"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="constant_field_equations"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="NL_model"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="dCaidt_NL" variable_2="dCaidt"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="constant_field_equations"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="time_independent_potassium_current"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="rapid_time_dependent_potassium_current"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="background_Kpl_current"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="background_KATP_current"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="background_lCa_current"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_lCa_Na" variable_2="i_lCa_Na"/>
<map_variables variable_1="i_lCa_K" variable_2="i_lCa_K"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="sodium_calcium_exchanger"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="sodium_calcium_exchanger"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="sodium_potassium_pump"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="external_ion_concentrations" component_2="sodium_potassium_pump"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="SR_calcium_pump"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_SR_U" variable_2="i_SR_U"/>
</connection>
<connection>
<map_components component_1="internal_ion_concentrations" component_2="RyR_channel"/>
<map_variables variable_1="i_RyR" variable_2="i_RyR"/>
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<rdf:value>This model has been curated by Penny Noble and is known to run in PCEnv and COR and reproduce the published results. </rdf:value>
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<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2008-02-25T11:29:40+13:00</dcterms:W3CDTF>
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<rdf:value>Removed initial value for variable Vm_old, removing model overconstraint problem in PCEnv.</rdf:value>
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<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">J</vCard:Other>
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<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Shinobu</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Kuratomi</vCard:Family>
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<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-10-23T00:00:00+00:00</dcterms:W3CDTF>
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<rdf:Description rdf:about="rdf:#$CGvhb2">
<ns7:endingValue xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">2000</ns7:endingValue>
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</rdf:value>
</dc:subject>
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<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Kyoichi</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Ono</vCard:Family>
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