Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons

Model Status

This model runs in both OpenCell and COR and the units are consistent. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.

Model Structure

Abstract: We develop a mechanistic mathematical model of the G-protein coupled signaling pathway responsible for generating current responses in frog olfactory receptor neurons. The model incorporates descriptions of ligand-receptor interaction, intracellular transduction events involving the second messenger cAMP, effector ion-channel activity, and calcium-mediated feedback steps. We parameterized the model with respect to suction pipette current recordings from single cells stimulated with multiple odor concentrations. The proposed model accurately predicts the receptor-current response of the neuron to brief and prolonged odorant exposure and is able to produce the adaptation observed under repeated or sustained stimulation.

Schematic diagram of the Dougherty et al model.

The complete original paper reference is cited below:

Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons, Daniel P. Dougherty, Geraldine A. Wright, Alice C. Yew, 2005, Proceeding of the National Academy of Sciences , 102, 10415- 10420. PubMed ID: 16027364