Quantitive Analysis of Mitochondrial Ca2+ Uptake and Release Pathways in Sympathetic Neurons Reconstruction of the Recovery after Depolarisation-evoked [Ca2+] Elevations

Model Status

This model can not be solved as it is unsuitably constrained.

ValidateCellML verifies this model as valid CellML with consistent units.

Model Structure

One of the central goals in the study of calcium signalling is to understand the basis of [Ca²⁺] dynamics. This is complicated by the fact that Ca²⁺ is present in several membrane-bound intracellular compartments, each of which uses a distinct Ca²⁺ transport system and the rate of Ca²⁺ transport between these compartments can exhibit a complex non-linear dependence on free [Ca²⁺].

In their 2000 model, Stephen L. Colegrove, Meredith A. Albrecht and David D. Friel have studied how mitochondrial Ca²⁺ transport contributes to the redistribution of intracellular Ca²⁺ during and after depolarisation-evoked Ca²⁺ entry in sympathetic neurons. The total Ca²⁺ flux during the recovery phase following membrane depolarisation was divided into three components (see the figure below): one representing net Ca²⁺ extrusion across the plasma membrane (J_extru), one representing mitochondrial Ca²⁺ uptake via the uniporter (J_uni) and one representing mitochondrial Ca²⁺ release via the Na⁺/Ca²⁺ exchanger (J_NaCa). This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in .

The complete original paper reference is cited below:

Quantitative Analysis of Mitochondrial Ca²⁺ Uptake and Release Pathways in Sympathetic Neurons Reconstruction of the Recovery after Depolarisation-evoked [Ca²⁺] Elevations , Stephen L. Colegrove, Meredith A. Albrecht and David D. Friel, 2000, The Journal Of General Physiology , 115, 371-388. PubMed ID: 10694264

Schematic of the model indicating Ca2+ compartmentalization in the extracellular matrix, cytosol and the mitochondrial matrix and pathways for Ca2+ ion movement between the compartments.